Researchers successfully transplanted human neural stem cells into nonhuman primate brains and observed their long-term survival and differentiation into neurons. The study holds promise for treating neurodegenerative diseases such as Parkinson's and Alzheimer's.
Researchers found that repeated hUCB MNC injections produced greater neuroprotection in mice modeled with MPS III B, preserving hippocampal structure and reducing microglial activation. The treatment also showed promise in modulating anxiety and inflammation.
Researchers found that human umbilical cord blood cells transplanted into rats with simulated myocardial infarction improved left ventricular heart function and preserved myocardial fiber structure. The study showed long-term benefits for the treated rats, suggesting a potential therapy for MIs.
Researchers successfully transplanted skin-derived stem cells into collagen tubes to bridge gaps in injured nerves, resulting in functional recovery and saving the upper arms from amputation. The study provides a promising new avenue for treating peripheral nerve injuries.
Researchers have discovered a novel approach to bridge the glial scar following chronic spinal cord injury using self-donated Schwann cells. This breakthrough enables regenerated and elongated brainstem axons to cross the bridge, potentially leading to improved hind limb movement in rats with spinal cord injury.
Researchers found that transitioning epithelial cells to mesenchymal cells improved cardiac regeneration by reducing infarct size. The study showed that this process enhanced the cardioprotective effects of human amniotic epithelial cells.
Researchers found that MSCs from MS patients exhibit higher senescence and decreased expression of immune system markers, suggesting a potential problem with autologous stem cell transplants. Allogenic bone marrow stem cells may be a preferable treatment option to maximize their therapeutic potential.
Researchers found that co-culturing hepatocytes with mesenchymal stem cells from umbilical cord or fat tissues improved albumin production, urea production, and viability of hepatocytes. The combination of transplanted hepatocytes and MSCs has great promise in treating acute liver failure.
Researchers found that co-transplanting Schwann cells and olfactory ensheathing cells, combined with daily treadmill training, promotes functional recovery in rats with spinal cord injuries. The study reveals a synergistic benefit of the combined therapy on axonal regeneration and motor function improvement.
Researchers found that co-transplanted endothelial progenitor cells (EPCs) improved the engraftment of pancreatic islet cells in mouse models, leading to a significantly improved cure rate and glycemic control. This study suggests that EPCs modulate the expression of connexin 36 and affect glucose-stimulated insulin release.
A study investigated the optimal site for cell transplantation to treat spinal cord injury, using laboratory mice with contusive spinal cord injuries. The researchers found that intralesional injection of neural stem/progenitor cells led to motor functional recovery and improved survival rates compared to other sites.
Researchers have developed a high-yield method for isolating viable hepatocytes from cryopreserved neonatal livers, showing better thawing recovery than those from adult livers. This breakthrough may provide an alternative source for liver cell transplantation, potentially improving patient outcomes.
Researchers found that mesenchymal stem cell transplantation can promote recovery from simulated childbirth injury and reduce symptoms of stress urinary incontinence. The treatment uses multipotent cells found in connective tissues, which home to damaged pelvic organs and release trophic factors to stimulate repair.
Researchers developed a protocol for isolating and expanding large numbers of multipotent fetal dermal cells (MFDCs) that display several advantages over adult dermal cells, including greater cellular yield after isolation and the retention of differentiation potential. The MFDCs were proven safe and efficacious in treating pediatric b...
Researchers transplanted fetal stem cells into lab animals with radiation-induced cognitive impairments, showing improved hippocampal spatial memory and fear-conditioning performance. The study suggests fetal stem cell transplantation may provide a potential treatment for cranially irradiated patients.
Researchers found that melatonin pre-treatment increased cell survival of mesenchymal stem cells (MSCs) after transplantation into laboratory animals with stroke damage. The pre-treated MSCs showed enhanced survival under oxidative stimulation, reducing infarct volume and improving neurobehavioral outcomes.
