A Mayo Clinic-led study found that a less-invasive procedure called sentinel lymph node surgery successfully identified whether cancer remained in lymph nodes in 91% of patients with node-positive breast cancer who received chemotherapy before their surgery. The procedure removed only a few lymph nodes, reducing surgical complications.
A Mayo Clinic study of 370 patients found that robotic mitral valve repair surgery had similar total hospital costs to conventional open-chest methods, but patients who underwent robotic repair recovered more rapidly and returned home earlier. The study also showed that systems innovations led to a significant decrease in costs over time.
Research shows that genetic factors and dietary choices interact to shape the microbiome in the host intestine. This combination determines the presence and activity of specific microbes, which can affect digestive health and increase the risk for conditions like Crohn's disease.
A Mayo-led study has found that sulfasalazine, a commonly prescribed medication for inflammatory bowel disease, fails to reduce diarrhea in patients receiving radiation therapy. The study suggests that the medication may actually increase the risk of diarrhea when used during pelvic radiation therapy.
The Sangre por Salud Biobank is a collaboration among Mayo Clinic, Mountain Park Health Center, and Arizona State University to support studies in obesity, metabolism and diabetes in the Latino population. The biobank aims to enroll 2,000 participants over four years, with a special emphasis on cardiometabolic risk and obesity.
Researchers have identified ASCL1 as a biomarker for aggressive adenocarcinomas in smokers' lungs. The protein is associated with increased expression of the RET oncogene, a key driver of cancer progression. Blocking ASCL1 may slow tumor growth and offer a promising target for potential drugs.
Mayo Clinic researchers have discovered a genetic mutation that alters lipid metabolism in Parkinson's patients, leading to higher levels of ceramides and glucosylceramides in the blood. This biomarker is associated with severe cognitive impairment and dementia in Parkinson's disease.
Obese teenagers who lose weight are at risk of developing eating disorders such as anorexia nervosa and bulimia nervosa. Early intervention is crucial for a good prognosis, but these adolescents often go undiagnosed due to positive provider perceptions of weight loss.
Researchers successfully resynchronized cardiac motion following a heart attack using engineered stem cells, preventing heart failure. The breakthrough introduces 'biological resynchronization' as a novel means to treat cardiac dyssynchrony.
Mayo Clinic researchers found that high-tech imaging technologies are leading to the overdiagnosis and overtreatment of low-risk papillary thyroid cancer. This is exposing patients to unnecessary treatments with potential complications such as nerve injury. The study calls for more research on care for these patients.
A Mayo Clinic study found that patients undergoing enhanced recovery pathway (ERP) for gynecologic surgery experienced decreased narcotic use, earlier discharge, and cost savings. The ERP standardized postoperative management to reduce complications and improve patient satisfaction.
Researchers at Mayo Clinic have discovered that decitabine can halt the ability of cancer cells to separate from a tumor and spread to distant organs. The study found that treating genes silenced in aggressive triple negative breast cancer with decitabine may promote re-expression of PRKD1.
A Mayo Clinic study found that patients with glioblastoma who died in 2010, after the FDA approved bevacizumab, lived significantly longer than those who died in 2008. The treatment strategy involving bevacizumab prolonged survival at a population level.
Patients with severe mitral valve regurgitation who undergo surgery early after diagnosis have improved long-term survival and lower risk of heart failure. Long-term survival rates were significantly higher for those who had surgery within three months of diagnosis compared to those who avoided surgery.
Pomalidomide shows promise in treating CNS lymphoma by improving survival and suppressing tumor growth. The clinical trial is now open at Mayo Clinic's three campuses.
Four research projects, including insulin gene therapy and a revolutionary sensor platform, will receive funding from the Minnesota Partnership for Biotechnology and Medical Genomics to develop new therapies for diabetes management and prevention. The selected researchers were awarded $2 million in total.
