Patients with grade 2 glioma who received radiation therapy plus PCV chemotherapy experienced longer progression-free and overall survival times compared to those who received radiation therapy alone. The treatment combination improved survival rates by up to 10 years.
Patients who received a physician discussion using Chest Pain Choice increased their knowledge about their risk and options, answering 53% of questions correctly. The study also found that patients who used the tool were more likely to recommend discussing their care with their physicians, 68.9% compared to 61.2%.
A Mayo Clinic study found a strong association between physician burnout and reducing clinical practice hours, particularly among primary care specialties. The research suggests that increased emotional exhaustion predicts physicians cutting back on work hours, exacerbating the existing US physician shortage.
A new study found that prostate-specific antigen screening publications led to a decrease in biopsy rates by one-third, while also increasing the relative risk of post-biopsy complications. The researchers identified factors that put patients at higher risk, such as age and prior cancer diagnosis.
Researchers found that a poor diet and lack of exercise accelerate cellular senescence and age-related conditions in mice. Exercise was shown to prevent premature senescent cell accumulation and protect against unhealthy diet-induced damage.
A study by Mayo Clinic researchers found that medical students are more prone to alcohol abuse, with one-third experiencing clinical problems. The causes include burnout, being young and unmarried, and substantial educational debt. The authors recommend wellness curricula for medical schools to address these issues.
A clinical study from Mayo Clinic found whole-exome sequencing to be a viable diagnostic approach for identifying rare genetic conditions, resolving diagnostic odysseys and improving patient management. The study reported a success rate of 29%, twice that of conventional genetic evaluations, with insurance coverage existing for the test.
A recent study published in Neurology found that maintaining mental activity can slow the onset of Alzheimer's symptoms in people without a family history of the disease. For those with the APOE4 gene, continued learning and intellectual activity in middle age can lower amyloid plaque levels.
Mayo Clinic researchers found that using frozen section analysis during lumpectomies can reduce the need for second operations by 95%, saving patients time and financial burdens. The study estimates annual cost savings of $90.9 million to payers and $1.8 million to providers.
A 10-year clinical trial found that both surgery and stenting reduce the risk of stroke by about 7%, with low rates of restenosis over time. The procedures are safe and durable for preventing stroke in various patient groups.
Researchers at Mayo Clinic have discovered that apraxia of speech can evolve into a neurodegenerative disease, causing significant difficulties with speech, movement, and daily activities. Early diagnosis and therapy are crucial to develop compensations for producing sounds and improving communication.
Researchers at Mayo Clinic have demonstrated significant health improvements in the vascular system of mice following repeated treatments to remove senescent cells. The study shows that regular clearance of senescent cells can improve age-related vascular conditions and may be a viable approach to reduce cardiovascular disease and death.
Researchers have discovered a new bacterial species, B. mayonii, that causes Lyme disease in people in the upper Midwestern US. The species was previously unknown and has been identified through PCR testing of patient samples.
A new study by Mayo Clinic reveals that only one-third of patients receive preemptive or early living donor kidney transplants, despite research suggesting improved patient outcomes. The study highlights the need for education and access to information about living donor kidney transplantation to improve long-term outcomes.
Researchers found that females with childhood ADHD are at a two-fold greater risk of developing obesity during childhood and adulthood. Obesity is not associated with stimulant treatment among childhood ADHD cases.
Researchers argue for greater support and research to help women make informed decisions about preventive mastectomies and ovary removal. The procedures can significantly reduce cancer risk but also carry risks and emotional challenges.
Researchers at Mayo Clinic have found that eliminating senescent cells in mice can delay tumor formation, preserve tissue function, and increase lifespan. The study's results suggest that targeting these cells could lead to new therapies against age-related disabilities and diseases.
Researchers at Mayo Clinic have developed a saliva gland test that can detect early Parkinson's disease. The test involves taking a biopsy of the submandibular gland, which has been shown to be effective in detecting the abnormal protein associated with the disease in 14 out of 19 patients.
A study by Mayo Clinic researchers found that people who quit smoking for over 15 years are still at a higher risk of developing lung cancer. Expanding lung cancer screening to include this group could detect more cases and further reduce mortality.
A Mayo Clinic study found no association between surgical anesthesia and development of mild cognitive impairment in people aged 40 and older. Researchers evaluated over 1,700 participants and found that exposure to anesthesia did not increase the risk of mild cognitive impairment.
Ongoing aerobic exercise has been shown to enhance factors that potentially have a protective effect on the brain, counteracting brain shrinkage and improving connections in individuals with Parkinson's disease. Aerobic exercise can also help manage symptoms such as rigid muscles, slowed movement, and impaired posture and balance.
A population-based study published in JACI found that adults with asthma are at a 70% greater risk of developing shingles compared to those without asthma. Additionally, individuals with atopic dermatitis also showed a higher risk of shingles, even when other factors were accounted for.
A Mayo Clinic study of 102 lung transplant patients found that those who were frail before surgery had lower survival rates at one and three years post-transplant. Frailty was associated with decreased survival and poorer outcomes.
Researchers have discovered proteins that could serve as diagnostic markers for bipolar I disorder, differentiating it from other mood disorders and potentially guiding treatment choices.
