Researchers identified an immune system deficiency that shows a fourfold higher likelihood of death. High levels of free light chains are associated with increased rates of death from cancer, diabetes, and cardiac respiratory disease.
The guidelines aim to improve diagnosis and treatment of childhood aggression, avoiding inappropriate medication use. They recommend a team-based approach, using proven psychological therapies before prescribing antipsychotic or mood stabilizer medications.
Mayo Clinic researchers present studies on adjuvant hormonal therapy for prostate cancer patients, finding no negative impact on overall survival. They also release results of a study on safe intervals for PSA screening in young men.
Researchers at Mayo Clinic have developed a minimally invasive technique to detect pancreatic cancer in the nearby small intestine using a light probe. The study found that this technology can detect all 10 pancreatic cancers tested, with high accuracy rates and potential for early detection without invasive procedures.
Rheumatoid arthritis patients face a higher risk of early death and cardiovascular disease due to inflammation. Conventional predictors of risk are inadequate for estimating this risk, emphasizing the need for more accurate tools to assess heart disease danger in these patients.
A Mayo Clinic study found a significant increase in C. diff infections in children between 2004 and 2009, with 75% of cases acquired in the community. The study also highlights the importance of prevention measures to reduce the spread of this environmental infection.
A nurse practitioner-driven consultation improved cancer patients' emotional health and quality of life, with a significant improvement in those who received the intervention. The study suggests that incorporating palliative care discussions into oncology practices can lead to better patient outcomes.
Researchers identify DNA methylation profiles as potential biomarkers for detecting prostate cancer months earlier than current methods. The discovery also predicts recurrence risk and identifies genes that can be targeted with new drugs.
A Mayo Clinic study has found that exhaustion affects immune cells fighting cancer, rendering them less effective. The research suggests a new approach to lymphoma and other cancers by dampening cell-signaling molecules like IL-12.
Researchers have identified a genetic factor called a trinucleotide repeat as a strong predictor of Fuchs' dystrophy. The study found that unusually long segments of repeated DNA nucleotides in the TCF4 gene cause havoc, impacting the coding of the protein.
Industry experts agree on ten recommendations to improve reporting of clinical research studies, including addressing clinically important questions and transparent disclosure of results. The consensus paper aims to enhance the credibility of medical research publications by promoting standardization and transparency.
A Mayo Clinic study of 926 people aged 70-93 found that combining mentally stimulating activities like computer use with moderate exercise decreases the risk of memory loss. The study suggests a synergistic interaction between computer activities and exercise in protecting brain function, particularly for those over 70.
A study published in Brain Pathology has found that halting the Kallikrein 6 enzyme can slow multiple sclerosis progression in mice. The researchers discovered an antibody that neutralizes the enzyme, which was shown to reduce inflammatory white blood cells and slow demyelination.
A Mayo Clinic study of 813 adults with rheumatoid arthritis found that obesity accounted for 52% of the increase in cases among women from 1985-2007. The study suggests a potential link between excess weight and autoimmune diseases like rheumatoid arthritis.
Researchers at Mayo Clinic have identified a single gene, MMP-10, that promotes the development and spread of lung cancer. This discovery suggests that targeting this gene may be an effective way to treat non-small cell lung cancer.
A Mayo Clinic expert and pediatrician refute three immunity-related misconceptions about vaccines, citing a recent review of 1,200 articles that found no autoimmune side effects. The experts also emphasize the risk of illness and death from under-vaccination, including whooping cough and measles.
A Mayo Clinic study found that therapeutic hypothermia, also known as body cooling, has reduced in-hospital deaths among sudden cardiac arrest patients. The research analyzed over 1 million patients and found mortality rates dropped from 69.6% to 57.8% between 2001 and 2009.
Researchers at Mayo Clinic have discovered a new class of molecular mutation in various forms of breast cancer, which may shed light on the development and growth of different types of breast tumors. Fusion transcripts, the mutated forms of RNA, could provide a way to identify tumor subtypes and offer new strategies for treatment.
