Mayo Clinic researchers found that statin use reduced stroke severity and improved outcomes, even in patients with ideal cholesterol levels. The study suggests benefits beyond lipid lowering, including plaque stabilization and anti-inflammatory effects.
Mayo Clinic researchers have found a promising drug candidate to prevent colon cancer development in mice. The study's senior investigator suggests that targeting PKCß and PKC/ isozymes could help prevent initial cancer development and progression, respectively.
A new study suggests that people with minimal manic symptoms or mixed depression presentations may be at greater risk of experiencing treatment-emergent mania when taking antidepressants. Researchers recommend exploring alternative treatments like mood stabilizers to manage depressive phases of bipolar illness.
A computer-based training program improved brain processing speed and accuracy, leading to double the improvement in certain aspects of memory compared to a control group. The study suggests that aging adults may be able to make better-informed decisions about ways to improve memory by focusing on improving brain processing speed.
Researchers at the Mayo Clinic have developed an insecticide that targets the soybean aphid, a pest ravaging Minnesota crops. The small molecule blocks acetylcholinesterase activity in aphids without inhibiting it in humans.
Researchers suspect a novel gene is causing restless legs syndrome in a large family study, with 30 relatives affected and 60% female prevalence. The discovery could lead to breakthroughs in understanding the disorder and developing new treatments.
Experts advise against routine cardiac imaging exams for those without heart disease symptoms due to low-dose radiation risks. However, scans are still recommended for patients with symptoms or at high risk of heart disease, as the benefits outweigh the small potential risks.
A new Mayo Clinic study reveals that younger men with erectile dysfunction are twice as likely to develop heart disease as those without the condition. Men with erectile dysfunction also face an 80% higher risk of heart disease over a 10-year period.
Researchers at Mayo Clinic have found that the experimental drug RS5444 turns on the RhoB tumor suppressor gene in cancer cells, inhibiting cell growth and blocking tumor growth. This finding suggests that other cancers may respond to this therapy, offering new hope for deadly anaplastic thyroid cancer treatment.
A Mayo Clinic-led international consortium discovered a genetic defect in the dynactin complex that may help explain neurodegenerative diseases like Parkinson's and amyotrophic lateral sclerosis. The mechanism implicated in Perry syndrome, a rare disorder, may also shed light on common depression and sleep disorders.
Researchers at Mayo Clinic have identified a gene variant on the X chromosome associated with an increased risk of developing late-onset Alzheimer's disease. Women who inherited two copies of the PCDH11X variant were found to be at substantially greater risk, while men with one copy also showed a significant increase in risk.
Mayo Clinic researchers studied 816 women who underwent global endometrial ablation (GEA) to assess its effectiveness in reducing menstrual bleeding. They found that only 16% of patients required hysterectomy five years after the procedure, which is nearly half of what was previously reported.
A recent Mayo Clinic study found adults with asthma are seven times more likely to develop invasive pneumococcal diseases, a serious and potentially fatal condition. The researchers recommend including asthma as an indication for pneumococcal vaccination in adults, which could significantly reduce instances of this disease.
Mayo Clinic researchers found that young women with atypical hyperplasia had a relative risk of developing breast cancer almost six times greater than those without BBD. A strong family history of breast cancer slightly increased the risk in two other forms of benign breast disease, but only marginally.
Researchers at Mayo Clinic found a strong association between dense breasts and increased breast cancer risk, citing tissue composition differences between dense and non-dense tissue. Dense breast tissue contains more epithelium and stroma, and higher aromatase enzyme levels than non-dense tissue.
Postmenopausal women with a deficiency in the CYP2D6 gene have a nearly fourfold higher risk of early breast cancer recurrence when taking tamoxifen. Mayo Clinic researchers recommend testing for the gene before starting therapy.
Two meta-analyses of global trials confirm aromatase inhibitors are more effective in preventing breast cancer recurrence and reducing mortality risk compared to tamoxifen. Patients using aromatase inhibitors had a 3% lower cancer recurrence rate and a 1.6% reduced risk of death from the disease, according to researchers.
