Researchers found a 28% reduced risk of developing breast cancer in women whose breasts decreased in density over time. The study suggests that measures of breast density may provide additional information for assessing breast cancer risk.
Researchers at the Mayo Clinic found that people with higher vitamin K intakes from their diet had a lower risk of developing Non-Hodgkin lymphoma. Vitamin K intake was estimated from a food questionnaire and was associated with a significant protective effect against the disease.
A study published in the New England Journal of Medicine found that patients with moderate to severe Crohn's disease who received combination therapy with infliximab and azathioprine had a higher chance of achieving remission compared to those treated with azathioprine alone. The researchers also discovered comparable safety results ac...
A study of nearly 100 early-stopped clinical trials found that many positive treatment effects were exaggerated. Researchers recommend continuing trials for longer periods to ensure accurate estimates of treatment effects.
A new virtual biopsy probe system has shown high accuracy in detecting precancerous polyps during colonoscopy, with a success rate of 91%. The system uses Confocal Laser Endomicroscopy to magnify cells and detect changes that may indicate cancer. This technology could potentially eliminate the need for biopsies in some patients.
A recent study found that approximately 30% of never-smoking lung cancer patients carry a rare variant of the GPC5 gene, leading to reduced expression levels and increased risk of cancer. The research suggests that GPC5 may be a critical tumor suppressor gene in lung cancer development.
The study found that daily cleaning of high-touch surfaces with a spore-killing bleach disinfectant wipe significantly reduced C. difficile infections in two high-incidence units. The team aimed to reduce hospital-acquired cases to over 20 days between infections but achieved an impressive 137-day streak without a single infection.
A multicenter study found that patients with mild to moderate hypoglycemia had nearly twice the rate of mortality compared to those without the condition. The study suggests that tolerating hypoglycemia may be undesirable and that continuous glucose monitoring could help avoid it.
Researchers at Mayo Clinic have found a novel theory about how the insulin-degrading enzyme (IDE) gene influences the risk of Alzheimer's disease. The study suggests that too little IDE expression may promote disease development, while increased expression appears to protect against it.
Patients who received stents and participated in cardiac rehabilitation had a significant reduction in mortality rates compared to those who did not participate. Cardiac rehabilitation programs improve health outcomes and quality of life through rigorous exercise and risk factor control.
A Mayo Clinic study identifies clinical traits that predict higher radiation doses in patients undergoing percutaneous coronary intervention (PCI) therapy, with men receiving higher doses due to body size and disease complexity. The study aims to reduce radiation risks and improve PCI safety and quality.
A study found that the average age of patients having total knee replacements decreased by two years between 1990-1994 and 2002-2006. The percentage of minorities also increased during this time period. Additionally, hospital stays decreased from 8.4 days to 3.9 days.
Postmenopausal women, especially those over 70, have a higher prevalence of cancer detected in the undiagnosed breast with MRI compared to premenopausal women. Detecting and treating both breasts at the same time may save costs and reduce patient stress.
A nationwide study found that blacks are substantially less likely than whites to know they have atrial fibrillation or use warfarin as treatment. This disparity could explain why the black population has a higher incidence of stroke and death from strokes compared to the white population.
Mayo Clinic researchers have developed a novel approach for sequencing RNA to study cancer tumors, revealing alterations in gene expression driven by chromosomal regions of gain and loss. This technology allows for detailed analysis of the transcriptome, enabling better understanding of individualized medicine and potential therapeutic...
Researchers at the Mayo Clinic have found that PKC-iota is over-produced in pancreatic cancer and is linked to poor patient survival. Genetically inhibiting PKC-iota led to a significant decrease in pancreatic tumor growth and spread in laboratory animals.
Mayo Clinic's first lung transplant from a donor after cardiac death (DCD) was successful in a 59-year-old man with alpha-1antitrypsin deficiency. The recipient, who had limited lung function before the transplant, is now able to walk and breathe normally.
A new method developed by Mayo Clinic and IBM uses analytics technology to detect brain aneurysms with a 95% accuracy rate, compared to 70% for manual interpretation. The system can identify images in 3-5 minutes, improving efficiency and saving radiologists' time.
A recent study published in Mayo Clinic Proceedings found that reducing the depth of sedation can decrease postoperative delirium prevalence by 50% in elderly patients undergoing hip fracture repair. Lighter sedation was associated with a reduction in delirium duration, averaging almost one day per patient.
Researchers have identified a molecular mechanism that controls energy expenditure in muscles and helps determine body weight. This discovery could lead to a new medical approach in treating obesity by targeting the ATP-sensitive potassium channel function in muscle tissue.
A recent study published in Mayo Clinic Proceedings found that young patients with primary myelofibrosis who received modern treatments lived longer than those diagnosed earlier, suggesting a beneficial effect from modern therapeutic approaches.
Using Herceptin with chemotherapy reduces the risk of cancer recurrence by 25% compared to using it after chemotherapy. This new standard of care may benefit up to 10,000 women worldwide each year.
Researchers demonstrate how aneuploidy, or abnormal number of chromosomes, causes cancer by eliminating tumor suppressor genes. The findings provide a new understanding of the mechanism underlying cancer development and may lead to targeted therapies.
Researchers used electrocorticography (ECoG) to record brain activity and found that patients could type alphanumeric characters on a screen by focusing on specific letters. The technique showed promise for people with disorders like Lou Gehrig's disease and spinal cord injuries.
Researchers found that vitamin D levels in patients with diffuse large B-cell lymphoma were strongly associated with cancer progression and overall survival. Patients with deficient vitamin D levels had a 1.5-fold greater risk of disease progression.
A Mayo Clinic-led study found that nearly 9% of US surgeons reported making a major error in the past three months, with burnout and depression being key factors. The researchers suggest that reducing work hours may not be enough to limit errors unless addressing burnout is also prioritized.
