Researchers identified five familial cases of spontaneous coronary artery dissection (SCAD), a condition where a tear occurs inside an artery leading to a heart attack. The study suggests that SCAD may be inherited, with implications for at-risk family members and a better understanding of the condition.
Researchers at Mayo Clinic developed a new scoring system to identify individuals at high risk of developing dementia. The study found that variables such as age, diabetes, heart health risk factors, slow gate, depression, and anxiety disorders are key contributors to the risk score.
A study by Mayo Clinic Cancer Center reveals the average price of cancer drugs in the US has increased significantly over the years, affecting patient care. The authors recommend six potential solutions to control high drug costs, including allowing Medicare to negotiate prices and implementing value-based pricing.
Researchers identified patients who donated their body to medical research and had undergone multiple MRI exams. Brain tissue samples showed measurable quantities of gadolinium deposited in the brain tissue of exposed patients, but no specific symptoms or diseases were linked to this finding.
A study by Mayo Clinic researchers found that energy drinks increase resting blood pressure, particularly in caffeine-naive individuals, doubling their blood pressure compared to a placebo.
Researchers found significant increases in blood pressure during nighttime hours among participants exposed to prolonged periods of shortened sleep. The study, conducted at Mayo Clinic, used a controlled protocol to mimic the effects of sleep loss on the body.
A study of over 12,000 TAVR patients in the US found a one-year death rate of 23.7% and a stroke rate of 4.1%. The median age of patients was 84 years old, with 52% female.
Researchers at Mayo Clinic and collaborators have identified a new class of senolytic drugs that clearly reduce health problems in mice by targeting senescent cells. These treatments aim to limit the effects of aging and extend patient healthspan.
A study published in Pediatrics found that the rate of inhaled nitric oxide (iNO) utilization in American NICUs increased by 23% between 2009 and 2013, with nearly half of all iNO users being preterm neonates. This trend has significant economic implications, estimated to be $153 million in 2013.
A Mayo Clinic study found that US women's awareness of breast density varies significantly by race, ethnicity, household income, education level, and healthcare experiences. More than half of women reported having heard of breast density, but only 53% knew it was associated with cancer risk.
Research at Mayo Clinic found that a decline in smoking rates may lead to fewer people qualifying for early detection of lung cancer through low-dose CT scans. As smokers quit earlier, more patients are diagnosed at a later stage, increasing mortality.
Researchers at Mayo Clinic and the University of Oslo have identified a molecule that transforms normal pancreatic cells into duct-like structures, which can become cancerous. Inhibiting this gene, PKD1, may halt progression and spread of pancreatic cancer.
A study of over 1,500 cigarette smokers found that combining varenicline with cutting back on cigarette consumption increased long-term success in quitting. Smokers who reduced their smoking rate before attempting to quit were four times more likely to succeed at six months and two times more likely to quit at 12 months.
Researchers at Mayo Clinic have identified Stearoyl-CoA desaturase 1 as an oncogenic enzyme crucial to the survival of anaplastic thyroid carcinoma cells. Inhibiting this molecule has been shown to effectively shut down ATC cell growth and induce cell death.
A Mayo Clinic study analyzed over 345,000 patients' surgical outcomes between 2009 and 2013, finding no association between NSQIP hospital participation and improved postoperative outcomes. The study suggests that surgical outcomes reporting systems do not provide a clear mechanism for quality improvement.
A genomic test helped doctors solve a medical mystery for a boy with painful spasms. Whole exome sequencing identified the rare condition Episodic ataxia type 1, allowing for targeted treatment and symptom relief. The patient's motor and cognitive functioning have improved since medication was started.
A new study published in Journal of Clinical Oncology finds that ultrasound can help surgeons decide whether to remove only a few or all underarm lymph nodes from breast cancer patients who have received chemotherapy, reducing the risk of complications and saving healthcare costs.
