A Mayo Clinic research study found that over one-third of young people who died suddenly and inexplicably had genetic heart defects. The defects were caused by mutations that impair the heart's rhythm center, leading to conditions such as Long QT syndrome and catecholaminergic polymorphic ventricular tachycardia.
A study found that three-fourths of cardiovascular clinical trials published in leading medical journals did not provide sex-based analysis, highlighting the lack of data on women's heart health. Researchers urge more women to be included in trials and for journal editors to require sex-specific reporting.
Researchers at Mayo Clinic Cancer Center found that giving patients both radiation and chemotherapy after completely removing invasive pancreatic cancer significantly improves patient survival rates. More than half of the 454 patients who received adjuvant therapy survived two years, with a five-year survival rate of 28%.
Mayo Clinic researchers use advanced MRI to predict surgical success in rare sciatic notch dumbbell-shaped tumors. The 3-Tesla MRI system provides detailed images of tumor and nerve relationships, allowing for safe removal of tumors while protecting nerves.
Two Mayo Clinic studies found no strong evidence supporting testosterone's safety from cardiovascular harm and inconsistent results regarding its impact on sexual dysfunction. The research highlights the need for large-scale trials to inform clinicians' decisions about prescribing testosterone.
A Mayo Clinic study shows that incorporating physical activity into video games can significantly increase energy expenditure, especially for obese children. The results suggest that more video and computer games with activity requirements could be a potential approach to reversing the obesity trend among kids.
A Mayo Clinic researcher has identified a target site in malaria-carrying mosquitoes that could be used to develop toxic pesticides. The residues are found in three mosquito species and the German cockroach, but not in mammals.
Researchers at Mayo Clinic isolated nanoparticles from human kidney stones in cell cultures, identifying proteins, RNA, and DNA linked to nanoparticles. The findings suggest that nanoparticles may play a role in the development of kidney stones.
Researchers at Mayo Clinic have developed a new gamma camera technique that can detect breast tumors as tiny as one-fifth of an inch in diameter with 88% accuracy. The device is sensitive enough to identify small cancers that were not found by mammography, and may be more comfortable for women due to less pressure needed during imaging.
Researchers found that breast cancer in men is rare and can often be detected on physical examination. In most cases, a mammogram is not necessary for confirming gynecomastia diagnosis.
Researchers at Mayo Clinic Cancer Center have led efforts to test new therapies in multiple myeloma, improving effectiveness and reducing toxicity. Studies show high response rates with lenalidomide and bortezomib, and a synergistic effect when targeting both tumor cells and microenvironment.
Researchers at Mayo Clinic Cancer Center found that tipifarnib can stall or reverse disease progression for patients with relapsed aggressive non-Hodgkin lymphoma. The study showed a partial response in 18% of patients and stable disease in 21%, while also improving quality of life.
Scientists have identified nine new genetic mutations in cancer cells that make patients more likely to respond to bortezomib, a common multiple myeloma treatment. These findings may help physicians tailor treatment to individual patients, increasing the effectiveness of the drug.
A novel regimen of three chemotherapy drugs resulted in a significant clinical response in patients with previously untreated chronic lymphocytic leukemia (CLL). The treatment showed promise for high-risk patients, with no age restrictions, and minimal side effects.
Men with knee osteoarthritis who smoke experience greater cartilage loss and more severe pain than non-smokers. Smoking is a potentially modifiable risk factor for worsening knee osteoarthritis.
The increasing prevalence of metabolic syndrome, a state characterized by cardiovascular risk factors such as obesity and high blood pressure, is a growing concern. Physicians emphasize the need for aggressive treatment and lifestyle modifications to prevent serious health problems.
Researchers at Mayo Clinic have discovered a protein interaction that may explain how Huntington's disease affects the brain, leading to dramatic accumulation of cholesterol.
Researchers are investigating the potential of nonsteroidal anti-inflammatory drugs (NSAIDs) to prevent various types of cancer, including colon, esophageal, and lung cancers. The studies focus on the preventive effects of sulindac, atorvastatin, and RaftiloseSynergy1 on cancer development.
Researchers found that a radical prostatectomy can be a viable option for select octogenarian patients with localized prostate cancer. The 10-year survival rate was similar to that observed in healthy patients 60-79 years old undergoing a radical prostatectomy.
A Mayo Clinic review found that gene expression profiling has limitations in predicting lung cancer prognosis, with conventional methods remaining more accurate. Despite promising results, the technology's accuracy varies greatly among studies, and its clinical relevance is unclear.
A Mayo Clinic study found a significant association between rheumatoid arthritis and chronic lung diseases, with cumulative incidence rates increasing over time. The study followed 603 patients with RA for up to 30 years, revealing higher rates of obstructive lung disease and diffuse parenchymal infiltrative lung disease.
A new Mayo Clinic study reveals that normal aging of breast tissue reduces breast cancer risk, particularly in women who experience complete lobular regression. Women with complete involution have half the risk of developing breast cancer compared to those without.
Researchers studied 100 patients and found symptoms recurred in 11% of patients, with physical stressors linked to worse survival rates. Abnormalities in small blood vessels may contribute to the condition.
Mayo researchers found that stronger quadriceps muscles can help reduce cartilage loss in the knee joint. Participants with greater quadriceps strength had less cartilage loss in the patellofemoral joint, which is frequently affected by osteoarthritis.
A study by Mayo Clinic researchers has found that people with psoriasis are more likely to develop heart disease, including heart attacks and heart failure. The study, which followed 622 adults with psoriasis and a control group of 622 people, found significant increases in cardiovascular events among those with psoriasis.
