A study published in the Journal of Clinical Microbiology found that 60% of bacteria present in women with intra-amniotic inflammations were missed by traditional culture testing. The researchers identified a comprehensive list of microbial species using new DNA methods, including harmful bacteria not previously linked to preterm birth.
A new study published in Pediatrics reveals that only 10% of overweight children receive a proper diagnosis, while 76% of severely obese children and 54% of obese children are accurately identified. The study emphasizes the need for early intervention and innovative solutions to improve pediatric weight detection.
The study reveals that small changes in nucleotide sequences near splice points can lead to significant changes in splice site choice and protein production. The discovery suggests that curing most genetic diseases will take longer than expected due to the complexity of alternative splicing mechanisms.
Case Western Reserve professor David Gurarie develops mathematical models to track symptoms, treatment outcomes and environmental conditions of diseases. These models allow doctors to make predictions about effective treatment and help identify areas where new diseases may emerge.
Joseph H. Nadeau, Ph.D., was elected as an American Association for the Advancement of Science (AAAS) Fellow for his contributions to mouse genetics and mouse genome informatics and analysis. The award recognizes his sustained and significant efforts to advance science in these areas.
A study found that variations within Acinetobacter baumannii bacteria can affect its response to antibiotics, highlighting the need for targeted therapy in infectious disease. The analysis of six genomes revealed unique sets of genes among isolates, with some genes shared but others specific to different subsets.
A new study from Case Western Reserve University reveals that retirement patterns for dual-income married couples are complex, with men more likely to move directly into retirement. The research found 41 work/retirement transition patterns for husbands and 49 patterns for wives, highlighting the need for additional considerations in pl...
A multidisciplinary research team discovers that the absence of the ERK2 gene is linked to birth defects affecting heart and head development. The study reveals a critical conserved role for ERK2 signaling in neural crest development, shedding light on how developmental errors occur.
Eben Alsberg, a biomedical engineering professor at Case Western Reserve University, has received the Ellison Medical Foundation New Scholar in Aging award. The award provides funding for his project to develop novel microenvironmental technology to rescue chondrogenic potential of mesenchymal stem cells from aged individuals.
Case Western Reserve University has launched a new program to prepare high-achieving science and math undergraduates for teaching careers. The NSF-funded Robert Noyce Teacher Scholarship Program provides scholarships, summer internships, mentoring, and post-graduation follow-up to encourage diversity in STEM education.
The St. Baldrick's Foundation has awarded $330,000 to Dr. Alex Huang at Case Western Reserve University School of Medicine to support his research on enhancing immune surveillance in pediatric sarcomas.
Researchers have developed a method for 3D optical imaging of anisotropic fluids like liquid crystals, allowing for detailed understanding of molecular order. The technique enables precise control over liquid crystal displays in devices such as TVs and laptops.
A new laboratory-engineered mouse model shows slowed AMD progression with retinylamine treatment, providing biochemical evidence for a potential therapeutic intervention. Researchers aim to prevent rapid eye degeneration and slow disease advancement.
The National Children's Study will investigate factors influencing autism, cerebral palsy, learning disabilities, birth defects, diabetes, asthma, and obesity. Case Western Reserve University School of Medicine will recruit participants from two study sites in Cuyahoga and Lorain counties.
Researchers from Case Western Reserve University studied Chernobyl-derived radionuclides in Swedish and Polish soil, finding higher levels of plutonium in Swedish soil. The team's findings help shed light on public health ramifications and differentiate radioactive elements from one-time events like the Chernobyl disaster.
Scientists measure radionuclides in soil to understand sediment sources in rivers, revealing that streambank erosion contributes significantly to sediment loads. The study's findings can inform efforts to rehabilitate streams and preserve aquatic populations.
The Case Western Reserve University collaboration has trained over 80 police supervisors to identify and assist with operational stress among officers. The program aims to break the stigma around job stress, promoting a culture of openness and seeking help.
A new Case Western Reserve University study aims to understand how college students cope with managing psychiatric medications, a growing concern for mental health providers. The research will survey 120 undergraduates and conduct intensive interviews with 30 students to track their experiences over two years.
A study by Case Western Reserve University found that caregivers of spouses with dementia report sadness, loneliness, and a lack of positive emotions. The research analyzed data from 391 caregivers and 226 non-caregivers, revealing that 25% of caregivers suffered from depression compared to 5% of non-caregivers.
A new pilot project aims to understand the eating habits of Latino migrant children and develop culturally appropriate interventions to combat obesity. The study will survey families in Ohio and Michigan farms and provide data to inform healthy food choices.
Researchers will explore how HIV infection causes immune activation and depletion, with potential for clinical applications in AIDS treatment. The grant supports four projects ranging from basic lab research to experimental models and translational research.
A group of women will test new exercises and educational programs to manage their recovery after bed rest and birth. Researchers hope to discover if longer intervention is needed to help women regain lost strength and stamina.
Researchers at Case Western Reserve University have developed a technique that can deliver cancer-fighting drugs to diseased areas within hours, reducing the current delivery time from two days. The system uses gold nanoparticle vectors to deliver photodynamic therapy (PDT) drugs through the bloodstream.
A new research project at Case Western Reserve University is developing simulated experiences for dental students to practice communicating with patients. The virtual scenarios aim to revolutionize dental education and national testing for patient-side communication skills.
Researchers from Case Western Reserve University School of Medicine and Penn State Hershey College of Medicine identified a novel ceramide that reduces sterile inflammation in the cornea. The nano-sized package allows for easy application as an eye drop, providing an effective alternative to steroid use.
Case Western Reserve University astronomers have upgraded their telescope to detect intracluster light, a type of starlight formed during galaxy collisions. The new camera system allows them to measure the color of these stars, which can indicate the age of the Virgo cluster.
