Researchers at Case Western Reserve University have successfully imaged the open state of a K+ channel, allowing for better understanding of its effectiveness in treating cardiovascular diseases. The study has implications for improving pharmaceutical efficiency and enhancing the quality of cardiovascular-related drugs.
Researchers at CWRU School of Dental Medicine discovered a biomarker called human beta defensin-3 (hBD-3), which is associated with the early stages of oral cancer and can serve as an early warning system. hBD-3 attracts molecules that help cancerous tumors grow and spread.
Case Western Reserve University has been named an International Center of Excellence for Malaria Research, a $7.9M seven-year grant to accelerate malaria control and elimination worldwide. The research will focus on regions where malaria is endemic in Africa, Asia, the Pacific Islands, and Latin America.
A CWRU study of 60 participants with visual impairment and sighted peers found that visually impaired individuals performed slightly better in dosing accuracy, despite using non-visual tools. The results challenge the common warning against visually impaired people using insulin pens.
The university's I-LEAD program aims to improve communication skills between medical and nursing students through real-life experiences and simulated patient exercises. The project seeks to develop interprofessional curriculum models that can be shared with other schools across the country.
A study by Case Western Reserve University found that using a composite infection prevention score predicts lower postoperative infection risk. The study suggests that hospitals should report on multiple measures rather than individual ones for more accurate predictions.
A major JAMA study found that patients with cystic fibrosis who tested positive for MRSA had a significantly higher risk of death compared to those without the infection. The study, which tracked over 19,000 CF patients, showed an approximate 1.3 times greater risk of death among those with detected MRSA.
A new study by Case Western Reserve University researchers found that leaded gasoline was the predominant source of lead exposure for African-American children in Cleveland during the latter half of the 20th century. The study used dental records and other data to show that lead levels in teeth increased dramatically during this period...
A new comic book aims to promote healthy lifestyles among migrant families, particularly Latina mothers. The 'Small Changes Big Results' comic book offers practical tips on nutrition and exercise, targeting a high percentage of overweight or obese children in these communities.
A recent study found that at least 90% of adolescents with mental illnesses reported experiencing stigma, leading to feelings of shame and isolation. Parents and schools can play a crucial role in mitigating these stigmas by promoting acceptance and inclusivity.
David Hanneke's research created a building block of quantum computing, performing what some call the most accurate experiment in science. He will receive the Michelson Postdoctoral Prize at Case Western Reserve University.
Researchers found several new bacteria originating in the mouth can travel through the blood to cause an inflammatory reaction in the placenta and lead to health issues such as miscarriages and stillbirths. Oral bacteria that colonize in the placenta can stimulate an inflammatory response leading to cervical and membrane weaknesses and...
Dr. Mandalakas will analyze social and economic barriers to implementing Isoniazid preventative therapy in children with latent tuberculosis infection in South Africa. She aims to promote the practical implementation of preventive therapy to improve child health outcomes.
Researchers at Case Western Reserve University have discovered a direct link between neural activity in an insect's brain and changes in behavior. The findings suggest that cockroaches can control their speed with their brains, which could inspire the development of more adaptive robots for search and rescue and space exploration.
A study by Case Western Reserve University found that subjects with both high gum inflammation levels and moderate to severe prostatitis had higher PSA or inflammation levels. This suggests that inflammation outside the prostate gland may be causing an inflammatory reaction, which could explain why PSA levels can be high in prostatitis.
Alfred R. Rives led the design and construction of the iconic bridge, but was denied recognition after joining the Confederacy. New research reveals his crucial role in the project's success.
Researchers at Case Western Reserve University are studying the effectiveness of TeleCare, a home monitoring device, in keeping patients with complex health issues healthy and out of the hospital. The study aims to find out which patients benefit most from telehealth monitoring.
RAM founder Stan Brock will be recognized for his 25-year commitment to delivering free healthcare worldwide. The Inamori Ethics Prize honors exemplary ethical leadership, and Brock joins Dr. Francis S. Collins and Mary Robinson as winners.
The university will provide administration and management support to contractors, helping primary care providers select products and use technology to improve patient care. The funding builds on a recent Center of Excellence designation for translating technology and research into better health.
Researchers have invented a 'smart' insulin protein molecule that binds less to cancer receptors and self-assembles under the skin. This new form of insulin reduces the risk of cancer associated with obesity and excess insulin in Type-2 diabetes patients.
A new empirical model has been developed to quantify and gauge an alcohol addict's level of engagement in Alcoholics Anonymous (AA)-related helping. The study found that both concrete acts of service and personal sharing are important in living sober, with adequate psychometric properties of the SOS tool.
Researchers identified KLF15 as a genetic factor regulating both heart failure and aneurysm disease. The study found that deficiency of this gene predisposes individuals to these cardiovascular diseases, but also discovered potential therapeutic targets through the inhibition of p53.
Researchers are exploring the role of beta defensins in chronic inflammation within the aging human brain, including Alzheimer's disease. Preliminary findings suggest that beta defensins may contribute to neuronal cell death due to compromised immunomodulation.
Researchers aim to develop blanket protection for vulnerable homes, more effective and environmentally-friendly than traditional wildfire measures. The team has tested over 40 fabrics to determine the right material, design, thickness, and weight for protection.
Researchers from CWRU Nursing School found that one year after a cardiac event, only 37% of participants exercised three times a week to maintain heart health. Women across all age groups were less inclined to make healthy changes compared to men, with younger men sustaining exercise patterns better than other groups.
A researcher at Case Western Reserve University is developing new materials inspired by nature, including scratch-resistant coatings and durable fabrics. The materials are engineered to mimic the incredible attributes of natural materials like squid beaks and spider webs.
