Researchers at Mayo Clinic have discovered that low doses of gabapentin substantially reduce hot flashes in patients undergoing anti-hormonal treatment for prostate cancer. The study found that gabapentin reduced the frequency and intensity of hot flashes by up to 46% in men receiving androgen deprivation therapy.
Recent studies conducted at Mayo Clinic have found that MRI is superior to mammography in detecting additional tumors in the same breast and identifying new tumors in the healthy breast. The technology has also revealed distinct patterns between ipsilateral and contralateral tumors, guiding its use.
A pilot study by Mayo Clinic researchers found that high-dose American ginseng improves fatigue and vitality in cancer patients. Patients receiving the highest dose showed significant improvements in overall energy levels, mental, physical, spiritual, and emotional well-being.
A recent study by Mayo researchers found that about 40% of patients referred for a second opinion on long QT syndrome (LQTS) did not show sufficient evidence to merit the diagnosis. The study highlights the challenge in diagnosing LQTS, which can be lethal if not diagnosed correctly, and emphasizes the need for cautious evaluation by e...
A Mayo Clinic research team has developed a simple tool to enhance medication adherence in diabetes patients, with 84% of users showing improved compliance. The decision aid sparks conversation between doctors and patients about medication risks and benefits, leading to better-informed decisions.
Researchers at Mayo Clinic have successfully developed a protocol for performing coronary angiography on the same day as elective valve surgery, reducing the need for separate hospital visits and improving patient outcomes. The study, which evaluated 226 consecutive patients, showed that 28.3% had severe coronary artery disease requiri...
Researchers at Mayo Clinic have developed a new imaging technique called magnetic resonance elastography (MRE) to diagnose liver diseases. MRE accurately measures the hardness or elasticity of the liver, enabling non-invasive diagnosis of fibrosis and cirrhosis.
Researchers at Mayo Clinic have discovered a correlation between violent rapid eye movement sleep behavior disorder and eventual onset of parkinsonism or dementia. Patients with the disorder may be exhibiting early signs of an evolving neurodegenerative disease caused by abnormal synuclein protein clumps.
A recent study published in Mayo Clinic Proceedings found that two-thirds of people using herbs do so without following scientific guidelines. The study, which analyzed data from a 2002 National Health Interview Survey, highlights concerns about the potential adverse effects and interactions of herbal supplements with therapeutic drugs.
A study by Mayo Clinic found that adalimumab is an effective treatment for adults with Crohn’s disease who do not respond to infliximab therapy. The therapy was shown to achieve remission in 21% of patients and improve symptoms in 52%.
A new immunosuppression regimen for heart transplant patients has been found to improve kidney function and prevent transplant coronary artery disease. The study, led by Sudhir Kushwaha, used sirolimus as an alternative to calcineurin inhibitors, with consistent improvement in kidney function in stable patients.
Researchers identify mutations in moonlighting enzyme dihydrolipoamide dehydrogenase (DLD) that contribute to the reduction of frataxin production, leading to increased severity of Friedreich's ataxia. The study suggests DLD as a potential target for therapies of this condition.
Researchers found that a miscue in the body's genetic repair system may cause Huntington's disease, a fatal condition that destroys the nervous system. The study revealed that repeated tracts of replacement repair segments become toxic and accelerate cell death.
Researchers at Mayo Clinic have developed a breast cancer vaccine that successfully stimulated an anti-tumor T cell response in female mouse models, slowing or stopping the progression of breast cancer. The vaccine's effectiveness was achieved by combining synthetic peptides with a Toll-like receptor stimulant and anti-CD25 antibodies.
Scientists at Mayo Clinic have isolated an enzyme called SULF2, which appears to be overexpressed in nasopharyngeal cancers. High levels of SULF2 are associated with increased risk of early recurrence and death within 10 years after radiation therapy.
