A study published in Neuropathology and Applied Neurobiology reveals that RAPGEF2 protein overexpression leads to synaptic damage and cognitive impairment in Alzheimer's disease. Silencing RAPGEF2 prevents synapse loss and cognitive decline, suggesting a potential therapeutic target for neurodegenerative diseases.
Researchers at Korea Brain Research Institute used GANs to analyze bulk RNA-seq data, finding that increased Amyloid-beta in the brain alters cholesterol biosynthesis. This study provides a new approach for projecting biological changes and aiding healthcare industry.
A recent study has found that elderly Alzheimer's patients are more susceptible to COVID-19 infection due to increased expression of the ACE2 gene, which acts as an entry receptor for SARS-CoV-2. The research, published in the Journal of Infection, suggests that elevated ACE2 levels can lead to a higher risk of infection.
A recent study published in Molecular Brain suggests that an imbalance of human gut microorganisms and excessive propionic acid consumption may contribute to autism. The researchers found that propionic acid disrupts autophagy, a natural cell mechanism, leading to reduced dendritic spine formation and hindering child brain development.
A joint research team has identified dopamine D2 receptors in cholinergic interneurons as a key factor in susceptibility to cocaine addiction. The study found that DRD2 overexpression and reduced cell activation in ChINs contribute to the development of cocaine addiction.
Researchers identified 115 MAM-specific proteins using a new technique, Contact-ID, which facilitates calcium transport and lipid metabolism. The discovery is significant for understanding neurodegenerative diseases such as Alzheimer's and Parkinson's.
A new biomarker for Alzheimer's disease has been identified in the blood of patients, according to a recent study published in IJMS. The Ube2h gene was found to have increased specific expression in the blood of AD patients and AD model mice.
A research team led by Dr. Kea Joo Lee found that MAP2 plays a crucial role in inducing long-term potentiation, a cellular mechanism underlying learning and memory. The study's discovery provides key insights into synaptic plasticity mechanisms and potential therapeutic strategies for memory-related diseases.
A Korea Brain Research Institute study found that the posterior parietal cortex plays a role in fear renewal in novel contexts. This discovery may lead to the development of new treatments for post-traumatic stress disorder (PTSD) and fear-related disorders.
Researchers at KBRI found a new molecular mechanism that can inhibit neuronal degeneration by TDP-43, which is a major cause of dementia and Lou Gehrig's disease. The discovery reveals a potential therapeutic strategy to remove abnormal protein accumulation in neurons of patients with dementia.
A research team found that Dasatinib, a leukemia treatment, suppressed glial cell activity and pro-inflammatory cytokine expression, inhibiting encephalitis reactions. The study revealed the efficacy of drug repositioning to treat degenerative brain diseases like Alzheimer's.
A team led by Dr. Lim Hyun-Ho identified a new structure and mechanism of a membrane protein that causes epilepsy and muscle problems. The study reveals four different structures in the ion exchange process for a single CLC protein, expanding our understanding of this protein's functions.
Research found that ATG7 is related to the onset of frontotemporal dementia and Lou Gehrig's disease. The study showed that activating autophagy through ATG7 can improve neurodegenerative symptoms in fruit flies, suggesting a potential treatment for neuro-degenerative diseases.
A research team at Korea Brain Research Institute has developed a technology to produce dorsal cortical neurons utilizing induced pluripotent stem cells and tropical fish collagen. The breakthrough could lead to the treatment of brain diseases such as Parkinson's Disease by mass producing neurons using stem cells.
A research team discovered that Tdp-43 cryptic exons are highly variable between cell types, potentially leading to early diagnosis and therapeutic agents for neurological diseases. This finding may elucidate the causes of Frontotemporal Dementia and Lou Gehrig's Disease.