Researchers at Mayo Clinic have discovered a single gene promoting development of essential tremor in some patients and Parkinson's disease in others. The study found a significant association between the LINGO1 gene variant identified in Iceland to both disorders, with mutations potentially responsible for five percent of patients.
Researchers at Mayo Clinic found high-dose ursodeoxycholic acid to be detrimental in treating primary sclerosing cholangitis. The six-year trial showed that serious adverse events were more common in the high-dose group, highlighting the need for further research on better treatment options.
Researchers analyzed 17,398 patient records and found only 14 real disease associations with MGUS, not 61 as previously reported. This finding may reduce unnecessary testing and treatment for patients with MGUS.
A new study found that relief of pain and improvement in function were similar in patients treated with vertebroplasty and simulated vertebroplasty without cement injections. The study raises questions about the procedure's long-term efficacy, suggesting that other factors may contribute to its benefits.
Researchers at Mayo Clinic found that children exposed to general anesthesia during C-section delivery have no higher risk of learning disabilities. Babies delivered via Cesarean with epidural anesthesia had a reduced risk of learning disabilities compared to those delivered vaginally or with general anesthesia.
Researchers at Mayo Clinic have discovered a mutated gene linked to restless legs syndrome, affecting 5-11% of the population. The study suggests that this genetic mutation may be a key factor in understanding the condition, which causes unpleasant sensations in the legs at rest.
Researchers successfully used induced pluripotent stem (iPS) cells to treat heart damage caused by infarction. The treatment restored heart muscle performance, stopped progression of structural damage, and regenerated tissue at the site of heart damage.
Mayo Clinic researchers found that prior exercise was significantly associated with milder impairments and better ability to care for oneself after a stroke. The study's lead investigator suggests that exercise can improve outcomes even if it doesn't reduce the risk of developing a stroke.
A new Mayo Clinic study found that clinical criteria for mild cognitive impairment are better at predicting Alzheimer's disease than a single memory test. The study identified individuals aged 70-79 years who were cognitively normal or had slight memory impairment as being most likely to develop Alzheimer's disease.
A Mayo Clinic study has developed a framework for MRI-based differential diagnosis of Alzheimer's disease, frontotemporal lobar degeneration, and Lewy body disease. The 'STructural Abnormality iNDex' or STAND-Map framework predicts an accurate pathological diagnosis 75 to 80 percent of the time.
The review examines the prevalence of prescription opioid addiction among patients and healthcare providers, citing risks and consequences. New approaches to minimize abuse and promote recovery are discussed, emphasizing the importance of awareness and treatment.
The Mayo Clinic Cancer Center has received a $28 million National Cancer Institute (NCI) funding grant for five years. This award extends the center's designation as a comprehensive cancer center, enabling it to continue delivering outstanding care and research programs across its three US sites.
Researchers at Mayo Clinic and University of California San Francisco have discovered a connection between DNA alterations on human chromosome 9 and glioblastoma. The study found that individuals with specific single nucleotide polymorphisms (SNPs) are 50% more likely to develop the aggressive brain cancer.
A Mayo Clinic study found celiac disease has become four times more common, with undiagnosed cases associated with a nearly quadrupled mortality risk. The study suggests increased awareness is needed among physicians and patients to diagnose the condition earlier.
A review in Mayo Clinic Proceedings suggests that deep brain stimulation (DBS) may be an effective treatment for hard-to-treat depression and obsessive-compulsive disorder (OCD). The therapy, which involves stimulating specific parts of the brain, has shown early results with a beneficial effect on these conditions.
Researchers used a combination of an immunotherapeutic agent called MDX-010 or ipilimumab with standardized hormone treatment and radiation therapy to treat advanced prostate cancer. The approach led to significant tumor shrinkage and cancer cell death, allowing surgery in two previously inoperable patients.
Researchers at Mayo Clinic have found a peptide that preserves and improves kidney function during heart failure, potentially reducing the risk of kidney damage. The new compound has been tested in laboratory and animal models and is expected to move into clinical trials next year.
