A Mayo Clinic review article highlights the risks associated with elective early-term deliveries, including morbidity in newborns and maternal health concerns. The study calls for increased patient awareness and public education to promote safe term pregnancies.
A Mayo Clinic study found that endoxifen, an active metabolite of tamoxifen, is safe and shows anti-tumor activity in early-stage trials. The findings suggest a potential new treatment for estrogen-positive breast cancer patients who don't respond to standard hormonal therapies.
Researchers discovered imetelstat, a telomerase inhibitor, induces morphologic, molecular and clinical remissions in some patients with myelofibrosis. The study showed five patients achieved complete or partial remissions, including reversal of bone marrow fibrosis.
Mayo Clinic researchers found that improved mood is associated with increased participation in daily activities and independent living after brain injury rehabilitation. The study suggests a holistic approach to care can address both physical and personal problems, leading to better outcomes for patients.
A Mayo Clinic-led study has found that two commonly used drugs, low-dose dopamine and low-dose nesiritide, do not improve kidney function in hospitalized acute heart failure patients. The study analyzed data from 360 patients with kidney dysfunction and showed no significant improvement in urine volume or serum cystatin-C levels.
Researchers are exploring the role of innate immunity in Alzheimer's disease, hoping to identify novel therapies. By analyzing gene expression and RNA transcripts, they aim to understand the immune response's impact on the disease.
A Mayo Clinic study published in the Journal of Bone and Mineral Research found that patients with type 2 diabetes have lower bone material strength, highlighting the need for conventional measurements to be reevaluated. The research suggests potential detrimental effects of poor glucose control on bone quality.
Elderly patients who start dialysis after age 75 have a high mortality rate, with half dying within one year. Healthier elderly patients do better than those with declining health.
Researchers found that Cul4 modifies histone proteins to weaken their interaction with chaperones, leading to genomic instability and tumor formation. The study suggests that cancer cells may have evolved mechanisms to disrupt proper nucleosome assembly, affecting genome stability.
A minimally invasive endoscopic procedure to remove superficial, early stage esophageal cancer is as effective as surgery that takes out and rebuilds the esophagus, according to a Mayo Clinic study. The research found that patients treated by endoscopy had similar overall survival times compared to surgery.
Fibromyalgia symptoms worsen with age, according to a Mayo Clinic study. Young and middle-aged patients experience more severe physical health problems and lower quality of life compared to their older counterparts.
A new Mayo Clinic study finds that young and middle-aged fibromyalgia patients experience more severe symptoms and poorer quality of life compared to their older counterparts. The research also highlights the importance of considering age as a factor in understanding the disorder's impact on physical and mental health.
Mayo Clinic studies reveal that patients with rheumatoid arthritis are at increased risk of heart disease, with early menopause and a strong immune response to certain viruses being major contributors. The research also identifies specific biomarkers and blood test results that may indicate cardiovascular complications.
A recent Mayo Clinic survey found that uterine fibroids significantly impact the quality of life and workplace performance of women, with African-American women experiencing more severe symptoms and delayed diagnosis. The study highlights the need for better treatment options and increased awareness about this common public health issue.
Many parents believe the HPV vaccine is unnecessary or unsafe, which poses a barrier to its success. Experts argue that clinicians must engage with parents and address their concerns through open conversations and science-based information. Social media may also play a role in future HPV vaccination programs.
A Mayo Clinic psychiatrist argues that mass shootings are carefully planned and can be executed within a short time frame, making it difficult to restrict access to firearms for the mentally ill. The expert suggests that gun restriction among suicidal people works, but not necessarily in cases of mass shootings.
A Mayo Clinic study reveals that individuals with speech and language disorders are 3.5 times more likely to be teachers, highlighting an occupational hazard for educators. The researchers also found no such correlation between other occupations and the development of these disorders.
A Mayo Clinic study found that cataract surgery rates are rising across all age groups, with a significant increase among 70- and 80-year-olds. The demand is expected to continue, highlighting the need to manage costs and ensure access to treatment.
