Researchers discovered that RAGE protein plays a crucial role in repairing DNA damage and healing tissue in the lungs. Treatment with RAGE protein reversed scarring and restored functionality in mice with pulmonary fibrosis. The study provides new insights into molecular therapy for lung damage and offers potential therapeutic benefits.
A study published in Diabetes Care found that diabetes-related mortality in Germany is higher than expected, with approximately 21% of all deaths attributable to the disease. The majority of deaths occurred among older adults, and men had a significantly higher number of preventable excess deaths compared to women.
Researchers found that a weight loss of more than 10% can lead to a significant reduction in disease risk for individuals with metabolically unhealthy obesity. This intermediate goal can serve as a low-hanging fruit, providing documented protection against obesity-related metabolic diseases, and improving patient motivation through doc...
A study found that increased DPP4 production in the liver contributes to obesity, fatty liver disease and insulin resistance. Elevated DPP4 levels also promote less sensitivity to insulin, increasing the risk of non-alcoholic fatty liver disease.
A study by researchers from the German Center for Diabetes Research found that nearly 22% of hospitalized patients in Tübingen had diabetes or prediabetes. Patients with diabetes required longer hospital stays and were at a higher risk of complications, highlighting the need for early detection and treatment.
Researchers found that fatty liver disease can cause damage to other organs, particularly the pancreas. The protein fetuin-A produced by the fatty liver triggers an inflammatory response in the pancreas, leading to reduced insulin secretion and worsening of blood glucose regulation.
Researchers found that low leg fat mass is a crucial factor in lean individuals at increased risk of cardiometabolic diseases, similar to lipodystrophy phenotypes. The study suggests personalized prevention and treatment strategies for metabolically unhealthy lean people.
Researchers found that intranasal insulin improves functional connectivity in brain regions involved in cognitive processes and appetite regulation. The study suggests that insulin in the brain may help regulate eating behavior and facilitate weight loss by suppressing the relationship between adiposity and hunger sensation.
A nutrition study found that men with impaired glucose metabolism experience a negative impact on blood glucose regulation when consuming high-carbohydrate foods in the evening. In contrast, healthy men do not show a significant effect of carbohydrate timing on blood glucose levels.
A single high-fat meal can reduce the body's sensitivity to insulin, leading to increased fat deposits in the liver and changes in energy metabolism. This study found that even a small amount of palm oil triggers insulin resistance, which can contribute to the development of type 2 diabetes and fatty liver disease.
Researchers developed an improved Fatty Liver Index (FLI) to predict non-alcoholic fatty liver disease with high accuracy. The new index includes parameters such as age, waist circumference, and triglyceride levels, as well as a gene variant for fatty liver, to provide more precise diagnosis and risk assessment.
A study published in Diabetes journal found epigenetic changes in the DPP4 gene are associated with fatty liver development in both mice and humans. These changes, detected at six weeks of age, lead to increased enzyme production and correlate with fat content in the liver.
A new study found that high-protein diets reduced liver fat in individuals with type 2 diabetes, with significant reductions seen in half of the participants. The diets were based on either plant or animal protein sources, and all participants benefited from the high-protein diet.
Research suggests that mutations in the FTO gene and variants of the dopamine D2 receptor gene increase the risk of developing obesity and diabetes. The study found that individuals with both genetic alterations had a higher percentage of body fat, more abdominal fat, and lower insulin sensitivity.
The updated DIfE German Diabetes Risk Score takes into account familial predisposition and provides personalized recommendations to reduce risk. The test is now available online and on mobile devices, offering a quick and precise assessment of type 2 diabetes risk.
Researchers found that epigenetic modifications in the Igfbp2 gene increase susceptibility to obesity and predict fatty liver disease. Young animals with this modification exhibit impaired glucose metabolism and morbid obesity.
Fatty liver and visceral obesity are key predictors of prediabetes and cardiovascular risk. Insulin secretion failure and resistance also play a significant role in modulating disease risk.
Researchers found isomaltulose reduces GIP secretion and increases GLP-1 secretion, preserving insulin secretion. This helps prevent severe fluctuations in blood glucose levels.
A recent study by DZD researchers found that height has a significant impact on the mortality from certain common diseases. Tall people have a lower risk of cardiovascular disease and type 2 diabetes, but a higher cancer risk. The study suggests that increased height may be related to overnutrition during growth stages.
A high-fat diet during pregnancy and lactation leads to epigenetic changes in the offspring, affecting metabolic pathways regulated by the gut hormone GIP. Adult offspring are more susceptible to obesity and insulin resistance, similar mechanisms cannot be ruled out in humans.