A new study found a possible link between resistance to immunomodulator therapy and the presence of protein cereblon. Lowering cereblon levels allows IMiDs to work properly, suggesting that other mechanisms may play a role in drug resistance.
A study by Mayo Clinic researchers found that obese patients with HER2-positive breast cancer had poorer outcomes, larger tumors, and were more likely to have lymph node involvement compared to normal-weight patients. The study's lead author notes that excess body weight may affect treatment outcome for this subtype of breast cancer.
Researchers precisely measured protein levels in 1,400 tumor biopsies and found no correlation between HER3 protein levels and Herceptin treatment outcome. The study suggests that single biomarkers like HER3 are not predictive of benefit from Herceptin treatment.
Researchers at Mayo Clinic have found a combination of drugs that destroys 70% of chemotherapy-resistant ovarian cancer cells. The discovery highlights the role of molecule RhoB in tumor response and may help identify patients who benefit from this therapy.
A new collaborative study from the Mayo Clinic and Cleveland Clinic suggests that multiple sclerosis may progress from the outermost layers of the brain to its deep parts. The researchers found that the cortex is involved early in MS and may even be the initial target of disease.
Neuromyelitis optica (NMO) is an inflammatory autoimmune disease that damages optic nerves and spinal cord. Mayo Clinic researchers have identified critical steps leading to myelin destruction, which could lead to better diagnosis and treatment of the disease.
Mayo Clinic has been awarded a $1.25 million grant by the Centers for Disease Control and Prevention (CDC) to develop online medical education in Ethiopia.
A Mayo Clinic study found that stem cells delivered two to three weeks after a heart attack do not improve heart function. The research provides vital information for the field of cell therapy and cautions against seeking stem cell treatment outside the US.
A recent Mayo Clinic study found that smoke-free workplaces significantly reduced the incidence of heart attacks and sudden cardiac deaths in Olmsted County, Minn. residents. The study showed a 50% reduction in sudden cardiac death rates after a comprehensive smoke-free ordinance took effect.
A Mayo Clinic study found that dual-energy computed tomography (DECT) CT scans can accurately identify patients with gout, even in those who receive negative results from traditional joint fluid analysis. This non-invasive method is particularly helpful for diagnosing people who cannot undergo the standard test.
Women under 50 with rheumatoid arthritis are more likely to break bones than their counterparts, according to a Mayo Clinic study. Researchers found that even in younger patients, the condition increases fracture risk, particularly in women.
A Mayo Clinic study finds that dual-energy computed tomography (DECT) CT scans can accurately diagnose gout in patients who test negative for the condition. The scans are valuable for diagnosing people with joint fluid that cannot be obtained or fluid analysis comes back negative, especially during acute gout attacks.
Researchers at Mayo Clinic found that eliminating senescent cells can prevent or delay the onset of age-related disorders and disabilities. The study showed that lifelong elimination of these cells delayed age-related disorders such as cataracts and muscle loss, and slowed their progression in already established diseases.
Researchers found that the measles virus uses a protein called nectin-4 to infect and leave from the throat, making it highly contagious. This discovery may also help in fighting ovarian, breast, and lung cancers.
A Mayo Clinic study of 1,382 procedures found no increased risk of bleeding in patients taking anti-clotting drugs during removal of precancerous lesions. Bleeding was more common when procedures were performed on the esophagus and stomach, but not linked to medication use.
A Mayo Clinic study found a dramatic increase in GERD diagnoses despite a decrease in symptoms, suggesting physician bias. The study also revealed that patients reporting both GERD and functional dyspepsia symptoms were more likely to be diagnosed with GERD only.
The Mayo Clinic Facebook group provides a platform for patients to share their experiences and challenges with esophageal cancer. The group, led by Dr. Herbert Wolfsen, has become an invaluable resource for patients, caregivers, and medical professionals.
Mayo Clinic researchers have developed a new assessment index for microscopic colitis, allowing physicians to objectively score the condition's severity. The Microscopic Colitis Disease Activity Index provides a consistent way to assess symptoms beyond just diarrhea frequency.
Researchers at Mayo Clinic found that a two-hour focused training significantly increased the ability of physicians to detect precancerous polyps in the colon. The study suggests new educational methods could increase colorectal cancer detection rates and reduce cancer deaths.
The Mayo Clinic has developed a new tool kit, Action Signs, to help identify symptoms of mental health disorders in youth. The toolkit aims to improve diagnosis and care for up to 75% of youth with mental health disorders who are currently not identified or receiving necessary treatment.
A Mayo Clinic study finds that nine out of ten commercially available thyroid support supplements contain animal-derived hormones, posing a risk to users' health. The supplements can cause significant side effects, including increased heart rate and nervousness, if taken in excess.
A Mayo Clinic study suggests that patients taking the age-related macular degeneration drug ranibizumab may experience increased intraocular pressure, a potential risk factor for glaucoma. The research found that a subset of patients had higher-than-normal eye pressure, regardless of pre-existing risk factors.
A Mayo Clinic study of over 5,200 patients found no significant correlation between shockwave lithotripsy for kidney stones and the development of diabetes. Researchers controlled for age, gender, and obesity to rule out any potential link.
A Mayo Clinic study has found that a baseline PSA test in men aged 40-60 can predict the risk of subsequent and low-risk prostate cancer. The study, which followed over 600 men for prostate outcomes, showed that men with elevated PSA levels were more likely to undergo biopsies and be diagnosed with low-risk cancer.
Recent studies support the use of C-11 choline positron emission tomography/computerized tomography (PET/CT) scans as a staging and potentially therapeutic tool for prostate cancer. The studies found that PET/CT scans can accurately diagnose localized disease recurrence, allowing for targeted treatment options.