Researchers at Mayo Clinic have made a breakthrough discovery about the origin of inflammation-driven pancreatic cancer. They found that chronic inflammation in the pancreas can push acinar cells to transform into duct-like cells, which can then acquire mutations leading to further progression of pancreatic cancer. The study identified...
Researchers found that bipolar patients who binge eat are more likely to experience mental health issues such as suicidal thoughts, psychosis, anxiety disorders, and substance abuse. In contrast, obese bipolar patients without binge eating were more prone to serious physical problems like arthritis, diabetes, and heart disease.
A new study reveals that US physicians believe they have a responsibility to address healthcare costs, but their primary concern is always the well-being of their patients. Most (85%) agree that containing costs is their responsibility, while nearly 80% prioritize patients' best interests over cost concerns.
Researchers at Banner Sun Health Research Institute and Mayo Clinic are working together on a diagnostic test to identify early Parkinson's disease in patients. They believe that transcutaneous submandibular gland biopsy may provide the needed accuracy, as they look for a protein in the cells from patients with early Parkinson's disease.
A recent study by Mayo Clinic and others reveals that rural women with breast cancer are less likely to receive guideline-recommended radiation therapy after a lumpectomy. The researchers found that rural women were also more likely to choose mastectomy over lumpectomy, leading to potential gaps in care.
A recent study found that nearly 70 percent of Americans are on at least one prescription drug, with 20 percent taking five or more medications. The study highlights the prevalence of antidepressants and painkilling opioids in prescriptions, which may raise concerns about their addictive nature.
Researchers have developed a vaccine that provides at least 60 percent protection against rotavirus in newborns, significantly reducing severe dehydration and hospitalizations. The study, published in the Journal of Infectious Diseases, suggests that early administration of the vaccine could save thousands of lives annually.
A new study published in Cancer Discovery identified two genetic variations associated with breast cancer risk in women receiving preventive therapy. Women with favorable variations were more likely to respond to the therapy, while those with unfavorable variations had a five-fold increased risk of developing breast cancer.
A study of Peruvian physicians found that patient involvement in medical decision-making was rare, with an average score of 14.3 on a 100-point scale. This suggests that the patient-centered care model is overlooked in healthcare systems in Peru.
A recent study published in the Journal of the American College of Cardiology found that obstructive sleep apnea is associated with a significantly higher risk of sudden cardiac death. The study, which followed over 10,700 participants for an average of 5.3 years, revealed that people with sleep apnea were almost twice as likely to exp...
Researchers at Mayo Clinic found that patients with gout who initially experience pain in other joints, such as the knee or elbow, are at higher risk of future flare-ups. Additionally, chronic blood pressure variability and smoking are linked to increased cardiovascular risk in rheumatoid arthritis patients.
Physicians suggest sin taxes could reduce smoking, obesity, and excessive drinking by making unhealthy products more expensive. The potential revenue generated from these taxes could be used to subsidize healthcare for the uninsured and promote healthier lifestyles.
A Mayo Clinic study suggests that dimming smartphone brightness and holding devices at least 14 inches from the face can reduce light exposure's impact on melatonin levels, leading to better sleep. The research found that only high brightness settings posed a risk to sleep, while mid or low settings were safe.
A Mayo Clinic-led study found that 45% of US oncologists experienced at least one symptom of burnout, despite 83% being satisfied with their careers. The study also revealed differences in practice characteristics between academic and private practices.
Revascularization procedures have reduced the need for amputations in peripheral arterial disease patients by 40% over two decades, according to Mayo Clinic research. The study analyzed patients with leg pain and found that as use of revascularization rose, the amputation rate dropped.
Researchers analyzed cerebrospinal fluid and plasma samples from patients with no cognitive decline, mild cognitive impairment, and Alzheimer's disease. They detected significant changes in metabolic pathways related to mitochondrial function, validating blood as a reliable source for biomarker development.