A new protocol has been developed to decontaminate human fetal tissues used for cell transplantation, reducing the risk of brain infections. The technique was tested on laboratory animals and shown to be effective in eliminating microbial contamination.
Researchers have successfully transplanted human embryonic stem cells into monkeys with Parkinson's disease, demonstrating robust survival and integration of the cells. The study found that the gene expression of dopamine-producing neurons was transient after transplantation, highlighting the need for further research to optimize cell ...
Researchers in Poland treated three paraplegic patients with transplanted olfactory ensheathing cells, showing improved spinal cord transmission and lower extremity muscle activity. The study found no adverse effects and modest improvements against intense neuro-rehabilitation.
A study found that autologous bone marrow-derived stem cell transplantation in patients with type 2 diabetes resulted in a significant reduction in insulin requirement. The treatment was associated with improved glycemic control, and the researchers suggest it may be a promising therapeutic option for managing the disease.
Researchers found that environmental enrichment, including running and exposure to novel objects, improved neurobehavioral function in mice after transplanting adipose-derived stem cells. Exercise-induced fibroblast growth factor 2 enhanced brain repair by promoting angiogenesis, neurogenesis, and astrocytic activation.
A team of researchers has discovered multipotent stem cells in deer antlers, which can differentiate into multiple cell types and have the potential to treat various injuries in veterinary medicine. The study highlights a novel source of stem cells for use in regenerative therapies.
Researchers found that allogeneic hematopoietic stem cell transplantation with mesenchymal stem cells from third-party donors improved poor graft function in five patients with acute GVHD and two with chronic GVHD. The treatment also showed promise in reducing morbidity and mortality.
Researchers found that non-self-donated stem cells survive better when injected into the striatum of the brain, accumulating along a 'pocket' between natural bordering regions. This discovery has important ramifications for designing cell therapies for neurological disorders.
Researchers compared ASCs and BMSCs from an elderly male donor to treat myocardial infarction in a rat model, finding that ASCs preserved more cardiac function. The study suggests age and health status of cell donors may impact the efficacy of stem cells in treating myocardial infarction.
Researchers investigated five cell types in CNS transplantation, finding none showed significant repair benefits. Despite differences in immune responses, only a few cells survived, highlighting the need for further research to better understand cell graft induced tissue damage.
Researchers have successfully transplanted genetically modified adipose cells into mice with liver disease, demonstrating their potential as a therapy. The study used bioluminescent imaging to track the cells' migration and engraftment in the liver, revealing their ability to persist for up to two months.
Researchers found that iron oxide nanoparticles can effectively label human endothelial cells for in vivo magnetic resonance tracking. However, high concentrations of INOPS can induce cell death and affect cell activity.
Researchers found that both skeletal muscle MSCs and adipose tissue MSCs improved left ventricle function and reduced infarct size after injection into the heart of laboratory rats. The study suggests that these cells may be a potential treatment modality for patients with acute myocardial infarction.
A new process of creating islet cell clusters has been successfully developed to improve pancreatic transplantation. The clusters were engineered to overcome challenges such as hypoxic conditions and immune reactions, resulting in higher viability rates and potential cure for type I diabetes.
Researchers have developed a safe co-culture system using human umbilical cord blood cells to support the expansion of human embryonic stem cells. This method eliminates the risk of tumor formation associated with traditional feeder cultures, making it a more feasible option for cell transplantation.
Researchers at Baylor University discovered that low temperatures can prevent hypoxia-induced damage to islet cells, improving insulin secretion. In a second study, neural cells derived from induced pluripotent stem cells showed altered oxygen metabolism associated with schizophrenia, offering potential targets for treatment.
Researchers developed positively charged nanoparticles that efficiently transduce into islet cells, enabling accurate monitoring via MRI. The study suggests these nanoparticles could be useful for evaluating graft survival and monitoring therapeutic interventions in islet transplantation.
A study found that transplantation within a 72-hour time window resulted in early functional recovery and reduced brain atrophy. The optimal therapeutic time window was determined to be between 72 hours and 120 hours after stroke onset, with no benefit observed when transplanted at 14 days.