Mayo Clinic researchers found that endoxifen, a tamoxifen metabolite, degrades estrogen receptors and inhibits the growth of breast cancer cells. The study suggests that an agent mimicking endoxifen might be a more effective treatment than tamoxifen.
Using a three-dimensional image-guided system to help place screws in the spine results in safe and accurate surgery with decreased nerve injuries and misplaced screws compared to traditional operations.
A new combination of medications has improved or stabilized disease in 76% of patients with relapsed multiple myeloma. Pomalidomide combined with dexamethasone showed promising results, with minimal side effects.
A Mayo Clinic study found that statins do not interfere with rituximab treatment for lymphomas. In fact, statins may slow the progression of certain types of lymphoma. The study included over 500 patients and showed that statin use did not affect treatment outcomes, but may even improve them in some cases.
A Mayo Clinic study found that withdrawing anti-seizure medication in children with epilepsy who have achieved seizure-freedom is generally safe and carries a low risk of developing intractable epilepsy. The study, which reviewed records of 241 children, found only 5% to develop intractable epilepsy after withdrawal.
Patients with low-grade gliomas who underwent aggressive surgeries were free of tumor recurrence an average of 15 years after diagnosis. Radiation therapy significantly extended their survival time, with patients living up to six years without tumor recurrence.
A new study from Mayo Clinic found that etanercept therapy was not effective in treating patients with moderate to severe alcoholic hepatitis, increasing six-month mortality rates due to increased infections. Abstinence is still considered the best policy for reversing liver damage and reducing disease progression.
A Mayo Clinic study reveals women with mitral valve prolapse and severe leakage often receive less aggressive treatment than men, with a higher risk of mortality. The underestimation of cardiac enlargement in women may be the primary reason for these disparities, highlighting the need for more precise evaluation and treatment strategies.
A recent study published in Pediatrics found that children with misaligned eyes are at a significantly increased risk of developing mental illness by early adulthood. Children with exotropia (eyes that diverge outward) were three times more likely to develop psychiatric disorders than those with normal eye alignment.
A Mayo Clinic study found that most stroke patients do not identify their symptoms correctly, leading to delayed medical attention. The delay can result in further damage and reduced recovery outcomes.
Researchers at Mayo Clinic have discovered a 'two-faced' protein, p120 catenin, that promotes both tumor growth and metastasis in breast cancer. The protein acts like a tumor suppressor when bound to E-cadherin but becomes a tumor promoter when it's not.
A new analysis by Mayo Clinic reveals that the positive US health trend of reducing heart disease risk over the past 30 years has flattened. Women are especially affected, with no significant decline in risk from 2000 to 2014.
Researchers at Mayo Clinic have identified associations between obstructive sleep apnea (OSA) and various eye diseases, including primary open-angle glaucoma, normal-tension glaucoma, flopsy eyelid syndrome, nonarteritic anterior ischemic optic neuropathy, and papilledema. Early diagnosis and treatment are crucial for patients with OSA.
A large study of nearly 11,000 adults suggests that obstructive sleep apnea may be a risk factor for sudden cardiac death, particularly in patients with low nighttime oxygen saturation. The study found that severe cases of OSA were associated with an increased risk of SCD, independent of other established risk factors.
Researchers found that the use of predictive biomarkers and targeted therapies significantly delayed the need for conventional chemotherapy in patients with early-stage but high-risk chronic lymphoid leukemia (CLL). The study resulted in a four-year delay in treatment compared to two years, showing promising results for personalized care.
A new study by the Mayo Clinic found that the Gail model, a widely used statistical tool for predicting breast cancer risk, was not reliable for women with atypical hyperplasia. The study tested the model in 331 women with atypia and found it predicted significantly fewer invasive breast cancers than were actually observed.
