A recent study published in Mayo Clinic Proceedings found that robotic surgery offers a less invasive alternative to traditional treatments for oropharyngeal cancer, resulting in high survival rates and improved patient quality of life. The treatment preserved patients' ability to swallow and maintained excellent speech performance.
Mayo Clinic researchers have gained insights into the function of a histone chaperone called Rtt106 using NMR spectroscopy and X-ray crystallography. The study reveals two novel domains in Rtt106 that enable it to interact with modified histones, promoting proper chromatin assembly and disassembly.
Researchers found that mitochondrial dysfunction occurs early in Alzheimer's disease, before symptoms like memory loss appear. The study discovered altered mitochondrial movement, structure, and energy dynamics in the brain of genetically modified mice with familial Alzheimer's disease.
The Southeast Minnesota Beacon Community, led by Mayo Clinic, is showcasing its work on health information exchange (HIE) technology at the HiMSS Conference. The team has developed a system that enables the transfer of patient data between healthcare providers in real-time, improving continuity of care and reducing costs.
A Mayo Clinic study found no link between prediabetes and diabetic polyneuropathy, suggesting alternative explanations for nerve damage. The five-year study tested nearly 550 people and concluded that impaired glucose does not cause polyneuropathy at high frequency.
Hospitalizations for US underage drinkers are common, with an estimated 700,000 young people hospitalized in 2008. The majority were drunk upon arrival, and the average age of those with alcohol-related discharges was 18 years old.
A recent study conducted by Mayo Clinic researchers has found that young children who are exposed to anesthesia multiple times before the age of three have a higher risk of developing attention-deficit/hyperactivity disorder (ADHD). The study, which utilized data from the Rochester Epidemiology Project, found that children with two or ...
Researchers have developed a small device that measures blood oxygen levels and can be used to monitor hospitalized patients for recurrent strokes in real time. The device has shown statistically similar results to traditional CT perfusion scans, but may not be suitable for all patients.
More than 6 percent of Americans age 70 to 89 develop mild cognitive impairment (MCI) each year, with men and those with lower education levels more affected. MCI affects the stage between normal forgetfulness and dementia, such as Alzheimer's disease.
A new, investigational colorectal cancer screening test developed by Mayo Clinic and Exact Sciences Inc. has shown highly accurate results in detecting precancerous tumors and early-stage cancer, improving the chances of better outcomes for patients. The test is noninvasive, patient-friendly, and requires no bowel preparation or diet c...
Researchers found that regorafenib slowed tumor progression and lengthened patient lives by 29% compared to placebo. The median survival time increased from 5 months to 6.5 months, with a 23% reduced risk of cancer-related death.
Recent Mayo Clinic studies identify risk factors for rising liver cancer cases, including hepatitis C infection and fatty liver disease. The studies suggest that screening for hepatitis C could improve treatment and survival rates for affected populations.
Mayo Clinic researchers identified a gene responsible for hereditary diffuse leukoencephalopathy with spheroids (HDLS), a devastating brain disorder that leads to death between ages 40 and 60. The finding suggests HDLS may be more common than previously thought, allowing for genetic diagnosis without brain biopsy or autopsy.
A study of 778 patients found that obesity significantly increases the risk of cancer recurrence and death after esophageal cancer surgery. Patients with a body mass index of 30 or higher had only an 18% five-year survival rate, compared to 36% for those of normal weight.
Mayo Clinic researchers found that elective angioplasties performed without on-site cardiac surgery capabilities pose no increased risk for patient death or emergency bypass surgery. The study included thousands of patients and showed mortality rates were similar for centers with and without on-site surgery.
Researchers have developed an intracellular, sustained-release drug delivery system using nanoparticles called dendrimers, targeting neuroinflammation in the retina. The treatment protects vision by preventing injury to photoreceptors and reduces neuroinflammation, providing potential relief for millions of patients worldwide.
