Transition-age youth experiencing suicidal thoughts and behaviors face substantial mental health care access disparities, with Asian, Black, and Latine youths receiving significantly lower treatment rates than white peers. Structural barriers are believed to drive these inequities rather than clinical or patient-related factors.
A qualitative study found that abortion bans disrupt clinical care beyond traditional abortion services, leading to treatment delays, patient autonomy erosion, and compromised trust between physicians and patients. The restrictions also create new gatekeeping roles for physicians, potentially exacerbating healthcare inequities.
A systematic review and network meta-analysis found that combining lifestyle treatment with obesity medications resulted in significant short-term weight loss and improved body composition in adolescents. Health behavior remained crucial to effective weight management.
A recent study found that medication use increased after implementation of Medicare annual out-of-pocket cost caps, particularly among the highest-cost medications. This policy change substantially improved patient access to these high-cost medications for Medicare-insured patients.
The study found that an abortion ban in Texas was associated with a worsening of maternal mental health among reproductive-age mothers. This highlights the need for strengthened support for post-Dobbs policy environments.
The study found that gestational exposure to 10 classes of priority chemicals was associated with differences in gestational age at birth and lower birth weight-for-gestational age z scores. Reducing exposure to these chemicals could promote healthy deliveries and better child outcomes.
The study found that antigenically drifted viruses caused substantial morbidity and mortality, but vaccines reduced risk of influenza among vaccinated individuals. Recommended antivirals remained effective in treating the virus.
A recent study published in JAMA found that prone positioning in infants with moderate to severe bronchiolitis receiving high-flow nasal cannula support did not significantly reduce escalation of care. The study suggests that further research is warranted due to the wide confidence interval around the observed odds ratio.
A cohort study found that demographic, clinical, and healthcare factors influence the uptake of metabolic bariatric surgery among US adults with obesity. The study suggests improving access to this life-changing procedure through targeted policies and interventions could have a significant impact.
The study found that 2024-2025 COVID-19 vaccination significantly reduced the likelihood of medically attended COVID-19-associated outcomes among immunocompetent and immunocompromised adults. This highlights the importance of adults receiving recommended COVID-19 vaccinations to prevent severe illness.
Dietary supplement use among US adults increased from 1999 to 2023, with diversification towards immune, anti-inflammatory, and joint health products. Older adults saw a substantial increase in supplement use, highlighting the need for ongoing monitoring of public health implications.
Differences were observed in parent and child mealtime media use patterns among racial and ethnic groups. Black parental race was positively associated with paired use, while Asian parental race was associated with individual use.
Machine learning models trained on brief clinical conversations identified cognitive impairment with high accuracy, supporting passive speech-based screening during routine primary care. The study's findings suggest a feasible and non-invasive method for early detection of cognitive decline.
Vaccines administered in autumn and winter 2025 to 2026 showed substantial short-term effectiveness but low uptake. This results in approximately 55% effectiveness against symptomatic COVID-19 among older adults within 2 months of vaccination, missed opportunities for preventing symptomatic disease among unvaccinated vulnerable groups.
The study found that COVID-19 vaccination was associated with a reduced risk of COVID-19-associated major adverse cardiovascular event (MACE), particularly among older adults and those with comorbidities. The vaccine also showed a substantial protective effect against all-cause MACE, suggesting its benefits extend beyond detected SARS-...
Adults with prediabetes who undergo lifestyle intervention show a lower burden of multimorbidity compared to those not receiving the intervention. Lifestyle programs can persistently reduce the development of chronic conditions in this population.
A cross-sectional study found that colorectal cancer screening participation increased after an organized population screening program, but socioeconomic disparities remained. Younger age groups, single households, and lower-income individuals still lag behind in screening uptake.
A study found that regularly assessing gastric residual volume in critically ill children being enterally fed significantly improved nutritional achievement at 72 hours. Not routine assessments every 6 hours had similar results, demonstrating noninferiority.
Remote monitoring approaches did not increase home time but reduced it for those 65 years and older, supporting tailored care after acute infections. The findings suggest reevaluating remote monitoring to align with patients' needs and desires.
A White House announcement on treating autism with leucovorin and against acetaminophen during pregnancy led to significant increases in internet searches for these topics. Nearly 1 million additional searches for leucovorin were recorded, alongside over 4 million searches for acetaminophen.
A new study published in JAMA found no significant difference between sodium bicarbonate and placebo in sustaining return of spontaneous circulation. The findings suggest that routine administration of sodium bicarbonate for patients with in-hospital cardiac arrest may not be necessary.
A study published in JAMA Network Open found that high consumption of sugar-sweetened beverages was linked to an increased risk of liver cancer. In contrast, artificially sweetened beverage intake showed no significant association with liver cancer risk.
In this serial survey study, wearable device use increased among U.S. adults, but daily use and clinician-directed data sharing remained limited. The findings suggest a need for approaches to help realize the potential of wearable devices as health care tools.
An integrated telehealth-based rehabilitation strategy improved 90-day health-related quality of life in mechanically ventilated adults, potentially reducing mortality. The study suggests that this approach can be delivered across intensive care unit, hospital, and postdischarge phases.
Researchers propose using low-dose lithium orotate to slow dementia progression in mild cognitive impairment, leveraging established neuroprotective mechanisms. The approach aims to mitigate kidney and thyroid risks associated with higher-dose formulations, offering a potentially accessible and inexpensive treatment option.
