A study published in the American Society of Clinical Oncology annual meeting showed that lenalidomide significantly improved response rates and complete remission in patients with transformed lymphoma. Patients treated with lenalidomide had a remarkable response rate, with some experiencing complete remission for over a year.
The review article provides a comprehensive guide to pain management in cirrhotic patients, recommending reduced dosing of acetaminophen and avoiding NSAIDs due to risk of acute renal failure. The authors emphasize the need for diligent follow-up for toxicity and adverse effects.
A large national clinical trial has shown that carotid artery surgery and stenting are equally effective in preventing stroke, with personalized treatment options available for individual patients. The study found excellent safety and long-term results for both symptomatic and asymptomatic patients.
Researchers at Mayo Clinic have found a new aggressive treatment approach for anaplastic thyroid carcinoma to be highly effective, resulting in 70% one-year survival rate. The treatment combines surgery, intensity modulated radiation therapy, and chemotherapy, and is being tested in a nationwide clinical trial.
Researchers at Mayo Clinic have identified a key gene called GATA3 that is silenced in common kidney cancer, promoting its development. The discovery suggests that a combination of agents may turn the gene back on, providing a much-needed therapy for difficult-to-treat kidney cancer.
Researchers at Mayo Clinic have discovered gene signatures that explain the biology of clear cell renal cell carcinoma (ccRCC), a common and difficult-to-treat kidney cancer. They identified master genes lost in ccRCC that likely drive its development, as well as stem cell-like properties that contribute to its resistance to treatment.
Researchers discovered a specific mutation that promotes fibril development, leading to organ damage and death. The study suggests this finding could be a target for future drug development in treating the fatal condition.
A Mayo-led research team has developed potent molecules that can inhibit the breakdown of insulin in the body, keeping it working longer and potentially leading to new treatments for diabetes. The discovery may also have implications for other diseases involving insulin, such as Alzheimer's disease.
Researchers found over 2,000 genes reprogrammed in peripheral nervous system of rodent models, leading to potential 'transcription therapy' for chronic pain. The study's high-throughput sequencing revealed novel exons and gene candidates, offering a new approach for neuroscientific research.
The Mayo Clinic research team identified genetic variants in serotonin genes that impact IBS, suggesting a complex molecular mechanism involving multiple genes. The study found several previously unknown associations between IBS and serotonin-related SNPs, providing new insights into the condition.
A Mayo Clinic study reveals a 50% decrease in the number of patients listed for a second liver transplant within three years, indicating improved treatment outcomes for some patients with hepatitis B. Researchers found that new medications have improved ability to control hepatitis B recurrence.
Research at Mayo Clinic reveals stool DNA testing can identify two types of colorectal pre-cancers in IBD patients and serrated polyps. The tests show a high detection rate for these precancerous lesions, offering promise for improving colon cancer prevention.
Researchers at Mayo Clinic are testing new endoscopic optics to detect precancerous polyps and micrometastasis. The pCLE system shows the highest accuracy yet in detecting small polyps, with a specificity of 100%. This technology has the potential to perform virtual biopsies, reducing unnecessary procedures.
Mayo Clinic researchers discovered chronic mild kidney injury in the kidneys of healthy adults, increasing with age. The study, published in Annals of Internal Medicine, highlights the need for new tests to detect mild kidney disease more accurately.
Researchers found that colon polyp detection rates remained consistent throughout the day at Mayo Clinic, contradicting previous findings. Shorter daily shifts did not result in decreased polyp detection rates, unlike traditional half-day shifts.
A Mayo Clinic study found a 30% difference in risk for failed transplant between transplant centers. The study analyzed data from 12,233 patients and showed that quality of care, donor organ selection, and geographical location all contribute to outcome differences.
A recent study published by Mayo Clinic has found that older women with diabetes are at a more than doubled risk for certain types of colorectal cancer. The research team analyzed data from over 37,000 participants and identified associations between diabetes and specific molecular markers.
Researchers found that patients dismissed from hospital with noncardiac chest pain continue to experience cardiac events, suggesting a need for more aggressive cardiovascular risk factor management. The study also identified a substantial number of cardiac deaths in this population, potentially related to overlapping risk factors.
Researchers found a 28% reduced risk of developing breast cancer in women whose breasts decreased in density over time. The study suggests that measures of breast density may provide additional information for assessing breast cancer risk.
Researchers at the Mayo Clinic found that people with higher vitamin K intakes from their diet had a lower risk of developing Non-Hodgkin lymphoma. Vitamin K intake was estimated from a food questionnaire and was associated with a significant protective effect against the disease.
A study published in the New England Journal of Medicine found that patients with moderate to severe Crohn's disease who received combination therapy with infliximab and azathioprine had a higher chance of achieving remission compared to those treated with azathioprine alone. The researchers also discovered comparable safety results ac...
A study of nearly 100 early-stopped clinical trials found that many positive treatment effects were exaggerated. Researchers recommend continuing trials for longer periods to ensure accurate estimates of treatment effects.
A new virtual biopsy probe system has shown high accuracy in detecting precancerous polyps during colonoscopy, with a success rate of 91%. The system uses Confocal Laser Endomicroscopy to magnify cells and detect changes that may indicate cancer. This technology could potentially eliminate the need for biopsies in some patients.
A recent study found that approximately 30% of never-smoking lung cancer patients carry a rare variant of the GPC5 gene, leading to reduced expression levels and increased risk of cancer. The research suggests that GPC5 may be a critical tumor suppressor gene in lung cancer development.
The study found that daily cleaning of high-touch surfaces with a spore-killing bleach disinfectant wipe significantly reduced C. difficile infections in two high-incidence units. The team aimed to reduce hospital-acquired cases to over 20 days between infections but achieved an impressive 137-day streak without a single infection.
