Researchers found that metformin treatment does not have a positive effect on the brain development of offspring mice. The study suggests that the maternal metabolic state is crucial in determining the impact of metformin on the child's health.
Researchers found that Kallistatin expression increases after weight loss, improving hepatic insulin sensitivity in obese mice. This protein may be an interesting therapeutic target for treating obesity and type 2 diabetes.
A landmark study stratifies people with type 2 diabetes using routine variables to visualize metabolic diversity. The algorithm identifies different subtypes of the disease, which can help in targeted prevention and treatment.
Researchers identified six novel protein biomarkers associated with incident coronary heart disease in individuals with and without type 2 diabetes. The study found that these biomarkers may offer potential new approaches to prevention and treatment of CHD.
Research reveals metformin treatment does not benefit offspring brain development despite positive effects on pregnant animals. Maternal metabolic state plays a crucial role in shaping the outcomes.
A study by the DZD found that losing abdominal fat can reverse prediabetes and reduce the risk of developing type 2 diabetes. Participants who achieved remission showed improved insulin sensitivity and reduced markers of kidney damage, while maintaining similar weight loss as non-responders.
Recent cluster analyses identify novel risk stratification concepts to better implement precision medicine in clinical practice. Metabolically unhealthy individuals, regardless of weight, face a higher CVD risk compared to obese, metabolically healthy peers.
Researchers from DZD and Harvard Medical School identified key hepatokines dysregulated in NAFLD, predicting type 2 diabetes and cardiovascular events. Hepatokine cluster analysis revealed distinct subtypes of people with fatty liver having different pathomechanisms of insulin resistance.
A global study found a significant increase in diabetic ketoacidosis cases among children diagnosed with type 1 diabetes during the COVID-19 pandemic. The observed prevalence was significantly higher than predicted, highlighting the need for better public awareness and screening programs.
A recent study shows that eight weeks of exercise can restore the brain's insulin sensitivity in severely overweight adults, leading to improved metabolism and reduced visceral fat. This opens up new therapeutic possibilities for reducing obesity and diabetes risk factors.
A new review article aims to improve the impact of human islet research on type 2 diabetes treatment by addressing challenges and proposing solutions. The study highlights the importance of standardizing islet collection and analysis protocols to accelerate progress in understanding T2D.
Diabetes-resistant mice develop a protective beta cell cluster with reduced glucose uptake and increased beta cell division, while diabetic-prone mice experience metabolic stress and beta cell failure. This study reveals the key role of adaptive gene expression in protecting against type 2 diabetes.
Researchers have combined tesaglitazar and GLP-1 in a new hormone combination for type 2 diabetes treatment, improving glucose metabolism with minimal doses. The new drug has shown promise in animal studies, reducing kidney damage and increasing insulin sensitivity.
A recent study found that obesity, impaired blood glucose metabolism, and high blood pressure significantly increase the risk of dying from COVID-19 in young and middle-aged people. Researchers analyzed data from the European case registry LEOSS and found that patients with all three conditions had a similar increased risk of death as ...
Researchers used lipidomics to identify lipids associated with cardiovascular disease and Type 2 diabetes, finding a link between unsaturated fatty acids in the diet and reduced risk. The study's findings support replacing saturated fats with unsaturated ones for preventing these diseases.
A recent study published in Microbiome found that a calorie-reduced diet can alter the gut microbiome, improving metabolism and delaying immune senescence. Researchers used a low-calorie diet to investigate its effects on the gut microbiome and its impact on metabolism and the immune system.
Researchers discovered specific ceramides in the blood are associated with unfavorable levels of diabetes-related compounds, linking unhealthy diets to increased risk. Ceramide profiling may enable more precise dietary approaches for preventing cardiometabolic diseases.
NAFLD and diabetes are linked through subclinical inflammation, insulin resistance, and dysregulated liver-derived proteins. Integrating knowledge from childhood to older age can help personalize prevention and treatment.
A comprehensive review found that prediabetes is associated with an increased risk of comorbidities such as cardiovascular disease, stroke, and chronic kidney disease. The study suggests that prediabetes poses a significant threat to public health due to its rising prevalence worldwide.
Researchers found that SGLT2 inhibitor empagliflozin can improve insulin sensitivity in the brain, leading to better glucose control and reduced liver fat content. This breakthrough discovery positions SGLT2 inhibitors as a potential treatment for insulin resistance in the brain.
Exercise modifies the adaptation of the liver to increased energy intake, regulating enzymes for glucose and fructose degradation. Regular physical activity also improves glucose control and reduces fat storage in the liver, offering a comprehensive insight into molecular adaptations to high-energy diets.
Individuals with high-risk prediabetes significantly improved their blood glucose levels through more exercise and healthy eating behavior, while those at low risk showed limited benefits from conventional lifestyle intervention. The study's findings support personalized interventions tailored to each patient's risk profile for effecti...
A study found that obesity is associated with severe COVID-19 outcomes, including hospital admission or death. Additionally, accelerated immunosenescence may be a key mechanism explaining the relationship between obesity and T2DM in severe COVID-19. Vaccination effectiveness may also be impacted by metabolic disorders.
Researchers used whole-body magnetic resonance imaging to detect diabetes based on fat distribution patterns. The study showed that lower abdominal fat accumulation is an important indicator of diabetes pathogenesis, allowing for better preventive and therapeutic options.
A transgenic pig model has been developed allowing for the first time the in vivo fluorescent labeling of age-distinct insulin secretory granule pools. This model enables researchers to study insulin turnover in normoglycemic conditions, closing the translational gap between humans and rodents.
