Researchers at Case Western Reserve University are developing new imaging agents to detect cancers earlier, exploiting enzyme overexpression in tumors to improve cancer surgery accuracy, and creating a system to control prosthetic arms with thought. The grants will support new researchers, equipment, and technology development.
A Case Western Reserve University engineering professor is developing a miniaturized low-power device to detect how electrical signals and neurotransmitters in the brain work. The device will record 16 channels of chemical and electrical neural activity, measuring neurotransmitters and action potentials in real time.
The CWRU Prevention Research Center for Healthy Neighborhoods aims to foster partnerships within urban neighborhoods to develop effective strategies in preventing chronic disease. The center will collaborate with neighborhood residents, leaders, and community organizations to address environmental and lifestyle issues that contribute t...
A two-year study will assess the impact of exercise on physical and mental health in ICU patients on ventilators. The research aims to improve recovery outcomes by reducing muscle loss and inflammation.
The university will receive a $20.5 million gift to support education and research programs at its schools of medicine and dental medicine. The gift has established two professorships, including the Dr. Donald and Ruth Goodman Professorship in Innovative Cancer Therapeutics.
Case Western Reserve University researchers are using pluripotent stem cells to study schizophrenia and gain a better understanding of the complex disease. The study aims to characterize brain cell function in adolescent patients with schizophrenia, with the goal of deciphering the underlying cause of the condition.
Researchers at Case Western Reserve University are developing a novel approach to building vascular networks in engineered tissues using custom-designed synthetic molecules and embryonic stem cells. Their goal is to produce networks that can grow and maintain themselves like natural blood vessels, paving the way for improved human lives.
Researchers will investigate the activation of TLR4 and responses inside human cornea cells, with a goal to identify potential targets for anti-inflammatory intervention. The study aims to discover specific toll-like receptor antagonists to regulate corneal inflammation, potentially leading to novel medication alternatives.
Researchers at Case Western Reserve University are testing a new intervention called Responsive Teaching, designed for parents and caregivers of children under 3 years old with autism. The study aims to improve social emotional functioning and daily routines, without direct instruction or rote learning activities.
Researchers at Case Western Reserve University found that Merkel cells, responsible for touch perception, originate from the skin, contradicting previous speculation. The study's results provide significant insights into the development and function of Merkel cells, which may hold implications for understanding Merkel cell carcinoma.
Case Western Reserve University scientist Dave Wilson has developed a cryo-imaging system that enables the identification of single molecules, counting of cells in organs, and comparison of normal and abnormal tissues. The system produces incredibly detailed images showing the effectiveness of different drug therapies.
Researchers at Case Western Reserve University School of Medicine are investigating the role of genetic susceptibility in colon cancer metastasis. By identifying specific genes and variants, they aim to develop new anti-cancer therapies and improve patient outcomes.
Case Western Reserve University researchers tested a key process for extracting oxygen from celestial soils on the 'vomit comet' ride, finding that sifters can work effectively in low gravity. The technology is essential for building a space outpost and has applications beyond lunar missions.
Researchers at Case Western Reserve University have developed a method to control the structure and function of single-walled carbon nanotubes. By varying the composition of a metal catalyst, they can produce semiconducting nanotubes with desired properties, opening up new possibilities for applications such as medicine delivery and en...
A study by Jeff Coller and his team reveals that messenger RNA (mRNA) is predominantly degraded on ribosomes, altering the common dogma of how gene expression is controlled within cells. This finding has significant implications for understanding genetic diseases linked to mRNA degradation.
The Case Center for Synchrotron Biosciences will provide three Technology Cores to support the study of proteins and nucleic acids. The center's facilities will enable researchers to understand the structure and function of proteins, including in vivo studies, as well as investigate the role of metal atoms in proteins.
A longitudinal study of nearly 400 teens, half of whom were prenatally exposed to cocaine, will investigate the association between prenatal exposure and substance use, sex, and delinquent behaviors. The study aims to understand how environmental factors shape developmental outcomes and inform targeted therapeutic interventions.
Researchers at Case Western Reserve University School of Medicine have discovered the prion protein as a novel biomarker for pancreatic cancer. The study found that the prion binds to filamin A in human pancreatic cancer cells, disrupting cell organization and signaling, and leading to aggressive tumor growth.
Scientists have developed a highly sensitive method to detect DNA methylation in colon cancer using Methyl-BEAMing technology. The test can identify 59% of colon cancers in blood samples, a significant improvement over existing methods.
A study by Case Western Reserve University Psychologist Joseph Fagan found an association between early ability to process information and IQ scores later in life. Infants who processed new information well at 6- and 12-months-old showed higher levels of academic achievement as young adults.
A team of researchers has identified the first gene associated with age-related cataracts. EphA2 encodes an enzyme that plays a role in repairing damaged proteins in the lens, which becomes cloudy and obstructs vision. The discovery provides new insights into the underlying causes of this leading cause of blindness.
Case Western Reserve researchers found that prenatal exposure to Plasmodium falciparum results in parasite tolerance, increasing susceptibility to malaria and anemia in young children. The study identified three groups: sensitized, exposed-not-sensitized, and not-exposed, with the latter group having a higher risk of malaria infection.
Researchers will investigate whether abnormal autonomic nervous system function is the primary cause of painful bladder syndrome, a condition affecting young women with severe bladder pain and disability. The five-year study aims to lead to better understanding of the causes and possible treatments for this condition.
Case Western Reserve researcher Yiping Han aims to understand how to build roadblocks against harmful oral bacteria that can turn deadly in an unborn child. Her research has discovered an adhesin protein molecule that allows bacteria to connect with receptors on epithelial cells and endothelial cells of the placenta.
