A recent study found that bypass surgery was more cost-effective than endovascular procedures for treating chronic limb-threatening ischemia, although uncertainty remains. The findings highlight the need for further research to identify subgroups where each approach may be more cost-effective.
A cohort study revealed racial differences in sonographic evaluation, with a 76% completion rate and excellent cancer exclusion ability in Black women despite fibroids impairing endometrial visibility. Fibroid presence did not hinder cancer detection accuracy.
A qualitative study found social license for AI in healthcare is conditional and dynamic, influenced by structural, performance, and relational factors. The findings provide evidence-based recommendations for designing and implementing AI tools that support both consumers and clinicians.
A cohort study found nearly 30% of screened patients had health-related social needs, with higher rates among racial and ethnic minority groups and those publicly insured. Inpatient HRSN screening workflows provide support for equitable reach, preserving benefits for patient groups with disproportionately high social needs.
This study examines associations between early life BMI and childbirth timing, as well as fertility outcomes among Danish women. Childhood body size is found to be associated with the timing of childbirth, highlighting the importance of addressing reproductive health early in life.
A cohort study identified risk factors for bacterial infection after firearm injury and found an association between bacterial infection and increased mortality among US adults. The study assesses the impact of firearm injuries on health outcomes in this population.
Autonomous oxygen titration increased the proportion of time spent in normoxemia and decreased time spent in hypoxemia compared to usual care. The intervention safely increased targeted normoxemia range time in acutely ill adults.
A study of 3786 children found no significant associations between screen use and developmental difficulties, except for very high use of electronic games. Early high screen use was associated with greater difficulties at 10 years old, but not sustained at 15 years.
This randomized clinical trial evaluates safety and efficacy of intra-arterial thrombectomy vs. medical management in patients with large-core infarcts after an acute ischemic stroke. The study found that endovascular treatment showed significant benefits in improving outcomes.
Researchers used connected speech analysis to distinguish between nonfluent, logopenic and semantic PPA variants with high accuracy. The study also showed expected atrophy associations and discriminated common neuropathologic classes in an autopsy-confirmed subset.
A cohort study of 2771 male children found no evidence that neonatal medical male circumcision is associated with an increased risk of autism spectrum disorder. The study also examined the effects of acetaminophen use during and after the procedure, but found it to be uncommon.
A phase 3 clinical trial found that adding high-dose vitamin D to standard treatment did not improve progression-free survival in patients with metastatic colorectal cancer. Median progression-free survival was 11.8 months with high-dose vitamin D compared to 10.3 months with standard dose.
A randomized clinical trial found that dexamethasone eye drops reduced the progression of retinopathy of prematurity to severe disease requiring invasive treatment in preterm infants. However, no differences in adverse events were observed.
A randomized clinical trial found video laryngoscopy with a Macintosh blade (VLM) and hyperangulated blade (VLH) to have significantly higher first-pass success rates compared to direct laryngoscopy (DL). The study supports the use of video laryngoscopy as a new standard for routine airway management in adult patients.
Artificial intelligence can exacerbate or mitigate inequities in correctional health systems. Designing AI for access, inclusion, and trust is crucial for ensuring health equity among incarcerated populations. The study outlines policy and implementation considerations necessary to address these concerns.
A survey study found that US women who own guns perceive themselves as safer than those who do not, with 41% believing owning a gun would increase their safety. The study suggests a need for targeted gun violence reduction interventions considering different perceptions of safety related to gun exposure.
A noninferiority randomized clinical trial found that an alternative first-line regimen containing doravirine, lamivudine, and tenofovir disoproxil fumarate produced less weight gain than a combination of dolutegravir, emtricitabine, and tenofovir alafenamide. The regimen was noninferior for viral suppression at 48 weeks.
US nursing homes have seen a significant increase in closures between 1985 and 2025, with changes in ownership and capacity reconfiguration being more common than permanent facility closure. The study highlights the need for policy and oversight considerations that take into account ownership transitions and capacity changes.
A nonrandomized trial found that aggregate neighborhood environmental interventions, including abandoned house remediation, significantly reduced fatal opioid overdoses. Community trash pickup and vacant lot cleanup were not associated with significant reductions or increases in opioid overdose rates.
The study highlights how school-entry vaccine requirements strengthen the connection between healthcare and education systems, ultimately improving children's health outcomes. By requiring vaccinations at school entry points, these policies create a valuable interface for public health interventions.
A decision analytical model and microsimulation study found that expanding alcohol screening and brief interventions in primary care could reduce premature mortality from major alcohol-related causes of death in US adults. By 2030, this expanded approach is projected to decrease annual alcohol-related potential years of life lost by −5...
A national study of obstetrician-gynecologists reveals that state abortion laws are linked to higher levels of clinical constraints and moral distress among OB-GYNs. The findings suggest that institution-level support is needed to address moral distress, regardless of the state's abortion policy context.
A recent study published in JAMA finds that nicotine e-cigarettes are an effective treatment for smoking cessation. The research suggests that e-cigarettes can help reduce the harms of cigarette smoking and support evidence-based pharmacologic treatment for smokers seeking to quit.
A study found geographic variation in measles-containing vaccine coverage among 7-year-old children in Northern California, highlighting the need for targeted vaccination efforts. The study assesses county-level data, revealing disparities in vaccination rates across different regions.
Combining cemiplimab, fianlimab, and paclitaxel-based neoadjuvant chemotherapy improved pathologic complete response rates in high-risk -negative breast cancer. Patients with the ImPrint immune signature showed enhanced sensitivity to the combination.
