Ewing's sarcoma treatment strategy proposed by Georgetown University Medical Center researchers, targeting EWS-FLI1 and helicase protein interaction to promote cancer development.
A recent study found that millions of dollars are being squandered on unnecessary medical tests ordered during routine doctor visits. The research estimated annual direct medical costs for the three most expensive 'D' category tests to be between $47 million and $194 million.
Researchers at Georgetown University Medical Center argue that medical journals should ban drug advertisements due to their potential influence on prescribing practices. The authors found that pharmaceutical ads in top medical journals reach a targeted audience and generate high returns for drug companies.
A new study published in Neuron suggests that facial recognition relies on a similar neural mechanism as other object recognition, rather than specialized processing. The researchers used computational modeling and fMRI to find that a small group of neurons in the fusiform face area is highly selective for different faces.
A meta-analysis of 18 studies suggests that soy food intake is associated with a reduced breast cancer risk, particularly in premenopausal women. However, the study found insufficient evidence to support the use of soy supplements as a breast cancer preventive measure.
Scientists discover that vitamin D can regulate an oncogenic protein called beta-catenin, which is involved in colon cancer development. A drug mimic of vitamin D could potentially prevent some cancers at early stages, but may not be effective for late-stage cancers.
Researchers found that Ginkgo biloba extract significantly slowed the growth of aggressive breast tumors in mice by 80 percent, while also reducing brain tumor size. The study suggests that Ginkgo biloba may have preventive effects on invasive cancers and is being explored as a potential treatment for Alzheimer's disease.
A study found that receptors on brain nerve cells bind to apolipoprotein E and glutamate, affecting memory formation. Efficient APOE levels may clog these binding sites, preventing glutamate from activating processes necessary for memories.
Researchers from Georgetown University Medical Center have discovered that certain vegetables, such as broccoli and soy beans, can increase the levels of BRCA1 and BRCA2 proteins in damaged DNA. This could explain how eating vegetables cuts a person's risk of developing cancer.
The study found that the BRCA1 gene interacts with progesterone receptors to inhibit growth, but its absence leads to increased growth in response to estrogen and progestin. This understanding could lead to new treatment options for hormone-dependent cancers and ordinary cancers resulting from under-expressed BRCA1 genes.
Researchers found that serotonin is passed between key cells in the immune system, activating an immune response. The study suggests that commonly used SSRI antidepressants could either restore healthy immune function or trigger autoimmune disease.
Chemotherapy has been shown to improve survival rates for patients with advanced colon cancer, regardless of age or sex. The study found that women and the elderly received the same benefit as younger adults, but were less likely to receive chemotherapy treatment.
A study published in the BMC Neurology Journal found that patients with chronic fatigue syndrome have a set of proteins in their spinal cord fluid not detected in healthy individuals. These proteins could serve as a 'biosignature' for the disease and may help diagnose CFS in the future.
A recent study found that African-American women with faulty cell cycle checkpoints are at a nearly five-fold increased risk of developing lung cancer. The study suggests that less effective cell cycle checkpoints may lead to genetic instability and increased cancer risk in this population.
A team of researchers has isolated a new defensin, plectasin, from fungi that is highly effective against drug-resistant bacteria. Plectasin targets specific strains of Streptococcus pneumoniae and Streptococcus pyogenes, including those resistant to conventional antibiotics.
A study confirms that couples using natural family planning have intercourse just as frequently as those using other methods. They engage in more frequent sex before and after fertile times, with less sex during fertile days.
A study published in Tissue and Cell reveals that defects in the adult stem cell niche can lead to breast cancer development. Researchers found that each cell population plays a different role in breast cancer and that environmental factors influence the risk of becoming cancerous.
Researchers discovered that compounds from cruciferous veggies can slow down benign to malignant tumors in mice, suggesting potential protection against lung cancer development. The studies also found that these compounds can push human lung cells to commit 'suicide', stopping fast-growing cancer cells.
Georgetown University researcher aims to create mathematical model of how the brain recognizes objects in different scenes. His work has applications in artificial intelligence and understanding neurodevelopmental disorders like autism.
Researchers are working on a next-generation HPV vaccine that is both protective and therapeutic, which can be converted into powder for easier transport. The new vaccine aims to be less expensive than existing options like Cervarix and has shown promise in preventing HPV infection.
Researchers found that activated Stat5 levels in prostate cancer cells predict disease progression and survival rates. Patients with high levels of activated Stat5 had a 15-year progression-free survival rate of 46% compared to 62% without activated Stat5.
Researchers have discovered that cyclin D1 overexpression disrupts BRCA1's normal role as a cancer inhibitor in breast tumors. Cyclin D1 binds to the same estrogen receptor as BRCA1, negating its tumor suppressor function and promoting cell proliferation.
Researchers at Georgetown University Medical Center have developed a cutting-edge matrix assembly technology to analyze large numbers of tumors. The new method allows scientists to discover and detect unique biomarkers of disease in patients, leading to more accurate patient diagnosis and treatment.
Researchers have found that an experimental drug can effectively prevent much of the brain damage caused by traumatic injury. In a study using rat models, the drug was shown to reduce brain damage and improve cognitive and motor function. The breakthrough could potentially lead to new treatments for human traumatic brain injuries.
Georgetown University is helping create a national cancer biomedical informatics grid to link research centers in real time, sharing data and results more rapidly. The $20 million grant aims to improve cancer research and treatment through the adoption of common research tools.