The study analyzed polygenic scores and simulated expectations to understand changes in genetic contributions to ASD and ADHD diagnoses by year of diagnosis. Findings suggest broadening diagnostic criteria as a possible explanation for increasing rates, which has significant implications for risk factors and clinical practice.
A recent study published in JAMA found that high-dose intravenous vitamin C did not reduce mortality and persistent organ dysfunction in patients with severe burn injury. Instead, the treatment may be harmful, suggesting alternative approaches for managing burn-related complications.
Hospitalized children with acute respiratory tract infections often have underlying chronic conditions that require intensive care. The study found that these patients are at a higher risk of severe disease and death. Understanding the epidemiologic profile of this population can help optimize outcomes for pediatric patients.
A cohort study found that smartphone acquisition at age 13 was linked to increased risk of insufficient sleep at age 14. Excessive smartphone use was also tied to higher odds of depression and obesity. Limiting screen time may protect adolescents from these outcomes.
A study found that implementing earlier egg introduction guidelines resulted in measurable decreases in egg allergy cases. The updated guidelines, based on randomized trial evidence, may contribute to a reduction in food allergy prevalence when effectively implemented.
A study found that adding orfglipron to titrated insulin glargine significantly improved glycemic control and body weight in participants with type 2 diabetes. The treatment did not increase the risk of hypoglycemia, compared to placebo.
Mazdutide, a GLP-1 receptor dual agonist, provides clinically meaningful weight reduction in Chinese adults with obesity. However, gastrointestinal adverse reactions are more common among those taking the drug compared to placebo.
The Medicare $35 insulin out-of-pocket cap implemented in 2023 decreased and stabilized insulin out-of-pocket cost, increasing insulin use. This finding can inform policies to boost insulin access among users with high out-of-pocket cost.
Patients described GLP-1 RA therapy as a facilitator of lifestyle change, highlighting the need for standardized guidelines on patient education and clinical support. The quality of care was highly variable, leading to potential expectation management issues around adverse effects and long-term management.
A study finds that maternal RSV prefusion F vaccination protects against RSV-associated acute respiratory illness and lowers hospitalization rates among infants under 1 year. The findings support the effectiveness of this vaccine in preventing severe respiratory illnesses.
In an exploratory analysis, finerenone was found to slow kidney function decline, reduce albuminuria, and lower the risk of kidney failure or substantial loss of kidney function in patients with glomerular diseases. These findings suggest a crucial role for finerenone in preserving kidney function in this population.
A cross-sectional study found early age–onset colorectal cancer patients with improved overall survival but delayed treatment experienced worse outcomes. Language barriers may be a modifiable risk factor contributing to these delays.
A 20-year study in the UK, Australia, and US reveals a significant increase in menopause-related search patterns focused on commercial products and services. This shift indicates a growing need for non-clinical guidance and support beyond traditional clinical encounters.
Adults with lower measured glomerular filtration rates had a higher risk of all-cause mortality, kidney failure, and major adverse cardiovascular events. Lower GFR values were also associated with increased hospitalization for heart failure and acute kidney injury.
In patients with advanced chronic kidney disease at high cardiovascular risk, low-dose rivaroxaban did not reduce the composite risk of a cardiovascular outcome. Major bleeding rates were significantly higher in the low-dose rivaroxaban group compared to the placebo group.
A recent study published in JAMA Surgery found that surgeons experiencing substantial social jet lag have a higher associated risk of major adverse events in their patients. Interventions promoting regular sleep timing and reducing circadian misalignment may help improve surgeon burnout and patient safety.
A cohort study of U.S. households with children found that high medical expenses can strain household resources, making it difficult to afford basic necessities like food and housing. The study suggests a link between financial burdens and adverse health outcomes among this vulnerable population.
A difference-in-differences analysis found that Georgia's Pathways to Coverage program worsened mental health among low-income adults. This suggests that work requirements may create barriers to coverage and care access, affecting population health and equity.
Prediagnostic statin use showed no association with higher survival rates, but postdiagnostic use was linked to lower all-cause and breast cancer-specific mortality among hormone receptor-positive subtypes. Statin therapy may improve survival of these patient groups.
A national cohort study found that living in high-segregation neighborhoods was associated with lower likelihood of live donor liver transplant (LDLT) access. Candidates from high-segregation neighborhoods with larger racial and ethnic minority populations had a lower likelihood of LDLT compared to those from white populations.
The study found that adjuvant nivolumab did not improve disease-free survival in patients with resected non–small cell lung cancer. The treatment was also not effective in sensitizing EGFR and ALK alterations.
Adding fovinaciclib to first-line aromatase inhibitor therapy confers significant progression-free survival benefits and consistent improvements in efficacy outcomes. The treatment also has manageable safety profiles with no negative impact on quality of life.
A randomized clinical trial found that an app-facilitated palliative care intervention maintained health-related quality of life and reduced acute care use. This digital self-management approach also boosted patient self-efficacy.
A cohort study found that introducing immunity in US nursing homes was associated with lower overall staffing and staff-to-resident time. During the COVID-19 pandemic, many states adopted immunity from tort liability for harms to nursing home residents.
A nationally representative survey of US adolescents and young adults found that a fifth used AI chatbots for mental health advice. Proactive discussion with parents and clinicians about chatbot use is necessary to promote safety and linkages to evidence-based care.