Researchers found that a radical prostatectomy can be a viable option for select octogenarian patients with localized prostate cancer. The 10-year survival rate was similar to that observed in healthy patients 60-79 years old undergoing a radical prostatectomy.
A Mayo Clinic review found that gene expression profiling has limitations in predicting lung cancer prognosis, with conventional methods remaining more accurate. Despite promising results, the technology's accuracy varies greatly among studies, and its clinical relevance is unclear.
A Mayo Clinic study found a significant association between rheumatoid arthritis and chronic lung diseases, with cumulative incidence rates increasing over time. The study followed 603 patients with RA for up to 30 years, revealing higher rates of obstructive lung disease and diffuse parenchymal infiltrative lung disease.
A new Mayo Clinic study reveals that normal aging of breast tissue reduces breast cancer risk, particularly in women who experience complete lobular regression. Women with complete involution have half the risk of developing breast cancer compared to those without.
Researchers studied 100 patients and found symptoms recurred in 11% of patients, with physical stressors linked to worse survival rates. Abnormalities in small blood vessels may contribute to the condition.
Mayo researchers found that stronger quadriceps muscles can help reduce cartilage loss in the knee joint. Participants with greater quadriceps strength had less cartilage loss in the patellofemoral joint, which is frequently affected by osteoarthritis.
A study by Mayo Clinic researchers has found that people with psoriasis are more likely to develop heart disease, including heart attacks and heart failure. The study, which followed 622 adults with psoriasis and a control group of 622 people, found significant increases in cardiovascular events among those with psoriasis.
A population-based study of 393 patients with rheumatoid arthritis found that they aged at approximately 1.25 times the rate of people in the general population. This accelerated aging was consistent with increased mortality rates among RA patients, emphasizing the need for early diagnosis and intervention to address total health.
A Mayo Clinic study found that minority medical students experience less personal satisfaction and have a lower sense of accomplishment compared to nonminority peers. They also face additional stressors such as personal illness and family responsibilities, highlighting the need for support programs to improve their well-being.
A new study suggests that a shearing injury of the tissue lining the tendons in the carpal tunnel may cause the condition. This could lead to earlier diagnosis and better treatments for preventing or reversing carpal tunnel syndrome.
Mayo Clinic researchers found that difficulties in the heart's ability to fill with blood are a frequent cause of heart failure, and can be just as deadly as deficiencies in pumping. The study suggests that filling problems are often undiagnosed and highlights the importance of testing for abnormalities in the heart's filling phase.
The Mayo Clinic Cancer Center's Specialized Programs of Research Excellence (SPORE) grant has been renewed for an additional five years. The grant will fund translational research projects aimed at identifying biomarkers to predict response to therapy and developing non-invasive imaging options for diagnosis and treatment.
A Mayo Clinic study reveals that children with recurrent strep throat who retain their tonsils are at triple the risk of developing subsequent episodes. Tonsillectomy is found to be an effective treatment for this condition, decreasing infections and improving quality of life.
Researchers at Mayo Clinic have devised a novel approach to improving the effectiveness and safety of heart stents by magnetizing healing cells from a patient's blood. The cells are quickly drawn to magnetically coated stents, reducing blood clot formation by lining the site fully and quickly.
A meta-analysis found that sustained oral contraceptive use prior to pregnancy increases a woman's risk of developing breast cancer. Premenopausal women who used oral contraceptives before having children are at a significantly increased risk of breast cancer, with a 44% higher risk compared to those who did not use them.
Mayo Clinic Cancer Center is conducting a clinical study using a vaccine strain of the measles virus to treat recurrent glioblastoma multiforme, a deadly brain tumor. The study has shown promising results in shrinking tumors and prolonging animal survival.
Researchers found that freezing and delaying embryo transfer reduces severe ovarian hyperstimulation syndrome and its life-threatening consequences, resulting in better overall outcomes. The study analyzed medical records of 1,002 patients who underwent IVF between 2000 and 2004.
Researchers at the Mayo Clinic have developed a novel method to digitally capture and analyze colonoscopy video files, extracting objective quality metrics. The study also found adalimumab effective in inducing remission in patients with moderate to severe Crohn's disease.
Researchers found that picornavirus-related infections can accumulate over an individual's lifetime, leading to clinical cognitive memory deficits. The study suggests a link between picornavirus infections and inflammation of the brain, particularly in the hippocampus region.
A Mayo Clinic study finds that newspaper articles tend to focus on young coma patients who are more likely to awaken and recover, creating a skewed public perception. The study also highlights the need for accurate representation of comas in media, noting that medical sources could provide more thorough information than police reports.
A Mayo Clinic study of 144 participants found that dehydroepiandrosterone (DHEA) supplements had no effect on age-related changes in body composition, physical performance, or quality of life. The study's findings contradict previous reports and suggest that DHEA should be treated as a regulated drug.
Researchers at Mayo Clinic have discovered a protein pair that could be used to prevent tumors. The study found that CDK2 modifies FOXO1 in damaged cells, triggering apoptosis and potentially halting cancer cell growth. This breakthrough provides new hope for the development of targeted anti-tumor therapies.
A Mayo Clinic researcher has identified a unique enzyme residue in greenbugs and aphids that could be targeted by a new generation of pesticides. This discovery opens the door to creating safer pesticides that would not harm humans and animals.
Researchers found a connection between celiac disease and cognitive decline in patients with documented symptoms. Three patients showed reversal of cognitive symptoms after gluten withdrawal, suggesting a potentially reversible form of cognitive impairment.
A recent study published in Mayo Clinic Proceedings found that all types of intravascular devices pose a significant risk of bloodstream infections to hospitalized adult patients. The study's findings suggest that IVDs have become the leading cause of bloodstream infections in healthcare settings worldwide.
