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Biophysical Society


Gut reactions to improve probiotics

Research explores how gut bacteria respond to common changes in their habitat, revealing that bacterial species can go extinct when environments are altered even slightly. This understanding could lead to the design of targeted probiotics and therapies to make gut microbes more resilient.

Fancy a jellyfish chip?

Researchers at the University of Southern Denmark have developed a new method to rapidly transform the soft body of jellyfish into a crunchy treat. The technique, which uses ethanol, produces crispy jellyfish chips that could be of potential gastronomic interest.

Electric eel-inspired device reaches 110 volts

Researchers developed an electric eel-inspired device that produced 110 volts from gels filled with varying strengths of salt water, leveraging ion gradients across hydrogels. The team hopes to increase the current and develop a power source for implantable devices utilizing existing human body ionic gradients.

What makes circadian clocks tick?

Cyanobacterial clock proteins were found to dictate their function through internal motions, providing important mechanistic insights into biological timekeeping. This discovery has implications for understanding circadian clocks in eukaryotic organisms, such as animals and humans.

Ras protein's role in spreading cancer

Researchers at the University of Illinois discovered how Ras protein binding to cell membranes impact the signaling pathways that cause cancer's uncontrolled growth. The study found that KRas4b binds more tightly to the cell membrane, but it needs to attach on the correct side.

Biophysical Society names 2018 award recipients

The Biophysical Society has announced its 2018 award recipients, honoring outstanding contributions to the field of biophysics. The winners include Jue Chen, Wonhwa Cho, Bianxiao Cui, Taekjip Ha, Leslie Loew, Carrie Partch, Madeline Shea, and James Spudich for their innovative research and advancements in biophysics.

Using graphene to fight bacteria

Scientists are studying graphene oxide to create bacteria-killing catheters and medical devices, reducing the need for antibiotics and speeding recovery times. Graphene oxide wraps around bacteria, puncturing its membrane and killing it, making it a potential alternative to traditional methods that are toxic to the environment.

A new way to stretch DNA

Researchers have developed a new way to controllably manipulate biomolecules like DNA using acoustic force spectroscopy. The technique stretches molecules by applying varying forces in a precise way, shedding light on chemical bonding and mechanical properties.

Shaving time to test antidotes for nerve agents

Lawrence Livermore National Laboratory researchers developed a simulation to predict the permeability of drug molecules across cell membranes, enabling faster testing and development of nerve-agent treatments. The simulation shaved weeks off compound testing, reducing the time required from six weeks to just 16 hours.

Mammalian fertilization, caught on tape

Researchers develop a novel microfluidic device called the 'IVF chip' that enables high-resolution imaging of the initial steps of fertilization. The device allows scientists to observe the fusion of sperm and egg, membrane remodeling, and sperm DNA incorporation into the egg.

Tarantula toxins converted to painkillers

Researchers convert tarantula toxins into painkillers by targeting neural receptors, providing an alternative to current treatments with limited pain relief and side effects. The study reveals the importance of cell membranes in peptide toxin activity and opens opportunities for designing new drugs.

SourceBiophysical Society·JournalBiophysical Journal·DateFeb 28, 2016

Feeling ducky

Researchers have identified ducks as an ideal model organism to study the cellular mechanisms of mechanosensation, a complex process involving sensory neurons. The study reveals that ducks have highly specialized trigeminal ganglion neurons that are capable of converting force into excitation more efficiently than other birds and mammals.

Better batteries inspired by lowly snail shells

Researchers at UMBC isolated a peptide that binds strongly to lithium manganese nickel oxide, improving the potential power and stability of electrode materials. The peptides can latch onto nanoscale components, forming a bridge between conductive components and maintaining a connection through multiple charging cycles.

Drug detectives

A new screening method uses lipid bilayer properties to predict toxicity, identifying probable cytotoxic drugs at an early stage in development. The Gramicidin-Based Fluorescence Assay (GBFA) tracks changes in protein function as a way of monitoring lipid bilayer alterations.

Bacteria's hidden traffic control

Researchers have mapped nearly every protein in a bacterial cell for its entire cell cycle, discovering a large number of distinct patterns with subtle spatial and temporal differences. This approach has implications for understanding how bacteria coordinate the timing and location of subcellular processes.

'Virtual virus' unfolds the flu on a CPU

Scientists at the University of Oxford have built a complete model of the outer envelope of an influenza A virion using a coarse-grained molecular dynamics simulation. The simulation reveals various characteristics about the membrane components, including the separation of spike proteins and their interactions with host cells. This res...

What's next in diets: Chili peppers?

A team of researchers at the University of Wyoming found that adding capsaicin from chili peppers to a diet can stimulate energy metabolism and burn stored fat, potentially preventing obesity. The study used mice on high-fat diets and found that dietary capsaicin increased metabolic activity and energy expenditure.