The GRACE study found that access to treatment was the most positive factor for patient enrollment, while difficulties in adherence included being a primary caregiver and transportation issues Women of color reported feeling differently about their health after participating in the trial
Researchers developed a novel approach to make ovarian cancer cells susceptible to an antitumor drug, potentially improving treatment outcomes. The strategy targets telomeres and shows promise in treating other epithelial cancers.
A new microsphere-based detection system uses multiple antibodies at once for early HIV detection and vaccine efficacy assessment. The novel multiplex immunoassay approach significantly improves sensitivity over standard ELISA techniques.
Researchers have discovered that processing bodies can contribute to immune defenses by responding to viral infections. Viruses alter the composition of processing bodies to enhance their replication, but PBs can limit this ability.
A genome-wide lethality screen using RNA interference technology identified 239 gene candidates essential for cell survival. The researchers developed a high-stringency analysis method to determine which genes result in cell death when knocked down.
A new study found that breastfeeding at 3 and 6 months of age was associated with a lower risk of attention-deficit/hyperactivity disorder (ADHD) in children. The research suggests that breastfeeding may have protective effects against ADHD, which is a common neurodevelopmental disorder.
A recent review article highlights the complex mechanisms underlying viral dsRNA sensing in animals, insects, and plants. Novel components of these antiviral recognition systems contribute to their effectiveness in protecting hosts against viral infection.
Noninvasive imaging tests like CT, MR, and PET may help evaluate and manage diabetes by assessing changes in fat composition and distribution. This can aid in early disease detection and identify functional abnormalities before symptoms appear.
The new journal MOOCs FORUM, launched in summer 2013, focuses on the development, design, and deployment of Massive Open Online Courses (MOOCs). The journal aims to provide a neutral platform for critical evaluation of MOOC components and modules.
Researchers identified five trajectories for patients with end-stage heart failure, providing a framework to predict the path to death and improve quality of life. The study's findings can help caregivers plan for the last months of life, enabling patients to gain control over their illness.
A novel high-throughput screening method has identified agents that can block EZH2 methyltransferase, a key enzyme in tumor development. This approach uses AlphaLisa technology to detect methylation and accelerates the identification of small molecule inhibitors for cancer treatment.
The new journal Violence and Gender will explore the difficult issues that are vital to threat assessment and prevention of violent acts. It aims to better understand and address differences in violent behavior between men and women to prevent tragic events.
A team-based approach to primary care delivers improved patient outcomes, enhanced practice workflows, and increased physician satisfaction. By sharing responsibility and consulting with each other regularly, healthcare teams can provide more sensitive and responsive patient-centered care.
Researchers propose strategies to enhance the therapeutic effects of interferon in cancer treatment. They explore mechanisms of interferon signaling that lead to tumor cell death and suggest directions for future research, such as alternative methods of delivering interferon-activated immune cells.
A special issue of Medical Acupuncture explores the basic science and mechanisms of action underlying medical acupuncture. The study found associations between neurotransmitters in the brain and patient responses to traditional vs. sham acupuncture, suggesting improved outcomes with matched treatments.
Researchers have developed a new solid form of bioactive plasma-based biomaterials that can promote healing at sites of tissue injury. These materials, known as PBMs, are easier to work with, inexpensive to produce, and safe to use.
Researchers have identified two key compounds produced by mast cells that promote fibrogenesis, leading to pulmonary fibrosis. Introducing mast cells into mice lungs can reverse disease protection and cause pulmonary fibrosis.
Researchers have developed nanoparticles that improve siRNA delivery, enabling more efficient silencing of specific genes. The approach shows promise in addressing the challenge of targeted delivery for gene therapies.
A new study suggests that medical therapy is a viable alternative to angioplasty in treating stable coronary artery disease, reducing the risk of complications and hospitalizations. The study proposes a targeted approach to shared decision-making, considering treatment options, risks, and outcomes for patients.
Researchers found that human hematopoietic stem cells can survive for longer periods when cultured with a feeder layer of adipocytes, or fat cells. The study demonstrates the potential for using fat cells to extend the lifespan of hHSCs in vitro, which could be crucial for developing advanced cell therapies.
The premier issue of New Space journal marks a significant milestone in the field of commercial space ventures. The inaugural issue features premium content from leading experts, including editorials, roundtable discussions, and peer-reviewed original articles.
Researchers have discovered that epileptic seizures in temporal-lobe epilepsy patients can propagate through anatomically and functionally connected brain networks. The study found reduced gray-matter concentrations in certain brain regions, which correlated with changes in functional connectivity and communication between brain areas.
A new study published in Brain Connectivity found evidence of aberrant neural communication in toddlers with autism, indicating a disorder of connectivity. The researchers observed reduced brain connectivity and diminished capacity for neural communication in autistic children's brains.
Chronic fatigue is three times more prevalent among adult cancer survivors than the general population. A persistent low-grade inflammatory response may contribute to chronic fatigue in these individuals. The study highlights the need for healthcare providers to communicate with cancer survivor patients about possible chronic fatigue.
Researchers develop a gene therapy technique to increase enkephalin, an opioid compound, in the bladder wall, reducing pain signals. The treatment approach shows promise for severe chronic pain conditions like bladder pain syndrome/interstitial cystitis.