A Mayo Clinic study provides guidance for treating sudden cardiac arrest patients with therapeutic cooling, which slows metabolism and preserves cell health. The study found that both patient groups awoke within three days, supporting the use of hypothermia when indicated.
A team of researchers led by Gloria Petersen, Ph.D., will examine family preferences and produce a detailed analysis of legal and ethical issues surrounding the sharing of genetic research results with relatives. The five-year study aims to establish best practices for navigating this complex issue as bio banks archive genetic data.
A Mayo Clinic study recommends adding categories to more effectively identify and treat people with preclinical Alzheimer's disease, a long latent stage of the disease. The researchers suggest two additional sub-groups: Stage 0 (normal biomarkers and no cognitive impairment) and SNAP patients (with suspected non-AD pathophysiology).
A new study found that patients' worry about disease was modestly elevated one week after genetic testing, but returned to normal levels a year later. Genetic tests also caused people to worry more about unfamiliar diseases like Graves' disease over common ones like diabetes.
Researchers found that children exposed to general anesthesia and surgery before their second birthday were approximately three times as likely to develop speech and language problems compared to those who never underwent procedures. The study, published in Pediatrics, suggests that anesthesia exposure may affect brain development and ...
Researchers at Mayo Clinic identified mutations linked to immune response to the measles vaccine, which could enable physicians to prescribe appropriate doses and timing based on routine genetic screening blood tests. The study's findings also have implications for the development of more effective vaccines and personalized vaccination.
A recent study by Mayo Clinic researchers has found a genetic abnormality that is the most common cause of two neurodegenerative diseases: frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). The mutation, located in the C9ORF72 gene, was found in nearly 12% of familial FTD patients and over 22% of familial ALS patients.
Researchers create cats with intrinsic immunity to feline AIDS by inserting protective protein genes. The technique, called gamete-targeted lentiviral transgenesis, also makes the offspring glow green for tracking purposes.
Researchers identify EIF4G1 gene mutation that leads to death of brain cells, resulting in Parkinson's disease and related neurodegenerative disorders. The study offers insights into how the gene controls protein levels to cope with biological stress.
Researchers found aerobic exercise can preserve cognitive abilities and slow dementia progression. The study, published in Mayo Clinic Proceedings, suggests exercise should not be overlooked as a therapy against dementia.
A recent Mayo Clinic study found that 51.5% of US internal medicine residents reported burnout symptoms, with those owing over $200,000 in debt experiencing lower quality of life and test scores. The study also revealed a link between resident distress and lower-quality patient care.
Mayo Clinic researchers analyzed over 600 studies on simulation-based training, finding it consistently better than no instruction for various learners and clinical topics. Simulation allows for practice without harming patients, repeated training to become more proficient, and structured learning for effective learning outcomes.
Researchers found a genetic variation in the LRRK2 gene that reduces the risk of Parkinson's disease by nearly 20% in many populations. The study also identified different variants of the same gene that increase Parkinson's risk in Caucasians and Asians, providing evidence for multiple genetic risks contributing to the disease.
The reappearance of measles is linked to unfounded fears about a link between the measles shot and autism, says Dr. Gregory Poland. Despite over 20 studies finding no connection between MMR vaccine and autism, some parents have turned against childhood vaccination.
A new strain of bacteria infecting humans with ehrlichiosis has been found in Wisconsin and Minnesota, according to a study published in the New England Journal of Medicine. The discovery highlights the importance of testing for tick-borne diseases in these states.
Mayo Clinic researchers are investigating why knee osteoarthritis disproportionately affects women. The study will analyze human tissues discarded during knee replacement surgery for possible biological differences in pain fibers and hormone receptors between female and male patients.
Researchers at Mayo Clinic and University of Washington highlight the potential benefits of primary care physicians in establishing treatment plans for patients at risk for suicide. A simple question from a family doctor can be enough to start a person toward help and treatment.
Researchers at Mayo Clinic discovered a genetic mutation in VPS35 that causes Parkinson's disease, leading to protein buildup in the brain. This finding opens up new avenues for understanding and treating the complex disease.
Researchers have successfully reprogrammed adult body cells into iPS cells, which can be taken directly from each patient and genetically redirected to replace ailing cells. While iPS technology holds promise, it still faces challenges and is not yet ready for widespread use.
Mayo Clinic researchers are developing an artificial pancreas that will deliver insulin automatically and with individualized precision, reducing the need for daily insulin dosing and finger pricks. The system includes a blood sugar monitor, automatic insulin pump, activity monitors, and a central processing unit.
A genome-wide association study found three SNPs associated with PSP, suggesting they may contribute to disease susceptibility. These genes are involved in tau protein regulation and membrane recycling.
Mayo Clinic researchers have developed a human vaccine that uses viruses to stimulate the immune system to attack and cure prostate cancer in mice. The vaccine has shown promise in treating other aggressive cancers, such as lung, brain, and pancreatic cancer, with no apparent side effects.
A Mayo Clinic research team has demonstrated a promising alternative strategy for treating type 2 diabetes by blocking the breakdown of insulin. In mouse studies, these mice showed increased insulin levels, weight loss, and improved blood sugar control.
A Mayo Clinic study found that flaxseed does not significantly reduce hot flashes in breast cancer patients and postmenopausal women. The researchers suggest alternative uses for flaxseed, such as managing constipation.
A Mayo Clinic study has found that a mutant gene thought to accelerate tumor growth actually inhibits the spread of malignant cells, showing promise for novel cancer therapies. The PAX8/PPARγ fusion protein functions as a tumor suppressor by upregulating anti-tumor agents.