The new guidelines aim to personalize therapy for patients with multiple myeloma by separating them into three risk groups: high, intermediate, and low. This approach allows for more tailored treatment plans that balance benefits with short- and long-term toxicity, ultimately improving patient outcomes.
A Mayo Clinic survey found that 85% of physician spouses/partners are satisfied in their relationships, similar to married adults overall. Most work outside the home, with nearly 40% working full-time or more, despite their partners' high non-sleeping time spent at work.
Researchers at Mayo Clinic Cancer Center identified the HNF1B gene as a contributor to ovarian cancer susceptibility through large-scale analysis of over 16,000 women. Variations in this gene are associated with different ovarian cancer subtypes and DNA methylation patterns.
A study by Mayo Clinic researchers found that histamine 2 receptor antagonists increase the risk of Clostridium difficile infection in hospitalized patients, particularly those receiving antibiotics. The study highlights the need for judicious use of these drugs to reduce C. diff infection rates.
Researchers at Mayo Clinic Cancer Center have identified new DNA sequences linked to an increased risk of developing breast and ovarian cancers. The findings, published in three studies, will help improve risk models and support new prevention strategies for these diseases.
A Mayo Clinic study found that men with dementia with Lewy bodies are five times more likely to have rapid eye movement (REM) sleep behavior disorder, which can appear decades before a diagnosis. The study suggests that screening for this sleep disorder could improve diagnosis and treatment of dementia with Lewy bodies.
Researchers found that cognitively normal people with high amyloid levels are likelier to develop dementia. Mayo Clinic neurologists also developed a test to gauge concussion severity using autonomic reflex testing, and discovered heart attack victims who received therapeutic hypothermia are unlikely to suffer cognitive impairment.
Researchers at Mayo Clinic have developed a new test that measures involuntary changes in heart rate and blood pressure to identify the severity of concussions. The test, known as autonomic reflex testing, shows significant changes in those with concussion, providing a potential tool for diagnosing and monitoring recovery.
A recent study by Mayo Clinic found that over 2 in 5 parents are hesitant to vaccinate their teenage daughters against human papillomavirus (HPV) due to potential side effects. The vaccine is recommended for teens to prevent cervical cancer and genital cancers, with the majority of experts agreeing on its necessity.
Researchers have created a single-molecule test for detecting methylated DNA, eliminating the need for current processes like bisulfite conversion and polymerase chain reaction. This assay could be a valuable tool for differentiating methylated from non-methylated DNA in cancer research.
A commonly used erectile dysfunction drug, sildenafil, was found to be ineffective in treating patients with heart failure and preserved ejection fraction. The RELAX study, a multicenter trial of 216 patients, showed no benefit from the drug in improving maximum exercise ability or walking distance.
A study of over 800 children found that those who avoided scary situations had stable anxiety scores after a year and were more anxious later. The approach may enable identifying kids at risk for anxiety disorders, which cognitive behavior therapy can help address.
A Mayo Clinic study has found that electric cars do not interfere with implanted cardiac devices like pacemakers and defibrillators. The study tested a hybrid car's electromagnetic interference (EMI) on six positions in the vehicle, including driver and passenger seats, to determine if it posed a risk to patients with implantable devices.
A Mayo Clinic study found that participants who received financial incentives lost more weight and remained in the program longer than those without incentives. The results suggest that financial incentives can improve weight loss outcomes and adherence, potentially helping to address the growing obesity epidemic in the US.
Researchers at Mayo Clinic discovered the first dystonia gene linked to an African-American family, paving the way for improved diagnosis and treatment. The study identified a genetic abnormality that led to muscle spasms and abnormal posture in affected individuals.
Mayo Clinic researchers found that steroid use can reduce hospital stays by an average of 1.21 days for pneumonia patients who survived the illness. Vaccination remains the most powerful tool in infection prevention, and more study is needed on the routine use of steroids.
Researchers identified a possible treatment window for brain plaques linked to Alzheimer's disease, suggesting that medications may be effective in slowing plaque buildup for several years. The study found that the rate of plaque accumulation accelerates initially before plateauing at high levels.
A new device encircles the esophagus valve to control chronic acid reflux, easing symptoms in 92% of patients and allowing 87% to stop using acid-suppressing drugs. Installation is minimally invasive, taking one to two hours, and patients experience significant improvement with 94% satisfaction.
A Mayo Clinic study found that nicotine lozenges and tobacco-free snuff can significantly reduce smokeless tobacco use in users who have no intention of quitting. Approximately one-third of participants cut back by 75% and 12% quit completely after 26 weeks.
A six-session program addressing cognitive, physical, emotional, social and spiritual well-being significantly improved patients' quality-of-life measures. Despite the benefits for cancer patients, caregivers showed no improvement in quality-of-life measures during treatment.
A recent Mayo Clinic study found that using high-definition imaging tools during screening colonoscopies can increase adenoma detection rates by up to 25% in women and 41% in men. The study suggests that national benchmarks for detecting polyps may be too low, especially when using advanced technology.
Researchers discover pairing Avastin with dasatinib can stop lethal spread of aggressive brain cancer glioblastoma multiforme. The combination reduces tumor growth and blocks further spread by inhibiting protein migration.
Researchers found that IQGAP1, a molecule controlling cell shape and movement, can suppress the growth of liver tumors when active in surrounding cells. The study provides new insight into cancer metastasis and points to potential therapeutic targets for preventing or treating liver metastases.
A Mayo Clinic study found that blood's tendency to clot may contribute to areas of brain damage called white matter hyperintensities, which can lead to memory problems and increased stroke risk. Women with higher levels of thrombogenic microvesicles were more likely to develop these changes.