Researchers have developed a vaccine that successfully attacks breast cancer in mice, with implications for treating ovarian, colorectal and pancreatic cancer. The vaccine targets MUC1, a protein found on over 90% of human breast and pancreatic cancer cases.
A multicenter study found ruxolinitib significantly reduces symptoms of myelofibrosis, including pain and enlarged spleen, compared to placebo. The study also showed ruxolinitib is more effective than best available chemotherapies in reducing symptoms.
A new study found a possible link between resistance to immunomodulator therapy and the presence of protein cereblon. Lowering cereblon levels allows IMiDs to work properly, suggesting that other mechanisms may play a role in drug resistance.
A study by Mayo Clinic researchers found that obese patients with HER2-positive breast cancer had poorer outcomes, larger tumors, and were more likely to have lymph node involvement compared to normal-weight patients. The study's lead author notes that excess body weight may affect treatment outcome for this subtype of breast cancer.
Researchers precisely measured protein levels in 1,400 tumor biopsies and found no correlation between HER3 protein levels and Herceptin treatment outcome. The study suggests that single biomarkers like HER3 are not predictive of benefit from Herceptin treatment.
Researchers at Mayo Clinic have found a combination of drugs that destroys 70% of chemotherapy-resistant ovarian cancer cells. The discovery highlights the role of molecule RhoB in tumor response and may help identify patients who benefit from this therapy.
A new collaborative study from the Mayo Clinic and Cleveland Clinic suggests that multiple sclerosis may progress from the outermost layers of the brain to its deep parts. The researchers found that the cortex is involved early in MS and may even be the initial target of disease.
Neuromyelitis optica (NMO) is an inflammatory autoimmune disease that damages optic nerves and spinal cord. Mayo Clinic researchers have identified critical steps leading to myelin destruction, which could lead to better diagnosis and treatment of the disease.
Mayo Clinic has been awarded a $1.25 million grant by the Centers for Disease Control and Prevention (CDC) to develop online medical education in Ethiopia.
A Mayo Clinic study found that stem cells delivered two to three weeks after a heart attack do not improve heart function. The research provides vital information for the field of cell therapy and cautions against seeking stem cell treatment outside the US.
A recent Mayo Clinic study found that smoke-free workplaces significantly reduced the incidence of heart attacks and sudden cardiac deaths in Olmsted County, Minn. residents. The study showed a 50% reduction in sudden cardiac death rates after a comprehensive smoke-free ordinance took effect.
A Mayo Clinic study found that dual-energy computed tomography (DECT) CT scans can accurately identify patients with gout, even in those who receive negative results from traditional joint fluid analysis. This non-invasive method is particularly helpful for diagnosing people who cannot undergo the standard test.
Women under 50 with rheumatoid arthritis are more likely to break bones than their counterparts, according to a Mayo Clinic study. Researchers found that even in younger patients, the condition increases fracture risk, particularly in women.
A Mayo Clinic study finds that dual-energy computed tomography (DECT) CT scans can accurately diagnose gout in patients who test negative for the condition. The scans are valuable for diagnosing people with joint fluid that cannot be obtained or fluid analysis comes back negative, especially during acute gout attacks.
Researchers at Mayo Clinic found that eliminating senescent cells can prevent or delay the onset of age-related disorders and disabilities. The study showed that lifelong elimination of these cells delayed age-related disorders such as cataracts and muscle loss, and slowed their progression in already established diseases.
Researchers found that the measles virus uses a protein called nectin-4 to infect and leave from the throat, making it highly contagious. This discovery may also help in fighting ovarian, breast, and lung cancers.
A Mayo Clinic study of 1,382 procedures found no increased risk of bleeding in patients taking anti-clotting drugs during removal of precancerous lesions. Bleeding was more common when procedures were performed on the esophagus and stomach, but not linked to medication use.
A Mayo Clinic study found a dramatic increase in GERD diagnoses despite a decrease in symptoms, suggesting physician bias. The study also revealed that patients reporting both GERD and functional dyspepsia symptoms were more likely to be diagnosed with GERD only.