A Mayo Clinic-led study found that a less-invasive procedure called sentinel lymph node surgery successfully identified whether cancer remained in lymph nodes in 91% of patients with node-positive breast cancer who received chemotherapy before their surgery. The procedure removed only a few lymph nodes, reducing surgical complications.
A Mayo Clinic study of 370 patients found that robotic mitral valve repair surgery had similar total hospital costs to conventional open-chest methods, but patients who underwent robotic repair recovered more rapidly and returned home earlier. The study also showed that systems innovations led to a significant decrease in costs over time.
Research shows that genetic factors and dietary choices interact to shape the microbiome in the host intestine. This combination determines the presence and activity of specific microbes, which can affect digestive health and increase the risk for conditions like Crohn's disease.
A Mayo-led study has found that sulfasalazine, a commonly prescribed medication for inflammatory bowel disease, fails to reduce diarrhea in patients receiving radiation therapy. The study suggests that the medication may actually increase the risk of diarrhea when used during pelvic radiation therapy.
The Sangre por Salud Biobank is a collaboration among Mayo Clinic, Mountain Park Health Center, and Arizona State University to support studies in obesity, metabolism and diabetes in the Latino population. The biobank aims to enroll 2,000 participants over four years, with a special emphasis on cardiometabolic risk and obesity.
Researchers have identified ASCL1 as a biomarker for aggressive adenocarcinomas in smokers' lungs. The protein is associated with increased expression of the RET oncogene, a key driver of cancer progression. Blocking ASCL1 may slow tumor growth and offer a promising target for potential drugs.
Mayo Clinic researchers have discovered a genetic mutation that alters lipid metabolism in Parkinson's patients, leading to higher levels of ceramides and glucosylceramides in the blood. This biomarker is associated with severe cognitive impairment and dementia in Parkinson's disease.
Obese teenagers who lose weight are at risk of developing eating disorders such as anorexia nervosa and bulimia nervosa. Early intervention is crucial for a good prognosis, but these adolescents often go undiagnosed due to positive provider perceptions of weight loss.
Researchers successfully resynchronized cardiac motion following a heart attack using engineered stem cells, preventing heart failure. The breakthrough introduces 'biological resynchronization' as a novel means to treat cardiac dyssynchrony.
Mayo Clinic researchers found that high-tech imaging technologies are leading to the overdiagnosis and overtreatment of low-risk papillary thyroid cancer. This is exposing patients to unnecessary treatments with potential complications such as nerve injury. The study calls for more research on care for these patients.
A Mayo Clinic study found that patients undergoing enhanced recovery pathway (ERP) for gynecologic surgery experienced decreased narcotic use, earlier discharge, and cost savings. The ERP standardized postoperative management to reduce complications and improve patient satisfaction.
Researchers at Mayo Clinic have discovered that decitabine can halt the ability of cancer cells to separate from a tumor and spread to distant organs. The study found that treating genes silenced in aggressive triple negative breast cancer with decitabine may promote re-expression of PRKD1.
A Mayo Clinic study found that patients with glioblastoma who died in 2010, after the FDA approved bevacizumab, lived significantly longer than those who died in 2008. The treatment strategy involving bevacizumab prolonged survival at a population level.
Patients with severe mitral valve regurgitation who undergo surgery early after diagnosis have improved long-term survival and lower risk of heart failure. Long-term survival rates were significantly higher for those who had surgery within three months of diagnosis compared to those who avoided surgery.
Pomalidomide shows promise in treating CNS lymphoma by improving survival and suppressing tumor growth. The clinical trial is now open at Mayo Clinic's three campuses.
Four research projects, including insulin gene therapy and a revolutionary sensor platform, will receive funding from the Minnesota Partnership for Biotechnology and Medical Genomics to develop new therapies for diabetes management and prevention. The selected researchers were awarded $2 million in total.