Researchers at Mayo Clinic discovered an abnormal protein C9RANT that accumulates in the brains of patients with ALS and frontotemporal dementia. The findings provide a potentially new therapeutic target and biomarker to confirm diagnosis of these diseases.
A Mayo Clinic-led study has identified two biomarkers, IGFBP-7 and TIMP-2, that can detect acute kidney injury in urine, allowing for early intervention and improved patient outcomes. The study's findings have the potential to revolutionize the diagnosis and management of this deadly condition.
Researchers at Mayo Clinic find that cardiac disease is associated with increased risk of mild cognitive impairment, particularly among women. The study suggests that preventing and managing cardiac disease may help reduce the risk of non-Alzheimer's dementias.
The new book, Navigating Life with a Brain Tumor, offers comprehensive guidance on managing brain tumors, including treatment options, side effects, and coping strategies. Written by neuro-oncologists from Mayo Clinic and Tufts Medical Center, the book aims to empower patients to be active participants in their care.
Newborns require gentle and careful skin care to prevent infection and irritation. The Mayo Clinic suggests bathing every other day, using warm water only a few inches deep, and selecting mild cleansers without dyes or fragrances.
Researchers at Mayo Clinic identified an association between the naturally occurring enzyme Kallikrein 6 and malignant brain tumors. Higher levels of KLK6 were associated with shorter patient survival rates, but blocking its receptors made tumor cells more susceptible to treatment.
A Mayo Clinic study found that skin issues and joint disorders are the most common reasons people visit their healthcare providers. The research team tracked over 140,000 residents who visited Mayo Clinic between 2005 and 2009 and discovered that these conditions affected both genders and all age groups.
Researchers at Mayo Clinic have discovered that testing a portion of the saliva gland may diagnose Parkinson's disease more accurately. The study found abnormal proteins associated with the disease in nine out of 11 patients, offering hope for improved diagnosis and treatment.
A Mayo Clinic-led study found that a combination of pazopanib and paclitaxel slows anaplastic thyroid cancer (ATC) by 50% in animal models. Researchers also observed marked tumor shrinkage in a human patient with metastatic ATC.
A Mayo Clinic-developed two-hour training course increased adenoma detection rates among experienced endoscopists, lowering colorectal cancer risk. The study found that even non-academic physicians can benefit from the training.
Researchers at Mayo Clinic have identified a new molecular pathway that promotes accelerated growth of pancreatic tumors, and discovered ways to disable it. The findings suggest using the drug bortezomib as a potential strategy for treating pancreatic cancer.
A new study by researchers from the Mayo Clinic and Austrian Breast and Colorectal Cancer Study Group found that genetic differences in liver enzyme CYP2D6 play a key role in tamoxifen's effectiveness. Women with altered CYP2D6 enzyme activity had higher rates of breast cancer recurrence and death, while those with normal enzyme activi...
A new Mayo Clinic study suggests that many people, especially men, with fibromyalgia symptoms are going undiagnosed. Researchers estimate that 6.4% of adults in Olmsted County have fibromyalgia, yet only a small percentage receive an official diagnosis.
Researchers at Mayo Clinic have identified an enzyme specifically linked to aggressive prostate cancer, which promotes the metastatic spread of the disease. A compound that inhibits this enzyme's ability has been developed and shows promise for future clinical applications.
Researchers have decoded the entire pathway regulating blood vessel leakiness, a condition linked to disorders like heart disease and cancer. Several agents already being tested for other conditions may reverse vessel leakiness, offering new directions for clinical treatment.
A Mayo Clinic study found that high levels of BubR1 preserve genomic integrity and reduce age-related disease in mice. The research suggests controlling levels of this regulator could extend healthy life span.
A Mayo Clinic study found that long working hours in residency can lead to driver distraction, fatigue, and emotional distress. Nearly half of the surveyed residents reported incidents, with 11% being involved in actual traffic accidents.
The Rochester Epidemiology Project is a comprehensive medical records pool making Olmsted County, Minn., one of the few places to study virtually an entire geographic population. The project has supported over 2,000 studies, including findings on dementia, ADHD, and skin cancer.
Mayo Clinic researchers have identified a toxic cellular process by which a protein deficiency leads to dementia. The study found that elevated levels of defective sortilin mRNA disrupts mRNA splicing, resulting in the generation of a defective protein that deprives neurons of progranulin's protective effects.
A Mayo Clinic study discovered 27 genes associated with a good outcome using concurrent trastuzumab and chemotherapy, while five genes linked to poor outcomes. The findings aim to develop a genetic test to select the best treatment for HER2-positive patients.
A new study conducted by Mayo Clinic reveals that sentinel lymph node surgery can accurately identify residual breast cancer in lymph nodes after chemotherapy, with a success rate of 91%. The procedure removed only a few lymph nodes, reducing surgical complications, and found complete eradication of cancer in 40% of patients.
A Mayo Clinic-led study found that patients with ovarian cancer who took metformin for their diabetes had a better survival rate than those who did not take the medication. After five years, 67% of metformin-takers were still alive compared to 47% of non-takers.
Mayo Clinic received the Healthcare Internet Hall of Fame award for its pioneering work in patient education, including online offerings. The organization also won five eHealthcare Leadership Awards for its website, digital communications, and health information content.
Resolving conflicts over end-of-life care is crucial for patients and their loved ones. Mayo Clinic experts recommend choosing objective surrogates to represent patients and involving third parties when necessary.
Researchers have developed a novel test that measures proteins from nerve damage deposited in blood and spinal fluid to predict the rate of progression in ALS. The test shows promise in identifying patients at most risk for rapid progression, who may be offered new therapies being developed or tested.
A Mayo Clinic case study validates teleconcussion as a useful means to assess concussed patients in rural Arizona. The program uses telemedicine technology to bring concussion expertise to underserved areas, addressing the lack of access to neurological expertise in metropolitan areas.