The Mayo Clinic has established a new program dedicated to finding answers and treatments for Lewy body dementia, a deadly disease causing progressive decline in mental and physical abilities. The program builds on previous research discoveries, including a genetic risk factor and severe sleep disorder linked to the disease.
A new breast cancer risk prediction model developed by the Mayo Clinic has been shown to be more accurate than the current screening standard in predicting breast cancer risk. The model uses histologic features of biopsied breast tissue and individual patient demographic information, classifying breast cancer risk with a concordance st...
Sepsis can be a complication of almost any type of infection, including influenza. Mayo Clinic expert Dr. Steve Peters explains the difference between severe sepsis and septic shock, symptoms to watch for, and treatment options.
Researchers at Mayo Clinic found that cancer biopsies do not increase the risk of cancer spreading, contrary to a long-held belief. Patients who underwent biopsies had significantly better overall survival rates compared to those who did not.
A Mayo Clinic study found that women with atypical hyperplasia have an increased risk of developing breast cancer over time. After five years, 7% had developed the disease, and after 10 years, 13%. The study suggests that these women should be considered high-risk and screened more intensively.
A study by Mayo Clinic physicians found that high-definition optical lenses during colonoscopies can accurately evaluate polyps' precancerous or benign nature. The assessment was 96-97% accurate, potentially saving patients and healthcare systems substantial costs.
Researchers found that trastuzumab benefits HER2-positive breast cancer patients do not depend on the number of tumor-infiltrating lymphocytes (S-TILs) in their tumors. The study, which measured S-TILs at diagnosis in over 1,000 patients, showed improved recurrence-free survival when chemotherapy alone was used.
Researchers found that up to 45% of breast tumors exhibit genetic alterations affecting the CYP2D6 gene, leading to distorted patient genotypes. This has significant implications for tamoxifen therapy, which relies on accurate CYP2D6 testing to guide treatment.
James Ingle, a renowned breast cancer expert at Mayo Clinic, has been awarded the 2014 William L. McGuire Memorial Lecture Award for his groundbreaking research on pharmacogenomics in breast cancer treatment. His work aims to develop personalized approaches to prevent breast cancer in high-risk women by identifying genetic biomarkers t...
Researchers found a significant benefit in adding carfilzomib to standard lenalidomide and dexamethasone treatment, extending disease-free periods by nearly 50%. The three-drug combination resulted in improved remission rates and overall survival, with patients reporting better quality of life.
A Mayo Clinic-led study found that nearly 15% of triple-negative breast cancer patients have deleterious mutations in predisposition genes, including BRCA1 and BRCA2. This suggests a different origin for the disease compared to other forms of breast cancer.
A phase 1/2 study found the combination of weekly ixazomib plus lenalidomide and dexamethasone to be generally well-tolerated and active in patients with newly diagnosed multiple myeloma, resulting in a partial response rate of 92%. The study supports the development of a phase 3 trial for this combination.
Mayo Clinic researchers have found a potential link between TNF inhibitors and increased risk of uveal melanoma in patients. Patients taking TNF inhibitors should undergo regular eye exams to monitor for any issues.
Research at Mayo Clinic reveals that patients with active asthma are at a twofold risk of having a heart attack. Patients with inactive asthma were not found to be at an increased risk, highlighting the need for better control of asthma symptoms and medication use.
A blood test shows promise as a marker to predict which rheumatoid arthritis patients will benefit from biologic medications, sparing them unnecessary side effects. The protein type 1 interferon appears to serve as a valid marker to tell whether individual patients will respond to biologics or need alternative treatments.
A chemotherapy regimen of procarbazine, CCNU, and vincristine (PCV) following radiation therapy improved progression-free survival and overall survival in adults with low-grade gliomas. This trial found patients with oligodendroglioma had better outcomes than those with astrocytoma or oligoastrocytoma.
Researchers at Mayo Clinic have identified key molecular steps in the formation of pancreatic cancer, suggesting new preventive strategies. The study found that Kras mutations can induce inflammatory macrophages, which loosen cell structure and lead to precancerous lesions.