Mayo Clinic is leading a six-year study to determine whether catheter ablation is more effective than drug therapy for treating atrial fibrillation. The trial will randomize patients over three years, examining effectiveness and safety of left atrial catheter ablation versus current state-of-the-art drug therapy.
Researchers at Mayo Clinic have found that bariatric surgery may be associated with an increased risk of fractures, particularly in the hands and feet. The study, which analyzed nearly 100 surgical cases over a 21-year period, showed that 21 individuals experienced 31 fractures within seven years after surgery.
A new study demonstrates the effectiveness of eculizumab in preventing antibody-mediated rejection in positive crossmatch kidney transplant patients. The treatment, which blocks the immune system's activation of the complement system, showed promising results with none of the treated patients developing antibody-mediated rejection.
A new DNA stool test has been developed by Mayo Clinic researchers to detect digestive cancers in multiple organs, including pancreas, stomach, and esophageal cancers. The test was shown to be highly sensitive, detecting cancers at each organ site with high accuracy.
Researchers at Mayo Clinic have developed new tests that significantly improve the detection rate of bile duct and pancreatic cancer, increasing it from 20% to 43%. The combination of cytology and FISH analysis was found to be more effective in diagnosing these cancers.
Researchers at Mayo Clinic found that low doses of carbon monoxide can reverse gastroparesis, a common complication in diabetes. The study showed that carbon monoxide normalizes gastric functioning without increasing oxidative stress or HO1 expression.
Researchers at Mayo Clinic have identified a novel molecular path linked to primary biliary cirrhosis, a disease affecting 1 in 2,500 Americans. The study found variants of two genes, interleukin 12A and interleukin 12RB2, strongly associated with the condition.
A Mayo Clinic study found that short preoperative team briefings can improve communication and reduce errors in cardiac surgery. The briefings were conducted prior to the first procedure of the day and resulted in a 53% reduction in miscommunication events.
Researchers at Mayo Clinic have found that patients with chronic lymphocytic leukemia (CLL) can tolerate high doses of green tea extract EGCG, leading to a significant reduction in lymphocyte count. The study also showed that many participants experienced regression of CLL symptoms, particularly those with enlarged lymph nodes.
Researchers redefine migraine as a potentially chronic disease, requiring a collaborative healthcare model with patients and professionals. This new understanding offers opportunities for personalized care and improved disease management.
A Mayo Clinic study reveals a history of child abuse significantly impacts the challenges faced by depressed inpatients, including increased suicide attempts and psychiatric hospitalizations. The research highlights the importance of aggressive approaches to prevent child abuse and stresses the need for more public health initiatives.
A Mayo Clinic study reveals that patients with bipolar disorder incur significantly higher specialty care costs compared to those with diabetes, depression, asthma, or coronary artery disease. Specialty care costs were especially high for bipolar patients, suggesting non-mental health provider-related expenses contribute to the disparity.
Researchers compared TV show crimes to real homicides and found significant differences in portrayal of alcohol use, relationships, and racial representation. The study highlights the need for accurate public health messages, as media influences individual health behaviors and perceptions.
Researchers at Mayo Clinic found that pazopanib stops new blood vessel growth, slowing aggressive differentiated thyroid cancer. The treatment showed promising results in about two-thirds of patients with fast-growing cancers that had spread to lungs and other organs.
A study published by Mayo Clinic researchers found that pregabalin decreases hot flash severity and frequency, offering a treatment option for women who cannot take hormonal therapies or antidepressants. The medication appears to have a similar benefit as gabapentin and newer classes of antidepressants, with a lower dosage requirement.
Researchers found that adding epratuzumab to a regimen of R-CHOP resulted in an overall 12-month survival rate of 88 percent in patients with diffuse large B-cell lymphoma. The combination was also shown to offer improved progression-free survival rates, particularly for high-risk patients.
