A study published in Cell Transplantation found that human umbilical cord-derived mesenchymal cells effectively reduced clinical and pathological severity of induced colitis in test mice. The treatment inhibited pro-inflammatory cytokine expression, indicating its potential for treating inflammatory bowel diseases.
Researchers found that a high-saturated-fat, high-cholesterol diet elevated microglial activation and reduced neuronal development in middle-aged laboratory rats. However, treatment with IL-1Ra alleviated these effects, suggesting potential use in neurological disorders involving neuroinflammation.
Researchers found that autologous bone marrow-derived mononuclear cell transplants can significantly induce vascular growth, reducing the number of amputations in patients with diabetes suffering from critical limb ischemia. The study showed a significant increase in neovasculogenesis and a decrease in PAD mortality.
A combination of treatments including a polymer scaffold, neurotrophin-3, and chondroitinase enhanced the benefits of neural stem cell transplantation in rat models. This approach promoted nerve growth, improved cell survival and migration, and restored neuroplasticity.
Researchers have found that bone marrow-derived stem cells can contribute to various neural cell types in different areas of the brain, including the olfactory bulb, through mechanisms of plasticity. This discovery suggests a new potential for using these cells for repairing damaged brain tissue and restoring lost neural function.
A study found that a combined immunosuppressive regimen improved the survival of human spinal stem cells in ALS rats. The results suggest that this treatment approach may be a potential therapy for ALS, a degenerative neurological disease.
Researchers successfully grafted deciduous canine teeth and dental pulp stem cells into parent canines, demonstrating bone regeneration after four weeks. The study found increased immunosuppressive activity of these stem cells, paving the way for potential clinical applications in allogenic in vivo stem cell transplantation.
Researchers have discovered that human amniotic fluid-derived stem cells (hAECs) can differentiate into various cell types, including those found in the lungs. Transplanted hAECs were shown to reduce pulmonary fibrosis and enhance lung regeneration in animal models of lung disease.
Researchers have found that human Sertoli cells can proliferate in vitro and retain their functionality, making them suitable for therapeutic applications. The cells have also been successfully used as delivery systems for therapeutics in the deep lung areas, potentially providing an effective treatment alternative.
A study published in Cell Transplantation investigated the optimal routes for transplanting neural stem/progenitor cells in animal models of spinal cord injury. Intralesional injection was found to be the best method, with high cell survival rates and no complications. This method holds promise for treating other disorders
Researchers have created a new model to study germ cell tumors in testes by transplanting embryonic stem cells into mouse models. The resulting tumors mimic the early stages of tumor development and offer valuable insights into the genetic regulation of these cancers. This approach has potential applications for developing novel therap...
Researchers developed a serum-free culture for mesenchymal stem cells (MSCs), increasing cellular growth and enhancing specific differentiation capacities. This breakthrough enables the use of 'off-the-shelf' serum-free media, promoting greater control over cell fate regulation and tissue engineering applications.
A study published in Cell Transplantation found that cryopreserved endothelial progenitor cells have the same phenotypic, structural, and functional properties as non-frozen cells. This discovery eliminates the need for cell isolation procedures before using these cells in clinical transplantation.
A Brazilian research team successfully established the first line of human embryonic stem cells (hES), but struggled to find a genetically diverse match for the diverse ethnic and genetic Brazilian population. The researchers overcame legal and ethical guidelines to create hES cell line BR-1, which is mostly European in origin.
Researchers found periodontal ligament stem cells to be the most efficacious in treating advanced gum disease, outperforming other dental stem cell types. The study suggests PDLSCs may offer a new treatment option for periodontitis, a common cause of tooth loss worldwide.
Researchers found that umbilical cord blood-derived mensenchymal stem cells (uMSCs) can delay renal function deterioration and alleviate symptoms of lupus nephritis. Early transplantation with allogenic MSCs showed the most promising results, supporting their potential use in treating systemic lupus erythematosus.