Research at Mayo Clinic found that 16% of men experience moderate or higher pain during prostate biopsies, with the injection of lidocaine causing more pain than ultrasound insertion. The location of biopsy, specifically the prostate apex, is a significant predictor of pain scores.
A new study by Mayo Clinic found that preventive ovary removal in younger women may lead to an increased risk of death from all causes, including estrogen-related cancers and diseases of the brain and cardiovascular system. The study suggests that hormone replacement therapy is crucial for these women.
Researchers at Mayo Clinic have discovered that HIV requires a specific human protein, LEDGF/p75, to integrate into the human genome. The study found that disrupting this connection could lead to new therapies for HIV or safer gene therapy methods.
Mayo Clinic researchers have developed MR Elastography (MRE), a new technique for measuring liver elasticity using MRI. This non-invasive method shows great promise for detecting liver fibrosis, which can lead to cirrhosis if left untreated.
The Mayo Clinic has discovered an asthma diagnostic test that can accurately predict a patient's response to inhaled corticosteroids for chronic cough. The exhaled nitric oxide test measures inflammation in the lungs' bronchial tubes, showing promise as a more accurate and efficient alternative to methacholine challenge testing.
Migraines are more common in women than previously thought, and prevention is effective but often underused. The study reviews various stages of a woman's life, including childhood, reproductive years, pregnancy, and menopause, to provide guidance for physicians treating female migraine patients.
A Mayo Clinic study found that physicians who report making a major error in the previous three months experience burnout and depression, increasing the risk of future errors. The study also discovered a reverse connection, where high burnout levels increase the likelihood of an error in the next three months.
Researchers at Mayo Clinic have identified a new type of sleep apnea called complex sleep apnea, which is a combination of obstructive and central sleep apneas. Complex sleep apnea patients often appear to have obstructive sleep apnea but do not fully respond to CPAP machines.
A study by Mayo Clinic researchers found that men who took nonsteroidal anti-inflammatory drugs (NSAIDs) had a 50 percent lower risk of developing an enlarged prostate and a 35 percent lower risk of moderate to severe urinary symptoms compared to non-users.
Researchers found that childhood polio survivors do not experience significant declines in strength as they age, with only moderate increases in weakness. The study suggests that polio survivors may not age differently than the general population and can expect years of stability without major lifestyle modifications.
The Mayo Clinic team has developed a consensus statement recommending the use of pamidronate over zoledronic acid for starting therapy, and stopping or reducing bisphosphonates after two years for safe management of multiple myeloma. The guidelines aim to minimize adverse reactions while maintaining effective bone disease prevention.
A large international study provides strong evidence that common genetic variants in the alpha-synuclein gene contribute to Parkinson's disease worldwide. Variability in this gene is associated with a 1.5 times greater risk for the disease, highlighting potential therapies to reduce alpha-synuclein protein production.
Researchers found that botulinum toxin injections in early healing phase improve scar appearance and prevent muscle movement wrinkling the wound site. The treatment shows promise for minimizing scarring and optimizing healing outcomes.
Researchers at Mayo Clinic have discovered an association between allergic rhinitis and the development of Parkinson's disease. The study found that people with allergic rhinitis are 2.9 times more likely to develop Parkinson's, highlighting a potential link between inflammation and the disease.
Researchers at the Mayo Clinic have engineered a modified measles virus that specifically targets and kills cancer cells by recognizing unique protein secretions. This breakthrough enhances the safety and effectiveness of oncolytic virotherapy, reducing the risk of unintended infections while improving cancer treatment outcomes.
A new study found that men with multiple sclerosis (MS) are more likely to pass the disease to their children than women. The researchers discovered that fathers with MS have twice as many children who develop MS as mothers with the disease.
Mayo Clinic researchers found robot-assisted, laparoscopic surgery to be effective in repairing vaginal vault prolapse. The procedure resulted in less recovery time, lower risk of bleeding and pain, and higher patient satisfaction compared to traditional open surgery.
Diastolic heart failure is increasingly common, now accounting for over half of heart failure cases. Women, particularly elderly women, are disproportionately affected. Therapies for diastolic heart failure may need to be distinct from those for systolic heart failure.
Researchers at Mayo Clinic have identified a gene mutation causing chaotic electrical activation of the heart muscle and atrial fibrillation. The study found that a specific genetic mutation in the KCNA5 gene leads to susceptibility for atrial fibrillation, providing new insight into its mechanism.
A new Mayo Clinic study finds that executive function, including concentration, decision-making, and higher-order problem solving, deteriorates after memory decline in Alzheimer's disease progression. This decline can cause people to become more impaired in daily activities.
Researchers have defined normal melanocyte numbers in sun-exposed skin, distinguishing sun damage from early melanoma. This finding allows for less tissue removal and trauma to the skin.
A new study using MRI scans has found that the drug donepezil slows brain deterioration in patients with mild cognitive impairment, a condition on the road to Alzheimer's disease. The treatment showed a positive effect on patients who carried the APOE 4 allele, which increases the risk of developing Alzheimer's.
Researchers discovered that women who develop dementia experience a decline in weight up to 10 years before memory loss. The study found that the brains of these women underwent changes before the onset of symptoms, potentially linked to postmenopausal hormonal changes or other factors.
A Mayo Clinic study found that older people and those with chronic illnesses have the highest rates of end-of-life intensive care unit (ICU) use. The study also found that expanding alternative health care settings, such as nursing homes or hospice care, might be a more cost-effective way to fund end-of-life care.
The study found that B7-H4, an immune system blocker, is present in aggressive kidney cancers and vessels, allowing the cancer to grow and spread. This discovery may lead to better treatment options for patients with renal cell carcinoma, a deadly form of kidney cancer.