A population-based study of 393 patients with rheumatoid arthritis found that they aged at approximately 1.25 times the rate of people in the general population. This accelerated aging was consistent with increased mortality rates among RA patients, emphasizing the need for early diagnosis and intervention to address total health.
A Mayo Clinic study found that minority medical students experience less personal satisfaction and have a lower sense of accomplishment compared to nonminority peers. They also face additional stressors such as personal illness and family responsibilities, highlighting the need for support programs to improve their well-being.
A new study suggests that a shearing injury of the tissue lining the tendons in the carpal tunnel may cause the condition. This could lead to earlier diagnosis and better treatments for preventing or reversing carpal tunnel syndrome.
Mayo Clinic researchers found that difficulties in the heart's ability to fill with blood are a frequent cause of heart failure, and can be just as deadly as deficiencies in pumping. The study suggests that filling problems are often undiagnosed and highlights the importance of testing for abnormalities in the heart's filling phase.
The Mayo Clinic Cancer Center's Specialized Programs of Research Excellence (SPORE) grant has been renewed for an additional five years. The grant will fund translational research projects aimed at identifying biomarkers to predict response to therapy and developing non-invasive imaging options for diagnosis and treatment.
A Mayo Clinic study reveals that children with recurrent strep throat who retain their tonsils are at triple the risk of developing subsequent episodes. Tonsillectomy is found to be an effective treatment for this condition, decreasing infections and improving quality of life.
Researchers at Mayo Clinic have devised a novel approach to improving the effectiveness and safety of heart stents by magnetizing healing cells from a patient's blood. The cells are quickly drawn to magnetically coated stents, reducing blood clot formation by lining the site fully and quickly.
A meta-analysis found that sustained oral contraceptive use prior to pregnancy increases a woman's risk of developing breast cancer. Premenopausal women who used oral contraceptives before having children are at a significantly increased risk of breast cancer, with a 44% higher risk compared to those who did not use them.
Mayo Clinic Cancer Center is conducting a clinical study using a vaccine strain of the measles virus to treat recurrent glioblastoma multiforme, a deadly brain tumor. The study has shown promising results in shrinking tumors and prolonging animal survival.
Researchers found that freezing and delaying embryo transfer reduces severe ovarian hyperstimulation syndrome and its life-threatening consequences, resulting in better overall outcomes. The study analyzed medical records of 1,002 patients who underwent IVF between 2000 and 2004.
Researchers at the Mayo Clinic have developed a novel method to digitally capture and analyze colonoscopy video files, extracting objective quality metrics. The study also found adalimumab effective in inducing remission in patients with moderate to severe Crohn's disease.
Researchers found that picornavirus-related infections can accumulate over an individual's lifetime, leading to clinical cognitive memory deficits. The study suggests a link between picornavirus infections and inflammation of the brain, particularly in the hippocampus region.
A Mayo Clinic study finds that newspaper articles tend to focus on young coma patients who are more likely to awaken and recover, creating a skewed public perception. The study also highlights the need for accurate representation of comas in media, noting that medical sources could provide more thorough information than police reports.
A Mayo Clinic study of 144 participants found that dehydroepiandrosterone (DHEA) supplements had no effect on age-related changes in body composition, physical performance, or quality of life. The study's findings contradict previous reports and suggest that DHEA should be treated as a regulated drug.
Researchers at Mayo Clinic have discovered a protein pair that could be used to prevent tumors. The study found that CDK2 modifies FOXO1 in damaged cells, triggering apoptosis and potentially halting cancer cell growth. This breakthrough provides new hope for the development of targeted anti-tumor therapies.
A Mayo Clinic researcher has identified a unique enzyme residue in greenbugs and aphids that could be targeted by a new generation of pesticides. This discovery opens the door to creating safer pesticides that would not harm humans and animals.
Researchers found a connection between celiac disease and cognitive decline in patients with documented symptoms. Three patients showed reversal of cognitive symptoms after gluten withdrawal, suggesting a potentially reversible form of cognitive impairment.
A recent study published in Mayo Clinic Proceedings found that all types of intravascular devices pose a significant risk of bloodstream infections to hospitalized adult patients. The study's findings suggest that IVDs have become the leading cause of bloodstream infections in healthcare settings worldwide.
Research at Mayo Clinic found that 16% of men experience moderate or higher pain during prostate biopsies, with the injection of lidocaine causing more pain than ultrasound insertion. The location of biopsy, specifically the prostate apex, is a significant predictor of pain scores.
A new study by Mayo Clinic found that preventive ovary removal in younger women may lead to an increased risk of death from all causes, including estrogen-related cancers and diseases of the brain and cardiovascular system. The study suggests that hormone replacement therapy is crucial for these women.
Researchers at Mayo Clinic have discovered that HIV requires a specific human protein, LEDGF/p75, to integrate into the human genome. The study found that disrupting this connection could lead to new therapies for HIV or safer gene therapy methods.
Mayo Clinic researchers have developed MR Elastography (MRE), a new technique for measuring liver elasticity using MRI. This non-invasive method shows great promise for detecting liver fibrosis, which can lead to cirrhosis if left untreated.
The Mayo Clinic has discovered an asthma diagnostic test that can accurately predict a patient's response to inhaled corticosteroids for chronic cough. The exhaled nitric oxide test measures inflammation in the lungs' bronchial tubes, showing promise as a more accurate and efficient alternative to methacholine challenge testing.
Migraines are more common in women than previously thought, and prevention is effective but often underused. The study reviews various stages of a woman's life, including childhood, reproductive years, pregnancy, and menopause, to provide guidance for physicians treating female migraine patients.
A Mayo Clinic study found that physicians who report making a major error in the previous three months experience burnout and depression, increasing the risk of future errors. The study also discovered a reverse connection, where high burnout levels increase the likelihood of an error in the next three months.