Researchers at Mayo Clinic have made a breakthrough discovery about the origin of inflammation-driven pancreatic cancer. They found that chronic inflammation in the pancreas can push acinar cells to transform into duct-like cells, which can then acquire mutations leading to further progression of pancreatic cancer. The study identified...
Researchers found that bipolar patients who binge eat are more likely to experience mental health issues such as suicidal thoughts, psychosis, anxiety disorders, and substance abuse. In contrast, obese bipolar patients without binge eating were more prone to serious physical problems like arthritis, diabetes, and heart disease.
A new study reveals that US physicians believe they have a responsibility to address healthcare costs, but their primary concern is always the well-being of their patients. Most (85%) agree that containing costs is their responsibility, while nearly 80% prioritize patients' best interests over cost concerns.
Researchers at Banner Sun Health Research Institute and Mayo Clinic are working together on a diagnostic test to identify early Parkinson's disease in patients. They believe that transcutaneous submandibular gland biopsy may provide the needed accuracy, as they look for a protein in the cells from patients with early Parkinson's disease.
A recent study by Mayo Clinic and others reveals that rural women with breast cancer are less likely to receive guideline-recommended radiation therapy after a lumpectomy. The researchers found that rural women were also more likely to choose mastectomy over lumpectomy, leading to potential gaps in care.
A recent study found that nearly 70 percent of Americans are on at least one prescription drug, with 20 percent taking five or more medications. The study highlights the prevalence of antidepressants and painkilling opioids in prescriptions, which may raise concerns about their addictive nature.
Researchers have developed a vaccine that provides at least 60 percent protection against rotavirus in newborns, significantly reducing severe dehydration and hospitalizations. The study, published in the Journal of Infectious Diseases, suggests that early administration of the vaccine could save thousands of lives annually.
A new study published in Cancer Discovery identified two genetic variations associated with breast cancer risk in women receiving preventive therapy. Women with favorable variations were more likely to respond to the therapy, while those with unfavorable variations had a five-fold increased risk of developing breast cancer.
A study of Peruvian physicians found that patient involvement in medical decision-making was rare, with an average score of 14.3 on a 100-point scale. This suggests that the patient-centered care model is overlooked in healthcare systems in Peru.
A recent study published in the Journal of the American College of Cardiology found that obstructive sleep apnea is associated with a significantly higher risk of sudden cardiac death. The study, which followed over 10,700 participants for an average of 5.3 years, revealed that people with sleep apnea were almost twice as likely to exp...
Researchers at Mayo Clinic found that patients with gout who initially experience pain in other joints, such as the knee or elbow, are at higher risk of future flare-ups. Additionally, chronic blood pressure variability and smoking are linked to increased cardiovascular risk in rheumatoid arthritis patients.
Physicians suggest sin taxes could reduce smoking, obesity, and excessive drinking by making unhealthy products more expensive. The potential revenue generated from these taxes could be used to subsidize healthcare for the uninsured and promote healthier lifestyles.
A Mayo Clinic study suggests that dimming smartphone brightness and holding devices at least 14 inches from the face can reduce light exposure's impact on melatonin levels, leading to better sleep. The research found that only high brightness settings posed a risk to sleep, while mid or low settings were safe.
A Mayo Clinic-led study found that 45% of US oncologists experienced at least one symptom of burnout, despite 83% being satisfied with their careers. The study also revealed differences in practice characteristics between academic and private practices.
Revascularization procedures have reduced the need for amputations in peripheral arterial disease patients by 40% over two decades, according to Mayo Clinic research. The study analyzed patients with leg pain and found that as use of revascularization rose, the amputation rate dropped.
Researchers analyzed cerebrospinal fluid and plasma samples from patients with no cognitive decline, mild cognitive impairment, and Alzheimer's disease. They detected significant changes in metabolic pathways related to mitochondrial function, validating blood as a reliable source for biomarker development.