Researchers found carotid endarterectomy to be a safe, less expensive treatment option for certain patients at risk for stroke. Mayo Clinic neurosurgeons also present findings on intracranial dural arteriovenous fistulas and giant aneurysms using flow diversion.
A Mayo Clinic study identified two genes that are optimal targets for a new noninvasive colon cancer test, developed by Mayo Clinic and Exact Sciences Corporation. The test uses stool sample analysis to detect specific DNA changes associated with cancer development.
A Mayo Clinic study reveals that people with rheumatoid arthritis are at a higher risk of developing lower gastrointestinal issues, which can be life-threatening. Smoking, steroid use, and prior abdominal surgery increase the risk, emphasizing the need for new prevention and treatment strategies.
A Mayo Clinic study found that the dietary supplement gamma-linoleic acid can inhibit the growth of a subset of pancreatic cancer cells and selectively promote cancer cell death in mice. Combining GLA with chemotherapy drug gemcitabine significantly inhibited tumor growth.
A Mayo Clinic-led study has found that a combination of the novel drug TH-302 with standard drug gemcitabine delays cancer worsening in patients with advanced pancreatic cancer. The 2-drug combo showed a 5.6-month progression-free survival, significantly extending the average survival of six to seven months.
The incidence of melanoma has escalated, with a dramatic rise in women in their 20s and 30s. Researchers attribute this to increased use of indoor tanning beds and childhood sunburns, leading to higher lifetime risk of melanoma.
A study led by Mayo Clinic researchers found that bone marrow-derived stem cells improved ejection fraction, a measure of the left ventricle's pumping ability, by 2.7% in patients with chronic heart failure. The most significant improvements were seen in younger patients and those with enriched CD34+ and CD133+ type of stem cells.
Researchers at Mayo Clinic and University of Glasgow discovered fruit flies can develop kidney stones, which may hold the key to treating humans. They identified a gene that encodes a protein transporting oxalate into fly kidneys, reducing stone formation.
Researchers at Mayo Clinic have made significant breakthroughs in developing a new melanoma vaccine that uses a genetic combination of human DNA from melanoma cells and a cousin of the rabies virus. Early studies show a cure rate of 60% in mouse models with minimal side effects. The vaccine delivers a broad spectrum of genes derived fr...
A Mayo Clinic study found that people with rapid eye movement sleep behavior disorder are twice as likely to develop mild cognitive impairment or Parkinson's disease within four years. Researchers used the Mayo Sleep Questionnaire to diagnose probable RBD in neurologically normal individuals.
Researchers will study new methods to detect impending seizures using real-time EEG data, aiming to prevent seizures through fast-acting drug therapies. The goal is reliable seizure forecasting and timely intervention for both canine and human epilepsy.
Researchers at the Mayo Clinic have found that the blood pressure drug prazosin is an effective treatment for PTSD-related nightmares. The medication was shown to be well-tolerated and take effect rapidly, within days to weeks, in a systematic literature review of 12 prazosin studies.
Researchers at Mayo Clinic are conducting a study to investigate the potential of a novel snake-venom peptide, cenderitide, to reduce cardiac and renal injury following a heart attack. The therapy may help prevent deterioration of cardiac and renal function in treated patients.
A team of researchers from Mayo Clinic and the University of Tennessee Health Sciences Center identified the CIZ1 gene as the cause of adult-onset primary cervical dystonia. The discovery sheds light on a movement disorder that has long been difficult to explain, with symptoms including involuntary neck twisting and muscle pain.
A recent study published in Mayo Clinic Proceedings found that robotic surgery offers a less invasive alternative to traditional treatments for oropharyngeal cancer, resulting in high survival rates and improved patient quality of life. The treatment preserved patients' ability to swallow and maintained excellent speech performance.
