A new study by the Mayo Clinic found that the Gail model, a widely used statistical tool for predicting breast cancer risk, was not reliable for women with atypical hyperplasia. The study tested the model in 331 women with atypia and found it predicted significantly fewer invasive breast cancers than were actually observed.
A Mayo Clinic study of nearly 3,000 heart attack survivors found that the risk of sudden cardiac death is highest in the first month after leaving the hospital. After that initial period, the risk drops significantly but rises again if symptoms of heart failure appear.
A new study shows that magnetic resonance elastography (MRE) can identify liver fibrosis with high accuracy, helping to avoid invasive biopsies. MRE produces color-coded images indicating internal organ stiffness, allowing doctors to diagnose liver disease earlier.
Research at Mayo Clinic suggests that teaching children to face their fears can improve functioning and complete exercises exposing them to their fears earlier than recommended treatment manuals. In contrast, focusing solely on managing anxieties yields less improvement.
Mayo Clinic researchers have discovered a way to control oncolytic viruses using microRNAs, which can restrict them to specific tissues and make them safer for use in cancer therapy. This discovery could lead to new methods of making safer vaccines.
Rheumatoid arthritis incidence and prevalence are on the rise among women in the US, with a 54% increase in female cases from 36 to 54 per 100,000 annually, according to a Mayo Clinic study. Researchers believe an environmental factor may be contributing to this trend, which could indicate a need for further research.
Research at the American College of Rheumatology 2008 Annual Meeting found that rheumatoid arthritis patients are at a higher risk of dying from heart-related complications after a heart attack. Biomarkers have been identified to determine the most effective treatment for muscle tissue inflammation and age-related bone loss in men and ...
Convergence insufficiency affects children's ability to focus and align their eyes while viewing objects up close, impacting reading and concentration. Researchers discovered that structured therapy sessions in a doctor's office and reinforcement eye exercises at home improve vision faster than home-based therapies alone. The study, sp...
Researchers at Mayo Clinic developed a probe that can detect cancerous cells in the colon with 90% accuracy, reducing the need for unnecessary polyp removal. The probe-based confocal laser endomicroscopy system could potentially cut colon polyp removal in half.
A study by Mayo researchers found that outpatient stem cell transplantation for multiple myeloma patients resulted in a high survival rate of 99% at 100 days. The treatment also showed significantly shorter hospital stays, with a median duration of four days for those who required some hospital care.
A Mayo Clinic-led study finds that infliximab administered alone or in combination with azathioprine is more effective for moderate to severe Crohn's disease than azathioprine alone. The study demonstrates improved patient outcomes, including higher remission rates and mucosal healing.
A Mayo Clinic-led study found that the first generation of a stool DNA test detected 20% of colorectal cancer and precancerous polyps, compared to fecal blood tests. The test's limitations include sample degradation and low sensitivity, but second-generation tests improved detection rates.
A Mayo Clinic study implemented a radio-frequency identification system to track biopsy specimens and automate identification. The initiative resulted in a significant reduction of specimen-labeling errors, from 765 in 2007 to 47 in 2008. The new labeling system improved safety and quality efforts in specimen management.
A Mayo Clinic study found that obese patients with specific genetic markers experienced greater weight loss when taking the medication sibutramine. Patients who lacked these genetic factors showed little to no weight loss during the 12-week trial.
Researchers have found a potential solution for diabetic gastroparesis by increasing production of a key molecule in the digestive process. The study, published in Gastroenterology, shows that a red blood cell derivative can restore normal gastric emptying and improve glucose control.
A study published in the Journal of the American Medical Association (JAMA) concludes that internet-based education is associated with large learning gains compared to traditional instructional methods. Internet-based instruction was shown to be as effective as traditional methods in teaching health-care professionals, offering unique ...
Researchers at Mayo Clinic have successfully used stem cells to regenerate heart tissue and repair dilated cardiomyopathy, a genetic defect. The treatment improved heart performance, synchronized electrical impulses, and halted deterioration in genetically altered mice with heritable dilated cardiomyopathy.
The new statistical model incorporates serum sodium and MELD scores to prioritize the sickest patients, reducing mortality by 7% among those with low sodium levels. Mayo Clinic's improved tool aims to ensure timely transplants for those with advanced liver disease.
Researchers compared online prescribing and traditional physician consultation for treating erectile dysfunction, finding that the online system outperformed in patient education and prescription appropriateness. The study concludes that a well-regulated Internet prescriber service can be comparable to traditional medical practice.
Researchers found that white patients with two distinct gene variations were more likely to experience remission of symptoms associated with major depression. Pharmacogenetic testing could improve patient outcomes by matching patients with the right drug from the start.
Researchers have found a gene mutation linked to one family's hereditary form of atrial fibrillation, leading to better understanding and potential new treatments. The discovery provides insight into pathways that may be applicable to people in the general population with atrial fibrillation.
Researchers found a significant reduction in LDL cholesterol and triglycerides in patients taking fish oil and red yeast rice supplements. The study suggests a comprehensive approach to lipid lowering could be effective for patients unwilling or unable to take statins.
A new implantable device blocks stomach nerve signals, resulting in significant weight loss in obese participants. The study found that a quarter of patients lost over 25% of their excess weight and three patients lost more than 30%. A follow-up double-blinded study will be conducted to assess the device's true effectiveness.
Researchers found that the measles virus can replicate only in immune cells, causing disease in monkeys and potentially improving cancer therapy efficacy. The study's findings challenge traditional textbook assumptions about how the virus spreads, paving the way for more effective vaccines and treatments.
Research by Mayo Clinic found that people with lower incomes and education levels are more likely to die after a heart attack. The study analyzed data from 705 patients treated for heart attack between 2002 and 2006, showing survival rates were lowest for those with the lowest income and education.
