Researchers used next-generation sequencing to analyze DNA alterations in adjacent Gleason patterns of the same tumor. The study found that some aggressive prostate cancers have identical genetic markers, enabling better prediction of cancer progression and management.
Mayo Clinic researchers found that positively charged gold nanoparticles can be effective against ovarian cancer cells when their cellular stress is increased. This is achieved by inhibiting calcium uptake into the mitochondria, which helps to make the nanoparticles more effective in destroying cancer cells.
Researchers at Mayo Clinic discovered that patients with inflammatory bowel disease (IBD) are at a 37% increased risk of developing melanoma. IBD causes chronic inflammation in the intestines, which may contribute to this elevated cancer risk.
Researchers at Mayo Clinic have developed a promising method to distinguish between pancreatic cancer and chronic pancreatitis. A molecular marker obtained from pancreatic 'juices' can identify almost all cases of pancreatic cancer, with a detection rate of 75%.
A large group of U.S. patients with PSC and primary biliary cirrhosis showed an association between coffee consumption and reduced risk of PSC. The study suggests that PSC differs from primary biliary cirrhosis in terms of lifestyle factors, potentially offering new insights into disease causes and treatment.
A recent study by Mayo Clinic researchers found that scheduled imaging studies are ineffective in detecting the relapse of diffuse large B-cell lymphoma. Only a handful of patients without symptoms were identified through scans, highlighting the need for individualized care approaches.
Researchers identified genetic differences in 27 genes responsible for antigen interactions, inflammation, and gene pathways involved between high and low responders. The study provides insights into developing alternative vaccines for individuals who do not respond effectively to the standard rubella vaccine.
Researchers studied over 900 patients with dementia and found that receiving general anesthesia for procedures after age 45 is not a risk factor for developing dementia. The study's findings provide reassurance for elderly patients undergoing surgery.
Researchers at Mayo Clinic discover a protein that is overly active in every human sample of kidney cancer and find an experimental drug designed to block its activity significantly reduces tumor growth. Combining it with another drug improves effectiveness.
The Mayo Clinic has created an institution-wide electronic warning system to identify patients at risk of premature death due to prolonged QT intervals. The system alerts physicians when a patient's ECG shows an abnormal heart rhythm, and has been shown to reduce mortality rates by nearly four times.
Researchers discover adult progenitor cells are subject to cellular senescence, leading to age-related deterioration of skeletal muscle and fat tissue. The study suggests a potential therapeutic target for future treatments, particularly the tumor suppressor p53.
Mayo Clinic researchers found that genetic differences affect immunity to smallpox vaccine. The study identified new targets for developing personalized vaccines, potentially benefiting non-responders.
A new Mayo Clinic survey reveals that support for living and deceased organ donation is increasing. Eighty-four percent would consider donating a kidney to a close friend or family member, while 49% would donate to someone they've never met.
Researchers found that the APOE gene and ABCA7 gene were significant risk factors for late-onset Alzheimer's disease in African Americans. The study also suggests that these genes may be shared with Caucasians, but with different variants. Further studies are needed to understand the biologic implications of these findings.
A first-in-humans study demonstrates that cardiopoietic stem cell therapy can improve heart pumping function and fitness in heart failure patients. Patients in the treatment group experienced a significant improvement in ejection fraction, compared to those in the control group.
A study of 91 unexplained fetal deaths found genetic mutations associated with long QT syndrome, a heart condition that can cause sudden death. The discovery sheds light on a potential cause of stillbirths and highlights the need for further research.
A Mayo Clinic study found gene variations that can predict chemotherapy-induced peripheral neuropathy, a debilitating condition affecting 20-30% of cancer patients. The study implicates genes EPHA5, ARHGEF10, and PRX, enabling clinicians to individualize treatment and improve patient outcomes.
The new software tool, CANARY, uses data from existing CT images to match each pixel of the lung nodule to one of nine unique radiological exemplars. This classification method has an excellent correlation with microscopic analysis and may help address issues with current screening methods.
The new guidelines aim to personalize therapy for patients with multiple myeloma by separating them into three risk groups: high, intermediate, and low. This approach allows for more tailored treatment plans that balance benefits with short- and long-term toxicity, ultimately improving patient outcomes.
A Mayo Clinic survey found that 85% of physician spouses/partners are satisfied in their relationships, similar to married adults overall. Most work outside the home, with nearly 40% working full-time or more, despite their partners' high non-sleeping time spent at work.
Researchers at Mayo Clinic Cancer Center identified the HNF1B gene as a contributor to ovarian cancer susceptibility through large-scale analysis of over 16,000 women. Variations in this gene are associated with different ovarian cancer subtypes and DNA methylation patterns.
A study by Mayo Clinic researchers found that histamine 2 receptor antagonists increase the risk of Clostridium difficile infection in hospitalized patients, particularly those receiving antibiotics. The study highlights the need for judicious use of these drugs to reduce C. diff infection rates.
Researchers at Mayo Clinic Cancer Center have identified new DNA sequences linked to an increased risk of developing breast and ovarian cancers. The findings, published in three studies, will help improve risk models and support new prevention strategies for these diseases.
A Mayo Clinic study found that men with dementia with Lewy bodies are five times more likely to have rapid eye movement (REM) sleep behavior disorder, which can appear decades before a diagnosis. The study suggests that screening for this sleep disorder could improve diagnosis and treatment of dementia with Lewy bodies.
Researchers found that cognitively normal people with high amyloid levels are likelier to develop dementia. Mayo Clinic neurologists also developed a test to gauge concussion severity using autonomic reflex testing, and discovered heart attack victims who received therapeutic hypothermia are unlikely to suffer cognitive impairment.