Trapping prostate cancer stem cells with self-assembling nanomaterials inhibits colony formation and cell division in vitro. The approach may offer a new treatment strategy for metastatic hormone-refractory prostate cancer by targeting cancer stem cells, which are thought to be the origin of tumor metastasis.
Recent studies published in Cell Transplantation suggest a link between exercise, brain cell regrowth, and improved mental health. Exercise has been shown to promote neurogenesis, which may help counteract stress-related disorders and improve mood and cognition.
Researchers have found that stem cells derived from umbilical cord blood cells and menstrual blood may offer therapeutic benefits for disorders such as stroke, Alzheimer's disease, and amyotrophic lateral sclerosis (ALS). These cells can differentiate into various types of cells and have anti-inflammatory properties.
Researchers found that transplanted EPCs from human umbilical cord blood significantly accelerated wound closure in diabetic mouse models. The study showed that growth factors and cytokines produced at the wounded skin sites contributed to healing. This experimental study opens the possibility of using endothelial progenitor cells deri...
Two studies investigate the role of bone marrow stem cells in diabetic therapy and islet cell regeneration, offering new therapeutic possibilities. Researchers also focus on improving pancreatic islet culture and preservation techniques to prolong the survival and functionality of islet cells in vitro.
Researchers found that transplanting autologous renal progenitor cells into rats with kidney damage from pyelonephritis improved kidney structure and function. The study demonstrated benefits for a disease characterized by severe inflammation, renal function impairment, and scarring.
Researchers found a statistically significant decrease in peritoneal cavity fluid and clinical and biochemical improvement in many patients. The study suggests that cell transplantation might be clinically significant beyond improving laboratory parameters, potentially through paracrine effects.
Researchers have isolated and characterized adult fat cell-derived stem cells, which maintain their stem cell characteristics and could aid in tissue regeneration. The study's findings suggest that these cells may be useful for cell-based therapies and represent a promising area of research for plastic surgery applications.
Researchers successfully transplanted cord blood-derived cells into a severely brain-injured child, showing improvement after six months. The study found that the cells persisted in the brain hemisphere and improved functional neurological impairment.
Two studies published in Cell Transplantation found that administering bone marrow stem cells promoted functional recovery and reduced damage after stroke, while VEGF administration provided near complete neurological protection. These findings suggest two potential treatments for stroke and could offer new recourse against its ravages.
Researchers tested three MRI contrast agents on different stem cell populations and found changes in stem cell proliferation depending on the agent used. The study revealed varying labeling efficiencies with each agent, but no significant alterations in cell phenotypes or differentiation.
Two Japanese research teams have reported breakthrough studies in liver cell transplantation, with one team finding that induced pluripotent stem cells (iPS) can differentiate into hepatocyte-like cells and another team successfully transplanting porcine hepatocytes into mice with acute liver failure, highlighting progress in overcomin...
The new journal aims to evaluate the safety and effectiveness of cell medicine in treating debilitating and fatal disorders. The journal features a diverse global editorial board and publishes papers on cell therapy with direct clinical relevance.
Researchers have successfully reprogrammed adult mouse fat cells and neural cells to become induced pluripotent stem cells (iPS) that can differentiate into various cell types. The study demonstrates that adipose tissue-derived cells are the most amenable to reprogramming, making them a promising source for clinical applications.
Researchers found that monocyte-derived cells can induce myocardial protection by reducing cardiac cell apoptosis and enhancing endothelial cell proliferation. The cells also secrete growth factors with anti-inflammatory properties, which help protect heart tissues from programmed cell death.
A team of researchers has developed a more consistent method for isolating pancreatic islet cells from brain-dead donors using ductal injection, resulting in three type 1-diabetes patients becoming insulin-independent. The study's success rate surpasses the standard 50% with an impressive 80% clinical islet transplantation rate.
The American Society for Neural Therapy and Repair (ASNTR) has awarded Dr. Shinn-Zong Lin with the 2010 Bernard Sanberg Memorial Award for Brain Repair in recognition of his significant research contributions in neuroscience. Dr. Lin's work focuses on neural and stem cell transplantation therapy for stroke and Parkinson's disease.