Researchers at Mayo Clinic Cancer Center have discovered that chaetocin, a by-product of common wood mold, is more effective than current therapies in killing multiple myeloma cells. The study found chaetocin induces oxidative stress and selectively kills myeloma cells with superior efficacy.
The new technology significantly improves the accuracy of radiologist interpretation by aligning 3D medical images in three-dimensional space. This enables quicker diagnoses and treatment for patients with diseases like cancer, reducing wait time and anxiety.
A detectable PSA level is first indicator of recurrent prostate cancer after radical prostatectomy, with a doubling time of less than three months indicating imminent death from prostate cancer. Patients with longer doubling times are at significant risk for disease recurrence and cancer-specific death.
Researchers analyzed data from 397 adults and children, finding that most asthma flare-ups led to step-up in medication doses. Fewer patients experienced step-down therapy changes when symptoms subsided, highlighting the need for more flexible treatment approaches for asthma patients.
The article examines the definition of pedophilia, characteristics of offenders, recidivism rates, and potential treatments. Researchers discuss how to determine pedophilic behavior and the impact of mandatory reporting laws on victims and abusers.
Researchers at Mayo Clinic have found that cryoablation is an effective treatment option for patients who are not good candidates for surgery due to size or location of the tumor. The procedure involves freezing the tumor with argon gas, resulting in short-term success in over 90% of selected patients.
Researchers design novel peptide-based drug to lower high blood pressure, targeting B-type natriuretic peptide (BNP) hormone, and create hybrid molecule for treating both heart and kidney impairment in acute heart failure.
A new Mayo Clinic study found that heart patients' likelihood of receiving a drug-eluting stent varies greatly by insurance type, hospital location, and procedural volume. Patients with private insurance are more likely to receive a drug-eluting stent than those with Medicare or Medicaid, while hospitals serving large numbers of Medica...
The FAST TRACK protocol dramatically reduces the time that elapses before patients undergo a life-saving procedure, saving both heart muscle and patient lives. The new system includes key elements such as single-call instant alerts, electrocardiograms within five minutes of arrival, and rapid loading by air ambulance.
A Mayo Clinic study found that using computerized reminders can increase mammography screening rates, with 64.3% of women in the intervention group getting a yearly mammogram compared to 55.3% in the control group. The program has expanded beyond mammograms to include other preventive services.
A study by Mayo Clinic researchers found that normal cell phone use has no noticeable impact on patient care equipment. The five-month test involving 300 calls and 192 medical devices revealed no problems incurred.
Researchers at Mayo Clinic are testing an engineered measles virus against multiple myeloma, a cancer of the bone marrow with no cure. The study aims to exploit the protein CD46 to target and kill cancer cells.
Mayo Clinic researchers successfully transplanted cardiac preprogrammed embryonic stem cells into diseased hearts, regenerating infarcted heart muscle without tumor formation. The study establishes a tumor-resistant approach to growing new heart tissue from an embryonic stem cell source.
A Mayo Clinic study has identified a genetic mutation associated with an inherited predisposition to atrial fibrillation, a type of irregular heartbeat. The discovery may lead to improved identification and treatment of younger patients affected by this condition.
A Mayo Clinic study found a link between dopamine agonist medications and compulsive gambling in RLS patients. The medication-induced behavior worsened with increasing doses, but was reversible when the dose was reduced or alternative medication was used.
The Mayo Clinic team has proposed a system of lung surgery quality indicators to demonstrate best practices for positive patient outcomes. The proposed measures include patient-centered processes prior to, during, and after surgery, such as pulmonary function testing, electrocardiogram, smoking history documentation, and timely pain co...
The Mayo Clinic suggests a reimbursement system based on value rather than traditional pay-for-performance, aiming to improve healthcare quality and reduce spending. The proposed system rewards hospitals for achieving good patient outcomes at lower costs, while penalizing those with worse outcomes.
A Mayo Clinic research study found that over one-third of young people who died suddenly and inexplicably had genetic heart defects. The defects were caused by mutations that impair the heart's rhythm center, leading to conditions such as Long QT syndrome and catecholaminergic polymorphic ventricular tachycardia.
