Researchers create cats with intrinsic immunity to feline AIDS by inserting protective protein genes. The technique, called gamete-targeted lentiviral transgenesis, also makes the offspring glow green for tracking purposes.
Researchers identify EIF4G1 gene mutation that leads to death of brain cells, resulting in Parkinson's disease and related neurodegenerative disorders. The study offers insights into how the gene controls protein levels to cope with biological stress.
Researchers found aerobic exercise can preserve cognitive abilities and slow dementia progression. The study, published in Mayo Clinic Proceedings, suggests exercise should not be overlooked as a therapy against dementia.
A recent Mayo Clinic study found that 51.5% of US internal medicine residents reported burnout symptoms, with those owing over $200,000 in debt experiencing lower quality of life and test scores. The study also revealed a link between resident distress and lower-quality patient care.
Mayo Clinic researchers analyzed over 600 studies on simulation-based training, finding it consistently better than no instruction for various learners and clinical topics. Simulation allows for practice without harming patients, repeated training to become more proficient, and structured learning for effective learning outcomes.
Researchers found a genetic variation in the LRRK2 gene that reduces the risk of Parkinson's disease by nearly 20% in many populations. The study also identified different variants of the same gene that increase Parkinson's risk in Caucasians and Asians, providing evidence for multiple genetic risks contributing to the disease.
The reappearance of measles is linked to unfounded fears about a link between the measles shot and autism, says Dr. Gregory Poland. Despite over 20 studies finding no connection between MMR vaccine and autism, some parents have turned against childhood vaccination.
A new strain of bacteria infecting humans with ehrlichiosis has been found in Wisconsin and Minnesota, according to a study published in the New England Journal of Medicine. The discovery highlights the importance of testing for tick-borne diseases in these states.
Mayo Clinic researchers are investigating why knee osteoarthritis disproportionately affects women. The study will analyze human tissues discarded during knee replacement surgery for possible biological differences in pain fibers and hormone receptors between female and male patients.
Researchers at Mayo Clinic and University of Washington highlight the potential benefits of primary care physicians in establishing treatment plans for patients at risk for suicide. A simple question from a family doctor can be enough to start a person toward help and treatment.
Researchers at Mayo Clinic discovered a genetic mutation in VPS35 that causes Parkinson's disease, leading to protein buildup in the brain. This finding opens up new avenues for understanding and treating the complex disease.
Researchers have successfully reprogrammed adult body cells into iPS cells, which can be taken directly from each patient and genetically redirected to replace ailing cells. While iPS technology holds promise, it still faces challenges and is not yet ready for widespread use.
Mayo Clinic researchers are developing an artificial pancreas that will deliver insulin automatically and with individualized precision, reducing the need for daily insulin dosing and finger pricks. The system includes a blood sugar monitor, automatic insulin pump, activity monitors, and a central processing unit.
A genome-wide association study found three SNPs associated with PSP, suggesting they may contribute to disease susceptibility. These genes are involved in tau protein regulation and membrane recycling.
Mayo Clinic researchers have developed a human vaccine that uses viruses to stimulate the immune system to attack and cure prostate cancer in mice. The vaccine has shown promise in treating other aggressive cancers, such as lung, brain, and pancreatic cancer, with no apparent side effects.
A Mayo Clinic research team has demonstrated a promising alternative strategy for treating type 2 diabetes by blocking the breakdown of insulin. In mouse studies, these mice showed increased insulin levels, weight loss, and improved blood sugar control.
A Mayo Clinic study found that flaxseed does not significantly reduce hot flashes in breast cancer patients and postmenopausal women. The researchers suggest alternative uses for flaxseed, such as managing constipation.
A Mayo Clinic study has found that a mutant gene thought to accelerate tumor growth actually inhibits the spread of malignant cells, showing promise for novel cancer therapies. The PAX8/PPARγ fusion protein functions as a tumor suppressor by upregulating anti-tumor agents.
A large study by Mayo Clinic and NCCTG found that PTEN status has no significant impact on disease-free survival when Herceptin is added to chemotherapy. Patients with HER2-positive breast cancer did equally well regardless of PTEN activity levels.
Raoul Tibes, M.D., Ph.D., receives a three-year grant totaling $200,000 to fund his translational research in acute myeloid leukemia. The award aims to make the drug Cytarabine more potent and effective for patients who have failed prior therapies.
A study by Mayo Clinic researchers found that discussing end-of-life care preferences with patients and families before LVAD surgery can provide relief to families, ease subsequent medical care, and help clinicians address end-of-life decision-making effectively.
Mayo Clinic researchers developed a protocol that increased testing for Lynch syndrome by nearly 90%, helping doctors make informed decisions on care timing and delivery. The testing caught 11% of MSI-H tumors that would have been missed, improving early cancer detection.
Researchers at Mayo Clinic found that patients diagnosed with advanced prostate cancer can enjoy long-term survival and a significant cancer-free interval. The study showed an 80% survival rate for patients with locally advanced prostate cancer at 20 years after surgery.
Patients with small kidney tumors are more likely to be offered partial nephrectomy based on surgeon's case volume and type of practice. Fellowship-trained surgeons in academic centers were 70-80% more likely to follow guidelines, while those in private practice saw fewer patients offered radical nephrectomy.
Researchers at Mayo Clinic have found a reliable method to detect pancreatic cancer through DNA testing of stool samples, with a marker detecting methylated genes in 70% of patients. This noninvasive test may lead to increased early detection and improved survival rates for those diagnosed with the disease.
A3309, a new medication, targets bile acid recycling to promote bowel movements and relieve constipation symptoms. In a Phase II study, patients with constipation reported significantly less straining and softer stool after taking A3309.
