Researchers sequenced the rock pigeon genome, revealing its evolutionary secrets and genetic diversity. The study found that major breed groups originated in the Middle East and that a specific gene controls the development of head crests.
A global research team has completed high-quality sequencing of 90 chickpea genomes, revealing clues on how to improve crop resilience. The study provides a map of the genes that define the chickpea plant, potentially leading to improved varieties with enhanced drought tolerance and disease resistance.
The completed genome sequencing of DBM provides insights into insect adaptation to host plants and opens new ways for more sustainable pest management. The study identified gene families involved in detoxification, including ABC transporters, P450 monooxygenases, glutathione S-transferases, and carboxylesterase.
The first genomic sequence of Chinese plum (Prunus mume) has been completed, providing a valuable resource for improving fruit trees. The genome sequence reveals important genetic information for understanding the evolution and diversity of Rosaceae family.
The completed goat genome provides a valuable reference for identifying SNP markers for breeding and improving biomedical models. The study also reveals the molecular mechanisms of cashmere formation and development, with implications for improving quality and quantity.
Researchers sequenced the genomes of two bat species to understand genetic mechanisms underlying flight and immunity. The study found unique changes in genes related to DNA damage repair and innate immune system, which may have evolved to minimize negative effects of reactive oxygen species generated during flight.
Researchers discovered rare genetic variants in genes related to blood pressure regulation also influence sensitivity to pain. The study suggests existing blood pressure treatments could be used to control chronic pain, offering a new approach to pain relief.
Researchers found a significant association between regional hypermutability and autism in monozygotic twins. The study also discovered that paternal age accounts for a substantial portion of variability in mutation rates, while maternal age has no significant effect.
Researchers reconstructed giant panda's continuous population history from origin to present, revealing global climate change as primary driver of fluctuations. Human activities likely underlie recent population divergence and decline, with local adaptations identified in sensory system genes.
The study provides a high-quality genome sequence of an East-Asia watermelon cultivar and resequencing of 20 watermelon accessions, shedding light on the molecular basis of disease resistance and evolutionary history. The results reveal clusters of resistance genes and tandem duplications as potential evolutionary bases for these traits.
The pear genome sequence offers a valuable resource for breeding improvement and studying evolutionary history, with similarities to apple and strawberry genomes. The sequence reveals diverse genetic information, including repetitive sequences and transposable elements, shedding light on the crop's unique characteristics.
The 1000 Genomes Project Consortium has successfully constructed an integrated map of genetic variation from 1,092 human genomes, capturing up to 98% of variants at 1% frequency. BGI contributed sequencing and bioinformatics expertise to the project, providing powerful approaches for researchers to conduct disease studies.
Researchers identify 60,000 T2D-associated metagenomic markers in Chinese patients and develop a new classification system using metagenomic linkage groups. Healthy individuals have higher butyrate-producing bacteria, while T2D patients show an increase in opportunistic pathogens.
Researchers sequenced and assembled the Pacific oyster genome, uncovering extensive genes that enable oysters to adapt to environmental stresses. The study also revealed a complex mechanism for shell formation, with diverse proteins playing important roles in matrix construction and modification.
A Chinese research team found strong genetic evidence linking mevalonate kinase gene (MVK) mutations to disseminated superficial actinic porokeratosis (DSAP), a rare skin disorder. MVK mutations were not detected in other clinical subtypes of Porokeratosis, suggesting they may be specific to DSAP patients.
The genome sequence of diploid cotton (Gossypium raimondii) has been completed, providing a valuable resource for studying cotton quality and output. The study reveals insights into the genetic characteristics and evolutionary mechanisms underlying cotton, with potential applications in improving its fiber production.
Researchers mapped ant genomes to reveal relationship between epigenetic regulation and caste differentiation. DNA methylation patterns correlated with alternative splicing events and caste-specific genes.
The medium ground finch's genome has been sequenced, allowing researchers to study the genetics of trait evolution and vocal learning. The data also have implications for conservation efforts and will aid in population studies.
Researchers identified NMNAT1 mutations as a cause of Leber congenital amaurosis, a leading cause of inherited blindness in children. The study provides important evidence for gene therapy targeting NMNAT1.
Researchers sequenced the salt cress genome, identifying genes that contribute to its high salt tolerance. The study sheds light on the genetic characteristics underlying plant stress tolerance, with potential applications for agricultural crop improvement.
The yak genome provides new insights into high-altitude adaptation, with distinct gene expansions related to sensory perception and energy metabolism. The study also identified genes that may play important roles in regulating body response to hypoxia and optimizing energy from poor foods.
The symposium brought together experts to exchange insights on high-throughput genomics and accelerate cancer research development. NGS technologies, particularly single-cell sequencing, were highlighted as enabling new levels of cancer studies.
Maize's impressive genetic diversity was comprehensively characterized, revealing over 55 million SNPs across 103 inbred lines. The studies also found that SVs were associated with important agronomic traits and influenced genome size variations.