Researchers used next-generation sequencing to analyze DNA alterations in adjacent Gleason patterns of the same tumor. The study found that some aggressive prostate cancers have identical genetic markers, enabling better prediction of cancer progression and management.
Mayo Clinic researchers found that positively charged gold nanoparticles can be effective against ovarian cancer cells when their cellular stress is increased. This is achieved by inhibiting calcium uptake into the mitochondria, which helps to make the nanoparticles more effective in destroying cancer cells.
Researchers at Mayo Clinic discovered that patients with inflammatory bowel disease (IBD) are at a 37% increased risk of developing melanoma. IBD causes chronic inflammation in the intestines, which may contribute to this elevated cancer risk.
Researchers at Mayo Clinic have developed a promising method to distinguish between pancreatic cancer and chronic pancreatitis. A molecular marker obtained from pancreatic 'juices' can identify almost all cases of pancreatic cancer, with a detection rate of 75%.
A large group of U.S. patients with PSC and primary biliary cirrhosis showed an association between coffee consumption and reduced risk of PSC. The study suggests that PSC differs from primary biliary cirrhosis in terms of lifestyle factors, potentially offering new insights into disease causes and treatment.
A recent study by Mayo Clinic researchers found that scheduled imaging studies are ineffective in detecting the relapse of diffuse large B-cell lymphoma. Only a handful of patients without symptoms were identified through scans, highlighting the need for individualized care approaches.
Researchers identified genetic differences in 27 genes responsible for antigen interactions, inflammation, and gene pathways involved between high and low responders. The study provides insights into developing alternative vaccines for individuals who do not respond effectively to the standard rubella vaccine.
Researchers studied over 900 patients with dementia and found that receiving general anesthesia for procedures after age 45 is not a risk factor for developing dementia. The study's findings provide reassurance for elderly patients undergoing surgery.
Researchers at Mayo Clinic discover a protein that is overly active in every human sample of kidney cancer and find an experimental drug designed to block its activity significantly reduces tumor growth. Combining it with another drug improves effectiveness.
The Mayo Clinic has created an institution-wide electronic warning system to identify patients at risk of premature death due to prolonged QT intervals. The system alerts physicians when a patient's ECG shows an abnormal heart rhythm, and has been shown to reduce mortality rates by nearly four times.
Researchers discover adult progenitor cells are subject to cellular senescence, leading to age-related deterioration of skeletal muscle and fat tissue. The study suggests a potential therapeutic target for future treatments, particularly the tumor suppressor p53.
Mayo Clinic researchers found that genetic differences affect immunity to smallpox vaccine. The study identified new targets for developing personalized vaccines, potentially benefiting non-responders.
A new Mayo Clinic survey reveals that support for living and deceased organ donation is increasing. Eighty-four percent would consider donating a kidney to a close friend or family member, while 49% would donate to someone they've never met.
Researchers found that the APOE gene and ABCA7 gene were significant risk factors for late-onset Alzheimer's disease in African Americans. The study also suggests that these genes may be shared with Caucasians, but with different variants. Further studies are needed to understand the biologic implications of these findings.
A first-in-humans study demonstrates that cardiopoietic stem cell therapy can improve heart pumping function and fitness in heart failure patients. Patients in the treatment group experienced a significant improvement in ejection fraction, compared to those in the control group.
A study of 91 unexplained fetal deaths found genetic mutations associated with long QT syndrome, a heart condition that can cause sudden death. The discovery sheds light on a potential cause of stillbirths and highlights the need for further research.
A Mayo Clinic study found gene variations that can predict chemotherapy-induced peripheral neuropathy, a debilitating condition affecting 20-30% of cancer patients. The study implicates genes EPHA5, ARHGEF10, and PRX, enabling clinicians to individualize treatment and improve patient outcomes.
The new software tool, CANARY, uses data from existing CT images to match each pixel of the lung nodule to one of nine unique radiological exemplars. This classification method has an excellent correlation with microscopic analysis and may help address issues with current screening methods.