The study proposes a public health agenda for AI to improve delivery of proven health interventions through patient identification, outreach, and care coordination. Government leadership, cross-sector partnerships, and sustained investment are essential for realizing this potential.
Active surveillance for favorable-risk prostate cancer increased significantly in the Veterans Affairs healthcare system, with high rates among low-risk and intermediate-risk patients. This trend suggests that many veterans are avoiding unnecessary treatment, but disparities in care persist.
A retrospective cohort study of 16,924 men found metabolic syndrome and related abnormalities during the first year of treatment. Hypertension was the most common metabolic outcome among patients receiving concurrent androgen deprivation therapy and an androgen receptor pathway inhibitor.
A randomized clinical trial of 698 patients with localized intermediate-risk prostate cancer found that stereotactic body radiotherapy was not superior to moderately hypofractionated IMRT for disease-free survival at 3 years. However, SBRT showed better bowel-related quality of life compared to IMRT.
A cohort study of 1,582,834 veterans with MDD found that most received recommended treatment, but there was an increasing trend in the proportion who did not. This highlights the need to investigate potential undertreatment and examine mental health service availability that influences treatment selection decisions.
This retrospective study examines patterns and trends of focal therapy for nonmetastatic prostate cancer in US cancer centers. Focal therapy procedures remained uncommon, occurring mostly in low-, high-, or very-high-risk disease settings.
A cross-sectional study found that exposure to Agent Orange and open-air burn pits were independently associated with poorer mental and physical health outcomes among US veterans. The study highlights the need for continued support and resources for veterans affected by these toxic exposures.
A retrospective cohort study found that patients treated with aripiprazole had a lower risk of hyponatremia than those on olanzapine. This association could inform clinical decision-making for high-risk patients, despite residual confounding considerations.
A new study emphasizes the importance of accessible maternity and psychiatric care for pregnant women suffering from major depressive disorder. The research highlights the need to balance treatment benefits with potential risks associated with SSRI exposure, suggesting a structured approach to decision-making.
Non-US-born physicians, including US medical graduates and international medical graduates, account for nearly half of the US internal medicine workforce. They provide a disproportionate share of care for underserved patient populations.
A recent study published in JAMA Network Open finds a strong association between gestational diabetes and an increased risk of postpartum cardiovascular, kidney, and metabolic disorders. The research highlights the importance of monitoring and managing gestational diabetes to prevent long-term health consequences for mothers.
Waiting times for cancer surgery have increased in the US, particularly at high-volume academic centers and among patients referred for definitive care. The study identifies factors that contribute to these delays, emphasizing the need for urgent system-level interventions to improve timely access to surgical care for cancer patients.
Surgical residents describe experiencing identity-related vigilance as a significant emotional and cognitive burden, contributing to fatigue and burnout. They identify opportunities on the programmatic level to mitigate negative consequences, highlighting the need for support.
Researchers reviewed grant data from 2015-2022, supporting investment in a strong evidence base for obesity and cancer research. Key areas of focus include obesity's impact on cancer treatment and survivorship, as well as disparities in cancer outcomes.
A cohort study investigates the association between bariatric surgery and preoperative use of GLP-1 receptor agonists. The results show a significant positive correlation between preoperative GLP-1 RA use and weight loss outcomes after surgery.
Celiac disease is a chronic autoimmune disorder caused by gluten intolerance, characterized by small intestine damage and malabsorption. Symptoms include diarrhea, abdominal pain, fatigue, and weight loss, with accurate testing and early treatment available to prevent complications.
A hybrid lifestyle program showed potential benefits for cardiometabolic health among adherent participants with obesity, but failed to achieve significant weight loss. The study suggests further investigation into the program's effects on metabolic health.
Researchers develop two virtual culturally grounded interventions to address substance use among urban American Indian and Alaska Native emerging adults. The studies show reduced substance use, including cannabis and alcohol consumption, as well as social connections with tribal communities.
A new international study defines clinical obesity as a significant predictor of increased disease burden, operative risk, and cardiovascular risk in patients undergoing metabolic bariatric surgery. The study found that the majority of patients met criteria for clinical obesity, while a minority had preclinical obesity.
Patients with severe traumatic brain injury in resource-limited settings are at higher risk of mortality. The study highlights the need for improved acute and postdischarge care to reduce mortality rates.
A study found that Nirsevimab was associated with a substantial reduction in respiratory syncytial virus-lower respiratory tract infection hospitalizations during the first year. It was not linked to reduced hospitalizations due to non-RSV infections or asthma, nor during the second year of follow-up.
Objective physical fitness assessments reveal a graded association between balance, agility, strength, and cardiorespiratory fitness with reduced all-cause mortality. This study suggests integrating fitness assessments into routine practice may improve risk stratification and guide function-oriented interventions.
A cohort study finds that childhood history of maltreatment is associated with increased biological age in late midlife, potentially impacting health outcomes. The study's epigenetic clock analysis sheds light on the long-term effects of early life trauma on aging processes.
Recent Supreme Court decisions have reduced federal agencies' independence and expanded state-level protections for public health. Federal health agencies now face increased scrutiny from the judiciary, compromising their ability to set standards without interference from elected officials.
A randomized phase 3 study found that first-line osimertinib plus chemotherapy significantly improved median progression-free survival compared to osimertinib alone in patients with advanced non–small cell lung cancer (NSCLC) and concurrent EGFR and TP53 mutations. This study provides evidence for incorporating TP53-based molecular ris...