A recent Mayo Clinic study found that rural, unmarried women have lower self-rated health status and are more prone to depression compared to their married counterparts. The study suggests that primary care physicians should take a proactive role in addressing health concerns of single women.
Gamma-secretase modulators, a class of agents in testing to treat Alzheimer's, work by reducing long Abeta peptides and increasing shorter ones that inhibit aggregation. This could lead to new treatments for the disease, with one such drug, tarenflurbil, showing promise in patients with mild Alzheimer's.
Researchers at Mayo Clinic found that heart patients who met regularly with cardiac 'disease managers' for three years had better control of risk factors and lower death rates. The approach demonstrated clear clinical benefits, including improved cholesterol levels, blood pressure, and medication compliance.
Scientists have identified p16 as a gene that accelerates cellular aging, while p19 slows it down. The study sheds light on the development of aging-related characteristics such as loss of muscle mass and cataracts.
Researchers found that prucalopride significantly improved bowel movements and quality of life for patients with severe chronic constipation. The study involved 620 patients who received either prucalopride or a placebo, showing that nearly half took notice in their bowel movements per week.
Researchers found that carrying alpha-1 antitrypsin deficiency increases lung cancer risk in smokers and nonsmokers, with the genetic disorder explaining up to 12% of lung cancer patients. Individuals who carry the gene should be screened for lung cancer and avoid potential carcinogens.
Researchers at Mayo Clinic have developed a high-resolution confocal endomicroscopy probe system that can accurately identify benign colon polyps without removal. The technology was tested in 37 patients and showed an accuracy rate of 98% in flagging non-cancerous polyps.
The study found that Mayo Clinic's intensive care unit (ICU) pneumonia prevention rate is similar to the national average, but lower for trauma ICUs. The most common pathogen causing VAP was Pseudomonas aeruginosa, highlighting the need for targeted antibiotic treatment.
Researchers at Mayo Clinic have developed a computer-based simulation program, CASPER, to help patients with asthma manage their disease. The program allows patients to practice making key decisions in a safe, simulated environment, improving their ability to consistently treat their asthma.
A new study suggests that the depth of cancer penetration in the bowel wall affects survival rates, and proposes changes to current guidelines. Patients with thin lesions confined to the bowel wall have better survival outcomes than those with thicker cancers.
Researchers at Mayo Clinic found a correlation between women who underwent pre-surgical breast MRI and an increased rate of mastectomy. The study suggests that MRI may lead to greater anxiety, prompting patients and physicians to choose mastectomy over lumpectomy.
A study presented at the American Society of Clinical Oncology annual meeting found that adding epratuzumab to standard chemotherapy (R-CHOP) resulted in a 95% response rate and 63% disease-free survival in patients with diffuse large B-cell lymphoma. The treatment was well-tolerated, but final results will be reported next year.
A study by Mayo Clinic researchers found that administering calcium and magnesium before and after oxaliplatin chemotherapy significantly reduces neurological side effects in patients with advanced colon cancer. This reduction enables patients to complete a full course of treatment, increasing the likelihood of successful therapy.
Mayo Clinic researchers found that baseline quality of life is a strong predictor of survival in cancer patients, with scores above 83 associated with increased survival time. The study suggests that identifying quality of life deficits can help physicians intervene and improve patient outcomes, potentially extending their length of life.
A study published in Mayo Clinic Proceedings found that men are overrepresented in research on conditions affecting both sexes, while women are underrepresented. The authors recommend standardizing mechanisms for sex-specific reporting and analysis in publications.
Recent research has identified seven LRRK2 gene mutations associated with Parkinson's disease, including a rare mutation that doubles the risk in ethnic Chinese. The findings suggest that genetic influences passed down through generations can significantly increase susceptibility to the disease.
A Mayo-led study found that smoking is associated with an increased risk of developing colorectal tumors lacking DNA repair proteins. Women who smoked were more likely to develop these tumors, which may be due to the loss of function in genes responsible for repairing genetic damage.
Researchers have found that increasing SULF2 expression enhances cancer cell growth and migration, while decreasing it reduces both. The study suggests that blocking SULF2 may lead to an effective treatment for liver cancer and potentially other types of cancer.
A recent study published in Mayo Clinic Proceedings found that 42% of patients who underwent transurethral microwave therapy experienced significant blood pressure surges. Men with enlarged prostates are at higher risk for cardiac events, and monitoring is crucial to manage these risks.
The study found that gut microbiota play a significant role in regulating weight and energy balance. Researchers suggest that manipulating the gut microbiota could be a useful strategy for treating obesity. However, more research is needed to establish the relationship between gut bacteria and obesity.
A Mayo Clinic study found that 82% of retired NFL players under 50 had abnormal artery narrowing and blockages. The researchers emphasize the need for regular cardiovascular screening in football players to prevent serious cardiovascular events.
A new study reveals that people with a normal body mass index (BMI) but high body fat percentage are at risk for metabolic disturbances and heart disease. The researchers found that these individuals had altered blood lipid profiles, high leptin levels, and higher rates of metabolic syndrome.
A study published in the American Journal of Geriatric Cardiology found that established ECG norms for older adults may need to be revised. The research team analyzed over 700 patient readings and discovered that average cutoffs for measuring ECG intervals were greater than current norms, particularly in men.
Researchers found that dopamine can block the growth of new blood vessels in cancer cells by binding to a specific receptor on endothelial progenitor cells. This could lead to a potential treatment for cancer patients, as it slows down cancer progression and reduces tumor growth.
Researchers found that COX-2 expression is a marker for cancer development in some benign breast biopsies, with higher levels associated with increased risk. The study's results may lead to targeted treatments using COX-2 inhibiting agents.