A multicenter study found that patients with mild to moderate hypoglycemia had nearly twice the rate of mortality compared to those without the condition. The study suggests that tolerating hypoglycemia may be undesirable and that continuous glucose monitoring could help avoid it.
Researchers at Mayo Clinic have found a novel theory about how the insulin-degrading enzyme (IDE) gene influences the risk of Alzheimer's disease. The study suggests that too little IDE expression may promote disease development, while increased expression appears to protect against it.
Patients who received stents and participated in cardiac rehabilitation had a significant reduction in mortality rates compared to those who did not participate. Cardiac rehabilitation programs improve health outcomes and quality of life through rigorous exercise and risk factor control.
A Mayo Clinic study identifies clinical traits that predict higher radiation doses in patients undergoing percutaneous coronary intervention (PCI) therapy, with men receiving higher doses due to body size and disease complexity. The study aims to reduce radiation risks and improve PCI safety and quality.
A study found that the average age of patients having total knee replacements decreased by two years between 1990-1994 and 2002-2006. The percentage of minorities also increased during this time period. Additionally, hospital stays decreased from 8.4 days to 3.9 days.
Postmenopausal women, especially those over 70, have a higher prevalence of cancer detected in the undiagnosed breast with MRI compared to premenopausal women. Detecting and treating both breasts at the same time may save costs and reduce patient stress.
A nationwide study found that blacks are substantially less likely than whites to know they have atrial fibrillation or use warfarin as treatment. This disparity could explain why the black population has a higher incidence of stroke and death from strokes compared to the white population.
Mayo Clinic researchers have developed a novel approach for sequencing RNA to study cancer tumors, revealing alterations in gene expression driven by chromosomal regions of gain and loss. This technology allows for detailed analysis of the transcriptome, enabling better understanding of individualized medicine and potential therapeutic...
Researchers at the Mayo Clinic have found that PKC-iota is over-produced in pancreatic cancer and is linked to poor patient survival. Genetically inhibiting PKC-iota led to a significant decrease in pancreatic tumor growth and spread in laboratory animals.
Mayo Clinic's first lung transplant from a donor after cardiac death (DCD) was successful in a 59-year-old man with alpha-1antitrypsin deficiency. The recipient, who had limited lung function before the transplant, is now able to walk and breathe normally.
A new method developed by Mayo Clinic and IBM uses analytics technology to detect brain aneurysms with a 95% accuracy rate, compared to 70% for manual interpretation. The system can identify images in 3-5 minutes, improving efficiency and saving radiologists' time.
A recent study published in Mayo Clinic Proceedings found that reducing the depth of sedation can decrease postoperative delirium prevalence by 50% in elderly patients undergoing hip fracture repair. Lighter sedation was associated with a reduction in delirium duration, averaging almost one day per patient.
Researchers have identified a molecular mechanism that controls energy expenditure in muscles and helps determine body weight. This discovery could lead to a new medical approach in treating obesity by targeting the ATP-sensitive potassium channel function in muscle tissue.
A recent study published in Mayo Clinic Proceedings found that young patients with primary myelofibrosis who received modern treatments lived longer than those diagnosed earlier, suggesting a beneficial effect from modern therapeutic approaches.
Using Herceptin with chemotherapy reduces the risk of cancer recurrence by 25% compared to using it after chemotherapy. This new standard of care may benefit up to 10,000 women worldwide each year.
Researchers demonstrate how aneuploidy, or abnormal number of chromosomes, causes cancer by eliminating tumor suppressor genes. The findings provide a new understanding of the mechanism underlying cancer development and may lead to targeted therapies.
Researchers used electrocorticography (ECoG) to record brain activity and found that patients could type alphanumeric characters on a screen by focusing on specific letters. The technique showed promise for people with disorders like Lou Gehrig's disease and spinal cord injuries.
Researchers found that vitamin D levels in patients with diffuse large B-cell lymphoma were strongly associated with cancer progression and overall survival. Patients with deficient vitamin D levels had a 1.5-fold greater risk of disease progression.
A Mayo Clinic-led study found that nearly 9% of US surgeons reported making a major error in the past three months, with burnout and depression being key factors. The researchers suggest that reducing work hours may not be enough to limit errors unless addressing burnout is also prioritized.
A Mayo Clinic study found that the incidence of stroke or mini-stroke related to angioplasty remained steady over a 15-year period. Researchers identified patients who suffered an angioplasty-related cerebrovascular accident (CVA), defined as a stroke, and compared outcomes with the remainder of the study population.
A Mayo Clinic study found that routine annual evaluation of prostate growth is not a reliable predictor for prostate cancer development. However, if PSA levels are rising quickly, a prostate biopsy is recommended to determine if prostate cancer exists.
Researchers at Mayo Clinic have found that robotic sacrocolpopexy surgery dramatically reduces patient hospital stay and recovery time. The procedure also shows fewer postoperative complications, shorter hospital stays, and faster postoperative recovery compared to traditional abdominal sacrocolpopexy.
A Mayo Clinic study found that genetic testing results are not binary but probabilistic, requiring physicians to meticulously interpret test results. The study also showed that about 4% of healthy Caucasian volunteers have rare variants present in the background noise of genetic tests.
Several new diagnostic methods, such as cardiac magnetic resonance imaging (MRI), are useful for diagnosing myocarditis. Endomyocardial biopsy is also used in certain cases. The study highlights the importance of these methods in improving diagnosis accuracy.
Researchers at Mayo Clinic found that consultation room design can enhance patient care by improving collaboration between clinicians and patients. The study, which included 63 pairs of patients and doctors, showed that experimental rooms with side-by-side seating increased clinician-patient information sharing and patient satisfaction.