Researchers at Mayo Clinic found that a new oral medication combination therapy is safe and beneficial for liver transplant patients, requiring only 12 weeks of treatment. The study showed excellent eradication of the virus with much fewer side effects compared to traditional interferon-based therapies.
Researchers have identified genetic markers that may help in identifying individuals who could benefit from acamprosate, a commonly prescribed drug used to aid patients in recovery from alcoholism. Patients carrying specific genetic variants stay sober longer during acamprosate treatment.
The International Myeloma Working Group has updated its criteria for diagnosing multiple myeloma, allowing for earlier diagnosis without symptoms. The new guidelines incorporate validated biomarkers to identify patients at risk of progression, enabling targeted therapy and improved patient outcomes.
A long-term study of patients with HER2-positive breast cancer shows that adding trastuzumab to chemotherapy improves overall and disease-free survival by 37% and 40%, respectively. The regimen is now the standard of care for early stage HER2-positive breast cancer.
The American Academy of Neurology and the American Association of Neuromuscular & Electrodiagnostic Medicine have developed a new guideline for determining the specific subtype of limb-girdle or distal muscular dystrophy. This guideline is based on a thorough review of available studies and provides recommendations for evaluating sympt...
A global trial involving over 8,000 women has reaffirmed trastuzumab's superiority in treating HER2-positive breast cancer. The study showed that patients receiving trastuzumab had better outcomes than those treated with lapatinib alone, including lower rates of disease recurrence and improved overall survival.
A Mayo Clinic study found that most women with breast cancer who underwent double mastectomies report being satisfied with their decision, regardless of whether they opted for breast reconstruction. The majority of women who had reconstruction also reported higher self-esteem and feeling more feminine.
Researchers at Mayo Clinic have discovered a defect in the Wnt signaling pathway that contributes to both overproduction of toxic protein and loss of communication between neurons in Alzheimer's patients. Targeting this specific defect with drugs may rejuvenate or rescue the pathway, potentially preventing or treating Alzheimer's disease.
A comprehensive study led by Mayo Clinic in 12 countries validates the accuracy of RNA genomic sequencing techniques and laboratories. The research establishes best practices for laboratories to ensure reproducible results, enabling clinicians to make informed decisions based on genomic data.
The Mayo Clinic has developed a scoring system to identify patients who can safely bypass the intensive care unit (ICU) after liver transplantation. The study found that 54.3% of patients can be fast-tracked, with better survival rates compared to those sent to the ICU.
A Mayo Clinic study found that patients with poor quality of life before cancer surgery are nearly three times more likely to experience serious postoperative complications. Addressing these quality-of-life issues may reduce stress, speed recoveries and save healthcare costs.
Researchers have created an online analytic platform called CellNet to aid stem cell engineering. The tool uses network biology methods to analyze and predict cell fate and corresponding engineering strategies, offering a reliable shortcut for drug development and individualized cancer therapies.
Scientists at Mayo Clinic and Scripps Research Institute developed a new therapeutic strategy to combat the most common genetic risk factor for ALS and FTD. They discovered a potential biomarker that can track disease progression and measure the efficacy of therapies.
A Mayo Clinic task force challenges recommendations in the updated ACC/AHA cholesterol treatment guideline, suggesting an individualized treatment approach with emphasis on lifestyle changes before prescribing statins. The task force also recommends considering additional tests to refine cardiovascular risk estimates.
A large study published in European Urology has found that needle-guided tumor destruction procedures, such as partial nephrectomy and radiofrequency ablation, offer near equivalent lengths of local cancer control compared to surgery for patients with small kidney cancer tumors.
A Mayo Clinic study found that 1 in 5 patients who went to the ER with gallbladder pain were sent home to schedule surgery, but returned within a month needing urgent surgery. Younger and older patients, as well as those with other health problems, are likelier to need emergency gallbladder removal.