Mayo Clinic researchers have gained insights into the function of a histone chaperone called Rtt106 using NMR spectroscopy and X-ray crystallography. The study reveals two novel domains in Rtt106 that enable it to interact with modified histones, promoting proper chromatin assembly and disassembly.
Researchers found that mitochondrial dysfunction occurs early in Alzheimer's disease, before symptoms like memory loss appear. The study discovered altered mitochondrial movement, structure, and energy dynamics in the brain of genetically modified mice with familial Alzheimer's disease.
The Southeast Minnesota Beacon Community, led by Mayo Clinic, is showcasing its work on health information exchange (HIE) technology at the HiMSS Conference. The team has developed a system that enables the transfer of patient data between healthcare providers in real-time, improving continuity of care and reducing costs.
A Mayo Clinic study found no link between prediabetes and diabetic polyneuropathy, suggesting alternative explanations for nerve damage. The five-year study tested nearly 550 people and concluded that impaired glucose does not cause polyneuropathy at high frequency.
Hospitalizations for US underage drinkers are common, with an estimated 700,000 young people hospitalized in 2008. The majority were drunk upon arrival, and the average age of those with alcohol-related discharges was 18 years old.
A recent study conducted by Mayo Clinic researchers has found that young children who are exposed to anesthesia multiple times before the age of three have a higher risk of developing attention-deficit/hyperactivity disorder (ADHD). The study, which utilized data from the Rochester Epidemiology Project, found that children with two or ...
Researchers have developed a small device that measures blood oxygen levels and can be used to monitor hospitalized patients for recurrent strokes in real time. The device has shown statistically similar results to traditional CT perfusion scans, but may not be suitable for all patients.
More than 6 percent of Americans age 70 to 89 develop mild cognitive impairment (MCI) each year, with men and those with lower education levels more affected. MCI affects the stage between normal forgetfulness and dementia, such as Alzheimer's disease.
A new, investigational colorectal cancer screening test developed by Mayo Clinic and Exact Sciences Inc. has shown highly accurate results in detecting precancerous tumors and early-stage cancer, improving the chances of better outcomes for patients. The test is noninvasive, patient-friendly, and requires no bowel preparation or diet c...
Researchers found that regorafenib slowed tumor progression and lengthened patient lives by 29% compared to placebo. The median survival time increased from 5 months to 6.5 months, with a 23% reduced risk of cancer-related death.
Recent Mayo Clinic studies identify risk factors for rising liver cancer cases, including hepatitis C infection and fatty liver disease. The studies suggest that screening for hepatitis C could improve treatment and survival rates for affected populations.
Mayo Clinic researchers identified a gene responsible for hereditary diffuse leukoencephalopathy with spheroids (HDLS), a devastating brain disorder that leads to death between ages 40 and 60. The finding suggests HDLS may be more common than previously thought, allowing for genetic diagnosis without brain biopsy or autopsy.
A study of 778 patients found that obesity significantly increases the risk of cancer recurrence and death after esophageal cancer surgery. Patients with a body mass index of 30 or higher had only an 18% five-year survival rate, compared to 36% for those of normal weight.
Mayo Clinic researchers found that elective angioplasties performed without on-site cardiac surgery capabilities pose no increased risk for patient death or emergency bypass surgery. The study included thousands of patients and showed mortality rates were similar for centers with and without on-site surgery.
Researchers have developed an intracellular, sustained-release drug delivery system using nanoparticles called dendrimers, targeting neuroinflammation in the retina. The treatment protects vision by preventing injury to photoreceptors and reduces neuroinflammation, providing potential relief for millions of patients worldwide.
Researchers have developed a vaccine that successfully attacks breast cancer in mice, with implications for treating ovarian, colorectal and pancreatic cancer. The vaccine targets MUC1, a protein found on over 90% of human breast and pancreatic cancer cases.
A multicenter study found ruxolinitib significantly reduces symptoms of myelofibrosis, including pain and enlarged spleen, compared to placebo. The study also showed ruxolinitib is more effective than best available chemotherapies in reducing symptoms.