A scoping review compared biosimilar regulatory guidelines across all WHO regions, identifying barriers to data transferability that may affect medication pricing, access, and reimbursement. The study aims to improve biosimilars' global accessibility.
The study found that population-based pathogenic variant testing reveals different subsets of high-risk women than clinical risk factors and polygenic risk scores. This highlights the importance of incorporating PV testing into risk-based screening for breast cancer.
Institutional Special Needs Plan (I-SNP) enrollment was associated with significantly fewer hospitalizations for nursing home residents with dementia at the end of life, according to a retrospective cohort study. Effect sizes were larger for UnitedHealthcare (UHC) I-SNPs vs non-UHC plans. Plan maturity and volume likely impact success.
A population-based screening trial evaluating a cell-free DNA multicancer early detection test found modest increases in diagnostic delay rates for head and neck, lung, and upper gastrointestinal cancers. These findings suggest that future trials may need to consider system-level spillover effects on healthcare resources.
A recent immigration ban could reduce the US physician and nurse workforce, exacerbating health care workforce shortages in already underserved communities. The study found nearly 24,000 physicians and 56,000 nurses from banned countries contributed to the US healthcare workforce in 2023.
In a cross-sectional study of ambulatory visits, digital after visit summary engagement was found to increase but remained low, especially among unmarried males, non-English-speaking populations, and publicly insured populations. This inefficiency highlights the need to reevaluate postvisit communication in these groups.
A study published in JAMA found that sitting less with greater light-intensity movement and steps was associated with significantly lower risks of adverse pregnancy outcomes. Adverse pregnancy outcomes include hypertensive disorders, gestational diabetes, preterm birth, and small for gestational age
A national analysis found that robotic-assisted cholecystectomy remained linked to increased bile duct injury risks despite growing use. The study suggests small differences in overall complication rates between approaches.
A recent study published in JAMA examines the effectiveness of hearing aids for adults with mild to moderate hearing loss, highlighting the benefits and limitations of both prescription and over-the-counter devices. The research suggests that personalized fitting and follow-up care are crucial for optimal outcomes.
A new study projects that climate change will significantly increase the risk of heat-related cardiovascular disease in the US by 2050. The Pacific Northwest and Southern/Midwestern states are expected to experience the highest and steepest increases, respectively. Targeted interventions for vulnerable communities are crucial to mitiga...
A new study published in JAMA Neurology finds ecopipam to be effective in suppressing tics in patients with Tourette syndrome. The medication was well-tolerated and showed no significant adverse effects over a period of up to 24 weeks.
A nationally representative study found a nearly 4-fold increase in type 2 diabetes prevalence among US children and adolescents between 10 to 17 years old. The substantial rise is concerning due to the disease's lifetime risk of severe complications and premature deaths.
A plasma-based staging model using eMTBR-tau243 and %p-tau217 demonstrated strong concordance with positron emission tomography-based staging and clinical severity of Alzheimer disease. This approach may provide a scalable, minimally invasive method for biological stratification and treatment selection.
A cohort study found that Medicaid prescription caps were associated with lower overall prescription medication use and greater frequency of acute care visits among young adults with opioid use disorder. This suggests that the implementation of these caps may have unintended consequences for individuals struggling with addiction.
A large cohort study found that antenatal opioid exposure was associated with impaired cerebral cortical folding in newborns. The extent of impairment differed based on the opioid type and presence of polysubstance exposure. Longitudinal assessments aim to inform early interventions for vulnerable populations.
Dropping the cancer label from grade group (GG)1 prostate disease redefines it as a precancerous lesion, leading to a net reduction in estimated prostate cancer deaths. This relabeling strategy may have minimal impact on screening rates.
A cohort study found two-thirds of newly diagnosed heart failure patients with reduced ejection fraction didn't undergo left ventricular ejection fraction reassessment, limiting treatment opportunities. Guideline-directed medical therapy was also underutilized among persistent heart failure patients who benefit most from it.
A nationwide implementation of a uniform multimodal prehabilitation program significantly reduced complication rates and length of hospital stay among patients undergoing colorectal cancer surgery. This study highlights the benefits of standardized preoperative care in improving patient outcomes.
A cohort study found increased pediatric capability was not linked to differences in imaging use by insurance or racial/ethnic groups. Additional efforts are needed to improve quality and equity of care for children.
Interleukin 6 is investigated as a treatment target for depression in this randomized clinical trial. The study highlights the therapeutic potential of IL-6 or IL-6 receptor inhibition and proposes suitable patient selection methods.
A low-calorie diet and behavioral support program significantly reduced weight in older patients with overweight and persistent atrial fibrillation at 8 months. The study found no safety concerns or impact on atrial fibrillation symptoms, cardiac remodeling, or need for further rhythm control interventions.
A cohort study found that participants with unfavorable long-term memory trajectories were less active and more sedentary, suggesting a link between cognitive change and later-life movement patterns. The study's results have implications for understanding the relationship between aging, cognition, and physical activity.
A post hoc analysis of a randomized clinical trial found high-dose vitamin D3 supplementation in pregnancy to be positively associated with visual memory, verbal memory, and flexibility among offspring at age 10. This strengthens evidence on the association between prenatal vitamin D exposure and childhood cognition.
A case-control study found that amateur-level soccer heading is associated with increased blood biomarkers of neural damage, including dose-response relationships. The findings suggest that even low-impact heading may acutely affect neural integrity.