Researchers at the Mayo Clinic have found a triple drug combination to be an effective and tolerable option for treating metastatic HER2+ breast cancer. The regimen, which combines capecitabine, vinorelbine, and trastuzumab, has shown promising results in reducing tumor size and improving survival rates compared to traditional treatments.
A large Mayo Clinic cohort study found that statin use is associated with a reduced risk of prostate cancer, with non-statin users three times more likely to develop the condition. Statins may also protect against erectile dysfunction, particularly among older men, and prevent prostate enlargement.
A new diagnostic technique using blue light and a special study drug has been shown to detect more bladder tumors, reducing the rate of recurrence by 22% in patients with papillary bladder tumors. The study found that this method detected an additional tumor in 16.9% of patients compared to traditional white-light detection.
A large study found that hormone therapy use was associated with a 28% lower incidence rate of colorectal cancer in older women. However, the mechanisms behind this protective effect are still unclear. The study also found no associations between hormone use and specific molecular markers or DNA methylation patterns.
Researchers at Mayo Clinic have identified two chemicals that can increase the activity of a molecule called insulin-degrading enzyme (IDE), which helps break down proteins associated with Alzheimer's disease. The study suggests that activating IDE may offer a new therapeutic approach for treating and preventing the disease.
Researchers at the Mayo Clinic have formulated a treatment combination that destroys up to 65% of pancreatic tumor cells in laboratory tests. The combination of rapamycin and panobinostat acts synergistically, offering new opportunities for patients with pancreatic cancer.
Researchers have confirmed six gene variants linked to chronic lymphocytic leukemia (CLL), the most common adult leukemia in the US. The study found that patients with CLL are more likely to have these genetic changes, increasing their risk of developing the disease.
A new study at the Mayo Clinic found that one in six patients taking therapeutic doses of dopamine agonist medications for Parkinson's disease developed new-onset compulsive gambling or hypersexuality. Researchers analyzed medical records of patients and found no such cases in those taking low doses or other treatments.
Researchers discovered a key checkpoint in cell growth and development that may allow investigators to benchmark progression of tumor cells or stop them from further development. The mechanism involves the activation of p21-activated kinase 2 (PAK2) in certain tissues but not others, and is controlled by the Erbin/Merlin complex.
Researchers at Mayo Clinic have discovered the molecular interplay that enables invasive tumor cells to move and invade other parts of the body. By manipulating this process, they hope to develop treatments to stop cancer from spreading.
A Mayo Clinic study reveals that 60% of retired National Football League (NFL) linemen suffer from sleep disordered breathing, with an average of 18.1 episodes per hour.
A noninvasive finger sensor test is highly predictive of major cardiac events for people at low or moderate risk. The EndoPAT test measures blood flow and identifies endothelial dysfunction, a condition that can lead to atherosclerosis and cardiovascular problems.
Researchers at Mayo Clinic found that children who require multiple surgeries under anesthesia during their first three years of life are at higher risk of developing learning disabilities later. The study, which analyzed data from over 5,000 children, suggests a possible link between anesthetic exposure and brain development.
A Mayo Clinic study found a correlation between inadequate vitamin D levels and the amount of narcotic medication taken by patients with chronic pain. Patients with low vitamin D levels were taking nearly twice as much pain medication, experiencing worse physical functioning and overall health perception.
The American College of Surgeons has recognized Mayo Clinic's two Minnesota hospitals, Rochester Methodist and Saint Marys, for achieving exemplary outcomes in five clinical areas. These hospitals demonstrated high quality of surgical care through tracking patient outcomes and implementing safety improvements.
Research shows that patients discharged against medical advice are at higher risk of morbidity and mortality, with some groups facing four-times-higher risks of readmission within 30 days. Identifying these high-risk patients is crucial, and providing informed consent can help manage the issue.
A Mayo Clinic study found significant effects of obesity on total hip replacements, with a 50% higher complication rate in superobese patients. The study also reported complications with knee implants under extreme weight stress, highlighting the need for weight loss management prior to surgery.