The Mayo Clinic Health System is part of a national learning collaborative to improve health care in rural communities. The project aims to standardize operations and efficiencies across Montana's medical practices, leveraging research to solve the nation's health care problems.
A Mayo Clinic study found that many patients with long QT syndrome can safely participate in competitive sports, contradicting current strict guidelines. The study of 353 LQTS patients showed that only one patient experienced a life-threatening event while competing.
Researchers at the Mayo Clinic found that slow gait and short stride are associated with an increased risk of cognitive decline. The study measured over 1,300 participants and found significant declines in global cognition, memory, and executive function among those with lower cadence and velocity.
Researchers found SCAD occurs most frequently in men during extreme exertion and in women after childbirth, with a higher-than-expected rate of recurrence in females. Conservative therapies may be a better approach for some SCAD patients, while invasive procedures are associated with complications.
Researchers at Mayo Clinic have developed a novel system to monitor real-time chemical changes in the brain using fast scan cyclic voltammetry and wireless neurochemical sensing. This technology can help treat brain disorders by adjusting neurotransmitter levels, reducing symptoms such as tremors.
Researchers mapped brain activity in 892 cognitively normal individuals and found that Alzheimer's patients spend more time using certain roads and less time with others. This suggests that varying brain activity may reduce the risk of Alzheimer's disease, potentially through activities like exercise, education, and social connections.
Researchers at Mayo Clinic found that early-stage lung cancer cells use a biological process called epithelial-mesenchymal transition (EMT) to bypass growth controls and enable uncontrolled growth. This discovery offers new clues for a potential approach to treating lung and possibly other cancers as early as possible.
The YES Board reduces time required to translate data, enabling physicians to forecast patient needs and track progress. The system provides overall situational awareness, helping detect at-risk patients and forecasting patient needs.
Rheumatoid arthritis patients face significant challenges including disability, life expectancy drops, heart attack risk, and joint destruction. Mayo Clinic researchers offer guidance on diagnosis, treatment, and management to improve outcomes for patients.
Researchers at Mayo Clinic have successfully used aptamers to stimulate regeneration and repair of nerve coatings in mice with multiple sclerosis. The finding suggests new possible therapies for MS patients, providing hope for a potential cure or treatment.
Preventive mammography rates in women aged 40-49 have dropped nearly 6 percent nationwide since the USPSTF recommended against routine mammograms. The decline is consistent with public resistance to the guidelines change and a modest effect seen in the first year after publication.
Researchers at Mayo Clinic discovered an association between Olmesartan and severe gastrointestinal issues. Patients taking the medication exhibited symptoms similar to celiac disease, but without typical test results or response to gluten-free diets.
A molecule believed to suppress tumor growth is found to accelerate anaplastic thyroid cancer cell growth when active. Researchers discovered a potential therapeutic target by identifying a gene promoting growth in cancer cells.
Researchers found distinct differences in how muscle affects bone microstructure between men and women, with muscle mass linked to bone strength at specific locations. The study also identified a biomarker, IGFBP-2, that can help predict people at higher risk for falls and fractures.
Gut bacteria play a crucial role in regulating the immune system and preventing autoimmune diseases such as rheumatoid arthritis. Larger-than-normal populations of specific gut bacteria may trigger disease development, particularly in genetically predisposed individuals.
Researchers at Mayo Clinic identified altered gene expression levels in over 2,000 genes associated with neurodegenerative diseases. These genetic variants contribute to disease development and progression, providing potential targets for new therapies.
Researchers used echocardiograms to spot early heart disease in rheumatoid arthritis patients. The study found that the condition is often underestimated by traditional risk assessment tools.
A Mayo Clinic-led study found that high doses of American ginseng reduced cancer-related fatigue in patients more effectively than a placebo. The herb showed significant improvement in general exhaustion at eight weeks, with no apparent side effects.
Researchers identified an immune system deficiency that shows a fourfold higher likelihood of death. High levels of free light chains are associated with increased rates of death from cancer, diabetes, and cardiac respiratory disease.
The guidelines aim to improve diagnosis and treatment of childhood aggression, avoiding inappropriate medication use. They recommend a team-based approach, using proven psychological therapies before prescribing antipsychotic or mood stabilizer medications.
Mayo Clinic researchers present studies on adjuvant hormonal therapy for prostate cancer patients, finding no negative impact on overall survival. They also release results of a study on safe intervals for PSA screening in young men.
Researchers at Mayo Clinic have developed a minimally invasive technique to detect pancreatic cancer in the nearby small intestine using a light probe. The study found that this technology can detect all 10 pancreatic cancers tested, with high accuracy rates and potential for early detection without invasive procedures.
Rheumatoid arthritis patients face a higher risk of early death and cardiovascular disease due to inflammation. Conventional predictors of risk are inadequate for estimating this risk, emphasizing the need for more accurate tools to assess heart disease danger in these patients.
A Mayo Clinic study found a significant increase in C. diff infections in children between 2004 and 2009, with 75% of cases acquired in the community. The study also highlights the importance of prevention measures to reduce the spread of this environmental infection.
A nurse practitioner-driven consultation improved cancer patients' emotional health and quality of life, with a significant improvement in those who received the intervention. The study suggests that incorporating palliative care discussions into oncology practices can lead to better patient outcomes.
Researchers identify DNA methylation profiles as potential biomarkers for detecting prostate cancer months earlier than current methods. The discovery also predicts recurrence risk and identifies genes that can be targeted with new drugs.
A Mayo Clinic study has found that exhaustion affects immune cells fighting cancer, rendering them less effective. The research suggests a new approach to lymphoma and other cancers by dampening cell-signaling molecules like IL-12.
