A gene variant known as R47H in TREM2 nearly triples the risk of Alzheimer's disease, according to a global team including Mayo Clinic researchers. The study identified rare variants in TREM2 associated with an increased risk of Alzheimer's, with the R47H variant showing strong association with the disease.
A Mayo Clinic study finds that a primary treatment for wet macular degeneration is effective even in patients with macular traction problems. This breakthrough may help physicians not give up on treating such patients, and understand the need for more doses of medication.
Researchers found that rheumatoid arthritis patients are at higher risk for cancer, broken bones increase cardiovascular disease and death, and corticosteroids remain a common treatment despite newer options. Gut bacteria also holds promise as an anti-inflammatory treatment for autoimmune disorders.
Patients who make $35,000 a year or less show improved pain management and knee function after two years following knee replacement surgery. Contrary to expectations, lower-income patients exhibit better outcomes than wealthier peers.
A study by Mayo Clinic found that an oral rinse of antidepressant doxepin significantly eased pain associated with oral mucositis in patients receiving radiation therapy for cancers of the head and neck. The treatment was well-tolerated, with common side effects including stinging and burning sensations.
Mayo Clinic researchers have developed new tools to better treat ADHD patients in early stages, including a method to enhance parental and teacher input for more effective treatment. The tools also show promise in diagnosing and treating children with both ADHD and oppositional defiance disorder.
A Mayo Clinic study found that a gene linked to Alzheimer's, heart disease, and diabetes becomes less important to quality of life once people reach their 90s. Researchers discovered that good friends, a positive attitude, and social connectedness have a bigger impact on well-being than the gene in question.
A Mayo Clinic study found that people aged 70 and older who consume high amounts of carbohydrates have nearly four times the risk of developing mild cognitive impairment. In contrast, those with diets high in fat and protein relative to carbohydrates are less likely to experience cognitive decline.
A Mayo Clinic study found that only 21% of urologists and radiation oncologists recommended active surveillance for low-risk prostate cancer, while 47% preferred surgery and 32% chose radiation therapy. The study suggests that physicians' recommendations may be influenced by their area of expertise.
Researchers have identified a new therapy that appears to stop inflammation in the eye nerves and spinal cord for patients with neuromyelitis optica (NMO), a debilitating central nervous system disorder. The treatment, eculizumab, was given to patients with severe symptoms, resulting in 12 symptom-free periods and two mild attacks.
Transplant recipients and lymphoma patients are at higher risk of developing melanoma, which can be fatal if not detected early. They should be aware of their skin changes and consult a dermatologist regularly.
A Mayo Clinic study confirms the effectiveness of smartphone teleradiology applications in evaluating stroke patients in remote settings. The study shows high agreement (92-100%) among reviewers on critical radiological features, paving the way for telemedicine expansion.
Cancer drugs are administered sequentially or in combination, creating a virtual monopoly for each drug. Value-based pricing is a potential solution to address the high cost of cancer therapy.
Researchers at Mayo Clinic have developed a way to detect and eliminate potentially troublemaking stem cells, making stem cell therapy safer. The new approach uses a chemotherapeutic agent that selectively damages the DNA of the stem cells, efficiently killing the tumor-forming cells without affecting healthy ones.
A recent study by Mayo Clinic researchers found that men with high levels of 'cancer-specific anxiety' after prostate cancer surgery are more likely to experience low sexual satisfaction and depression. Counseling may be beneficial in addressing these concerns and improving quality of life for these patients.
Mayo Clinic researchers have developed an efficient editing toolkit for customizing zebrafish genomes, eliminating a bottleneck in biomedical research. This breakthrough enables targeted genetic modifications for studying human diseases, including modeling point mutations and regulating gene expression.
Researchers at Mayo Clinic discovered a new enzyme called BACE2 that destroys beta-amyloid, a toxic protein fragment associated with Alzheimer's disease. The discovery suggests that impairments in BACE2 may increase the risk of Alzheimer's disease and could lead to gene therapy as a potential treatment.
A Mayo Clinic psychiatrist proposes four steps to curb military suicide: gun locks, improved depression care, better sleep monitoring, and more. The expert emphasizes the need for ongoing resources to prevent, diagnose, and treat psychiatric illnesses among service members.
A Mayo-led study finds that pancreatic cancer develops from the interaction of KRAS mutations, inflammation, and epidermal growth factor receptor (EGFR), requiring multiple genetic factors for tumor formation. The study suggests that EGFR inhibitors may be effective in treating patients with chronic pancreatitis or normal p53 activity.
A Mayo Clinic study found that endovascular repair has a low rate of complications, even in high-risk patients. Researchers analyzed data from 1,008 consecutive patients and found a lower mortality rate than open-abdominal surgery when aneurysms ruptured.
A Mayo Clinic study developed an infection risk score for rheumatoid arthritis patients, using factors like age, corticosteroid use and inflammation levels. The score helps physicians identify high-risk patients and take measures to prevent infections.
Researchers at Mayo Clinic found that patients without a pancreas can control their blood sugar levels as effectively as type 1 diabetes patients using insulin replacement. The study's findings suggest that removing the entire pancreas is reasonably safe and effective for diabetes management.
A Mayo Clinic study found that exercise can reduce cancer recurrence by up to 50 percent in breast and colon cancer patients. However, many patients are reluctant to exercise due to lack of awareness about its benefits.
Research by Mayo Clinic found that individuals with a normal body mass index but central obesity have the highest risk of cardiovascular death and all-cause mortality. The distribution of body fat is crucial, even in those with normal weight, and waist-to-hip measurements can determine this.