A study found that three-fourths of cardiovascular clinical trials published in leading medical journals did not provide sex-based analysis, highlighting the lack of data on women's heart health. Researchers urge more women to be included in trials and for journal editors to require sex-specific reporting.
Researchers at Mayo Clinic Cancer Center found that giving patients both radiation and chemotherapy after completely removing invasive pancreatic cancer significantly improves patient survival rates. More than half of the 454 patients who received adjuvant therapy survived two years, with a five-year survival rate of 28%.
Mayo Clinic researchers use advanced MRI to predict surgical success in rare sciatic notch dumbbell-shaped tumors. The 3-Tesla MRI system provides detailed images of tumor and nerve relationships, allowing for safe removal of tumors while protecting nerves.
Two Mayo Clinic studies found no strong evidence supporting testosterone's safety from cardiovascular harm and inconsistent results regarding its impact on sexual dysfunction. The research highlights the need for large-scale trials to inform clinicians' decisions about prescribing testosterone.
A Mayo Clinic study shows that incorporating physical activity into video games can significantly increase energy expenditure, especially for obese children. The results suggest that more video and computer games with activity requirements could be a potential approach to reversing the obesity trend among kids.
A Mayo Clinic researcher has identified a target site in malaria-carrying mosquitoes that could be used to develop toxic pesticides. The residues are found in three mosquito species and the German cockroach, but not in mammals.
Researchers at Mayo Clinic isolated nanoparticles from human kidney stones in cell cultures, identifying proteins, RNA, and DNA linked to nanoparticles. The findings suggest that nanoparticles may play a role in the development of kidney stones.
Researchers at Mayo Clinic have developed a new gamma camera technique that can detect breast tumors as tiny as one-fifth of an inch in diameter with 88% accuracy. The device is sensitive enough to identify small cancers that were not found by mammography, and may be more comfortable for women due to less pressure needed during imaging.
Researchers found that breast cancer in men is rare and can often be detected on physical examination. In most cases, a mammogram is not necessary for confirming gynecomastia diagnosis.
Researchers at Mayo Clinic Cancer Center have led efforts to test new therapies in multiple myeloma, improving effectiveness and reducing toxicity. Studies show high response rates with lenalidomide and bortezomib, and a synergistic effect when targeting both tumor cells and microenvironment.
Researchers at Mayo Clinic Cancer Center found that tipifarnib can stall or reverse disease progression for patients with relapsed aggressive non-Hodgkin lymphoma. The study showed a partial response in 18% of patients and stable disease in 21%, while also improving quality of life.
Scientists have identified nine new genetic mutations in cancer cells that make patients more likely to respond to bortezomib, a common multiple myeloma treatment. These findings may help physicians tailor treatment to individual patients, increasing the effectiveness of the drug.
A novel regimen of three chemotherapy drugs resulted in a significant clinical response in patients with previously untreated chronic lymphocytic leukemia (CLL). The treatment showed promise for high-risk patients, with no age restrictions, and minimal side effects.
Men with knee osteoarthritis who smoke experience greater cartilage loss and more severe pain than non-smokers. Smoking is a potentially modifiable risk factor for worsening knee osteoarthritis.
The increasing prevalence of metabolic syndrome, a state characterized by cardiovascular risk factors such as obesity and high blood pressure, is a growing concern. Physicians emphasize the need for aggressive treatment and lifestyle modifications to prevent serious health problems.
Researchers at Mayo Clinic have discovered a protein interaction that may explain how Huntington's disease affects the brain, leading to dramatic accumulation of cholesterol.
Researchers are investigating the potential of nonsteroidal anti-inflammatory drugs (NSAIDs) to prevent various types of cancer, including colon, esophageal, and lung cancers. The studies focus on the preventive effects of sulindac, atorvastatin, and RaftiloseSynergy1 on cancer development.