Researchers have identified a genetic factor called a trinucleotide repeat as a strong predictor of Fuchs' dystrophy. The study found that unusually long segments of repeated DNA nucleotides in the TCF4 gene cause havoc, impacting the coding of the protein.
Industry experts agree on ten recommendations to improve reporting of clinical research studies, including addressing clinically important questions and transparent disclosure of results. The consensus paper aims to enhance the credibility of medical research publications by promoting standardization and transparency.
A Mayo Clinic study of 926 people aged 70-93 found that combining mentally stimulating activities like computer use with moderate exercise decreases the risk of memory loss. The study suggests a synergistic interaction between computer activities and exercise in protecting brain function, particularly for those over 70.
A study published in Brain Pathology has found that halting the Kallikrein 6 enzyme can slow multiple sclerosis progression in mice. The researchers discovered an antibody that neutralizes the enzyme, which was shown to reduce inflammatory white blood cells and slow demyelination.
A Mayo Clinic study of 813 adults with rheumatoid arthritis found that obesity accounted for 52% of the increase in cases among women from 1985-2007. The study suggests a potential link between excess weight and autoimmune diseases like rheumatoid arthritis.
Researchers at Mayo Clinic have identified a single gene, MMP-10, that promotes the development and spread of lung cancer. This discovery suggests that targeting this gene may be an effective way to treat non-small cell lung cancer.
A Mayo Clinic expert and pediatrician refute three immunity-related misconceptions about vaccines, citing a recent review of 1,200 articles that found no autoimmune side effects. The experts also emphasize the risk of illness and death from under-vaccination, including whooping cough and measles.
A Mayo Clinic study found that therapeutic hypothermia, also known as body cooling, has reduced in-hospital deaths among sudden cardiac arrest patients. The research analyzed over 1 million patients and found mortality rates dropped from 69.6% to 57.8% between 2001 and 2009.
Researchers at Mayo Clinic have discovered a new class of molecular mutation in various forms of breast cancer, which may shed light on the development and growth of different types of breast tumors. Fusion transcripts, the mutated forms of RNA, could provide a way to identify tumor subtypes and offer new strategies for treatment.
Researchers found carotid endarterectomy to be a safe, less expensive treatment option for certain patients at risk for stroke. Mayo Clinic neurosurgeons also present findings on intracranial dural arteriovenous fistulas and giant aneurysms using flow diversion.
A Mayo Clinic study identified two genes that are optimal targets for a new noninvasive colon cancer test, developed by Mayo Clinic and Exact Sciences Corporation. The test uses stool sample analysis to detect specific DNA changes associated with cancer development.
A Mayo Clinic study reveals that people with rheumatoid arthritis are at a higher risk of developing lower gastrointestinal issues, which can be life-threatening. Smoking, steroid use, and prior abdominal surgery increase the risk, emphasizing the need for new prevention and treatment strategies.
A Mayo Clinic study found that the dietary supplement gamma-linoleic acid can inhibit the growth of a subset of pancreatic cancer cells and selectively promote cancer cell death in mice. Combining GLA with chemotherapy drug gemcitabine significantly inhibited tumor growth.
A Mayo Clinic-led study has found that a combination of the novel drug TH-302 with standard drug gemcitabine delays cancer worsening in patients with advanced pancreatic cancer. The 2-drug combo showed a 5.6-month progression-free survival, significantly extending the average survival of six to seven months.
The incidence of melanoma has escalated, with a dramatic rise in women in their 20s and 30s. Researchers attribute this to increased use of indoor tanning beds and childhood sunburns, leading to higher lifetime risk of melanoma.
A study led by Mayo Clinic researchers found that bone marrow-derived stem cells improved ejection fraction, a measure of the left ventricle's pumping ability, by 2.7% in patients with chronic heart failure. The most significant improvements were seen in younger patients and those with enriched CD34+ and CD133+ type of stem cells.
Researchers at Mayo Clinic and University of Glasgow discovered fruit flies can develop kidney stones, which may hold the key to treating humans. They identified a gene that encodes a protein transporting oxalate into fly kidneys, reducing stone formation.
Researchers at Mayo Clinic have made significant breakthroughs in developing a new melanoma vaccine that uses a genetic combination of human DNA from melanoma cells and a cousin of the rabies virus. Early studies show a cure rate of 60% in mouse models with minimal side effects. The vaccine delivers a broad spectrum of genes derived fr...
A Mayo Clinic study found that people with rapid eye movement sleep behavior disorder are twice as likely to develop mild cognitive impairment or Parkinson's disease within four years. Researchers used the Mayo Sleep Questionnaire to diagnose probable RBD in neurologically normal individuals.
Researchers will study new methods to detect impending seizures using real-time EEG data, aiming to prevent seizures through fast-acting drug therapies. The goal is reliable seizure forecasting and timely intervention for both canine and human epilepsy.
Researchers at the Mayo Clinic have found that the blood pressure drug prazosin is an effective treatment for PTSD-related nightmares. The medication was shown to be well-tolerated and take effect rapidly, within days to weeks, in a systematic literature review of 12 prazosin studies.
Researchers at Mayo Clinic are conducting a study to investigate the potential of a novel snake-venom peptide, cenderitide, to reduce cardiac and renal injury following a heart attack. The therapy may help prevent deterioration of cardiac and renal function in treated patients.
A team of researchers from Mayo Clinic and the University of Tennessee Health Sciences Center identified the CIZ1 gene as the cause of adult-onset primary cervical dystonia. The discovery sheds light on a movement disorder that has long been difficult to explain, with symptoms including involuntary neck twisting and muscle pain.