A Mayo Clinic-led study found that a combination of pazopanib and paclitaxel slows anaplastic thyroid cancer (ATC) by 50% in animal models. Researchers also observed marked tumor shrinkage in a human patient with metastatic ATC.
A Mayo Clinic-developed two-hour training course increased adenoma detection rates among experienced endoscopists, lowering colorectal cancer risk. The study found that even non-academic physicians can benefit from the training.
Researchers at Mayo Clinic have identified a new molecular pathway that promotes accelerated growth of pancreatic tumors, and discovered ways to disable it. The findings suggest using the drug bortezomib as a potential strategy for treating pancreatic cancer.
A new study by researchers from the Mayo Clinic and Austrian Breast and Colorectal Cancer Study Group found that genetic differences in liver enzyme CYP2D6 play a key role in tamoxifen's effectiveness. Women with altered CYP2D6 enzyme activity had higher rates of breast cancer recurrence and death, while those with normal enzyme activi...
A new Mayo Clinic study suggests that many people, especially men, with fibromyalgia symptoms are going undiagnosed. Researchers estimate that 6.4% of adults in Olmsted County have fibromyalgia, yet only a small percentage receive an official diagnosis.
Researchers at Mayo Clinic have identified an enzyme specifically linked to aggressive prostate cancer, which promotes the metastatic spread of the disease. A compound that inhibits this enzyme's ability has been developed and shows promise for future clinical applications.
Researchers have decoded the entire pathway regulating blood vessel leakiness, a condition linked to disorders like heart disease and cancer. Several agents already being tested for other conditions may reverse vessel leakiness, offering new directions for clinical treatment.
A Mayo Clinic study found that high levels of BubR1 preserve genomic integrity and reduce age-related disease in mice. The research suggests controlling levels of this regulator could extend healthy life span.
A Mayo Clinic study found that long working hours in residency can lead to driver distraction, fatigue, and emotional distress. Nearly half of the surveyed residents reported incidents, with 11% being involved in actual traffic accidents.
The Rochester Epidemiology Project is a comprehensive medical records pool making Olmsted County, Minn., one of the few places to study virtually an entire geographic population. The project has supported over 2,000 studies, including findings on dementia, ADHD, and skin cancer.
Mayo Clinic researchers have identified a toxic cellular process by which a protein deficiency leads to dementia. The study found that elevated levels of defective sortilin mRNA disrupts mRNA splicing, resulting in the generation of a defective protein that deprives neurons of progranulin's protective effects.
A Mayo Clinic study discovered 27 genes associated with a good outcome using concurrent trastuzumab and chemotherapy, while five genes linked to poor outcomes. The findings aim to develop a genetic test to select the best treatment for HER2-positive patients.
A new study conducted by Mayo Clinic reveals that sentinel lymph node surgery can accurately identify residual breast cancer in lymph nodes after chemotherapy, with a success rate of 91%. The procedure removed only a few lymph nodes, reducing surgical complications, and found complete eradication of cancer in 40% of patients.
A Mayo Clinic-led study found that patients with ovarian cancer who took metformin for their diabetes had a better survival rate than those who did not take the medication. After five years, 67% of metformin-takers were still alive compared to 47% of non-takers.
Mayo Clinic received the Healthcare Internet Hall of Fame award for its pioneering work in patient education, including online offerings. The organization also won five eHealthcare Leadership Awards for its website, digital communications, and health information content.
Resolving conflicts over end-of-life care is crucial for patients and their loved ones. Mayo Clinic experts recommend choosing objective surrogates to represent patients and involving third parties when necessary.
Researchers have developed a novel test that measures proteins from nerve damage deposited in blood and spinal fluid to predict the rate of progression in ALS. The test shows promise in identifying patients at most risk for rapid progression, who may be offered new therapies being developed or tested.