A Mayo Clinic study found that it takes an average of 275 procedures to reach minimal cognitive and motor competency in gastroenterology fellows performing colonoscopies. The research team used a validated testing method to assess the performance of 41 fellows who performed over 6,600 colonoscopies.
Researchers at Mayo Clinic's Zebrafish Core Facility successfully switched individual genes on and off in zebrafish, allowing them to observe embryonic and juvenile development. This breakthrough enables the study of protein function and its relation to health problems like cancer, heart attacks, and addiction.
A 54-year-old man collapsed and was without a pulse for 96 minutes, but made a complete recovery thanks to continuous CPR, defibrillator shocks, and capnography. The case suggests further study of advanced life support techniques is warranted.
A large waist circumference or high waist-to-hip ratio significantly increases the risk of death in coronary artery disease patients, even among those with a normal Body Mass Index (BMI). The study refutes the obesity paradox, suggesting that central obesity is a more critical factor than overall weight.
Researchers identified two mutations responsible for hereditary sensory and autonomic neuropathy type 1 (HSAN1), causing cognitive decline, hearing loss, and sensory impairments in young adults. The study provides insights into the disease's mechanisms and potential future research directions.
A team of surgeons from Mayo Clinic has found robotic surgery effective in treating larynx cancer, with patients able to resume normal eating and speaking after surgery. The study showed that robotic surgery was easier to perform than traditional approaches and resulted in clean, disease-free margins.
Global Bridges, a healthcare alliance for tobacco dependence treatment, is launching training in the Eastern Mediterranean Region. The first training will engage 15 health care professionals from Jordan and focus on culturally appropriate tobacco dependence treatment.
A healthcare alliance has launched a training program in Mexico to address the significant rates of tobacco usage in Latin America. The program aims to enhance access to proven treatment methods and promote effective tobacco control policies across the region.
A Mayo Clinic case study finds Botox effective in treating disabling low cerebrospinal fluid headaches. The patient's headaches improved significantly after receiving Botox treatments, allowing her to live a more normal life.
A new research study found that a commonly used strategy to reduce the spread of resistant bacteria in hospital ICUs had no significant effect. The study, which used active surveillance and expanded use of barrier precautions, did identify a large subgroup of patients not previously known to be colonized with MRSA or VRE.
Researchers at Mayo Clinic have created a tool that uses cerebrospinal fluid test results to predict disability timelines for patients with progressive multiple sclerosis. The study found that patients with higher levels of certain proteins in their CSF are more likely to experience a faster onset of disability.
A new study published in American Journal of Transplantation found that progressive damage to kidney transplants is less common and less severe than previously reported. The study, involving 797 patients, showed that 87% of patients had mild or no signs of progressive scar damage at one year after transplant.
A study by Mayo Clinic researchers found that the cost of heart medications is a significant deterrent for patients with heart failure. Younger patients and women were more likely to skip or not take their prescribed drugs due to financial concerns.
Cardiac pacing has been shown to reduce falls in epilepsy patients with ictal asystole, a condition where the heart stops beating during an epileptic seizure. The study found significant reductions in fall rates and seizures after implantation, suggesting potential anti-seizure properties of pacemaker implants.
The Harry T. Mangurian, Jr., Foundation has awarded Mayo Clinic a $1 million gift to understand how Lewy body dementia develops, how to treat it more effectively, and how to diagnose it earlier. Researchers will use genetics, new drugs, and imaging techniques to advance knowledge about the disorder.
A study published in Mayo Clinic Proceedings found that residential treatment for tobacco dependence significantly increases the chances of long-term abstinence. Compared to standard outpatient treatment, residential patients showed a higher success rate, with 52% still not smoking after six months.
A study by Mayo Clinic researchers suggests that new duty-hour limitations for medical residents may not address the issue of physician fatigue, but rather compromise the quality of their training. The survey found that many residency program directors are concerned that shortened shifts will disrupt patient care and education.
Mayo Clinic researchers confirmed that patients who receive therapeutic hypothermia after resuscitation from cardiac arrest have favorable chances of surviving the event. High NSE levels in the blood were shown to predict poor outcomes in non-hypothermia cases, but elevated levels also occurred in some patients who recovered well.
A collaboration between Mayo Clinic and local educators has resulted in improved science test scores and increased participation in the Minnesota science fair. The project, InSciEd Out, introduced a new curriculum that incorporates zebrafish research into the classroom, with positive outcomes for grades six to eight.
A Mayo Clinic research team has pinpointed the function of the MMSET gene, revealing how it enables disease-causing mutations to occur. Normally-functioning MMSET plays a restorative role within the genome, but when impaired, cells lose the correct response to DNA damage.
A new study published in Mayo Clinic Proceedings found that shingles recurrences are more common than previously thought, occurring in over 5% of patients within eight years. Patients experiencing prolonged pain after the initial episode were more likely to face a recurrence.
A study by Mayo Clinic researchers identifies LRP1, a lipoprotein receptor, as a co-receptor with the leptin receptor that regulates appetite and metabolism. Mice engineered to lack LRP1 gained weight and became obese, indicating its critical role in lipid metabolism and energy balance.
Researchers at Mayo Clinic describe the crucial initial steps of measles virus attachment to host cells, revealing a complex dance-like movement. The findings provide insight into the disease mechanism, which could lead to new therapeutic strategies.
Researchers estimate lifetime risk of rheumatoid arthritis for both sexes using data from the Rochester Epidemiology Project. The study finds that 8.4% of women and 5.1% of men will develop an inflammatory autoimmune disease in their lifetime.