A recent study published in Human Molecular Genetics found that increasing a brain enzyme called puromycin-sensitive aminopeptidase can remove toxic tau proteins from neurons. This removal restored neuronal density and slowed down disease progression without any adverse effects. The research suggests that elevating this naturally occur...
Researchers found enzyme replacement therapy beginning at birth can eliminate almost all symptoms of mucopolysaccharidosis type I, a rare genetic disorder. Early treatment also showed significant improvements in brain pathology and reduced disease severity in animal models.
A recent study by LA BioMed researchers found that children with higher waist circumferences are more likely to have cardiac risk factors, including significantly higher pulse pressures. This suggests that pediatricians should add waist measurements to their routine screening of children to identify those at risk for heart disease.
Dr. Casaburi will receive the award on Oct. 8 at the American Association of Cardiovascular and Pulmonary Rehabilitation's annual meeting in Milwaukee, recognizing his many contributions to the field of respiratory research and pulmonary rehabilitation. He is a leading researcher at LA BioMed, directing the Rehabilitation Clinical Tria...
The commentary calls for a core medical school course that incorporates health policy, ethics, and evidence-based medicine to reflect economic influences on clinical decisions. This approach aims to improve physicians' critical capacity to assess factors affecting their decisions, as well as their social and ethical implications.
Researchers found that psilocybin improved mood and reduced anxiety in advanced-stage cancer patients, with benefits lasting up to six months. The study provides new hope for alleviating psychiatric symptoms in patients who often do not respond well to conventional treatments.
Research suggests that requiring a five-hour rest period for surgical residents after 16 hours of work may not improve outcomes in commonly performed operations. The study compared outcomes in laparoscopic cholecystectomies and appendectomies performed during the day versus at night, finding similar good outcomes.
Researchers at LA BioMed developed a novel approach to efficiently identify disease-relevant genes in human complex neurological disorders. This method was successfully applied to Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig's Disease, revealing new insights into the disease and potential diagnostic tests.
Researchers will test a combination of two hormonal gels on men's skin to suppress sperm production and prevent pregnancy. The study aims to develop a male contraceptive that would give men greater control over their reproductive choices.
LA BioMed researchers created a collaborative team mentored approach to learning for assessing medical teaching methods. This new model enables large-scale studies to measure the effectiveness of educational programs, ultimately improving patient safety and medical outcomes.
LA BioMed is participating in the international IPM020 study of a dapivirine-containing microbicide gel to evaluate its safety and absorption. The study aims to reduce HIV transmission among women, with the goal of reducing the cycle of infection that has led to millions of deaths worldwide.
LA BioMed will receive a $9.7 million grant from the National Institutes of Health to construct a new research center focused on chronic diseases such as COPD, cardiac disease, and HIV/AIDS. The center is expected to create up to 190 new jobs and enhance clinical research activities.
Researchers at LA BioMed found that patients with mild gallstone pancreatitis can safely undergo surgery within 48 hours of admission, reducing hospital stay lengths by a day. This new approach aims to shorten hospital stays and improve outcomes for these patients.
LA BioMed will receive over $4.5 million in Recovery Act grants to support groundbreaking research on Sudden Infant Death Syndrome, heart disease, liver disease, cancer, and a vaccine against Candida infections. The grants will also create jobs and fund vital research.
A new study released on World AIDS Day found that viral failure was twice as likely among patients given Epzicom when compared to those treated with Truvada, especially in those starting therapy with high viral loads. The study also showed a shorter time to virologic failure and adverse events for patients taking Truvada.
The American College of Physicians has awarded the Ralph O. Claypoole Sr. Memorial Award to Dr. Melvin R. Kaplan, one of LA BioMed's founders and a renowned internist. Dr. Kaplan has dedicated his career to patient care for over 60 years.
A study by LA BioMed found sustained improvements in exercise capacity among PAH patients treated with ambrisentan for two years. The researchers also observed a low risk of death and clinical worsening from the disease.
A large national study on testosterone's effectiveness will be conducted at LA BioMed, focusing on its impact on anemia, cardiovascular disease, and other health conditions in older men with low testosterone levels. The Testosterone Trial will involve 800 men across 12 sites, including LA BioMed, to evaluate the treatment's benefits.
Researchers at LA BioMed will investigate the potential of ESAI's drug, KRONOS IV, to activate adult stem cells and provide long-term correction for male erectile dysfunction in an aged population. The study aims to understand how the drug works on tissue repair and identify potential systemic effects.
Researchers have discovered protein aggregates in Sanfilippo syndrome type B that are similar to neurofibrillary tangles found in Alzheimer's disease. This finding suggests that new dementia treatments may also benefit patients with this rare genetic disorder, offering hope for improved treatment options.
Pulmonary rehabilitation improves aerobic function, reducing breathlessness in COPD patients. Supervised exercise also decreases anxiety and depression by enabling patients to master new skills.
A study from the Women's Health Initiative found that postmenopausal women who stopped taking combined estrogen plus progestin experienced a marked decline in breast cancer risk. The researchers also discovered that continued use of the hormone therapy after five years doubles subsequent breast cancer risk each year.
Spanish-speaking Hispanics take longer to respond to medication for depression and are less likely to go into remission than English-speaking counterparts. Socioeconomic factors such as education level and income play a significant role in treatment outcomes.
A new non-invasive cardiac imaging technology has been found to be highly accurate in detecting coronary artery stenosis, comparable to the traditional and more expensive invasive method. The study, conducted at 16 sites, involved 230 research volunteers with chest pain but no known coronary artery disease.
