The 2026 American College of Cardiology/American Heart Association guideline substantially expands the U.S. population recommended for primary prevention statin therapy, targeting lower-risk individuals. The updated recommendations aim to reduce atherosclerotic cardiovascular disease risk and improve public health outcomes.
Long-term exposure to road traffic noise was associated with a higher risk of Parkinson's disease, according to the study. Having a quiet facade mitigated this association, suggesting that reducing noise levels may be a viable strategy for preventing or managing the condition.
A nationally representative analysis found substantial gaps in LDL-C control, with increasing disparities across primary prevention categories and underuse of lipid-lowering therapy. The study provides a contemporary population-level benchmark for the updated guideline framework.
Clesrovimab, a long-acting monoclonal antibody, demonstrates safety and efficacy in reducing severe respiratory syncytial virus (RSV) disease in high-risk infants over two RSV seasons. The study supports the use of clesrovimab in children at increased risk for severe RSV disease during their second season.
Same-day naloxone availability differs across pharmacy types, with independent and medical-affiliated pharmacies facing challenges in rural and underserved areas. Expanding pharmacist education is crucial to improve naloxone access following OTC approval.
A cohort study found that increased problematic social media use during mid-adolescence was directly associated with higher ADHD symptoms. The association was strongest among male participants.
The GLP-1 RA market experienced a surge in demand following the semaglutide and tirzepatide shortages. Compounded GLP-1 RAs sourced from unlicensed facilities pose clinical and regulatory challenges.
A cross-sectional study reveals substantial commercial price variation for common cardiovascular services, influenced by payer contracting strategies and market dynamics. The findings underscore the need for greater transparency and regulatory oversight to promote efficient healthcare spending.
The study found significant progress in reducing cancer mortality disparities for breast and uterine corpus cancers, but persistence in prostate cancer remains. The findings highlight the need for targeted interventions to accelerate progress in equitable cancer prevention and control.
This economic evaluation characterizes U.S. lobbying spending in the mental health field from 2014 to 2024, revealing significant growth. The study highlights increasing lobbying efforts in psychiatry and psychology, suggesting a shift towards more prominent advocacy for mental health issues.
Research highlights the significant impact of modifiable risk factors on ischemic heart disease mortality in the US. High body mass index (BMI) and fasting plasma glucose levels have increased attributable risk over the study period, emphasizing the importance of addressing these factors to reduce mortality.
A blood test measuring phosphorylated tau 217 (P-tau217) can estimate an individual's risk of developing cognitive impairment over 2, 5, and 10 years. Higher P-tau217 levels are associated with increased risk of progression to cognitive impairment in cognitively unimpaired older adults.
Researchers investigated hantavirus infection's neurological effects, finding that they can be severe and uncommon. The study aims to improve understanding of the pathophysiology, identify therapeutic targets, and develop management guidelines for these manifestations.
A cohort study reveals that colorectal cancer treatment delays are associated with increased metastasis risk. This finding highlights the need for integrated care and tailored benchmarks for treatment initiation to improve timely and equitable care.
A clinical trial of Ceperognastat, a novel O-linked N-acetylglucosaminidase inhibitor, found no significant slowing of Alzheimer's disease progression in early symptomatic patients. The study published in JAMA suggests that Ceperognastat may not be effective in treating this stage of the disease.
A meta-analysis of individual participant data found that amyloid PET quantitation using centiloids can accurately diagnose Alzheimer's disease. The study suggests that scans in the 11-26 Centiloid range require caution, and a positivity cutoff of around 18 Centiloids is recommended.
A cohort study suggests a possible association between medically assisted reproduction and an increased risk of hormone-related cancers. However, the estimated difference in expected cancer cases was found to be small, potentially due to unmeasured confounding and detection bias.
A cohort study in Sweden found that infants without vitamin K prophylaxis at birth have a significantly higher risk of bleeding episodes, including intracranial hemorrhages. The study highlights the importance of intramuscular vitamin K administration to prevent such episodes and the need for continued education on its significance.
The study reveals a growing dementia burden in Latin America and the Caribbean, contrasting with declining trends in high-income countries. Strengthened surveillance and investment in dementia care infrastructure are needed to address this uneven distribution of disease.
A secondary imaging analysis found free water was the most responsive cerebrovascular MRI marker to lifestyle intervention, showing attenuated small-vessel disease-related injury. Intensive lifestyle intervention implemented earlier in late life provided greater microvascular benefits.
Amyloid clearance after amyloid-targeting therapy reduces downstream neuropathologic changes, particularly in gyral crests. Extensive amyloid clearance may be necessary for beneficial effects.
Using the YEARS diagnostic algorithm is as safe as computed tomographic pulmonary angiography (CTPA) for diagnosing suspected pulmonary embolism in patients with cancer. This strategy saved 22% of patients from undergoing CTPA, highlighting its potential to streamline cancer care.
A study found that measles-containing vaccines were administered to only 15% of children in this age group between 2015 and 2025. This proportion remained stable over time, but disparities in vaccine uptake existed among minoritized racial and ethnic groups.
The study found that patient engagement with open notes increased to 55% within two months of implementation, but significant sociodemographic disparities remained. Language barriers may also contribute to the digital divide in open note adoption.
A recent study found that frequent formulary rejections of single-source branded drugs in the US lead to delayed or absent treatment, highlighting trade-offs between cost and access to medicines. The study highlights the need for more affordable medication options, particularly for patients with chronic conditions.
