Researchers found that adding epratuzumab to a regimen of R-CHOP resulted in an overall 12-month survival rate of 88 percent in patients with diffuse large B-cell lymphoma. The combination was also shown to offer improved progression-free survival rates, particularly for high-risk patients.
Researchers at the Mayo Clinic have found a triple drug combination to be an effective and tolerable option for treating metastatic HER2+ breast cancer. The regimen, which combines capecitabine, vinorelbine, and trastuzumab, has shown promising results in reducing tumor size and improving survival rates compared to traditional treatments.
A large Mayo Clinic cohort study found that statin use is associated with a reduced risk of prostate cancer, with non-statin users three times more likely to develop the condition. Statins may also protect against erectile dysfunction, particularly among older men, and prevent prostate enlargement.
A new diagnostic technique using blue light and a special study drug has been shown to detect more bladder tumors, reducing the rate of recurrence by 22% in patients with papillary bladder tumors. The study found that this method detected an additional tumor in 16.9% of patients compared to traditional white-light detection.
A large study found that hormone therapy use was associated with a 28% lower incidence rate of colorectal cancer in older women. However, the mechanisms behind this protective effect are still unclear. The study also found no associations between hormone use and specific molecular markers or DNA methylation patterns.
Researchers at Mayo Clinic have identified two chemicals that can increase the activity of a molecule called insulin-degrading enzyme (IDE), which helps break down proteins associated with Alzheimer's disease. The study suggests that activating IDE may offer a new therapeutic approach for treating and preventing the disease.
Researchers at the Mayo Clinic have formulated a treatment combination that destroys up to 65% of pancreatic tumor cells in laboratory tests. The combination of rapamycin and panobinostat acts synergistically, offering new opportunities for patients with pancreatic cancer.
Researchers have confirmed six gene variants linked to chronic lymphocytic leukemia (CLL), the most common adult leukemia in the US. The study found that patients with CLL are more likely to have these genetic changes, increasing their risk of developing the disease.
A new study at the Mayo Clinic found that one in six patients taking therapeutic doses of dopamine agonist medications for Parkinson's disease developed new-onset compulsive gambling or hypersexuality. Researchers analyzed medical records of patients and found no such cases in those taking low doses or other treatments.
Researchers discovered a key checkpoint in cell growth and development that may allow investigators to benchmark progression of tumor cells or stop them from further development. The mechanism involves the activation of p21-activated kinase 2 (PAK2) in certain tissues but not others, and is controlled by the Erbin/Merlin complex.
Researchers at Mayo Clinic have discovered the molecular interplay that enables invasive tumor cells to move and invade other parts of the body. By manipulating this process, they hope to develop treatments to stop cancer from spreading.
A Mayo Clinic study reveals that 60% of retired National Football League (NFL) linemen suffer from sleep disordered breathing, with an average of 18.1 episodes per hour.
A noninvasive finger sensor test is highly predictive of major cardiac events for people at low or moderate risk. The EndoPAT test measures blood flow and identifies endothelial dysfunction, a condition that can lead to atherosclerosis and cardiovascular problems.
Researchers at Mayo Clinic found that children who require multiple surgeries under anesthesia during their first three years of life are at higher risk of developing learning disabilities later. The study, which analyzed data from over 5,000 children, suggests a possible link between anesthetic exposure and brain development.
A Mayo Clinic study found a correlation between inadequate vitamin D levels and the amount of narcotic medication taken by patients with chronic pain. Patients with low vitamin D levels were taking nearly twice as much pain medication, experiencing worse physical functioning and overall health perception.
The American College of Surgeons has recognized Mayo Clinic's two Minnesota hospitals, Rochester Methodist and Saint Marys, for achieving exemplary outcomes in five clinical areas. These hospitals demonstrated high quality of surgical care through tracking patient outcomes and implementing safety improvements.
