A new study published in Journal of Neurotrauma reveals that the premotoneuronal system in the cervical spine may be involved in permanent limb impairment after spinal cord injury. The research proposes a potential target for therapeutic strategies to promote recovery and repair.
A new rat model simulates traumatic muscle tissue loss in humans, enabling the testing of tissue engineering solutions. The model shows successful repair using a biological scaffold, providing valuable insights for developing treatments.
Researchers developed a novel approach to deliver cholesterol-conjugated small interfering RNAs (siRNAs) to liver cells using an endosomolytic polymer. The method significantly improves siRNA efficacy for targeted gene silencing, opening new possibilities for disease treatment.
A bioartificial liver machine has been scaled up and tested in a large animal model, providing temporary support for liver regeneration. The system uses encapsulated human-derived liver cells grown in a bioreactor and can be transported to a patient's bedside within 48 hours.
The US healthcare system is a $2.5 trillion industry heavily reliant on the internet, making it a target for cyberterrorism. Experts predict a wave-like attack that could leave staff untrusting of electronic data and demoralize IT teams. To protect itself, the healthcare system must remain vigilant and implement better security measures.
The Association of Environmental Engineering and Science Professors (AEESP) has selected Environmental Engineering Science as its official journal, promoting innovative solutions to environmental problems. The journal will publish state-of-the-art studies on air, water, and land contamination and waste disposal.
A review article examines the feasibility of algae-derived oils for large-scale biofuels production, with projected economic benefits. Microalgae have high yield potential, but require long-term commitment to achieve commercial scale, according to experts.
Researchers found that compressed propane increased inulinase activity, but the effect depended on enzyme structure and experimental conditions. The study explored the potential of compressed fluids to boost biotransformation reactions in industrial processes.
Researchers developed a new method to create long-lived stem cells for bone replacement by inserting human telomerase into mesenchymal stem cells. This allows the stem cells to retain their ability to become bone cells and divide repeatedly, making them suitable for tissue engineering applications.
A study found that Asian-Indian American children have the lowest rate of overweight or obesity (15.6%), while Vietnamese-American children have the highest rate (34.7%). This contrasts with other ethnic groups, highlighting the variability in obesity risk among different Asian-American communities.
A genetic variation in the vitamin D receptor has been linked to a decreased risk of developing osteoporosis, according to a meta-analysis of 26 studies. The study suggests that individuals with this variation may have a significantly lower risk of bone mineral density loss.
Soft Robotics is a peer-reviewed journal dedicated to the science and engineering of soft materials in mobile machines. The journal covers topics such as device development, flexible electronics, and control and simulation of highly deformable structures.
A growing body of literature suggests that alterations in regulatory T cell function may contribute to the development of sepsis. Manipulating these cells may offer a promising approach to treating patients with septic shock. The Journal of Interferon & Cytokine Research reviews the current understanding of this complex immune response.
Researchers compare three immunoassay methods to detect EBV infection in patients with mononucleosis or immunosuppressed adult liver transplant recipients. The study suggests that molecular tests identifying early protein markers may have value for diagnosing active infection.
A prospective trial evaluated HBO2 therapy on post-concussion symptoms in military servicepersons with at least one combat-related mild TBI. Both treatment groups showed significant improvement in concussion assessment and cognitive testing scores over the course of the study.
Researchers explored the benefits of adding radionuclide therapy to cancer treatment regimens for patients with advanced disease. Studies found improved tumor control rates and longer patient survival without significant side effects, suggesting a potential paradigm shift in cancer control.
Researchers have developed targeted T-cell therapies that can recognize and destroy glioma stem cells, which are resistant to traditional treatments. The new approaches involve genetically modifying T-cells to target specific antigens on tumor cells, potentially improving treatment efficacy and reducing cancer recurrence.
A new focus section discusses a new, improved shingles vaccine and alternative therapies to control symptoms. Experts emphasize the need for continued attention from public health, physicians, and researchers to address this debilitating condition.
Research highlights the potential impact of airport security scanners on diabetes devices, including insulin pumps and continuous glucose monitoring systems. The Editorial calls for more research to understand and potentially repair this issue affecting hundreds of thousands of people worldwide who use insulin pump therapy.
The new Big Data journal will publish peer-reviewed content on novel technologies, policies, and innovations in the field. It aims to facilitate collaboration among researchers, analysts, and business leaders to address challenges and discover breakthroughs in big data.
The new journal will publish innovative research, interviews, roundtable discussions, and briefs on emerging space-based technologies and initiatives. It aims to facilitate collaborations among industry, academia, and government agencies, advancing knowledge and society through space exploration.
The Fourth Annual Summit on Breastfeeding highlighted ongoing disparities in breastfeeding, with only 44% of African-American women reporting breastfeeding compared to 66 and 68% for Hispanic and white women. The summit also explored the role of access to support, counseling, and equipment as a means to increase breastfeeding rates.
A comprehensive review article discusses progress and application of Cell-SELEX technology, which uses live cells as targets for binding aptamers. The technique offers stability, short length, and ease of manufacturing, making it an attractive option for drug compound screening.
Research suggests that pulmonary vaccine delivery can induce a local immune response more effectively than traditional injections, potentially combating pathogens that cause pulmonary diseases. The unique physiology of the respiratory tract makes it an attractive alternative to injections.