A new study has identified risk factors for a severe course of COVID-19 in people with diabetes, including male sex, older age, high blood glucose levels, and existing comorbidities. Chronic metformin treatment was found to be associated with a reduced risk of severe COVID-19.
Researchers have identified five novel diabetes subgroups with distinct biomarker profiles, highlighting the importance of inflammation in diabetes-related complications. These differences may enable early detection and therapy in individual subgroups, particularly those with severe insulin resistance.
Researchers discover adolescent adipose tissue differs from adult white fat in terms of precursor cell properties. Modulating Asc-1 function may help obese patients maintain a healthy metabolism and delay obesity treatment.
Researchers have discovered a new target for developing a drug treatment for obesity and type 2 diabetes. Glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via a receptor in the brain, according to a recent study published in Cell Metabolism.
A recent study published in Nature Reviews Endocrinology highlights the interconnection between obesity, impaired metabolic health, and COVID-19 severity. The research found that obesity, visceral fatness, and impaired metabolic health are significant risk factors for a more severe course of COVID-19.
A large observational study published in Diabetologia found that obesity is associated with a higher risk of microvascular complications in people with type 2 diabetes. The study suggests that maintaining a healthy body mass index (BMI) before and after a diabetes diagnosis can help prevent these complications. Furthermore, the researc...
Researchers have identified six distinct subtypes of prediabetes, differing in disease development and risk. These subtypes can be used to predict individual risk of developing diabetes and secondary diseases, enabling targeted prevention measures.
Researchers have identified 105 epigenetic changes in blood cells that precede the onset of type 2 diabetes. These changes are associated with altered methylation activity and expression patterns in islets of Langerhans, suggesting a potential diagnostic marker for early detection.
A study found that endurance exercise improves mitochondrial respiration in skeletal muscles but has no impact on adipose tissue. This difference affects insulin sensitivity, with women showing higher cellular respiration in adipose tissue than men.
A genetic variant of the DUSP8 gene impairs brain response to insulin, leading to increased risk of type 2 diabetes. Research reveals protein Dusp8's regulatory effects on hypothalamic insulin sensitivity and inflammatory processes.
A high-protein diet with a calorie-reduced intake was found to decrease liver fat by around 40% in obese individuals with non-alcoholic fatty liver disease. The study suggests that the positive effect of the high-protein diet is due to suppressed uptake, storage, and synthesis of fat in the liver.
Elevated NT-proBNP levels are associated with a reduced risk of developing type 2 diabetes, especially in women. However, those who develop diabetes with elevated NT-proBNP have a higher risk of macro- and microvascular complications such as heart attack, stroke, or severe damage to eyes, kidneys, or nerves.
Research suggests that a high amount of hip and leg fat mass is crucial to maintain metabolic health. Studies show that low visceral fat and high lower body fat may be equally important for retaining cardiometabolic health.
Researchers have identified three new genes that play a role in preventing fatty liver development. The genes IRGM, Ifgga2, and Ifgga4 produce regulatory proteins that counteract fat accumulation in the liver, but genetic variations lead to reduced protein production, resulting in increased fat content.
Researchers from DZD and Boston Children's Hospital highlight the importance of body weight and metabolic health in understanding COVID-19 severity. Studies suggest that obesity may increase the risk of severe illness, independent of cardiometabolic diseases.
A long-term study found that brain insulin sensitivity determines both body weight and the distribution of fat in the body. Participants with high insulin sensitivity in the brain experienced a significant reduction in visceral fat and weight, which was maintained over nine years.
Researchers deciphered a mechanism impairing regulatory T cell differentiation and stability in type 1 diabetes. Inhibiting the miRNA142-3p molecule increased functional Tregs and reduced autoimmune activation.
Researchers found that intermittent fasting reduced pancreatic fat in mice, a key finding in the development of type 2 diabetes. The study suggests that excess weight-induced fat accumulation in the pancreas contributes to the onset of diabetes.
Researchers discovered a sex-specific obesity locus for the Lyplal1 gene, finding that females have a higher mitochondrial activity and produce more brown adipose tissue, reducing fat mass and insulin resistance. In contrast, males exhibit low mitochondrial activity and increased weight and insulin resistance.
Research finds that socio-economic conditions in regions affect T1 diabetes treatment, with disadvantaged areas having higher blood glucose levels, lower use of pump therapy and CGMS, and better outcomes for severe hypoglycemia. Frequent use of pump therapy and CGMS could improve treatment outcomes in these regions.
Research reveals epigenetic changes in IGFBP2 gene influence type 2 diabetes risk. Higher IGFBP2 levels in blood lower diabetes risk.
Fatty liver disease is a complex condition that can lead to severe complications like type 2 diabetes and cardiovascular disease. A new review article proposes the use of new diagnostic and therapeutic approaches to enable specific risk prognosis and individualized treatment.
A study has identified six biomarkers of inflammation associated with the risk of polyneuropathy in people with type 2 diabetes. The findings suggest a complex interaction between innate and adaptive immunity in the development of this complication.
A recent study published in Respiration has found that people with type 2 diabetes are significantly more likely to suffer from breathlessness and restrictive lung disease. The research team also discovered an association between albuminuria and RLD, suggesting a possible link between lung and kidney diseases.
A novel adipokine, WISP1, secreted by abdominal fat promotes insulin resistance and systemic inflammation. Researchers identified a link between poor oxygen supply and increased WISP1 production, which could lead to improved insulin action and alternative treatment approaches for obesity-related diseases.