Researchers found that 10% of Duffy-negative people in Madagascar were infected with P. vivax, contradicting the long-held assumption of resistance. The study suggests that population mixing and disease evolution have led to the emergence of new parasite strains that can infect Duffy-negative red blood cells.
Researchers at Case Western Reserve University have found a way to use the sleeve-like cover on bone to heal serious bone injuries faster and more simply than current methods. They developed an artificial sleeve that spurs fast healing when a car wreck, bomb blast or disease leaves too little cover.
A specific protein called Dab2 has been found to trigger the process of cancer cells spreading from the original tumor and developing into new tumors. The discovery could lead to the development of drugs to delay or halt this process, which is a major step in cancer progression.
A recent study published in Journal of the American Geriatrics Society found that older married women who survived cancer had more health problems than their non-cancer counterparts. The study, which matched women for age, ethnicity, and race, revealed higher levels of fatigue, physical limitations, and depression among cancer survivors.
A study of cancer survivors found that they become advocates for others but not themselves, suggesting a transition from passive to active care. They advise peers with cancer to seek second opinions, check doctors' credentials, and stay positive.
Case Western Reserve University has received a $250,000 challenge grant from Johnson & Johnson Services Inc. to support science and medicine projects aimed at improving human health. The university will match or exceed the commitment, with grants ranging from $50,000 to $100,000.
Case Western Reserve University School of Medicine has received six Department of Defense grants totaling $2.8 million to advance breast cancer research. The grants will support innovative medical research in the field of breast cancer, including studies on novel oncogenes and antitumor T-Cell responses.
Researchers have developed a micro-implant that clears scar tissue and delivers progenitor cells to the eye, increasing cell survival by 9-fold. The implant's scaffolding uses electrospinning to produce biodegradable fibers with pockets containing enzymes that degrade local scar tissue.
Researchers found Fusobacterium nucleatum in the lungs and stomach of a stillborn baby, linked to its mother's pregnancy-associated gum disease. The study suggests that oral bacteria can be transmitted from mother to fetus through the blood, emphasizing the importance of good oral health care during pregnancy.
A new predictor of cornea transplant success has been identified by the Cornea Donor Study Investigator Group. The study found that a patient's endothelial cell count six months post-transplant is a better indicator of subsequent failure of the graft rather than the donor's cell count.
Researchers created stimulus-specific sustained activity patterns in brain circuits maintained in vitro, revealing the possibility of storing information in isolated brain tissue. The study found that semilunar granule cells played a critical role in this process.
Mark A. Smith, Ph.D., has been awarded the American Association for the Advancement of Science (AAAS) Fellowship for his distinguished contributions to neurodegenerative disorders and Alzheimer's disease research. He is recognized for his work on oxidative stress and cell cycle alterations in Alzheimer's disease.
A team of researchers led by Erin Lavik developed synthetic platelets that show promise in halting internal and external bleeding. The synthetic platelets are designed to home in and link up with natural platelets at the site of an injury, resulting in clotting times about 25% faster than current treatments.
Key advances in DNA sequencing technology and gene mutations have identified candidate cancer genes that contribute to colorectal cancer. The study also highlights the importance of understanding biological pathways deregulated in colon cancer, which can form the basis of new therapeutic agents.
The university's School of Medicine will oversee two international trial sites in Uganda and the Philippines to test new TB treatments and regimens. The contract aims to improve TB treatment and control programs globally, benefiting millions of people affected by the disease.
Case Western Reserve researchers identified two new metabolic pathways involving 4-hydroxyacids, a breakthrough that sheds light on the mechanisms of action for lipid peroxidation and drug abuse products. The study, published as 'Paper of the Week' in the Journal of Biological Chemistry, has significant implications for understanding o...
A recent study by Case Western Reserve University researchers found that CCI patients who leave hospitals on ventilators have poor outcomes, with only a small percentage achieving 'better' outcomes. The study suggests that knowledge of these outcomes is crucial for ICU clinicians and families in care planning and decision-making.
The Ohio Research Association for Public Health Improvement (RAPHI) aims to investigate how public health does what it does, with an initial focus on improving services using information technology. The RAPHI project will advance RWJF's efforts to enhance the evidence base for public health policy and practice.
The National Science Foundation has awarded a nearly $1 million grant to support career advancement of women and underrepresented minority men in sciences and engineering. The program aims to foster environments conducive to recruiting, advancing, and retaining faculty in these fields.
Groundbreaking studies will help hospice patients and families address unresolved issues before and after a loved one passes away. The research focuses on marshaling patients' inner strengths, such as hope, optimism, and connectedness, to improve psychological outlooks.
The university is leading an NIH-funded study to create avatar doctors for role-playing practice, aiming to bridge communication gaps between patients and healthcare providers of different backgrounds. The technology aims to empower patients with the skills needed to manage chronic illnesses.
The study aims to determine if lowering systolic blood pressure in hypertensive patients can reduce the incidence of cardiovascular and kidney disease, as well as slow cognitive decline. The results will be used to reevaluate optimal blood pressure levels and establish new guidelines for healthcare providers.
A team led by Case Western Reserve University physicist Tom Shutt is planning the world's largest WIMP catcher, a 20-ton liquid xenon detector that could increase detection chances by 30,000 times. The experiment aims to confirm the dark matter theory and understand the universe's composition.
The school has received six stimulus grants to fund projects including a center of excellence on end-of-life science, scholarships for disadvantaged students, and a nurse faculty loan program. The grants will help improve healthcare for patients across the lifespan and increase opportunities for underrepresented groups.