Research shows that patients discharged against medical advice are at higher risk of morbidity and mortality, with some groups facing four-times-higher risks of readmission within 30 days. Identifying these high-risk patients is crucial, and providing informed consent can help manage the issue.
A Mayo Clinic study found significant effects of obesity on total hip replacements, with a 50% higher complication rate in superobese patients. The study also reported complications with knee implants under extreme weight stress, highlighting the need for weight loss management prior to surgery.
Mayo Clinic researchers found that statin use reduced stroke severity and improved outcomes, even in patients with ideal cholesterol levels. The study suggests benefits beyond lipid lowering, including plaque stabilization and anti-inflammatory effects.
Mayo Clinic researchers have found a promising drug candidate to prevent colon cancer development in mice. The study's senior investigator suggests that targeting PKCß and PKC/ isozymes could help prevent initial cancer development and progression, respectively.
A new study suggests that people with minimal manic symptoms or mixed depression presentations may be at greater risk of experiencing treatment-emergent mania when taking antidepressants. Researchers recommend exploring alternative treatments like mood stabilizers to manage depressive phases of bipolar illness.
A computer-based training program improved brain processing speed and accuracy, leading to double the improvement in certain aspects of memory compared to a control group. The study suggests that aging adults may be able to make better-informed decisions about ways to improve memory by focusing on improving brain processing speed.
Researchers at the Mayo Clinic have developed an insecticide that targets the soybean aphid, a pest ravaging Minnesota crops. The small molecule blocks acetylcholinesterase activity in aphids without inhibiting it in humans.
Researchers suspect a novel gene is causing restless legs syndrome in a large family study, with 30 relatives affected and 60% female prevalence. The discovery could lead to breakthroughs in understanding the disorder and developing new treatments.
Experts advise against routine cardiac imaging exams for those without heart disease symptoms due to low-dose radiation risks. However, scans are still recommended for patients with symptoms or at high risk of heart disease, as the benefits outweigh the small potential risks.
A new Mayo Clinic study reveals that younger men with erectile dysfunction are twice as likely to develop heart disease as those without the condition. Men with erectile dysfunction also face an 80% higher risk of heart disease over a 10-year period.
Researchers at Mayo Clinic have found that the experimental drug RS5444 turns on the RhoB tumor suppressor gene in cancer cells, inhibiting cell growth and blocking tumor growth. This finding suggests that other cancers may respond to this therapy, offering new hope for deadly anaplastic thyroid cancer treatment.
A Mayo Clinic-led international consortium discovered a genetic defect in the dynactin complex that may help explain neurodegenerative diseases like Parkinson's and amyotrophic lateral sclerosis. The mechanism implicated in Perry syndrome, a rare disorder, may also shed light on common depression and sleep disorders.
Researchers at Mayo Clinic have identified a gene variant on the X chromosome associated with an increased risk of developing late-onset Alzheimer's disease. Women who inherited two copies of the PCDH11X variant were found to be at substantially greater risk, while men with one copy also showed a significant increase in risk.
Mayo Clinic researchers studied 816 women who underwent global endometrial ablation (GEA) to assess its effectiveness in reducing menstrual bleeding. They found that only 16% of patients required hysterectomy five years after the procedure, which is nearly half of what was previously reported.
A recent Mayo Clinic study found adults with asthma are seven times more likely to develop invasive pneumococcal diseases, a serious and potentially fatal condition. The researchers recommend including asthma as an indication for pneumococcal vaccination in adults, which could significantly reduce instances of this disease.
Mayo Clinic researchers found that young women with atypical hyperplasia had a relative risk of developing breast cancer almost six times greater than those without BBD. A strong family history of breast cancer slightly increased the risk in two other forms of benign breast disease, but only marginally.
Researchers at Mayo Clinic found a strong association between dense breasts and increased breast cancer risk, citing tissue composition differences between dense and non-dense tissue. Dense breast tissue contains more epithelium and stroma, and higher aromatase enzyme levels than non-dense tissue.
