Researchers found that early neurodevelopmental assessments can predict long-term cerebral palsy outcomes in high-risk infants as young as 3 to 4 months corrected age. However, these tests are limited in identifying cognitive and neurodevelopmental impairments beyond CP diagnosis.
Black and Hispanic patients with atrial fibrillation were less likely to initiate direct oral anticoagulants at study onset, but these disparities narrowed over time. The study highlights the need to address unequal access to novel therapies for Black and Hispanic populations.
A pediatric observation unit with a psychiatric comanagement model significantly lowers pediatric emergency department length of stay and inpatient psychiatric admission rates. This innovative approach also avoids contributing to 30-day readmission rates, presenting potential savings for inpatient psychiatric resources.
A recent study reveals significant racial and ethnic disparities in all-cause and cause-specific mortality among US youth. The findings highlight a disproportionate burden of mortality among American Indian or Alaska Native and Black youth, particularly those involving firearms.
A cohort study found that individuals with a first colonoscopy with negative findings for colorectal cancer may benefit from longer screening intervals, potentially up to 15 years. This could lead to fewer unnecessary invasive examinations and improved patient outcomes.
Increasing varenicline dosage enhanced abstinence rates in individuals who initially failed with the medication. For non-abstainers, a dosage increase or switch to varenicline also showed promise as rescue strategies.
Menopausal hormone therapy is appropriate to treat vasomotor symptoms in early menopause without contraindications. WHI evidence does not support routine supplementation with calcium plus vitamin D or a low-fat diet for preventing fractures and breast/colorectal cancer, respectively.
A plant-based diet after prostate cancer diagnosis was associated with lower cancer progression risk. Higher intake of plant foods was linked to reduced disease progression in men with prostate cancer.
A study found that US state abortion bans primarily impact American Indian and Black female populations of reproductive age. These policies concentrate in regions with higher proportions of these groups, leading to unequal access to reproductive healthcare.
This cross-sectional study investigates differences in cardiovascular health metrics among diverse populations. It reveals significant disparities in cardiovascular health at the intersection of race, ethnicity, and sexual identity.
The USPSTF updates its breast cancer screening recommendation to biennial mammography for women ages 40-74. However, the balance of benefits and harms is unclear for women over 75 or those with dense breasts. Breast cancer is a common cause of death among US women.
A randomized clinical trial of 3,020 patients with high-risk nonmetastatic breast cancer found daily aspirin therapy had no effect on breast cancer recurrence or survival in early follow-up. Aspirin should not be recommended as an adjuvant breast cancer treatment despite its potential benefits and wide availability
A systematic review and meta-analysis found no association between new-onset seizures and SARS-CoV-2 vaccination. The study included over 118,000 participants from randomized clinical trials and found the incidence proportion of new-onset seizures to be similar across vaccine recipients and unvaccinated participants.
A study of 26,000 US participants found that both individual- and area-level social determinants contribute to cardiovascular disease risk. The findings suggest that these factors should be considered in future risk assessment tools, especially for Black individuals.
A significant disparity in mortality rates was observed between lesbian, bisexual, and heterosexual female nurses, highlighting the need to address modifiable risks and social forces driving these disparities. The study's findings underscore the importance of promoting inclusive workplaces and addressing LGBTQ+ health inequities.
A nationally representative study of 25,000 participants found that US adults with post-COVID-19 condition are more likely to experience depression and anxiety symptoms than the general population. Individuals with these symptoms reported higher rates of cost-related barriers to accessing mental health treatment.
Contemporary US heart failure mortality rates have surpassed those in 1999 due to reversals from 2012 to 2021. The COVID-19 pandemic may have accelerated these increases, partly due to healthcare access limitations.
A repeated cross-sectional study of recreational marijuana laws and teen marijuana use from 1993-2021 found no evidence of an encouraging effect. The logistic regression and interaction-weighted models showed no significant association between the two variables.
A cohort study found statistical signals for myocarditis and pericarditis after BNT162b2 vaccination in children aged 12-17 years, consistent with previous reports. Seizures after mRNA-1273 vaccinations in younger age groups require a robust epidemiologic investigation to confirm findings.
Administration of antenatal corticosteroids to late preterm babies was not linked to increased risk of neurodevelopmental problems by age 6. Long-term follow-up study suggests the medication may be safe for these high-risk infants.
Researchers found that objective taste dysfunction disappeared one year after COVID-19 exposure, while nearly a third of individuals experienced lasting smell loss. Infection with Alpha variants was associated with the greatest degree of smell loss, highlighting a potential link between variant types and symptom severity.
A large-scale study of 3.9 million children found that COVID-19 vaccination significantly reduced the incidence of SARS-CoV-2 infection and hospitalization among kids in California. The study suggests that vaccination is an effective strategy to prevent severe COVID-19 cases in pediatric populations.
A recent study found that preoperative GLP-1 receptor agonist use is not associated with an increased risk of postoperative respiratory complications. The results suggest liberalizing withholding guidelines for these medications may be beneficial.
A new study finds that initiating antihypertensive medication in older long-term care residents increases fracture risk, particularly among those with dementia. The study advises caution when prescribing antihypertensives to this vulnerable population.
A study of 50,000 US children found modest decreases in developmental screening scores, sparking cautious optimism and concern for long-term implications. Continued surveillance is crucial to understand the population-level effects of the pandemic on child development.