Researchers found that coronary arterial calcium scans can detect overall death risk in elderly adults, predicting those likely to suffer a heart attack or stroke. The study validated the use of CT scans to assess death risk, enabling physicians to advise patients on lifestyle changes and preventive measures.
LA BioMed investigator Dr. Ronald S. Swerdloff is recognized for his 39 years of teaching and training over 130 endocrine fellows. He has made significant contributions to the field of reproductive endocrinology, inspiring a legacy of outstanding trainees.
A new study by LA BioMed researcher Rajnish Mehrotra found that black patients with early-stage chronic kidney disease are 78% more likely to die than whites. The study suggests that socio-economic factors such as poverty, lack of education and medical insurance contribute to the higher mortality rates among blacks.
Dr. Criley developed the paramedic model in 1969, training firefighters to provide emergency care to heart attack victims. The program was later adopted nationwide, thanks in part to a TV show about it, and continues to save lives today.
A recent study found that post-menopausal women who stopped taking combined hormone therapy experienced an increased risk of all cancers, including lung cancer. The research, led by Rowan T. Chlebowski, confirms previous findings on the risks of hormone therapy.
A recent study published in Archives of Internal Medicine found that combined hormone therapy significantly increases the risk of abnormal mammograms and breast biopsies, compromising their diagnostic performance. The research involved 16,608 post-menopausal women and revealed a four percent greater risk of mammogram abnormalities afte...
A team of LA BioMed researchers developed a new, more reliable method for measuring protein synthesis and turnover using deuterated water and mass spectrometry. This breakthrough enables scientists to study the dynamics of every protein in the human body accurately for the first time.
A recent survey by LA BioMed researchers found that only 6% of emergency rooms in the US have all the necessary equipment and medicine for treating children. The majority of pediatric visits occur in non-child-friendly hospitals or rural facilities, highlighting a need for improvement in pediatric preparedness.
A new model for predicting breast cancer risk in postmenopausal women is as accurate as the Gail Model, but easier to use. The model uses only three factors: age, family history of breast cancer, and previous breast biopsy.
LA BioMed researchers found that African-Americans and Latinos responded less well to medication for depression than whites, with socioeconomic factors playing a key role. The study suggests these groups may need more treatment beyond medication, including talk therapy.
New clues from immune system molecules hold hope for overcoming antibiotic resistance, with shared structural and functional characteristics enabling these molecules to inhibit or kill microbial pathogens.
A sharp decline in breast-cancer incidence in 2003, followed by relative stabilization, is attributed to the drop in hormone-replacement therapy among postmenopausal women. Researchers estimate a 44,000 fewer breast cancers over two years, with the reduction most evident in estrogen-receptor-positive tumors.
Investigators at LA BioMed found evidence linking insulin-like growth factor receptor (IGF-1R) to the development of Graves' disease, a common cause of hyperthyroidism. The discovery suggests a potential therapeutic strategy for autoimmune diseases.
Studies by LA BioMed researchers found that close contacts of patients with CA-MRSA infection may be at higher risk of acquiring an infection. The findings suggest that CA-MRSA strains are more transmissible than traditional S. aureus strains, emphasizing the need for cautious treatment and contact isolation.
The study found that most LA County hospitals have limited disaster preparedness, with only 16% integrating emergency services in their plans. The researchers highlight the need for integration of hospital disaster plans with EMS and community resources to ensure effective response to disasters.
The LBD-CPR device's effectiveness is influenced by its use details, including patient population selection and deployment timing. Out-of-hospital cardiac arrests claim over 1,000 daily US lives.
The study found a reduced risk of breast cancer among women taking calcium and vitamin D supplements, with a significant interaction between those using supplements and those not. The researchers suggest further analysis of vitamin D metabolites may help clarify the findings.
Researchers have found that hormonal male contraception can be fully reversible in just a few months, with all men regaining fertility. The study, which analyzed data from over 1,500 men, showed that sperm production can be fully inhibited by hormone treatment combinations, allowing for reliable contraception.
A new study found that patients who saw visual proof of plaque buildup after an EBT scan were more likely to comply with prescribed statin therapy, exceeding 90% compliance. The study also suggests that this method can improve overall health behaviors beyond just medication adherence.
Researchers found that specific immunoglobins 'turn on' the IGF-1R, triggering inflammation and T lymphocyte activation. Blocking this interaction arrests molecular events leading to T cell activation, offering promise for a common therapeutic strategy for autoimmune diseases.
The study found significant improvements in mood and sexual performance, with sustained increases in lean body mass and bone mineral density over 3.5 years. Researchers observed minimal skin irritation and no major adverse effects, paving the way for testosterone gel as a safe treatment option.
Despite a growing need for new antibiotics, only six are being developed out of 506 drugs, with FDA approvals declining by 56% over the past 20 years. Researchers have identified a novel structural signature in antimicrobial peptides that could accelerate development of new treatments.
Diverse classes of antimicrobial peptides share a common structural signature, revealing fundamental interactions between host and pathogen. This discovery offers new insights into immune defense and drives technology to combat antibiotic-resistant infections.
Researchers have discovered that short-term use of estrogen plus progestin is associated with a decreased incidence of colorectal cancers. However, these cancers are diagnosed at more advanced stages, suggesting further study is needed to understand this phenomenon.
A clinical trial was stopped early after showing an unacceptably high risk of breast cancer recurrence in women who received hormone therapy. The study found that even short-term use of HRT poses a significant risk, prompting the need for alternative safe and effective strategies for managing menopausal symptoms in these women.
A new study suggests that using CT scans to measure coronary artery calcium scores can help evaluate risk and determine preventative therapy for patients at middle risk of coronary disease. This improvement allows doctors to make faster and more aggressive treatment decisions, such as prescribing drugs or lifestyle changes.