A Mayo Clinic study of nearly 3,000 heart attack survivors found that the risk of sudden cardiac death is highest in the first month after leaving the hospital. After that initial period, the risk drops significantly but rises again if symptoms of heart failure appear.
A new study shows that magnetic resonance elastography (MRE) can identify liver fibrosis with high accuracy, helping to avoid invasive biopsies. MRE produces color-coded images indicating internal organ stiffness, allowing doctors to diagnose liver disease earlier.
Research at Mayo Clinic suggests that teaching children to face their fears can improve functioning and complete exercises exposing them to their fears earlier than recommended treatment manuals. In contrast, focusing solely on managing anxieties yields less improvement.
Mayo Clinic researchers have discovered a way to control oncolytic viruses using microRNAs, which can restrict them to specific tissues and make them safer for use in cancer therapy. This discovery could lead to new methods of making safer vaccines.
Rheumatoid arthritis incidence and prevalence are on the rise among women in the US, with a 54% increase in female cases from 36 to 54 per 100,000 annually, according to a Mayo Clinic study. Researchers believe an environmental factor may be contributing to this trend, which could indicate a need for further research.
Research at the American College of Rheumatology 2008 Annual Meeting found that rheumatoid arthritis patients are at a higher risk of dying from heart-related complications after a heart attack. Biomarkers have been identified to determine the most effective treatment for muscle tissue inflammation and age-related bone loss in men and ...
Convergence insufficiency affects children's ability to focus and align their eyes while viewing objects up close, impacting reading and concentration. Researchers discovered that structured therapy sessions in a doctor's office and reinforcement eye exercises at home improve vision faster than home-based therapies alone. The study, sp...
Researchers at Mayo Clinic developed a probe that can detect cancerous cells in the colon with 90% accuracy, reducing the need for unnecessary polyp removal. The probe-based confocal laser endomicroscopy system could potentially cut colon polyp removal in half.
A study by Mayo researchers found that outpatient stem cell transplantation for multiple myeloma patients resulted in a high survival rate of 99% at 100 days. The treatment also showed significantly shorter hospital stays, with a median duration of four days for those who required some hospital care.
A Mayo Clinic-led study finds that infliximab administered alone or in combination with azathioprine is more effective for moderate to severe Crohn's disease than azathioprine alone. The study demonstrates improved patient outcomes, including higher remission rates and mucosal healing.
A Mayo Clinic-led study found that the first generation of a stool DNA test detected 20% of colorectal cancer and precancerous polyps, compared to fecal blood tests. The test's limitations include sample degradation and low sensitivity, but second-generation tests improved detection rates.
A Mayo Clinic study implemented a radio-frequency identification system to track biopsy specimens and automate identification. The initiative resulted in a significant reduction of specimen-labeling errors, from 765 in 2007 to 47 in 2008. The new labeling system improved safety and quality efforts in specimen management.
A Mayo Clinic study found that obese patients with specific genetic markers experienced greater weight loss when taking the medication sibutramine. Patients who lacked these genetic factors showed little to no weight loss during the 12-week trial.
Researchers have found a potential solution for diabetic gastroparesis by increasing production of a key molecule in the digestive process. The study, published in Gastroenterology, shows that a red blood cell derivative can restore normal gastric emptying and improve glucose control.
A study published in the Journal of the American Medical Association (JAMA) concludes that internet-based education is associated with large learning gains compared to traditional instructional methods. Internet-based instruction was shown to be as effective as traditional methods in teaching health-care professionals, offering unique ...
Researchers at Mayo Clinic have successfully used stem cells to regenerate heart tissue and repair dilated cardiomyopathy, a genetic defect. The treatment improved heart performance, synchronized electrical impulses, and halted deterioration in genetically altered mice with heritable dilated cardiomyopathy.
The new statistical model incorporates serum sodium and MELD scores to prioritize the sickest patients, reducing mortality by 7% among those with low sodium levels. Mayo Clinic's improved tool aims to ensure timely transplants for those with advanced liver disease.