A new low-cost nano-biosensor can detect Listeria monocytogenes, a foodborne pathogen that causes listeriosis. The biosensor uses gold nanoparticles and has the potential for commercial development.
Research shows energy drinks containing caffeine can enhance physical performance in cyclists, with average cycling times improving by 3% after consumption. However, the impact on cognitive function is unclear and likely unrelated to the energy drink.
A recent study suggests that new national policies designed to reduce hospital readmissions will have uncertain success. The study identifies three critical challenges that stand in the way of policy success, including the need for collaborative relationships within the medical community and more evidence-based policy decisions.
The new guidelines aim to improve glycemic control in type 1 diabetes by standardizing glucose monitoring data collection, reporting, and analysis. The recommendations also focus on implementing practical solutions for healthcare providers and patients.
The new forum will examine key issues affecting MOOC success, such as completion rates and course content security. Established thought leader Jack M. Wilson is Editor-in-Chief of the journal.
A pilot study shows that qigong therapy significantly reduced cocaine cravings and depression symptoms in individuals undergoing residential substance abuse treatment. This promising treatment approach may have profound consequences in drug rehabilitation programs.
A novel drug delivery strategy has been shown to neutralize mutant RNA toxicity and eliminate myotonia symptoms in mice with myotonic dystrophy. The approach uses antisense oligonucleotides and peptide-linked morpholino oligonucleotides to target the disease-causing mutation.
A study published in Population Health Management found that eliminating co-payments for diabetes-related medications and supplies improved patient self-management of their condition. Nearly 90% of participants reported better disease management after the program's initiation.
A large study found that as coffee drinking increased, the risk of death decreased in older adults. The study's author discusses potential links between coffee consumption, caffeine intake, and various causes of disease.
Researchers have discovered a vast potential for noncoding RNAs to be used as therapeutic and diagnostic tools. Long noncoding RNAs play significant roles in various diseases, including cancer, diabetes, and other conditions. The emerging concept of microRNAs functioning as hormones has also led to new avenues for disease treatment.
The inaugural issue of Big Data journal launched at the Strata Conference, featuring premium content from leading experts on big data. The Journal aims to facilitate dialogue among researchers, analysts, and policymakers on the challenges and opportunities in big data, published under the Creative Commons Attribution license.
A review of published studies suggests that interactions with therapy dogs can help children with ASD develop emotional attachments and interaction in a social setting, leading to improved interpersonal communication. Larger studies are needed to confirm these findings and build on the current evidence.
The journal features world-class content on innovative applications of emerging space-based technologies, including commercial cargo and crew services, tourism, colonization, deep space research, and resource utilization. The first issue includes an original article on the B612 Foundation Sentinel Space Telescope and a roundtable discu...
Two new methods for detecting and measuring the levels of antisense drugs in cells have been developed, allowing researchers to track PMO delivery to individual cells and quantify its presence in tissue. These methods will advance the field of PMO research and provide valid alternatives to current time-consuming detection techniques.
A systematic review of medical literature on metabolic syndrome in children found that obesity, male sex, and increasing age are significant risk factors. The prevalence of metabolic syndrome increased substantially when comparing groups of overweight or obese children to whole populations of youths.
A special issue of Industrial Biotechnology explores innovative uses of nanotechnology in food and agriculture, including nanoparticle bioactivity, soil denitrification, and nutrient microencapsulation. Researchers discuss promising applications and methods for industrial biotech innovation.
A new peer-reviewed journal will identify crucial LGBT healthcare needs and provide a much-needed authoritative source for LGBT health research. The journal will promote optimal healthcare for millions of sexual and gender minority persons worldwide by focusing on their specific health concerns.
A novel aptamer has been developed that specifically targets and stimulates human immune cells, significantly increasing the effectiveness of immunotherapeutic drugs. The aptamer enhances the ability of activated T cells to proliferate and produce immunostimulatory cytokines.
The first series of debates on cancer development explores two major theories: Somatic Mutation Theory and Tissue Organization Field Theory. Researchers propose focusing on explaining paradoxes to advance cancer research.
Researchers developed a new gene therapy approach called exon skipping, which bypasses disease-causing mutations in genes to restore normal expression and protein production. This strategy has shown promising results in treating muscular dystrophy, with improved muscle force and increased body weight and muscle mass.
A systematic review of four studies suggests that acupuncture may have a positive effect on exercise performance and recovery after exercise. However, additional trials with larger sample sizes and randomized designs are required to confirm these findings.
Researchers developed a method to create stretched polymer scaffolds that support the growth of human mesenchymal stem cells, promoting consistent alignment and elongation into tissues. This innovative approach has potential applications in regenerating damaged or diseased tissue.
Researchers found that children and young adults are at increased risk of repeat traumatic brain injury due to a metabolic slowdown in the brain. A specific time frame after initial injury, hours to days, poses the greatest risk.
Exposure to environmental toxins can cause chronic health problems like respiratory, endocrine, reproductive, and neuropsychiatric disorders in children. Unique risk factors include their small size, developmental stage, and habit of putting things in their mouths.
A special issue of the peer-reviewed journal Zebrafish highlights the development and implementation of student-led, inquiry-based active learning opportunities. The research articles focus on new curricula that emphasize process-oriented learning and scientific literacy.