Researchers at Mayo Clinic have developed a new test that measures involuntary changes in heart rate and blood pressure to identify the severity of concussions. The test, known as autonomic reflex testing, shows significant changes in those with concussion, providing a potential tool for diagnosing and monitoring recovery.
A recent study by Mayo Clinic found that over 2 in 5 parents are hesitant to vaccinate their teenage daughters against human papillomavirus (HPV) due to potential side effects. The vaccine is recommended for teens to prevent cervical cancer and genital cancers, with the majority of experts agreeing on its necessity.
Researchers have created a single-molecule test for detecting methylated DNA, eliminating the need for current processes like bisulfite conversion and polymerase chain reaction. This assay could be a valuable tool for differentiating methylated from non-methylated DNA in cancer research.
A commonly used erectile dysfunction drug, sildenafil, was found to be ineffective in treating patients with heart failure and preserved ejection fraction. The RELAX study, a multicenter trial of 216 patients, showed no benefit from the drug in improving maximum exercise ability or walking distance.
A study of over 800 children found that those who avoided scary situations had stable anxiety scores after a year and were more anxious later. The approach may enable identifying kids at risk for anxiety disorders, which cognitive behavior therapy can help address.
A Mayo Clinic study has found that electric cars do not interfere with implanted cardiac devices like pacemakers and defibrillators. The study tested a hybrid car's electromagnetic interference (EMI) on six positions in the vehicle, including driver and passenger seats, to determine if it posed a risk to patients with implantable devices.
A Mayo Clinic study found that participants who received financial incentives lost more weight and remained in the program longer than those without incentives. The results suggest that financial incentives can improve weight loss outcomes and adherence, potentially helping to address the growing obesity epidemic in the US.
Researchers at Mayo Clinic discovered the first dystonia gene linked to an African-American family, paving the way for improved diagnosis and treatment. The study identified a genetic abnormality that led to muscle spasms and abnormal posture in affected individuals.
Mayo Clinic researchers found that steroid use can reduce hospital stays by an average of 1.21 days for pneumonia patients who survived the illness. Vaccination remains the most powerful tool in infection prevention, and more study is needed on the routine use of steroids.
Researchers identified a possible treatment window for brain plaques linked to Alzheimer's disease, suggesting that medications may be effective in slowing plaque buildup for several years. The study found that the rate of plaque accumulation accelerates initially before plateauing at high levels.
A new device encircles the esophagus valve to control chronic acid reflux, easing symptoms in 92% of patients and allowing 87% to stop using acid-suppressing drugs. Installation is minimally invasive, taking one to two hours, and patients experience significant improvement with 94% satisfaction.
A Mayo Clinic study found that nicotine lozenges and tobacco-free snuff can significantly reduce smokeless tobacco use in users who have no intention of quitting. Approximately one-third of participants cut back by 75% and 12% quit completely after 26 weeks.
A six-session program addressing cognitive, physical, emotional, social and spiritual well-being significantly improved patients' quality-of-life measures. Despite the benefits for cancer patients, caregivers showed no improvement in quality-of-life measures during treatment.
A recent Mayo Clinic study found that using high-definition imaging tools during screening colonoscopies can increase adenoma detection rates by up to 25% in women and 41% in men. The study suggests that national benchmarks for detecting polyps may be too low, especially when using advanced technology.
Researchers discover pairing Avastin with dasatinib can stop lethal spread of aggressive brain cancer glioblastoma multiforme. The combination reduces tumor growth and blocks further spread by inhibiting protein migration.
Researchers found that IQGAP1, a molecule controlling cell shape and movement, can suppress the growth of liver tumors when active in surrounding cells. The study provides new insight into cancer metastasis and points to potential therapeutic targets for preventing or treating liver metastases.
A Mayo Clinic study found that blood's tendency to clot may contribute to areas of brain damage called white matter hyperintensities, which can lead to memory problems and increased stroke risk. Women with higher levels of thrombogenic microvesicles were more likely to develop these changes.
Researchers at Mayo Clinic discovered an abnormal protein C9RANT that accumulates in the brains of patients with ALS and frontotemporal dementia. The findings provide a potentially new therapeutic target and biomarker to confirm diagnosis of these diseases.
A Mayo Clinic-led study has identified two biomarkers, IGFBP-7 and TIMP-2, that can detect acute kidney injury in urine, allowing for early intervention and improved patient outcomes. The study's findings have the potential to revolutionize the diagnosis and management of this deadly condition.
Researchers at Mayo Clinic find that cardiac disease is associated with increased risk of mild cognitive impairment, particularly among women. The study suggests that preventing and managing cardiac disease may help reduce the risk of non-Alzheimer's dementias.
The new book, Navigating Life with a Brain Tumor, offers comprehensive guidance on managing brain tumors, including treatment options, side effects, and coping strategies. Written by neuro-oncologists from Mayo Clinic and Tufts Medical Center, the book aims to empower patients to be active participants in their care.
Newborns require gentle and careful skin care to prevent infection and irritation. The Mayo Clinic suggests bathing every other day, using warm water only a few inches deep, and selecting mild cleansers without dyes or fragrances.
Researchers at Mayo Clinic identified an association between the naturally occurring enzyme Kallikrein 6 and malignant brain tumors. Higher levels of KLK6 were associated with shorter patient survival rates, but blocking its receptors made tumor cells more susceptible to treatment.
A Mayo Clinic study found that skin issues and joint disorders are the most common reasons people visit their healthcare providers. The research team tracked over 140,000 residents who visited Mayo Clinic between 2005 and 2009 and discovered that these conditions affected both genders and all age groups.
Researchers at Mayo Clinic have discovered that testing a portion of the saliva gland may diagnose Parkinson's disease more accurately. The study found abnormal proteins associated with the disease in nine out of 11 patients, offering hope for improved diagnosis and treatment.