Researchers developed a multiprotein approach to predict advanced tau pathology among amyloid-positive individuals, outperforming p-tau217 alone. This study suggests a scalable alternative to tau PET staging for clinical or research settings.
Kirsten Bibbins-Domingo has extended her contract as JAMA and JAMA Network Editor in Chief through 2031. She brings fresh perspective and intellectual rigor to the prestigious journal, strengthening its influence worldwide. The JAMA Network has launched initiatives to expand engagement and support medical researchers.
The US Food and Drug Administration (FDA) has been working to regulate synthetic food dyes, with recent federal and state actions taking place. The regulatory landscape is being contextualized, which has implications for policy, industry, and clinical practice.
A cross-sectional study found that over one-third of high-risk therapeutic medical devices were recalled due to lack of consistent association between device characteristics, premarket evidence, and regulatory factors. Postmarket surveillance is crucial for ensuring patient safety.
A health coaching intervention combined with self-measured blood pressure monitoring increased healthcare engagement and BP control by 12 months postpartum. This strategy supports reducing long-term uncontrolled hypertension among patients with high blood pressure during pregnancy.
A cross-sectional study examines state-level type 1 diabetes burden and pediatric endocrinology resource distribution in the US. The study found that type 1 diabetes incidence has increased over time, while pediatric endocrinology resources are not evenly distributed across states.
The Lancet Diabetes and Endocrinology Commission on Obesity definition of obesity was found to have similar diagnostic accuracy as other definitions. The study compared the commission's definition with those from other reputable sources, including the World Health Organization (WHO) and the National Institutes of Health (NIH).
A qualitative study reveals multilayered health care barriers faced by Afghan refugee women in the US, including displacement-related trauma and sociocultural norms. Culturally sensitive public health interventions are needed to improve healthcare access for these women.
A cohort study found associations between perinatal factors and changes in brain maturation among adolescents. The study used conditional-longitudinal models to assess individual growth trajectories and mental health symptoms.
Participation in mandatory value-based payment programs is associated with higher hospital administrative costs, highlighting the need for policymakers to consider administrative burden when designing and evaluating payment reforms. The study suggests that these reforms may increase complexity without improving cost, quality, and access.
A review of cannabis and cannabinoids' therapeutic use reveals potential health benefits while emphasizing the need for risk assessment and harm reduction strategies. The study highlights the importance of evidence-based guidelines for safe and effective treatment.
This cross-sectional study found that melatonin use was associated with a small reduction in REM sleep percentage, but not with differences in total sleep time or other sleep stages. The study suggests that further research is needed to clarify the effects of melatonin on children's sleep.
A qualitative study investigates the experiences of out-of-state individuals who travel to receive abortion care, highlighting challenges and emotional impacts. The study aims to improve reproductive health access and reduce barriers faced by women seeking abortion services.
A new study uses mathematical biomarkers to accurately predict prostate cancer patient outcomes and survival, outperforming traditional PSA monitoring. These metrics can inform personalized treatment protocols, enabling more effective adaptive therapy.
A systematic review and meta-analysis investigated changes in mental health symptoms before and during the COVID-19 pandemic. The study found significant differences in symptom changes between sexes and genders, highlighting the need for targeted interventions.
This study investigates the link between vegan diets and dietary energy density, finding that adopting a vegan diet may lead to lower energy intake. The randomized clinical trial analyzed data from over 10,000 participants, suggesting that a well-planned vegan diet can be an effective way to reduce energy consumption.
A randomized clinical trial found that digital patient-reported outcome (PRO) monitoring with alert-based interventions led to clinically meaningful reductions in fatigue and improved physical functioning in metastatic breast cancer patients. This study supports further evaluation of PRO monitoring in routine oncology care.
A cross-sectional study found that US physicians with a rural background and training experience in rural settings are more likely to practice in rural locations. The study assessed the interdependence of these factors on rural practice among US physicians.
Individuals in psychotherapy for trauma from killing in war experienced improvements in psychosocial functioning. IOK participants showed greater improvements in work, social, and family life compared to PCT group at posttreatment.
This viewpoint discusses how inflammation can coexist with hyperpigmentation, particularly in individuals with darker skin tones. The authors propose an approach where hyperpigmentation prompts continued assessment for persistent inflammation, addressing the potential underrecognition of this condition.
A U-shaped association exists between LVEDD and mortality in HF, suggesting high risk for both abnormally small and large ventricles. The findings support integrating LV size assessment into routine risk stratification to guide personalized management.
A study of comatose survivors treated with therapeutic hypothermia found that longer cooling durations did not improve neurological outcomes. Increasing cooling duration was ineffective in improving patient recovery after out-of-hospital cardiac arrest, suggesting alternative treatments may be more effective.
A cohort study evaluates histotripsy's short-term outcomes for liver tumors, highlighting its potential as a treatment option. The study also examines national practice patterns and adult patient results.
After COVID-19 pandemic restrictions relaxed, Kawasaki disease incidence rebounded in Japan, with distinct age-dependent patterns. Nonpharmaceutical interventions may have contributed to the observed greater rebound in older children, while infants showed minimal changes, suggesting different exposure pathways.
A cohort study analyzing factors associated with abandoned buprenorphine prescriptions found that US adults are increasingly dropping their medication for opioid use disorder. The study, published in JAMA Network Open, examines the decline of prescribed buprenorphine from 2020 to 2024.