Researchers found that Cell Banker 3 outperformed other cryopreservation solutions in preserving induced pluripotent stem (iPS) cell viability and proliferation. The solution allows iPS cells to be preserved for up to a year without significant loss of function.
A team of Japanese researchers found that using specific transcription factors and Sendai virus vectors can facilitate the differentiation of mouse pancreatic stem cells (mPSCs) into insulin-producing cells. The combination of Pdx-1, NeuroD, and MafA transcription factors showed the greatest impact on this process.
Researchers used magnetic particles to target transplanted stem cells to specific retinal locations, improving biochemical changes in the target tissue. Magnetic targeting also enhanced cell retention in a rat model of ischemia/reperfusion injury by over five-fold.
Researchers found that human placenta-derived endothelial colony-forming cells (ECFCs) are more proliferative and better at forming new blood vessels than those derived from umbilical cord blood. The study, published in Cell Medicine, suggests that the placenta could be an abundant source of ECFCs for therapeutic use.
A special issue of Cell Transplantation features studies on clinical translational medicine for successful neurorestoration in human patients with various neurological conditions. The field of neurorestoratology aims to optimize regimes and develop treatment guidelines through the integration of current methods.
Researchers found that mesenchymal stem cell transplantation in animal models of amyotrophic lateral sclerosis (ALS) and spinal cord injury promotes functional recovery. Bone marrow cell transplantation coupled with granulocyte colony-stimulating factor also shows neuroprotective and angiogenic effects in ALS animal models.
Researchers have discovered that cells from burn eschar can differentiate into multipotent mesenchymal stromal cells, which could be used to treat burn injuries. The study found that these cells had a resemblance to adipose-derived stem cells and may play a crucial role in wound healing.
Researchers found that insulin-like growth factor (IGF1) enhances migration and integration of photoreceptor cells into the adult mouse retina by manipulating the retinal recipient microenvironment. This study suggests a potential novel strategy for retinal repair using stem cell replacement therapy.
Researchers used magnets to guide iron oxide nanoparticles-laden cells to damaged heart sites, improving homing and retention. Visualizations revealed a good correlation between MRI tracking and cell fate assessment.
Researchers in Japan have concluded that adult-derived induced pluripotent stem (iPS) cells and mouse embryonic stem (ES) cells demonstrate similar survival and neural differentiation capabilities when transplanted into mouse cochleae. However, iPS cell transplantation is associated with a risk of tumor growth, highlighting the importa...
Researchers in Japan have successfully generated a new liver system using hepatocyte cell transplantation. The study demonstrated the feasibility of propagating mouse hepatocytes by creating a vascularized platform and uniform hepatocyte sheets, leading to the functionality of the engineered liver system.
Researchers found that fresh islet cells are superior to cultured islet cells in terms of success rate and blood glucose levels after transplantation. However, the results of islet isolation did not correlate with clinical outcomes for kidney transplantations from non-heart-beating donors.
Researchers found that olfactory neural stem cells can be derived from a patient's own cells and have shown promise in pre-clinical models of disease. They demonstrated multipotency by acquiring the phenotype of resident cells, making them a potential source for cell therapy.
Researchers found that autologous lung-derived mensenchymal stem cell transplantation improved functional outcomes in sheep with emphysema, with increased blood perfusion and ECM content. The study suggests a practical alternative to conventional stem cell therapy for treating emphysema.
Researchers found that mature hepatocytes offered better repopulation efficiency than stem/progenitor cells after transplantation into liver-injured rats. The mature hepatocytes continued to survive and proliferate for up to one year, while the stem/progenitor cells died within two months.
Researchers from Brazil and Korea used human immature dental pulp stem cells to create induced pluripotent stem cells, showing promising characteristics for therapeutic applications. The studies suggest that dental stem cells may be a valuable alternative source for regenerative medicine, including tooth regeneration and repair.