A large study by Mayo Clinic and NCCTG found that PTEN status has no significant impact on disease-free survival when Herceptin is added to chemotherapy. Patients with HER2-positive breast cancer did equally well regardless of PTEN activity levels.
Raoul Tibes, M.D., Ph.D., receives a three-year grant totaling $200,000 to fund his translational research in acute myeloid leukemia. The award aims to make the drug Cytarabine more potent and effective for patients who have failed prior therapies.
A study by Mayo Clinic researchers found that discussing end-of-life care preferences with patients and families before LVAD surgery can provide relief to families, ease subsequent medical care, and help clinicians address end-of-life decision-making effectively.
Mayo Clinic researchers developed a protocol that increased testing for Lynch syndrome by nearly 90%, helping doctors make informed decisions on care timing and delivery. The testing caught 11% of MSI-H tumors that would have been missed, improving early cancer detection.
Researchers at Mayo Clinic found that patients diagnosed with advanced prostate cancer can enjoy long-term survival and a significant cancer-free interval. The study showed an 80% survival rate for patients with locally advanced prostate cancer at 20 years after surgery.
Patients with small kidney tumors are more likely to be offered partial nephrectomy based on surgeon's case volume and type of practice. Fellowship-trained surgeons in academic centers were 70-80% more likely to follow guidelines, while those in private practice saw fewer patients offered radical nephrectomy.
Researchers at Mayo Clinic have found a reliable method to detect pancreatic cancer through DNA testing of stool samples, with a marker detecting methylated genes in 70% of patients. This noninvasive test may lead to increased early detection and improved survival rates for those diagnosed with the disease.
A3309, a new medication, targets bile acid recycling to promote bowel movements and relieve constipation symptoms. In a Phase II study, patients with constipation reported significantly less straining and softer stool after taking A3309.
A Mayo Clinic study found that it takes an average of 275 procedures to reach minimal cognitive and motor competency in gastroenterology fellows performing colonoscopies. The research team used a validated testing method to assess the performance of 41 fellows who performed over 6,600 colonoscopies.
Researchers at Mayo Clinic's Zebrafish Core Facility successfully switched individual genes on and off in zebrafish, allowing them to observe embryonic and juvenile development. This breakthrough enables the study of protein function and its relation to health problems like cancer, heart attacks, and addiction.
A 54-year-old man collapsed and was without a pulse for 96 minutes, but made a complete recovery thanks to continuous CPR, defibrillator shocks, and capnography. The case suggests further study of advanced life support techniques is warranted.
A large waist circumference or high waist-to-hip ratio significantly increases the risk of death in coronary artery disease patients, even among those with a normal Body Mass Index (BMI). The study refutes the obesity paradox, suggesting that central obesity is a more critical factor than overall weight.
Researchers identified two mutations responsible for hereditary sensory and autonomic neuropathy type 1 (HSAN1), causing cognitive decline, hearing loss, and sensory impairments in young adults. The study provides insights into the disease's mechanisms and potential future research directions.
A team of surgeons from Mayo Clinic has found robotic surgery effective in treating larynx cancer, with patients able to resume normal eating and speaking after surgery. The study showed that robotic surgery was easier to perform than traditional approaches and resulted in clean, disease-free margins.
Global Bridges, a healthcare alliance for tobacco dependence treatment, is launching training in the Eastern Mediterranean Region. The first training will engage 15 health care professionals from Jordan and focus on culturally appropriate tobacco dependence treatment.
A healthcare alliance has launched a training program in Mexico to address the significant rates of tobacco usage in Latin America. The program aims to enhance access to proven treatment methods and promote effective tobacco control policies across the region.
A Mayo Clinic case study finds Botox effective in treating disabling low cerebrospinal fluid headaches. The patient's headaches improved significantly after receiving Botox treatments, allowing her to live a more normal life.
A new research study found that a commonly used strategy to reduce the spread of resistant bacteria in hospital ICUs had no significant effect. The study, which used active surveillance and expanded use of barrier precautions, did identify a large subgroup of patients not previously known to be colonized with MRSA or VRE.
Researchers at Mayo Clinic have created a tool that uses cerebrospinal fluid test results to predict disability timelines for patients with progressive multiple sclerosis. The study found that patients with higher levels of certain proteins in their CSF are more likely to experience a faster onset of disability.
A new study published in American Journal of Transplantation found that progressive damage to kidney transplants is less common and less severe than previously reported. The study, involving 797 patients, showed that 87% of patients had mild or no signs of progressive scar damage at one year after transplant.
A study by Mayo Clinic researchers found that the cost of heart medications is a significant deterrent for patients with heart failure. Younger patients and women were more likely to skip or not take their prescribed drugs due to financial concerns.
Cardiac pacing has been shown to reduce falls in epilepsy patients with ictal asystole, a condition where the heart stops beating during an epileptic seizure. The study found significant reductions in fall rates and seizures after implantation, suggesting potential anti-seizure properties of pacemaker implants.
The Harry T. Mangurian, Jr., Foundation has awarded Mayo Clinic a $1 million gift to understand how Lewy body dementia develops, how to treat it more effectively, and how to diagnose it earlier. Researchers will use genetics, new drugs, and imaging techniques to advance knowledge about the disorder.
A study published in Mayo Clinic Proceedings found that residential treatment for tobacco dependence significantly increases the chances of long-term abstinence. Compared to standard outpatient treatment, residential patients showed a higher success rate, with 52% still not smoking after six months.
A study by Mayo Clinic researchers suggests that new duty-hour limitations for medical residents may not address the issue of physician fatigue, but rather compromise the quality of their training. The survey found that many residency program directors are concerned that shortened shifts will disrupt patient care and education.