A study reviews the efficacy and safety of inhaled drugs commonly used in ICU settings, including antibiotics and diuretics. The article discusses the challenges of aerosol drug delivery and advances in devices contributing to its increasing use and success.
Researchers have successfully developed a stable population of neural crest cells from mice that can differentiate into multiple cell types. This breakthrough enables the study of stem cell biology and human development, as well as potential applications in understanding diseases.
A recent study published in the Journal of Neurotrauma found that children who suffered moderate or severe traumatic brain injuries may still experience substantial functional disabilities and reduced quality of life two years after the injury. The authors suggest that a plateau is reached in recovery beyond this period.
Young adults with advanced cancer experience life disruption and losses, affecting their educational, career, and personal goals. Clinical interventions can help patients cope with grief associated with cancer-related losses and life transition.
The new guidelines provide updated recommendations for diagnosing and treating hypothyroidism, a complex condition affecting millions worldwide. The guidelines aim to address issues with inappropriate thyroid hormone administration and suboptimal dosing.
A review article highlights the role of interleukin-18 (IL-18) in inflammation and its potential as a therapeutic target for pulmonary inflammatory diseases. Therapies blocking IL-18 activity may offer effective treatment options for conditions like bronchial asthma and COPD.
Researchers highlight RNA's self-assembling properties, but also discuss challenges such as stability and targeting in therapeutic applications. The article provides a detailed review of the field, discussing its potential for treating various diseases.
The article highlights advancements in biomass characterization technology to overcome recalcitrance issues in lignocellulosic biomass. Researchers share their work and perspectives on improving methods for analyzing biomass chemistry, structure, and interaction.
The West Nile virus has caused 26 deaths and nearly 700 cases in the US this year, with Texas being a hotspot. The cause of the increased cases remains unclear, but experts emphasize the need for continued research and public health efforts.
Researchers have identified a biochemical marker, SSEA4, that can be used to identify and purify human pancreatic stem cells. These stem cells can differentiate into insulin-producing cells when grown in culture with high glucose levels, potentially offering a new approach for treating type 1 diabetes.
Prosperous Native-American tribes are concerned that state-legalized internet gambling could harm their revenues and economies. Experts, including Joseph M. Kelly, PhD, JD, argue that federal regulation would be preferable to prevent negative impacts.
A special issue of Childhood Obesity journal explores ways schools can improve food culture, practices, and nutrition standards to combat the obesity epidemic. The issue features articles on salad bars, Farm to School programs, and school lunch nutritional quality.
A study published in AIDS Patient Care and STDs found that HIV-specialized community pharmacies can significantly improve treatment adherence among patients. Users of these pharmacies had greater persistence with their antiviral drug regimens compared to those using traditional pharmacies.
Researchers have successfully derived human embryonic stem cells from frozen embryos after 18 years of storage. This breakthrough provides a valuable alternative source of ES cells for drug screening and medical research.
The US Navy recently defended its use of renewable fuels, citing a 50% biofuels blend during the RIMPAC 2012 exercises. The Navy believes that these resources are crucial for enhancing national security and energy independence.
A meta-analysis of clinical trials found no statistically significant differences in viral load after 48 weeks between women and men with HIV. However, subgroup analyses revealed significant gender differences favoring males in certain outcomes.
A new prediction model for long-term functional outcomes after traumatic spinal cord injury is presented, combining acute functional measures with imaging factors. The model has the potential to guide treatment decisions and improve patient care.
Advances in laparoscopic surgery have improved the care of patients with gallbladder disease, offering a less invasive alternative to open surgery. New tools and techniques have enhanced surgical outcomes, including reduced recovery times and fewer complications.
Research on Alzheimer's disease is gaining momentum, with over 150 companies working on innovative approaches to tackle the debilitating disease. New therapies, such as Antisenilin and Gammagard, are in Phase III trials and show promise in addressing the underlying biology of the disease.
A novel method using immune cells has been shown to induce tolerance to specific proteins in mice, allowing them to tolerate gene therapy designed to deliver the protein. This approach may prevent rejection and improve the long-term success of gene therapies for various diseases.
A comprehensive review of the recent medical literature evaluates the potential for reducing HPV-related illness burden by expanding routine vaccination to include young males. The authors present their recommendations on the cost-effectiveness of male HPV vaccination, which could lead to significant public health benefits.
Biotech Boulevard features companies making a mark on the global bioindustry through novel therapeutics and technologies. The microsite provides a platform for discovery, investment, and collaboration among these promising young companies.
A study published in Therapeutic Hypothermia and Temperature Management found that therapeutic hypothermia can limit the devastating consequences of brain injury after cardiac arrest. The survey results show a wide variation in patient selection criteria for therapeutic hypothermia across New Jersey hospitals.
Researchers found that herbal agents can prevent sunburn and limit UV damage, with golden serpent fern and Asian ginseng showing promising photoprotective properties when taken orally. Green tea applied topically also offers photoprotection in sufficient doses.
A recent study published in Cancer Biotherapy and Radiopharmaceuticals suggests that high-dose interleukin-2 (IL-2) should continue to be the initial treatment for patients with stage IV metastatic melanoma. The researchers recommend intensive IL-2 therapy as a viable option, either alone or in combination with newer therapeutic agents.
A novel gene therapy approach has been developed to increase frataxin protein levels in Friedreich's ataxia patients. The method, using TALE proteins, successfully boosted frataxin production by 2-3 fold, offering a potential solution for treating the genetic disorder.