Case Western Reserve University researchers discover that gravitational radiation can be produced by a mechanism other than inflation, which could redefine the concept of a 'smoking gun' for early universe theories. This finding strengthens motivation for detecting primordial gravitational radiation, which is crucial for understanding ...
Francis S. Collins, a renowned geneticist and former Human Genome Project leader, has been awarded the inaugural Inamori Ethics Prize at Case Western Reserve University. The prize recognizes his outstanding contributions to promoting ethical leadership in genetics and improving human health.
A study by Case Western Reserve University psychologist found that skills play a significant role in winning at poker, rather than luck. The research involved college students playing multiple rounds of Turbo Texas Hold'em, with those given strategies performing better and improving their games.
Case Western Reserve University researchers identified genes associated with hereditary components of colorectal cancer in a genome-wide scan. The study found susceptibility genes on chromosomes 1p, 15q, and 17p, which may lead to better cancer screening strategies.
The team created artificial materials that can change from hard plastic to soft rubber when exposed to water, addressing a problem with existing brain signal recording devices. This adaptability could alleviate damage to surrounding brain tissue and improve treatment for conditions like Parkinson's disease and spinal cord injuries.
A study led by Julie Juola Exline found that men are more likely to hold grudges and exhibit vengeful behavior compared to women, who tend to be more empathetic and forgiving. This difference can be reduced when men develop empathy towards offenders, making the offense seem smaller.
A study published in the Journal of Health Care for the Poor and Underserved found that elderly adults are more likely to deny smoking when asked. Researchers used biomarkers like cotinine to validate self-reported nicotine use, revealing a significant discrepancy between true smokers and those who denied it.
A recent study by Kristian E. Baker and Ambro van Hoof directly challenged the 'faux 3' UTR model of mRNA decay, revealing a critical flaw in the existing understanding of this process. This breakthrough discovery has significant implications for gene expression regulation and potential therapeutic strategies for genetic diseases.
International brain aging expert Peter Whitehouse questions current approaches to Alzheimer's diagnosis and treatment, suggesting that AD represents our culture's attempt to make sense of natural brain aging. The book offers practical advice and information on how to maintain cognitive vitality and a sense of fulfillment as we age.
A team of researchers from Case Western Reserve University, VA and NASA Glenn Research Center has unveiled a method for developing mechanically-reinforced polymer nanocomposites. The approach uses a process to assemble nanoparticles into a three-dimensional network before filling it with a polymer, resulting in compatible materials. Th...
Researchers at Case Western Reserve University School of Medicine have identified a Duffy binding protein-based vaccine that could provide protection against P. vivax malaria. The vaccine targets the specific interaction between the parasite and human red blood cells, offering a promising path toward eliminating the disease.
Researchers will focus on three projects utilizing different strategies to study psoriasis, including a novel photodynamic therapy and analysis of the role of S100A8/9 protein. The goal is to control inflammation and develop safer therapies for patients with the debilitating disease.
Case Western Reserve researchers have bred a line of 'mighty mice' with the ability to run five to six kilometers at high speeds. The mice utilize fatty acids for energy and produce little lactic acid, allowing them to maintain endurance over extended periods.
Researchers found that Tibetans have 10 times more nitric oxide in their blood than low-altitude dwellers, leading to increased blood flow and improved oxygen delivery. This adaptation allows them to thrive at high altitudes despite low oxygen levels in the air.
Researchers at Case Western Reserve University discovered a natural product derived from the Amazon rainforest that prevents tissue destruction by blocking matrix metalloproteinases. The findings have potential therapeutic applications in various joint, skin, and gastrointestinal diseases.
Researchers from Case Western Reserve University found that blocking receptors responding to bacterial infections can nearly halve preterm deaths in mice. A synthetic TLR4 antagonist appears safe for mice mothers and pups.
Physicists Tanmay Vachaspati, Dejan Stojkovic, and Lawrence M. Krauss propose a solution to the long-standing problem of information loss in black holes. They suggest that non-thermal radiation can carry information about collapsing matter beyond the event horizon.
Kurt C. Stange has been named an American Cancer Society Clinical Research Professor, a prestigious award recognizing his innovative research on cancer prevention and treatment. The five-year grant will support work to identify emerging models of personalized, integrated care.
A nationwide research study is being conducted at Case Western Reserve University School of Medicine to determine the safety and effectiveness of a new smallpox vaccine. The vaccine, IMVAMUNE, contains a weakened form of the live-virus, which may minimize side effects for all individuals, including those with compromised immune systems.
Researchers will investigate the immune response to TB, developing new vaccines, diagnostics, and treatments. The study aims to understand how the infection is transmitted and why some people develop active disease.
Scientists at Case Western Reserve University have isolated cochlear stem cells, which may regenerate damaged hair cells and restore normal hearing. The discovery offers a potential therapy for noise-induced and genetic hearing loss affecting millions worldwide.
A team of international scientists, including Case Western Reserve University's Matthew Sobel, has proposed eight ways to improve biodiversity forecasting in the face of global warming. The researchers aim to provide more accurate predictions and reduce misinformation that can divert resources away from other areas. By acknowledging th...
A recent study by Case Western Reserve University found that caregivers with strong cultural beliefs and religious practices can shield themselves from mental health difficulties, however elevated cortisol levels indicate a risk of physical problems. Caregivers with stronger positive cultural beliefs about caring for elders were more l...
Researchers found that lightning fires in Appalachian forests can deter the encroachment of shade-tolerant hardwoods, such as red maples. This natural mechanism can aid in the regeneration of oak forests, which are approaching extinction due to human alterations and fire suppression.