Mayo Clinic researchers confirmed that patients who receive therapeutic hypothermia after resuscitation from cardiac arrest have favorable chances of surviving the event. High NSE levels in the blood were shown to predict poor outcomes in non-hypothermia cases, but elevated levels also occurred in some patients who recovered well.
A collaboration between Mayo Clinic and local educators has resulted in improved science test scores and increased participation in the Minnesota science fair. The project, InSciEd Out, introduced a new curriculum that incorporates zebrafish research into the classroom, with positive outcomes for grades six to eight.
A Mayo Clinic research team has pinpointed the function of the MMSET gene, revealing how it enables disease-causing mutations to occur. Normally-functioning MMSET plays a restorative role within the genome, but when impaired, cells lose the correct response to DNA damage.
A new study published in Mayo Clinic Proceedings found that shingles recurrences are more common than previously thought, occurring in over 5% of patients within eight years. Patients experiencing prolonged pain after the initial episode were more likely to face a recurrence.
A study by Mayo Clinic researchers identifies LRP1, a lipoprotein receptor, as a co-receptor with the leptin receptor that regulates appetite and metabolism. Mice engineered to lack LRP1 gained weight and became obese, indicating its critical role in lipid metabolism and energy balance.
Researchers at Mayo Clinic describe the crucial initial steps of measles virus attachment to host cells, revealing a complex dance-like movement. The findings provide insight into the disease mechanism, which could lead to new therapeutic strategies.
Researchers estimate lifetime risk of rheumatoid arthritis for both sexes using data from the Rochester Epidemiology Project. The study finds that 8.4% of women and 5.1% of men will develop an inflammatory autoimmune disease in their lifetime.
Researchers at Mayo Clinic report significant improvements in fertility preservation techniques, including egg freezing and embryo storage. The advancements provide new options for young cancer patients seeking to conceive after treatment.
Researchers at Mayo Clinic have identified a gene variant that appears to protect against frontotemporal lobar degeneration (FTLD) in high-risk individuals with progranulin mutations. The study found that carrying two copies of the protective TMEM106B allele delays or prevents FTLD onset, suggesting it may increase progranulin levels.
HER2 test results can vary in up to 10% of patients when multiple tumor blocks are analyzed, according to Mayo Clinic researchers. This variability has significant implications for patient treatment and highlights the need for additional testing.
Researchers developed a new imaging technique that uses single photon emission computed tomography (SPECT) with computerized tomography (CT) scans to pinpoint critical lymph nodes under the arm. This allows physicians to block these nodes from X-ray beams, reducing radiation and subsequent lymphedema in breast cancer patients.
Researchers found that brain regions surrounding seizure-generating areas have reduced synchrony, a key finding in understanding epilepsy. The study suggests that this isolation could be used as a clinical biomarker to identify individuals with abnormal brain function.
The Mayo Clinic Health Policy Center hosted a symposium on high-value health care, emphasizing the need for payment reform and collaborative approaches. Panelists stressed the importance of integrated care, ACOs, and electronic health records in achieving better health outcomes.
The Mayo Clinic study found that more than half of children with cryptogenic epilepsy had a significantly better long-term outcome than those with symptomatic epilepsy. Approximately 68% of the cryptogenic group achieved seizure freedom compared to 46% in the symptomatic group.
Researchers at Mayo Clinic found that JAK inhibitors CYT387 and TG101348 effectively reduce spleen size and alleviate constitutional symptoms in myelofibrosis patients. These targeted treatments have shown significant clinical benefits, including improved anemia rates and reduced white blood cell counts.
New analysis suggests that stenting can perform as well as surgery for treating narrowed carotid vessels, with age being a significant factor. For younger patients (under 70) with symptoms related to the condition, stenting proved effective in reducing stroke risk.
Researchers found that certain mutations in the virus render it ineffective against drugs, but also impair its ability to kill immune cells. This discovery may lead to a new diagnostic tool and more effective treatments for HIV patients.
Researchers found increased vascular reactivity and decreased endothelial function in women with broken heart syndrome compared to postmenopausal women and those who had regular heart attacks. This unique risk factor highlights the importance of mental stress in ABS syndrome, which may lead to the development of specific therapies.
A Mayo Clinic study found that aggressive surgery to completely remove low-grade brain tumors (gliomas) in children offers the highest chance of overall survival. If complete removal is not possible, adding radiation therapy yields similar results.
Mayo Clinic researchers discovered a connection between two proteins, progranulin and sortilin, which may lead to new treatment options for frontotemporal lobar degeneration. The study found strong associations between genetic variants in the same region of chromosome 1 and plasma progranulin levels.
Researchers tested genetic variations in 1,262 people with no history of heart disease and found that genetic scores can modify the estimated risk of heart attack. The study suggests that genetic screening may be most valuable for individuals thought to be at intermediate risk using current models.
Researchers at Mayo Clinic have shown that iron buildup is prevalent in unstable coronary artery plaque, making it a potential marker for risk of myocardial infarction and sudden death. Non-invasive imaging techniques, such as micro-CT scans, may soon be able to detect these plaques, allowing for earlier intervention.
A Mayo Clinic study found that morbidly obese heart failure patients who underwent bariatric surgery experienced significant improvements in disease symptoms and quality of life. The surgery led to better breathing during exercise and reduced swelling in the legs, even if most patients remained obese after weight loss.
Researchers found that CLL patients with insufficient vitamin D levels progressed faster, were twice as likely to die, and had shorter survival times. Vitamin D supplements may offer a way to slow leukemia progression.
Researchers found that khat chewing increases the risk of stroke and death in patients with acute coronary syndrome, while excess energy beverage consumption may lead to adverse effects. Withdrawing pacemakers and ICDs at end-of-life raises complex questions about patient autonomy and medical professional perspectives.