A new study presents dual immunization against respiratory syncytial virus (RSV) using RSVpreF and nirsevimab, showing reduced hospitalizations among infants in France. The study found that this combined approach demonstrates potential for enhanced RSV prevention and protection
After Dobbs v Jackson, US abortion management shifted towards expectant approaches in ban states, with persistent reliance on suboptimal misoprostol-only regimens. State-level abortion bans were associated with a decrease in management options for individuals with spontaneous abortion in ban states.
A new AI-powered cardiopulmonary resuscitation instructor has been developed to support bystanders during out-of-hospital cardiac arrests. The study suggests that this technology could be a scalable public health intervention to save lives.
A cohort study found chronic obstructive pulmonary disease (COPD) associated with reduced life expectancy. Adults with COPD had shorter lifespans compared to those without the condition, regardless of smoking history.
A recent cohort study found that COVID-19 vaccination is associated with a lower risk of SARS-CoV-2 transmission. The study suggests that vaccination may indirectly reduce overall exposure to the virus.
Children and adolescents in Gaza who suffered penetrating traumatic brain injury during armed conflict experienced substantial morbidity and mortality. Survivors often endured neurological impairments and long-term psychosocial challenges.
A single dose of psilocybin was associated with rapid antidepressant effects, persisting for more than 3 months. The study suggests that psilocybin may provide a rapid and relatively long-lasting antidepressant effect on major depressive disorder.
A longitudinal study found that mothers with hypertensive disorders during pregnancy had children with suboptimal cardiovascular health and arterial injury in early adulthood. Optimizing pregnancy health may support offspring cardiovascular well-being.
A case-control study found associations between ambient particulate matter and nitrogen dioxide exposure and increased risks of Lewy body dementia and Parkinson disease-related dementia. The study's findings suggest air pollution may impact brain health, warranting concern.
A parental support package significantly mitigated postpartum burnout among childbearing physicians in training. This study highlights the importance of work-life balance for physician well-being.
A study found a significant decrease in metabolic bariatric surgery utilization between 2022 and 2024, with a 34.1% drop, while glucagon-like peptide-1 (GLP-1) use increased by 140.4% during the same period. This trend may continue due to growing prescribing of GLP-1s.
A survey study found that over 1 in 5 adult firearm owners living with children under 18 years store at least one loaded gun in an unlocked location, posing a significant risk to child safety. More effective strategies are needed to motivate parents to secure their firearms and prevent accidents.
The study found that stage IV breast cancer incidence increased across ages and sexes, while overall survival improved despite the increase. Researchers highlight the need for further investigation into factors contributing to the rise in incidence, including potential changes in breast cancer screening and other conditions.
A recent study found that ivermectin-benzimidazole prescribing increased rapidly following a celebrity endorsement in January 2025. This trend was particularly concerning among patients with cancer who may delay conventional treatments for unproven therapies, potentially worsening their disease progression.
A nationwide study found no significant association between telemedicine adoption and changes in US ambulatory visits or total medical spending. The expansion of telemedicine has eased concerns about increased utilization and spending, as the growth did not lead to large increases in these areas.
A cohort study found a potential association between GLP-1 RA use and improved survival rates among obese breast cancer patients with related metabolic conditions. Further evaluation of GLP-1 RA therapy in randomized clinical trials is warranted based on these findings.
The study found substantial state-level variation in HPV vaccine uptake, with Northeastern states exhibiting higher rates and Southern states showing lower rates. Several sociodemographic factors were not significant predictors of vaccination rates, highlighting the need for targeted interventions to improve vaccine uptake.
In patients with symptomatic rheumatic heart disease, digoxin significantly reduced the risk of a composite of all-cause death or new-onset or worsening heart failure. The treatment had little risk of toxicity, making it a promising therapeutic option for these patients.
Treatment with digitalis glycosides reduces worsening heart failure events in HFmrEF and HFrEF patients, suggesting its use as additional therapy to reduce worsening heart failure events. The study found no significant interaction with other important study characteristics.
This qualitative study explores the use of edible cannabis among older adults as a management strategy for pain, sleep, and mental health concerns. The study highlights the importance of physician awareness and informed counseling for these patients.
The US experienced substantially higher death rates than other high-income countries between 1999 and 2022, despite having comparable access to medical technology. These excess deaths could be avoided by adopting successful health and social policies from other high-income countries.
A cluster randomized trial found comparable improvements in 6-month outcomes between intervention and control groups, indicating no independent effect of the clinical decision support system. The study suggests that other factors may be responsible for the observed benefits.
A nationwide cohort study found a bidirectional association between premenstrual disorders and psychiatric disorders, highlighting the need for sex- and menstrual cycle–informed care in psychiatry. The study's findings emphasize the importance of considering menstrual cycles when diagnosing and treating psychiatric conditions.
A large language model-based agentic workflow produced AI-generated hospital course summaries with minimal risk of harm identified, reducing physician burnout. The study supports the viability of AI summarization to mitigate documentation burden.
Adjunctive intravenous tirofiban increased the likelihood of an excellent outcome at 90 days in patients with acute ischemic stroke who had inadequate response to tenecteplase. The study found improved outcomes in these patients, providing new insights into treatment options.
A study published in JAMA found that intravenous tenecteplase prior to endovascular treatment did not improve clinical outcomes compared to EVT alone for patients with proximal middle cerebral artery occlusion. The results suggest that EVT may be the preferred treatment option for this patient population.