A Mayo Clinic case study validates teleconcussion as a useful means to assess concussed patients in rural Arizona. The program uses telemedicine technology to bring concussion expertise to underserved areas, addressing the lack of access to neurological expertise in metropolitan areas.
A gene variant known as R47H in TREM2 nearly triples the risk of Alzheimer's disease, according to a global team including Mayo Clinic researchers. The study identified rare variants in TREM2 associated with an increased risk of Alzheimer's, with the R47H variant showing strong association with the disease.
A Mayo Clinic study finds that a primary treatment for wet macular degeneration is effective even in patients with macular traction problems. This breakthrough may help physicians not give up on treating such patients, and understand the need for more doses of medication.
Researchers found that rheumatoid arthritis patients are at higher risk for cancer, broken bones increase cardiovascular disease and death, and corticosteroids remain a common treatment despite newer options. Gut bacteria also holds promise as an anti-inflammatory treatment for autoimmune disorders.
Patients who make $35,000 a year or less show improved pain management and knee function after two years following knee replacement surgery. Contrary to expectations, lower-income patients exhibit better outcomes than wealthier peers.
A study by Mayo Clinic found that an oral rinse of antidepressant doxepin significantly eased pain associated with oral mucositis in patients receiving radiation therapy for cancers of the head and neck. The treatment was well-tolerated, with common side effects including stinging and burning sensations.
Mayo Clinic researchers have developed new tools to better treat ADHD patients in early stages, including a method to enhance parental and teacher input for more effective treatment. The tools also show promise in diagnosing and treating children with both ADHD and oppositional defiance disorder.
A Mayo Clinic study found that a gene linked to Alzheimer's, heart disease, and diabetes becomes less important to quality of life once people reach their 90s. Researchers discovered that good friends, a positive attitude, and social connectedness have a bigger impact on well-being than the gene in question.
A Mayo Clinic study found that people aged 70 and older who consume high amounts of carbohydrates have nearly four times the risk of developing mild cognitive impairment. In contrast, those with diets high in fat and protein relative to carbohydrates are less likely to experience cognitive decline.
A Mayo Clinic study found that only 21% of urologists and radiation oncologists recommended active surveillance for low-risk prostate cancer, while 47% preferred surgery and 32% chose radiation therapy. The study suggests that physicians' recommendations may be influenced by their area of expertise.
Researchers have identified a new therapy that appears to stop inflammation in the eye nerves and spinal cord for patients with neuromyelitis optica (NMO), a debilitating central nervous system disorder. The treatment, eculizumab, was given to patients with severe symptoms, resulting in 12 symptom-free periods and two mild attacks.
Transplant recipients and lymphoma patients are at higher risk of developing melanoma, which can be fatal if not detected early. They should be aware of their skin changes and consult a dermatologist regularly.
A Mayo Clinic study confirms the effectiveness of smartphone teleradiology applications in evaluating stroke patients in remote settings. The study shows high agreement (92-100%) among reviewers on critical radiological features, paving the way for telemedicine expansion.
Cancer drugs are administered sequentially or in combination, creating a virtual monopoly for each drug. Value-based pricing is a potential solution to address the high cost of cancer therapy.
Researchers at Mayo Clinic have developed a way to detect and eliminate potentially troublemaking stem cells, making stem cell therapy safer. The new approach uses a chemotherapeutic agent that selectively damages the DNA of the stem cells, efficiently killing the tumor-forming cells without affecting healthy ones.
A recent study by Mayo Clinic researchers found that men with high levels of 'cancer-specific anxiety' after prostate cancer surgery are more likely to experience low sexual satisfaction and depression. Counseling may be beneficial in addressing these concerns and improving quality of life for these patients.
Mayo Clinic researchers have developed an efficient editing toolkit for customizing zebrafish genomes, eliminating a bottleneck in biomedical research. This breakthrough enables targeted genetic modifications for studying human diseases, including modeling point mutations and regulating gene expression.