A randomized clinical trial found self-administered acupressure to be efficacious and cost-effective in reducing knee pain and improving mobility in middle-aged and older adults with probable osteoarthritis. The treatment also showed significant benefits in terms of quality of life.
Women with germline BRCA pathogenic variants face increased risk of mortality from postpartum breast cancer, particularly those diagnosed under 10 years after giving birth. The study highlights the importance of genetic counseling and tailored prevention strategies for these high-risk individuals.
Only 4% of cancer survivors met all four American Cancer Society guidelines, with a mean of 2.0 guidelines met. This study aims to improve understanding of guideline adherence and inform recommendations for patients who have completed cancer treatments.
A national cohort study found that neighborhood disadvantage was independently associated with shorter breast cancer–specific survival. The study suggests potential unaccounted-for mechanisms, including both nonbiologic and biologic factors, and highlights the need for further research.
A study of 322 participants found racial discrimination to predispose Black young adults to metabolic syndrome through sleep issues and chronic inflammation. This discovery could inform targeted prevention strategies to address existing health disparities in minority populations.
Research suggests that mentally active employees are less likely to experience cognitive decline and dementia-related issues. The study analyzed various interventions aimed at boosting mental performance, revealing promising results for those looking to reduce the risk of age-related brain decline.
A study of over 1 million Swedish children reveals that genetic differences contribute to phenotypic variation in autism spectrum disorder, differing significantly between males and females. The findings suggest underlying causes of autism may differ between the sexes, partly explaining the skewed sex ratio in the condition.
Research suggests that controlling blood pressure through antihypertensive treatment can help prevent newly diagnosed uterine fibroids in midlife. The study of 2,570 participants found an increased risk of fibroids among those with untreated hypertension.
A study found that trauma-exposed individuals with posttraumatic stress disorder (PTSD) experience swift emotional transitions between neutral and negative states. Therapeutic approaches to moderate these transitions may help alleviate PTSD symptoms. The research suggests a potential new treatment direction for this condition.
Contraceptive services experienced downward trends from an initial increase in the month after Dobbs v. Jackson, indicating growing challenges for access. The study found decreasing workforce numbers providing contraception methods.
Over five RSV seasons, researchers found that nearly one-quarter of hospitalized adults aged 50+ experienced an acute cardiac event, mostly heart failure. The risk of severe outcomes was nearly twice as high in patients with cardiac events compared to those without.
Research using 2011-2021 data found limited associations between recreational cannabis legalization and adolescent substance use. Recreational cannabis retail sales were linked to lower e-cigarette use and an increased frequency of cannabis use among users, leading to no overall change in cannabis use.
A national cohort study of over 2 million Swedish women found that those experiencing five major adverse pregnancy outcomes had significantly higher mortality rates. The study highlights the importance of early preventive evaluation and long-term follow-up for detection and treatment of chronic disorders associated with premature morta...
A recent study found improvements in vaccination timeliness among US children from 2011 to 2021, however widening disparities by socioeconomic indicators highlight the need for increased efforts to facilitate timely vaccination among lower-income families.
Endoscopic sleeve gastroplasty is a cost-saving option compared to semaglutide for treating class II obesity. A study found that achieving price parity with semaglutide requires a significant discount of at least 3-fold.
Researchers observed a significant increase in permanent contraception procedures for young adults following the Dobbs decision, with females being disproportionately affected. The study highlights the gendered dynamics of permanent contraceptive use and its implications for women and people with reproductive capacity.
A study of 1,470 adults with chronic low back pain found that physician empathy was associated with improved outcomes over 12 months. Greater efforts to cultivate and improve physician empathy are warranted.
Young breast cancer survivors without germline pathogenic variants are at lower risk for developing a second primary breast cancer within the first decade after diagnosis. This study informs treatment decision-making and follow-up care considerations in this population.
A study of health care personnel reveals delayed COVID-19 testing was more common among non-Hispanic Black HCP and those with other racial backgrounds compared to non-Hispanic white HCP with graduate degrees. The findings highlight sociodemographic disparities in the response to COVID-19.
Midlife mortality rates for deaths of despair, including suicide, overdose, and liver disease, vary by race and ethnicity, with higher rates among Black and American Indian/Alaska Native populations. Early mortality from drug- and alcohol-related causes contributes to these disparities.
A cross-sectional study of 7,887 nurses found planned retirement, burnout, insufficient staffing, and family obligations as leading reasons for leaving healthcare employment. These factors highlight opportunities for employers to reattract existing nurses and retain currently employed staff.
A recent study published in JAMA Network found no association between acetaminophen use during pregnancy and increased risk of autism, ADHD, or intellectual disability in offspring. The study suggests that familial confounding may have contributed to previous associations observed in other models.
A recent survey study of 12,000 participants found that firearm owners were only moderately more supportive of political violence than nonowners. Firearm owners who always carried firearms in public were more likely to support and engage in political violence, highlighting the need for risk-based prevention efforts.
Most cancer drugs granted accelerated approval show no benefit in overall survival or quality of life within five years. Patients should be informed about the limited effectiveness of these drugs.
The randomized clinical trial demonstrates plozasiran's potential to reduce triglyceride levels in patients with severe hypertriglyceridemia. Additional studies are needed to determine its impact on complications associated with the condition.