The Mayo Clinic Facebook group provides a platform for patients to share their experiences and challenges with esophageal cancer. The group, led by Dr. Herbert Wolfsen, has become an invaluable resource for patients, caregivers, and medical professionals.
Mayo Clinic researchers have developed a new assessment index for microscopic colitis, allowing physicians to objectively score the condition's severity. The Microscopic Colitis Disease Activity Index provides a consistent way to assess symptoms beyond just diarrhea frequency.
Researchers at Mayo Clinic found that a two-hour focused training significantly increased the ability of physicians to detect precancerous polyps in the colon. The study suggests new educational methods could increase colorectal cancer detection rates and reduce cancer deaths.
The Mayo Clinic has developed a new tool kit, Action Signs, to help identify symptoms of mental health disorders in youth. The toolkit aims to improve diagnosis and care for up to 75% of youth with mental health disorders who are currently not identified or receiving necessary treatment.
A Mayo Clinic study finds that nine out of ten commercially available thyroid support supplements contain animal-derived hormones, posing a risk to users' health. The supplements can cause significant side effects, including increased heart rate and nervousness, if taken in excess.
A Mayo Clinic study suggests that patients taking the age-related macular degeneration drug ranibizumab may experience increased intraocular pressure, a potential risk factor for glaucoma. The research found that a subset of patients had higher-than-normal eye pressure, regardless of pre-existing risk factors.
A Mayo Clinic study of over 5,200 patients found no significant correlation between shockwave lithotripsy for kidney stones and the development of diabetes. Researchers controlled for age, gender, and obesity to rule out any potential link.
A Mayo Clinic study has found that a baseline PSA test in men aged 40-60 can predict the risk of subsequent and low-risk prostate cancer. The study, which followed over 600 men for prostate outcomes, showed that men with elevated PSA levels were more likely to undergo biopsies and be diagnosed with low-risk cancer.
Recent studies support the use of C-11 choline positron emission tomography/computerized tomography (PET/CT) scans as a staging and potentially therapeutic tool for prostate cancer. The studies found that PET/CT scans can accurately diagnose localized disease recurrence, allowing for targeted treatment options.
A Mayo Clinic study provides guidance for treating sudden cardiac arrest patients with therapeutic cooling, which slows metabolism and preserves cell health. The study found that both patient groups awoke within three days, supporting the use of hypothermia when indicated.
A team of researchers led by Gloria Petersen, Ph.D., will examine family preferences and produce a detailed analysis of legal and ethical issues surrounding the sharing of genetic research results with relatives. The five-year study aims to establish best practices for navigating this complex issue as bio banks archive genetic data.
A Mayo Clinic study recommends adding categories to more effectively identify and treat people with preclinical Alzheimer's disease, a long latent stage of the disease. The researchers suggest two additional sub-groups: Stage 0 (normal biomarkers and no cognitive impairment) and SNAP patients (with suspected non-AD pathophysiology).
A new study found that patients' worry about disease was modestly elevated one week after genetic testing, but returned to normal levels a year later. Genetic tests also caused people to worry more about unfamiliar diseases like Graves' disease over common ones like diabetes.
Researchers found that children exposed to general anesthesia and surgery before their second birthday were approximately three times as likely to develop speech and language problems compared to those who never underwent procedures. The study, published in Pediatrics, suggests that anesthesia exposure may affect brain development and ...
Researchers at Mayo Clinic identified mutations linked to immune response to the measles vaccine, which could enable physicians to prescribe appropriate doses and timing based on routine genetic screening blood tests. The study's findings also have implications for the development of more effective vaccines and personalized vaccination.
A recent study by Mayo Clinic researchers has found a genetic abnormality that is the most common cause of two neurodegenerative diseases: frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). The mutation, located in the C9ORF72 gene, was found in nearly 12% of familial FTD patients and over 22% of familial ALS patients.