Researchers at Case Western Reserve University School of Medicine discovered a novel connection between ITCH and NOD2 genes, which may lead to new treatments for Crohn's disease. The study highlights the potential for individually-tailored therapies for patients with the NOD2 mutation.
Case Western Reserve University has received funding to support multiple stem cell and regenerative medicine commercial, emerging, and pilot projects. The $5 million grant will help advance technologies to benefit patients in Ohio, building on previous investments that have brought in $170 million in new commercial development.
A five-year study funded by the National Institutes of Health will examine the impact of cataract surgery on everyday life for people with dementia. Researchers aim to document how restored vision improves daily tasks and overall well-being.
Researchers will investigate the human innate immune system and its role in protecting against infections like HPV, which is more frequently associated with the genital tract. The study aims to understand how oral health plays a crucial role in overall health and why some people are better protected than others.
Researchers at Case Western Reserve University have identified a critical role of interleukin-1β in protecting against oral colonization by Candida albicans. The study found that IL-1β is secreted by human immune cells in response to Candida infection and helps modulate the immune system, providing new avenues for therapeutic targets.
Researchers found that treating gum disease improved rheumatoid arthritis symptoms, including reduced swollen joints and morning stiffness. The study's results suggest a link between periodontal disease and rheumatoid arthritis, highlighting the importance of good oral health in overall well-being.
A simplified chart created by a pediatrician can help identify children with high blood pressure, improving diagnosis rates. The revised chart uses age and gender to determine abnormal readings, reducing the need for height percentile verification.
A new study finds that individuals with low levels of the 'Celebrex gene' are resistant to Celebrex treatment for colon tumor prevention. High levels of colonic 15-PGDH expression are necessary for Celecoxib to prevent colon tumors.
Researchers test blue-white lamp prototypes to regulate sleep-wake cycles in people with dementia. The study shows promise in raising activity levels during daytime hours and increasing sleep at nighttime.
The Center for Proteomics and Bioinformatics at Case Western Reserve will expand its activities in HIV/AIDS research with a $989,108 grant from NIDA. The grant aims to develop reliable biomarkers for chronic immune activation during HIV disease and explore the effects of current or prior drug use on disease progression.
A study by Case Western Reserve University found that vaccination records may not accurately predict a child's protection from disease, even with valid written records. Serologic testing revealed immunization levels did not consistently match those of the written records.
Researchers at Case Western Reserve University have discovered a form of synaptic memory in the olfactory bulb, which could explain how we store information about specific smells. This finding provides a new perspective on the brain's processing of sensory information and has implications for understanding human memory.
Researchers create a line of patented foam-like and environmentally friendly polymers called clay aerogel composites, which can take on various shapes and sizes. The materials have potential applications in insulation, electronics, and other industries.
The university is exploring the impact of molecular pathways on inner ear dysfunction in Usher Syndrome, a clinically and genetically heterogeneous disorder causing congenital deafness and retinitis pigmentosa. The grant aims to prevent hair cell death and promote otoprotection therapy.
Researchers from Case Western Reserve University, Duke and University of Massachusetts created magnetic particles that nudge free-floating human cells to form chains in response to external magnetic fields. These chains may accelerate the creation and growth of tiny blood vessels.
A study from Case Western Reserve University found that mothers' depressive symptoms significantly impact family functioning and problem-solving abilities. Mothers with higher levels of depression struggle to create normal family lives, while those with greater problem-solving skills fare better.
The school has received a record-breaking $1 million grant, including three individual awards totaling up to $925,000. The grants will support research into age-related macular degeneration, rhodopsin structure and function, and the pathogenesis of cataract and diabetic retinopathy.
A new intervention being tested at Case Western Reserve University aims to improve the lives of men with incontinence problems from prostate cancer treatments. The 'Stay Dry' program combines pelvic floor muscle exercises with biofeedback techniques and therapy, and will be compared to standard care in a four-year study.
Case Western Reserve researchers have developed a new method for stimulating brain circuits wirelessly using light-activated semiconductor nanoparticles. This technology eliminates the need for cumbersome wiring and has potential applicability in treating nerve or brain impairments.
Dan Akerib, Chair of the Case Western Reserve University Physics Department, has been elected an American Physical Society (APS) Fellow for his significant contributions to direct dark matter detection experiments. He will discuss current and planned research in 'The Search for Dark Matter' at the AAAS conference on February 16.
Case Western Reserve researchers are investigating the physical and chemical consequences of sunlight absorption by toxic nitro-aromatic pollutants in the environment. The goal is to understand how these compounds transform into more harmful products and predict their environmental fate.
Researchers discovered that many processed and fast foods contain phosphorus additives, which can be just as dangerous for patients with advanced kidney disease as naturally high-phosphorus foods. Studies found that avoiding these additives significantly lowers phosphorus levels among patients.
Researchers at Case Western Reserve University have discovered a link between a genetic pathway and autism, finding that mutations in this pathway are associated with both autism and other developmental disorders. The study suggests that the lack of specific genes may play a role in the development of autism.
Researchers at Case Western Reserve University discovered a nanotechnology-based technique to block damaging gas transport through polymers, making them stronger and more efficient. This breakthrough has potential applications in food and medicine packaging, as well as electronic equipment protection.
The university will develop an informatics infrastructure to collect, manage and analyze diverse data types across institutions. This project aims to improve collaboration and sharing of information between investigators, leading to new approaches for screening, diagnosing and treating illnesses.
A comprehensive elimination strategy is proposed to significantly block the spread of schistosomiasis, a chronic inflammatory disease affecting over 207 million people worldwide. The approach incorporates supplementary education and sanitation with secondary environmental benefits.