Postmenopausal women with a deficiency in the CYP2D6 gene have a nearly fourfold higher risk of early breast cancer recurrence when taking tamoxifen. Mayo Clinic researchers recommend testing for the gene before starting therapy.
Two meta-analyses of global trials confirm aromatase inhibitors are more effective in preventing breast cancer recurrence and reducing mortality risk compared to tamoxifen. Patients using aromatase inhibitors had a 3% lower cancer recurrence rate and a 1.6% reduced risk of death from the disease, according to researchers.
Mayo Clinic researchers found that endoxifen, a tamoxifen metabolite, degrades estrogen receptors and inhibits the growth of breast cancer cells. The study suggests that an agent mimicking endoxifen might be a more effective treatment than tamoxifen.
Using a three-dimensional image-guided system to help place screws in the spine results in safe and accurate surgery with decreased nerve injuries and misplaced screws compared to traditional operations.
A new combination of medications has improved or stabilized disease in 76% of patients with relapsed multiple myeloma. Pomalidomide combined with dexamethasone showed promising results, with minimal side effects.
A Mayo Clinic study found that statins do not interfere with rituximab treatment for lymphomas. In fact, statins may slow the progression of certain types of lymphoma. The study included over 500 patients and showed that statin use did not affect treatment outcomes, but may even improve them in some cases.
A Mayo Clinic study found that withdrawing anti-seizure medication in children with epilepsy who have achieved seizure-freedom is generally safe and carries a low risk of developing intractable epilepsy. The study, which reviewed records of 241 children, found only 5% to develop intractable epilepsy after withdrawal.
Patients with low-grade gliomas who underwent aggressive surgeries were free of tumor recurrence an average of 15 years after diagnosis. Radiation therapy significantly extended their survival time, with patients living up to six years without tumor recurrence.
A new study from Mayo Clinic found that etanercept therapy was not effective in treating patients with moderate to severe alcoholic hepatitis, increasing six-month mortality rates due to increased infections. Abstinence is still considered the best policy for reversing liver damage and reducing disease progression.
A Mayo Clinic study reveals women with mitral valve prolapse and severe leakage often receive less aggressive treatment than men, with a higher risk of mortality. The underestimation of cardiac enlargement in women may be the primary reason for these disparities, highlighting the need for more precise evaluation and treatment strategies.
A recent study published in Pediatrics found that children with misaligned eyes are at a significantly increased risk of developing mental illness by early adulthood. Children with exotropia (eyes that diverge outward) were three times more likely to develop psychiatric disorders than those with normal eye alignment.
A Mayo Clinic study found that most stroke patients do not identify their symptoms correctly, leading to delayed medical attention. The delay can result in further damage and reduced recovery outcomes.
Researchers at Mayo Clinic have discovered a 'two-faced' protein, p120 catenin, that promotes both tumor growth and metastasis in breast cancer. The protein acts like a tumor suppressor when bound to E-cadherin but becomes a tumor promoter when it's not.
A new analysis by Mayo Clinic reveals that the positive US health trend of reducing heart disease risk over the past 30 years has flattened. Women are especially affected, with no significant decline in risk from 2000 to 2014.
Researchers at Mayo Clinic have identified associations between obstructive sleep apnea (OSA) and various eye diseases, including primary open-angle glaucoma, normal-tension glaucoma, flopsy eyelid syndrome, nonarteritic anterior ischemic optic neuropathy, and papilledema. Early diagnosis and treatment are crucial for patients with OSA.
A large study of nearly 11,000 adults suggests that obstructive sleep apnea may be a risk factor for sudden cardiac death, particularly in patients with low nighttime oxygen saturation. The study found that severe cases of OSA were associated with an increased risk of SCD, independent of other established risk factors.
Researchers found that the use of predictive biomarkers and targeted therapies significantly delayed the need for conventional chemotherapy in patients with early-stage but high-risk chronic lymphoid leukemia (CLL). The study resulted in a four-year delay in treatment compared to two years, showing promising results for personalized care.