A specific genetic variation found in people who carry a 'G' instead of an 'A' at a particular spot in their genetic code is associated with a six-fold higher risk of developing certain types of brain tumors. Researchers hope this discovery will lead to better surveillance and diagnosis.
Researchers at Mayo Clinic and University of California, San Francisco found that infantile hemangiomas, also known as 'strawberry' birthmarks, grow rapidly in infants between 5.5 and 7.5 weeks old. Early referral to dermatologists for further evaluation is recommended to prevent potential complications.
A Mayo Clinic physiologist argues that lack of exercise should be treated as a medical condition, rather than just a cause or symptom of other health problems. This approach could lead to the development of treatments and public health measures to promote physical activity and limit sedentary behavior.
A Mayo Clinic study reveals that mice exposed to low doses of a staph protein developed a lupus-like disease, with kidney damage and autoantibodies. The findings suggest that the protein may play a role in exacerbating lupus in genetically predisposed patients.
Off-label drug use is a widespread practice in medicine, with roughly 1 in 5 prescriptions filled for an off-label use. Patients may not be aware when their prescribed medications are being used off-label, as there is no requirement for physicians to disclose this information through informed consent.
Researchers at Mayo Clinic have completed the world's first genome-wide sequencing analysis of peripheral T-cell lymphomas, unlocking genetic secrets of this poorly understood and highly aggressive cancer. The study identifies 13 genomic abnormalities, including five related to production and behavior of the p53 protein.
A new approach to treating triple negative breast cancer and clear cell renal cell carcinoma has been discovered by researchers at Mayo Clinic. The approach involves activating a potent tumor suppressor gene called sFRP1, which is silenced in these cancers. Once activated, the laboratory tumor cells stopped growing and died.
A Mayo Clinic-led analysis found that approximately 1.8 million Americans suffer from undiagnosed celiac disease, while 1.6 million use a gluten-free diet without medical confirmation. The study highlights the need for increased awareness and testing to accurately diagnose and treat this common condition.
The Mayo Clinic Health System is part of a national learning collaborative to improve health care in rural communities. The project aims to standardize operations and efficiencies across Montana's medical practices, leveraging research to solve the nation's health care problems.
A Mayo Clinic study found that many patients with long QT syndrome can safely participate in competitive sports, contradicting current strict guidelines. The study of 353 LQTS patients showed that only one patient experienced a life-threatening event while competing.
Researchers at the Mayo Clinic found that slow gait and short stride are associated with an increased risk of cognitive decline. The study measured over 1,300 participants and found significant declines in global cognition, memory, and executive function among those with lower cadence and velocity.
Researchers found SCAD occurs most frequently in men during extreme exertion and in women after childbirth, with a higher-than-expected rate of recurrence in females. Conservative therapies may be a better approach for some SCAD patients, while invasive procedures are associated with complications.
Researchers at Mayo Clinic have developed a novel system to monitor real-time chemical changes in the brain using fast scan cyclic voltammetry and wireless neurochemical sensing. This technology can help treat brain disorders by adjusting neurotransmitter levels, reducing symptoms such as tremors.
Researchers mapped brain activity in 892 cognitively normal individuals and found that Alzheimer's patients spend more time using certain roads and less time with others. This suggests that varying brain activity may reduce the risk of Alzheimer's disease, potentially through activities like exercise, education, and social connections.
Researchers at Mayo Clinic found that early-stage lung cancer cells use a biological process called epithelial-mesenchymal transition (EMT) to bypass growth controls and enable uncontrolled growth. This discovery offers new clues for a potential approach to treating lung and possibly other cancers as early as possible.
The YES Board reduces time required to translate data, enabling physicians to forecast patient needs and track progress. The system provides overall situational awareness, helping detect at-risk patients and forecasting patient needs.
Rheumatoid arthritis patients face significant challenges including disability, life expectancy drops, heart attack risk, and joint destruction. Mayo Clinic researchers offer guidance on diagnosis, treatment, and management to improve outcomes for patients.
Researchers at Mayo Clinic have successfully used aptamers to stimulate regeneration and repair of nerve coatings in mice with multiple sclerosis. The finding suggests new possible therapies for MS patients, providing hope for a potential cure or treatment.
Preventive mammography rates in women aged 40-49 have dropped nearly 6 percent nationwide since the USPSTF recommended against routine mammograms. The decline is consistent with public resistance to the guidelines change and a modest effect seen in the first year after publication.
Researchers at Mayo Clinic discovered an association between Olmesartan and severe gastrointestinal issues. Patients taking the medication exhibited symptoms similar to celiac disease, but without typical test results or response to gluten-free diets.
A molecule believed to suppress tumor growth is found to accelerate anaplastic thyroid cancer cell growth when active. Researchers discovered a potential therapeutic target by identifying a gene promoting growth in cancer cells.
Researchers found distinct differences in how muscle affects bone microstructure between men and women, with muscle mass linked to bone strength at specific locations. The study also identified a biomarker, IGFBP-2, that can help predict people at higher risk for falls and fractures.
Gut bacteria play a crucial role in regulating the immune system and preventing autoimmune diseases such as rheumatoid arthritis. Larger-than-normal populations of specific gut bacteria may trigger disease development, particularly in genetically predisposed individuals.
Researchers at Mayo Clinic identified altered gene expression levels in over 2,000 genes associated with neurodegenerative diseases. These genetic variants contribute to disease development and progression, providing potential targets for new therapies.
Researchers used echocardiograms to spot early heart disease in rheumatoid arthritis patients. The study found that the condition is often underestimated by traditional risk assessment tools.
A Mayo Clinic-led study found that high doses of American ginseng reduced cancer-related fatigue in patients more effectively than a placebo. The herb showed significant improvement in general exhaustion at eight weeks, with no apparent side effects.