This cohort study examines trends in US Department of Veterans Affairs disability compensation receipt and benefit amounts between 2010 and 2024. Sociodemographic characteristics and disability type are associated with changes in these benefits.
Nicotine pouches are a new form of nicotine delivery that has sparked concerns over safety and efficacy. Researchers warn of potential harms, side effects, and accidental use, as well as the risk of dependence on these products.
A cross-sectional study examines trends in US FDA-approved cancer medicines for adult solid tumors between 2006 and 2025. The analysis reveals significant increases in approvals, particularly for original indication approvals.
Traveling patients from restrictive states experience mistrust of online sources, legal concerns, and knowledge gaps regarding remote services. Health policies should address these issues to improve understanding and trust in safe, reliable options.
Liquid biopsy targeting viral ctDNA holds promise as a diagnostic and surveillance tool for head and neck cancer. The study aims to monitor treatment response and assess minimal residual disease (MRD) to adapt treatment via precision oncology.
Research highlights importance of cardiovascular care in breast cancer patients and survivors throughout life. Cardiovascular risk factors and interventions are essential to prevent disease progression and improve quality of life.
This study analyzed 9845 Ukrainian refugee children aged 5 and under in Southern Poland, identifying 5 distinct health care utilization profiles. The findings suggest that refugee-hosting countries must prioritize emergency and inpatient care following a crisis to rapidly adapt health care resources.
High LDL-C led to 3.6 million deaths and 90.7 million disability-adjusted life years in 2023, despite declining mortality rates. The absolute burden increased due to population growth and aging, with regional disparities emerging.
A cross-sectional study identified critical methodological limitations in RCTs of CHM, including unclear hypotheses and inadequate allocation concealment. The study highlights the need for improved planning and conduct of CHM RCTs, with superior designs published in English-language journals.
A case-control study found that individuals with delinquent mortgage payments, repossessions, late credit card payments, and lower credit scores had a significantly increased risk of suicide. The study's findings suggest that financial stressors play a critical role in the development of suicidal thoughts and behaviors.
Researchers found a significant increase in binge drinking and heavy drinking among pregnant women in the US between 2011 and 2024. The study highlights the importance of addressing alcohol consumption during pregnancy, particularly among vulnerable populations such as those with tobacco use or mental health concerns.
A phase 3 randomized controlled trial found that gefurulimab significantly improved clinical benefits for adults with generalized myasthenia gravis, resulting in meaningful improvements in daily living and muscle strength scores. Most side effects were mild and similar between treatment and control groups.
A randomized clinical trial in South Delhi, India found that an integrated package of health, nutrition, and early stimulation support significantly improved the growth of term small-for-gestational-age infants. Infants who received this intervention had a higher weight at 12 months compared to those receiving usual government care.
A cross-sectional study evaluates state-level limitations and exemptions regarding cellphone use among public school students. State laws regulating cellphone use vary significantly across the US, with some states allowing or restricting phone use during school hours.
A cluster randomized clinical trial found that portable high-efficiency particulate air (HEPA) filters reduced winter respiratory infection rates among older adult residents in some care homes. However, the study showed no significant difference in infection rates between homes with HEPA filters and those without them.
A cross-sectional study investigates whether the time of day for influenza vaccination affects its effectiveness in preventing subsequent infections. The study found that vaccinations given later in the day may be less effective than those administered at other times.
A study of 997,701 ED visits in Alberta and Ontario found a significant association between wildfire-sourced PM2.5 and a 6% increase in ED visits for migraine and primary headache syndromes. Associations were attenuated in less deprived areas, suggesting that wildfire-sourced PM2.5 may trigger severe headache episodes requiring ED care.
A cross-sectional study of 172 venture capital-backed maternal health startups identified significant gaps in pregnancy care delivery, particularly for low-income populations. The study found that while startups have the potential to facilitate innovation, few address health equity concerns.
Direct patient or caregiver prior authorization engagement is associated with adverse outcomes, including delays and suboptimal care. This study may inform future research and intervention development to navigate PA-related administrative burden.
A cohort study of California educators found associations between trihalomethanes in drinking water and increased uterine cancer risk, including with endometrioid tumors. Further investigation is warranted to understand the role of drinking water contaminants as modifiable risk factors for this common gynecologic cancer.
This study found that young, non-Hispanic white women who are physically active and drink heavily are more likely to engage in intentional outdoor tanning. Intentional tanning is associated with increased risk of sunburn and skin cancer, highlighting the need for targeted strategies to reduce this behavior.
A recent cohort study found similar rates of secondary treatment receipt among men with localized prostate cancer by race, but observed mortality disparities persisted. These findings raise concerns about healthcare inequities and the need for targeted interventions to address racial disparities in cancer care.
A cohort study of Korean patients with lung cancer found that international screening guidelines excluded 64.6% of patients, many without smoking history. Ineligible patients had lower mortality risk than eligible patients, suggesting tailored approaches are necessary to enhance early detection.
A cohort study in Taiwan found that spouses of individuals with dementia had a significantly higher risk of developing dementia compared to unexposed spouses. The association varied depending on the family context and socioeconomic status, highlighting the importance of considering household factors in dementia risk assessment.
The 2026 American College of Cardiology/American Heart Association/Multisociety Dyslipidemia Guideline reclassified approximately one-quarter of adults, with two-thirds reassigned to lower-risk categories and one-third to higher-risk categories. This shift was driven by differences in risk factors among males, non-Hispanic Black indivi...