Researchers at Georgetown University Medical Center discovered a chocolate compound that stops cancer cell cycles in lab experiments. The compound, pentamer, deactivates tumor suppressor genes and proteins involved in regulating the cell cycle, preventing cancer cells from dividing.
A Georgetown University researcher reveals hidden sponsorship of articles and lectures in medical journals, compromising patient care. A public database is needed to disclose conflicts of interest.
The research found that active Stat5 suppressed invasive tumor cell activities and aggregated breast cancer cells into clusters resembling healthy cells. Loss of Stat5 stimulated invasion, supporting its potential as a biomarker to predict risk and outcome in early-stage breast cancer patients.
A new study finds that adult dyslexics can improve their reading skills with a phonological intervention program, revealing potential for late-life literacy gains. The brain scans also showed activity changes in specific regions, including the right hemisphere, as a way to compensate for deficiencies.
A new study by Georgetown University Medical Center reveals that functional endoscopic sinus surgery significantly improves fatigue levels in patients with sinusitis. The procedure has been shown to offer substantial benefits for those not responding to medications, with cost savings also a consideration.
Georgetown University is launching a new trauma center with a $2.5 million NIH grant, partnering with local organizations to develop innovative treatment approaches for low-income women and their families. The Center will conduct research on culturally appropriate methods for trauma intervention and provide training and mentoring.
A review found no reliable scientific evidence supports the use of C. aurantium for weight loss, and high doses may not be safe. The herb interacts with drugs in a manner similar to grapefruit juice, increasing blood levels and potential side effects.
A recent study found a significant correlation between active Stat5 protein and high-grade prostate cancer. The research suggests that blocking the signals that turn on Stat5 may lead to effective treatment strategies for advanced prostate cancer.
Researchers have identified a possible connection between the IRF1 gene and tamoxifen resistance in breast cancer. By adding interferon to antiestrogen therapy, tumors may become sensitive to treatment, potentially inhibiting new cancers or disease reoccurrences.
Researchers found that women with breast tumors retaining the Stat5 protein biomarker have a highly favorable prognosis and may be cured by surgery alone. The study suggests that detection of this marker could lead to improved individualized therapy, including more careful follow-up and aggressive treatment for high-risk patients.
Researchers at Georgetown University Medical Center have discovered that axons are highly sensitive to tiny changes in molecular gradients. This finding has significant implications for understanding neural development and regeneration. The team plans to further investigate the role of molecular gradients in guiding axon growth.
Research suggests that women with BRCA1 or BRCA2 mutations are more likely to choose double mastectomy, with 48% of those who tested positive opting for the surgery compared to 24% without a mutation. Genetic counseling and testing can help patients make informed decisions about their treatment.
Children with cerebral palsy (CP) exhibit difficulty controlling muscles due to brain damage, rendering everyday tasks challenging. An innovative therapy approach has yielded significant benefits in enhancing motor function and overall quality of life for treated children.
Children with hyperlexia display exceptional reading skills, often exceeding their age, yet struggle with social interactions. FMRI studies reveal distinct brain activity patterns, highlighting the neural mechanisms underlying this rare condition.
The new guidelines call for searches within the National Marrow Donor Program registry conducted by histocompatibility specialists, with patients HLA typed to a high degree of resolution. High-resolution HLA typing is essential for all transplant patients, and the guidelines encourage considering transplants even without a perfect match.
A new study by Georgetown University Medical Center researchers found that low-dose CT screenings can accelerate smoking cessation rates by 14%, significantly higher than the national average. This promising finding suggests it's never too late to treat nicotine dependence, and further research may lead to more effective interventions.
Georgetown University Medical Center has received a $6.5 million NIH grant to develop an innovative medical surveillance system that connects DC emergency rooms during crises. The system, known as Project Sentinel Collaboratory, will utilize the InSight real-time data repository and analyze de-identified medical information, weather, t...
Researchers found that Peptide T significantly reduced HIV levels in cellular reservoirs, with some participants experiencing undetectable virus and increased CD4 counts. The therapy showed promise as a complement or alternative to existing treatments for HIV/AIDS.
Researchers at Georgetown University Medical Center have discovered a direct link between genes causing breast and other cancers, and those linked to diabetes. The study suggests that drugs blocking the effects of one gene may be useful in stopping the conversion of normal tissue to malignant tissue.
A study found that patients with unexplained chronic fatigue had nine times more prevalent sinus symptoms than the control group, and six times more common in those with unexplained chronic pain. Sinusitis may be a contributing factor to chronic fatigue syndrome in some cases.
A new study measures the emotions of doctors-in-training, finding that anxiety, guilt, and compassion are prevalent feelings. The research highlights the importance of acknowledging and managing these complex emotions to improve medical education and patient care.
Researchers found a direct link between low dose cadmium exposure and increased risk for breast cancer in female rats. Cadmium mimics estrogen's effects, leading to changes in mammary gland density and uterine weight, similar to early onset of breast cancer.
The Lombardi Cancer Center will investigate how drinking affects breast cancer risk, focusing on estrogens, free radicals, and gene mutations. The center aims to improve public health recommendations and inform individual lifestyle choices.
Researchers found that medication and cognitive behavioral psychotherapy (CBT) treatments significantly alleviated symptoms of depression in young Latinas and African-American women. The study, funded by the National Institute of Mental Health, confirmed that standard treatments can be effective for low-income minority women.
A new NIH-funded study found that low-dose naproxen and rofecoxib do not slow cognitive decline in patients with mild-to-moderate Alzheimer's disease. In fact, patients taking rofecoxib experienced more rapid cognitive decline than those on placebo or naproxen.