A whole-genome sequencing study found that HBV integration is a common event in liver tumors, associated with tumor size, serum HBsAg levels, and α-fetoprotein. The study identified three novel genes linked to recurrent HBV integrations, which may lead to targeted therapies for liver cancer.
Researchers from Sichuan Agricultural University and BGI reported the atlas of DNA methylomes in porcine adipose and muscle tissues, providing a valuable epigenomic source for obesity prediction and prevention. The study found that different methylated regions in promoters play a more important role in regulating gene expression and ar...
The BGI has completed the genome sequence of foxtail millet, a crop with significant potential for improving yield and stress tolerance. The study provides valuable resources for genetic improvement and functional gene studies at a genome-wide level.
BGI's single-cell sequencing technology enables researchers to analyze genetic characteristics of essential thrombocythemia and clear cell renal cell carcinoma. The method provides clearer intratumoral genetic pictures and developmental history than previous bulk tissue sequencing, opening new ways for the genetic study of tumors.
Researchers identified 22,688 RNA editing events, with most converting adenosine to inosine. The study suggests a potential connection between RNA editing and miRNA-mediated regulation.
Researchers identified 23 significantly mutated genes in kidney cancer, including two tumor suppressor genes. The study suggests that alteration of the ubiquitin-mediated proteolysis pathway may contribute to kidney cancer tumorigenesis by activating the hypoxia regulatory network.
BGI unveils new global collaborative projects including the Million Genomes Project, Rice Genome Project, and 1% Danes' Genome Project. These initiatives will advance our understanding of species genome, agricultural productivity, and human disease. The projects aim to sequence millions of genomes to improve crop yields, develop person...
The ICRISAT-led team has completed the genome sequence of pigeonpea, a legume crop grown by millions of poor farmers worldwide. With this breakthrough, scientists can now identify genes for drought tolerance and improve crop productivity, tackling pests and disease constraints in production.
A collaborative study by the University of Melbourne and BGI sequenced the draft genome of Ascaris suum, a parasitic roundworm of pigs. The study provides a comprehensive resource to combat ascariasis and other nematodiases, with potential drug targets identified.
Researchers sequenced the genomes of two non-human primate species, Chinese rhesus macaque and cynomolgus, and compared them with a previously sequenced Indian rhesus macaque. The study reveals abundant genetic heterogeneity among the three macaques, which may facilitate biomedical analysis and application.
Researchers have sequenced the naked mole rat genome, revealing genes related to its exceptional traits such as longevity, cancer resistance, and low oxygen tolerance. The study identified stable gene expression of TERT and tumor suppressor p16Ink4a, which may contribute to NMR's longevity mechanism and cancer resistance.
Researchers have sequenced the Aboriginal Australian genome, demonstrating that they descended directly from an early human expansion into Asia around 70,000 years ago. This study provides new insights into the dispersal of the first humans to leave Africa and re-writes the story of their journey to Australia.
The genome of mesopolyploid crop Brassica rapa has been sequenced and analyzed, revealing a gene space covering over 98% and identifying 41,174 protein-coding genes. The study provides new insights into the evolutionary history of polyploid genomes and offers opportunities for genetic improvement of Brassica oil and vegetable crops.
A study published in Nature Genetics identified 49 new significantly mutated genes associated with TCC, including eight genes related to chromatin remodeling. These genetic aberrations were found in 59% of individuals with TCC, suggesting a potential role for UTX gene in bladder cancer classification and diagnosis.
The CHO-K1 genome provides a better understanding of the genetics of CHO cells, accelerating the discovery and development of new recombinant protein therapies. The study identified homologs to 99% of human glycosylation-associated genes in the CHO-K1 genome.
A team of scientists used BGI's rapid, bench-top DNA sequencing technology to analyze the deadly E. coli O104:H4 outbreak in Germany, revealing a new model of international collaboration for infectious disease control. The study found that genome sequencing provides the foundation to identify and characterize novel pathogens.
Researchers at BGI developed a novel pipeline to detect structural variations (SVs) in whole genome assembly, identifying 277,243 SVs with high accuracy and precision. The study demonstrates the potential of de novo assembly for creating comprehensive SV maps.
A comprehensive whole sequence variation map of rhesus macaque has been published, providing a valuable resource for evolutionary and biomedical research. The study identified 5.5 million SNPs and 125,150 structural variations, including annotated nonsynonymous SNPs related to human disease and drug-target genes.
The Potato Genome Sequencing Consortium completed the genome sequence and analysis of the potato, revealing new insights into its evolutionary history and potential mechanisms for tuber initiation and development. BGI's bioinformatics expertise facilitated the annotation of 39,031 protein-coding genes.
The release of pig genomic sequences has significant implications for biomedical research, production, food safety, and animal health. The data reveals genetic similarities between pigs and humans, which may lead to improved models for medical testing and drug development.