Researchers at Mayo Clinic discovered a new enzyme called BACE2 that destroys beta-amyloid, a toxic protein fragment associated with Alzheimer's disease. The discovery suggests that impairments in BACE2 may increase the risk of Alzheimer's disease and could lead to gene therapy as a potential treatment.
A Mayo Clinic psychiatrist proposes four steps to curb military suicide: gun locks, improved depression care, better sleep monitoring, and more. The expert emphasizes the need for ongoing resources to prevent, diagnose, and treat psychiatric illnesses among service members.
A Mayo-led study finds that pancreatic cancer develops from the interaction of KRAS mutations, inflammation, and epidermal growth factor receptor (EGFR), requiring multiple genetic factors for tumor formation. The study suggests that EGFR inhibitors may be effective in treating patients with chronic pancreatitis or normal p53 activity.
A Mayo Clinic study found that endovascular repair has a low rate of complications, even in high-risk patients. Researchers analyzed data from 1,008 consecutive patients and found a lower mortality rate than open-abdominal surgery when aneurysms ruptured.
A Mayo Clinic study developed an infection risk score for rheumatoid arthritis patients, using factors like age, corticosteroid use and inflammation levels. The score helps physicians identify high-risk patients and take measures to prevent infections.
Researchers at Mayo Clinic found that patients without a pancreas can control their blood sugar levels as effectively as type 1 diabetes patients using insulin replacement. The study's findings suggest that removing the entire pancreas is reasonably safe and effective for diabetes management.
A Mayo Clinic study found that exercise can reduce cancer recurrence by up to 50 percent in breast and colon cancer patients. However, many patients are reluctant to exercise due to lack of awareness about its benefits.
Research by Mayo Clinic found that individuals with a normal body mass index but central obesity have the highest risk of cardiovascular death and all-cause mortality. The distribution of body fat is crucial, even in those with normal weight, and waist-to-hip measurements can determine this.
A specific genetic variation found in people who carry a 'G' instead of an 'A' at a particular spot in their genetic code is associated with a six-fold higher risk of developing certain types of brain tumors. Researchers hope this discovery will lead to better surveillance and diagnosis.
Researchers at Mayo Clinic and University of California, San Francisco found that infantile hemangiomas, also known as 'strawberry' birthmarks, grow rapidly in infants between 5.5 and 7.5 weeks old. Early referral to dermatologists for further evaluation is recommended to prevent potential complications.
A Mayo Clinic physiologist argues that lack of exercise should be treated as a medical condition, rather than just a cause or symptom of other health problems. This approach could lead to the development of treatments and public health measures to promote physical activity and limit sedentary behavior.
A Mayo Clinic study reveals that mice exposed to low doses of a staph protein developed a lupus-like disease, with kidney damage and autoantibodies. The findings suggest that the protein may play a role in exacerbating lupus in genetically predisposed patients.
Off-label drug use is a widespread practice in medicine, with roughly 1 in 5 prescriptions filled for an off-label use. Patients may not be aware when their prescribed medications are being used off-label, as there is no requirement for physicians to disclose this information through informed consent.
Researchers at Mayo Clinic have completed the world's first genome-wide sequencing analysis of peripheral T-cell lymphomas, unlocking genetic secrets of this poorly understood and highly aggressive cancer. The study identifies 13 genomic abnormalities, including five related to production and behavior of the p53 protein.
A new approach to treating triple negative breast cancer and clear cell renal cell carcinoma has been discovered by researchers at Mayo Clinic. The approach involves activating a potent tumor suppressor gene called sFRP1, which is silenced in these cancers. Once activated, the laboratory tumor cells stopped growing and died.
A Mayo Clinic-led analysis found that approximately 1.8 million Americans suffer from undiagnosed celiac disease, while 1.6 million use a gluten-free diet without medical confirmation. The study highlights the need for increased awareness and testing to accurately diagnose and treat this common condition.