A Mayo Clinic study found that the incidence of stroke or mini-stroke related to angioplasty remained steady over a 15-year period. Researchers identified patients who suffered an angioplasty-related cerebrovascular accident (CVA), defined as a stroke, and compared outcomes with the remainder of the study population.
A Mayo Clinic study found that routine annual evaluation of prostate growth is not a reliable predictor for prostate cancer development. However, if PSA levels are rising quickly, a prostate biopsy is recommended to determine if prostate cancer exists.
Researchers at Mayo Clinic have found that robotic sacrocolpopexy surgery dramatically reduces patient hospital stay and recovery time. The procedure also shows fewer postoperative complications, shorter hospital stays, and faster postoperative recovery compared to traditional abdominal sacrocolpopexy.
A Mayo Clinic study found that genetic testing results are not binary but probabilistic, requiring physicians to meticulously interpret test results. The study also showed that about 4% of healthy Caucasian volunteers have rare variants present in the background noise of genetic tests.
Several new diagnostic methods, such as cardiac magnetic resonance imaging (MRI), are useful for diagnosing myocarditis. Endomyocardial biopsy is also used in certain cases. The study highlights the importance of these methods in improving diagnosis accuracy.
Researchers at Mayo Clinic found that consultation room design can enhance patient care by improving collaboration between clinicians and patients. The study, which included 63 pairs of patients and doctors, showed that experimental rooms with side-by-side seating increased clinician-patient information sharing and patient satisfaction.
Researchers at the Mayo Clinic found that high-definition colonoscopy detected 29% more polyps than standard colonoscopy, with a 20% increase in detecting precancerous polyps. This study, conducted on 2,430 patients, marked the first comparison of these two methods in clinical practice.
Dr. Jay Smith, a Mayo Clinic physician, has received the first-ever PASSOR Legacy Award and Lectureship for his groundbreaking contributions to musculoskeletal physiatry. The award recognizes Dr. Smith's innovative approaches to patient care, education, and research in this field.
A new Mayo Clinic study has found that video capsule endoscopy is safe for patients with heart devices, contradicting previous FDA contraindication. The study, involving 84 patients, showed no complications or interference between the procedure and implanted cardiac devices.
Researchers found that Barrett's esophagus patients have comparable survival rates to the general population, with a 10-year overall survival rate of 68%. Esophageal cancer was not significantly more common among these patients.
A Mayo Clinic study found that Clostridium difficile infections are rising in outpatient settings, with a higher proportion of cases in younger populations. The study suggests that antibiotic use may be contributing to the increased incidence and severity of C. difficile infections.
Researchers at Mayo Clinic found that inflammation in the brain helps clear amyloid deposits, contradicting long-standing scientific belief. The study suggests that manipulating brain inflammation could be a potential therapeutic approach to treat Alzheimer's disease.
A new decision aid tool, developed by Mayo Clinic clinicians and designers, helps patients with type 2 diabetes make informed decisions about their medication. The tool, a set of cards, involves patients in the decision-making process and leads to better patient-centered care.
Researchers at Mayo Clinic have achieved an impressive 93% success rate in animal tests of non-incision, endoscopic ulcer repair using Natural Orifice Translumenal Endoscopic Surgery (NOTES). The technique, which minimizes physical impact on the patient, may soon be tested in human clinical trials.
Mayo Clinic researchers found that certain structural features within breast tissue can indicate a woman's individual cancer risk. The percentage of acini present per lobule at a given age indicates cancer risk. This method is more accurate in predicting risk for an individual than the Gail model.
A new study published in the October 2009 issue of Gastroenterology found that patients with moderate-to-severe active ulcerative colitis had a 41 percent reduction in colectomy after one year when treated with infliximab. Treatment with infliximab reduced the incidence of colectomy through 54 weeks by 41 percent.
A large study by Mayo Clinic researchers found that patients treated with radiotherapy after prostate cancer surgery experienced very few complications, contradicting concerns about toxicity and side effects. The study suggests that radiation treatment is an effective and safe option for patients with recurrent cancer.
A Mayo Clinic survey published in the New England Journal of Medicine found that most physicians agree on their professional obligation to address health policy issues and expand access to basic healthcare. However, some physicians oppose measures such as underinsuring patients or using cost-effectiveness data in treatment decisions.
A Mayo Clinic study found that distress and fatigue among medical residents significantly contribute to self-perceived medical errors. The research used standardized survey tools to measure burnout, symptoms of depression, sleepiness, and fatigue, and found that both factors increased the risk of errors.
Researchers developed an artificial neural network (ANN) to evaluate symptoms and predict endocarditis diagnoses. The ANN achieved high accuracy in distinguishing between infected and non-infected cases, eliminating the need for invasive transesophageal echocardiography.
A Mayo Clinic study has found two genes associated with good central nervous system repair in mice with multiple sclerosis. The identification of these genes may lead to the development of new therapies and a better prediction of patient outcomes.
Researchers at the Mayo Clinic have discovered that the lung cancer oncogene PKCiota is necessary for the proliferation of lung cancer stem cells. The study found that an agent called aurothiomalate substantially inhibits growth of these cancer stem cells, suggesting a potential new treatment target.
A team of researchers from Mayo Clinic and Harvard Medical School found that the protein FOXO3a, previously believed to prevent cancer development, can actually fuel tumor growth in certain situations. This discovery sheds light on the complex roles proteins play in cancer progression.
Researchers at Mayo Clinic have found that early stage cancers of the esophagus can be treated effectively with less-invasive, organ-sparing endoscopic therapy. This approach was compared to traditional surgical removal of the esophagus and showed comparable overall mortality rates.