A recent hantavirus outbreak on a nature cruise has sparked concerns about the potential for a global pandemic. Experts warn that Ebola-like viruses pose significant threats to public health.
Subjective olfactory impairment consistently associated with depression, while objective impairment linked to aging and anosmia. The study suggests partly distinct underlying mechanisms for subjective and objective impairments.
A cohort study of California public high schools found that dedicated health courses were associated with modestly lower prevalence in several common forms of adolescent substance use. The study suggests that sustained, dedicated health coursework may be a scalable component of school-based substance use prevention.
This cohort study of 38,535 singletons found that birth weight decile was associated with early-life growth patterns. The use of birth weight decile group may help identify high-risk children missed by conventional thresholds.
Depression is associated with a greater tendency to be reinforced by social rewards on Twitter, contrary to laboratory-based findings of blunted reinforcement learning in depression. This suggests potential mechanisms linking social media use to worse mental health outcomes.
Between 2003 and 2024, annual US deaths caused by law enforcement increased significantly, with non-Hispanic Black males experiencing the highest mortality rates. Firearms were responsible for more than 87% of these deaths, highlighting persistent racial disparities in the US.
A cohort study of opioid-naive patients found that most achieved pain resolution within 3 weeks, but some reported prolonged opioid use. Current guidelines may not serve all patients, emphasizing the need for tailored treatment approaches.
Adolescents in the US are unaware of the dangers of fentanyl misuse, emphasizing the importance of public education programs and clinical communication. The study reveals a significant portion of younger adolescents are not aware of the risks associated with fentanyl use.
The study found that primary care clinicians can make a significant impact on diabetes management by initiating continuous glucose monitoring, leading to improved glycemic control and reduced acute care utilization. This scalable strategy has the potential to improve diabetes outcomes in underserved populations.
A secret shopper study found that online prescription vendors for GLP-1 receptor agonists often lack clinician interaction, relying on patient-reported questionnaires. This may lead to prescriptions being issued without important clinical and social history, compromising patient safety.
A cross-sectional study of Medicare beneficiaries age 65 and older found friend caregivers to be an integral part of the caregiving network. They provide essential care without expecting compensation or reimbursement.
A cohort study found that mid-urbanicity neighborhoods had the highest dementia mortality rates, while dense urban cores and rural areas showed lower risks. The study suggests targeted improvements in neighborhood conditions could reduce dementia mortality and promote equity.
A cohort study found that upper secondary school settings are associated with mental health trajectories in adolescents, suggesting a link between peer environments and risk of mental disorders. The study's findings highlight the importance of considering environmental factors in understanding adolescent mental health.
A standardized on-pitch concussion assessment protocol has been developed and recommended internationally for safe player return to play in football. The protocol is informed by research evidence and expert opinion, aiming to improve diagnosis and treatment of concussions.
A population-based study found no association between prenatal paracetamol exposure and risk of autism spectrum disorder or attention-deficit/hyperactivity disorder in offspring. The study suggests that positive signals from previous research may be due to familial confounding.
A mindfulness-based group medical visit program for persons with chronic low back pain showed significant improvements in pain intensity and interference compared to usual care. However, the changes did not meet the minimal clinically important difference threshold.
A cross-sectional study found significant increases in glucagon-like peptide-1 (GLP-1) per-patient days supplied in employer plans from 2021 to 2024, driven by higher growth in weight loss coverage. This could signal a growing financial burden on patients and payers as drug costs increase over time.
A cohort study found that a dietary pattern with lower inflammatory potential was associated with lower dementia risk among individuals with Alzheimer disease pathology. Targeted dietary strategies may help prevent dementia in those already at elevated risk.
A recent study published in JAMA Otolaryngology–Head & Neck Surgery reveals a higher incidence of smell and taste disturbances among GLP-1 RA users. The findings underscore the importance of regular monitoring and awareness to mitigate these adverse effects.
Comprehensive smoke-free laws were associated with sustained reductions in cardiovascular disease mortality across US counties. However, the magnitude of these associations varied significantly by demographic groups, suggesting a need for additional strategies to address disparities in tobacco exposure and improve cardiovascular outcomes.
A study of high school students found that total abortion bans in states were associated with increased suicidal ideation among females, with similar but less precise estimates for suicide attempts. The findings suggest that these policies may adversely impact female adolescents' mental health.
A recent study found that self-directed cognitive behavioral therapy for chronic pain (CBT-CP) resulted in modest improvements in pain interference, sustained over 12 months. Additionally, self-directed CBT showed higher session-completion rates compared to clinician-delivered CBT-CP.
A cross-sectional study found that GLP-1 receptor agonists are misused by people with eating disorders to maintain rapid restriction and weight loss. The prevalence of lifetime use was higher among those with eating disorders than the general adult population, highlighting a need for safe prescribing practices.
A Japanese cohort study found that better maternal cardiovascular health during pregnancy is associated with lower risks of offspring developmental delay at age 4. The study suggests a potential protective effect of optimal maternal cardiovascular health on child development.
The study's findings suggest that adults can reduce their likelihood of severe COVID-19-associated outcomes by obtaining a 2025-2026 COVID-19 vaccination. Receipt of the vaccine was associated with additional protection against medically attended COVID-19, including emergency department/urgent care encounters and hospitalizations.