Researchers have found that olfactory ensheathing cells (OECs) transplanted into children and adolescents with cerebral palsy can improve neurological function without causing significant side effects. The study suggests OEC transplantation may be a promising treatment for this incurable disorder.
A study published in Cell Transplantation has found that using ICG to label human embryonic stem cell-derived cardiomyocytes substantially improves efforts to optically track stem cells after transplanting them into heart tissues. The labeling procedure did not impair the viability or functional integrity of the cells.
Researchers have found that bone marrow cell transplants can improve heart function and relieve symptoms of refractory angina. Apelin, a newly described peptide, was also shown to increase significantly in patients who received the transplants, leading to improved cardiac function.
Researchers found that transplanted hepatocyte cells and growth factor genes rapidly infiltrate damaged livers, promoting regeneration. Prolonged HSC activation is beneficial for proliferation of transplanted cells.
Researchers developed a self-assembling nanofiber scaffold to regulate cell activity, delaying growth and differentiation. The innovation enhances the survival rate of implanted stem cells, allowing them to maintain their youthful state and promote neural circuit regeneration.
Researchers found that transplanted human-derived umbilical cord blood stem cells had positive therapeutic effects on specific lung and heart disorders in animal models. The study showed that MSCs have anti-inflammatory effects and can differentiate into various cell types, including lung-specific cells.
A study by the Cell Transplantation Center of Excellence found that autologous brain cell transplants can provide brain protection and repair neural damage in donor primates. The cells survived at an impressive 50% rate for four months post-implantation, offering a promising new approach to treating neurological disorders.
Researchers found that trophoblast stem cells (TSCs) can survive in female mice livers without ovarian hormones, but not in male liver's even after castration. This study suggests a new approach for therapeutic cell transplantation using TSCs.
Researchers found that green tea component EGCG can prolong the preservation of stored blood platelets by up to six days via anti-apoptosis properties. Additionally, EGCG was shown to preserve skin tissues by controlling cell division and preventing oxidation, allowing for the storage of skin grafts up to seven weeks.
Researchers have found that placenta-derived stem cells can reduce lung fibrosis and inflammation in mice with bleomycin-induced injury. The study's findings suggest these cells may be useful for cell therapy of fibrotic diseases in the future.
Researchers explore two bone marrow cell delivery methods to treat heart attacks and limb ischemia. Studies show that anterograde intra-coronary delivery improves left ventricle function, while bone marrow stem cell transplants increase blood flow in severely ischemic limbs.
Guided fat precursor cells lead to wider nerves and less muscle atrophy in injured peripheral nerves of laboratory rats. The study demonstrates the potential benefit of adult precursor cells, such as those from adipose tissue, for nerve repair and functional recovery.
The American Society for Neural Therapy and Repair (ASNTR) endorses the new NIH Guidelines, enabling research on human embryonic stem cells derived from IVF embryos. This move aims to facilitate the development of stem cell therapies for central nervous system diseases by reducing restrictions on cell line acquisition.
Co-transplanting bone marrow stem cells with embryonic stem cells eliminates tumor formation in spinal cord injury (SCI) laboratory animals. The study suggests that BMSCs induce differentiation of undifferentiated ES cells into a neuronal lineage, resulting in suppression of tumor growth.
Howard J. Federoff has received the Bernard Sanberg Memorial Award from the American Society for Neural Therapy and Repair (ASNTR) for his significant contributions to the field of neural therapy and repair. The award recognizes his research on gene therapy and neurodegenerative diseases such as Alzheimer's and Parkinson's.
Researchers found significant benefits in glycemic control and reduced insulin requirements in patients with type 2 diabetes who received stem cell infusion and hyperbaric oxygen treatment. The combination therapy showed promising results in decreasing type 2 diabetes morbidity and mortality.
Researchers reported on eight patients with spinal cord injury (SCI) who received multiple route bone marrow stem cell injections, showing functional improvements such as bladder control. The study demonstrated the safety and feasibility of multiple route administration of bone marrow-derived stem cells for SCI treatment.