A Mayo Clinic study reveals that adults with type 2 diabetes are often tested more frequently than needed, resulting in unnecessary costs and time burden. The researchers found that excessive testing increases the odds of overtreatment with hypoglycemic drugs.
Researchers at Mayo Clinic found significant evidence of chronic traumatic encephalopathy (CTE) in males who participated in amateur contact sports, including football, wrestling, and rugby. The study suggests that these sports may increase the risk of developing CTE, a progressive degenerative disease caused by repetitive brain trauma.
Burnout among U.S. physicians has increased by 10% over three years, with nearly all specialties affected. The study highlights the need for healthcare organizations to improve practice environments, reduce clerical burden, and provide greater flexibility for doctors.
A consensus report by Mayo Clinic researchers provides a standardized approach to diagnosing glomerulonephritis based on the underlying cause of the disease. This new method aims to improve personalized diagnosis and targeted treatment for patients with kidney disease.
Researchers discovered that the TCF7L2 gene variant impairs glucose balance by suppressing glucagon, raising blood sugar levels. This finding sheds light on the novel mechanism of predisposition to diabetes and may lead to new therapies.
A study by Mayo Clinic researchers found that women with a history of oral contraceptive use have improved progression-free survival and overall survival rates compared to those who did not use the pill. The study suggests that oral contraceptives may reduce DNA mutations, leading to less aggressive ovarian cancer at a later date.
A study found that isosorbide mononitrate, a common medication for heart failure with preserved ejection fraction (HFpEF), did not improve exercise tolerance or daily activity levels in patients. The drug actually decreased daily activity by 18 minutes per day at the highest dose.
Disclosing genetic risk information for coronary heart disease results in lower low-density lipoprotein (bad) cholesterol levels. Participants who received genetic risk information showed nearly 10 milligrams per deciliter of blood lower LDL levels six months after risk disclosure.
A Mayo Clinic study found that consuming a single 16-ounce energy drink can significantly increase blood pressure and stress hormone responses, potentially increasing the risk of cardiovascular events. The study also showed increases in norepinephrine levels and systolic blood pressure after energy drink consumption.
Deaths from cardiovascular disease among people with rheumatoid arthritis are declining, according to a new study. Researchers found that efforts to prevent and diagnose heart problems may be paying off for patients with the chronic condition.
A recent study by Mayo Clinic reveals that only one in five US pancreatic cancer patients receive the CA 19-9 tumor marker test at diagnosis, which can help predict treatment outcomes and guide personalized treatment. The test eliminates negative effects on survival when chemotherapy is administered before surgery.
Researchers found that Janus kinase inhibitors decreased factors released by human senescent cells and reduced inflammatory mediators in mice. The treatment improved physical function, including grip strength, endurance, and physical activity, in aged mice over two months.
A new stool DNA test has been found accurate in screening for colorectal cancer among Alaska Native people, a population with one of the world's highest rates of the disease. The test detected significantly more screen-relevant neoplasms than traditional fecal occult blood testing methods.
A new consensus guideline recommends that researchers share genomic findings with family members when necessary to avert imminent harm. The guidelines also emphasize the importance of protecting participant privacy and involving relatives in decision-making.
A Mayo Clinic study found stepping down daily asthma medicines can be done safely and at less cost for patients with stable asthma. Patients who stepped down their medicines saved an average of $34 per month compared to those who maintained the same level, without increased costs or reduced quality of life.
Researchers at Mayo Clinic have discovered a specific protein in the blood that can serve as an early indicator of end-stage renal disease and death in people with hypertension. This finding may enable doctors to intervene more effectively, potentially improving patients' quality and quantity of life.
A Mayo Clinic study found that genetic differences among races affect colon cancer recurrence. Tumors from whites were twice as likely to have BRAF mutations, while black tumors had the highest frequency of KRAS mutations, leading to a higher risk of recurrence among young blacks.
A Mayo Clinic study found that nearly three-quarters of patients with autoimmune cerebellar ataxia were women. The median duration from symptom onset to last follow-up was 25 months, with 51 patients experiencing physician-reported neurologic improvement with immunotherapy and cancer therapy.
A new study from Mayo Clinic shows that simple conversation cards can dramatically improve patients' and clinicians' satisfaction with antidepressant discussions. The tool increased patients' comfort in making decisions by 5 points and their satisfaction likelihood by 2.4-fold, while also improving physicians' decision-making comfort a...
A recent study by Mayo Clinic Children's Research Center found that kids with asthma who are exposed to secondhand smoke are twice as likely to be hospitalized for an asthma flare. The study analyzed data from over 430,000 children and strengthens the link between secondhand smoke exposure and increased asthma symptoms.
A Mayo Clinic study examines the adoption and cessation of calcium magnesium (CaMg) use for oxaliplatin-induced neuropathy, highlighting the challenges of translating research into clinical practice. The study reveals a decade-long cycle of rapid changes in treatment, driven by emerging evidence and public perception.
Individualized medicine is revolutionizing patient care through precision diagnostics, such as preventing drug-related adverse effects and identifying disease susceptibility. Whole exome sequencing is also offering new diagnoses for patients with undiagnosed diseases.
Researchers have identified the protein marker Bim as a potential predictor for patient response to PD-1 immunotherapy for melanoma. Patients with high levels of Bim and soluble PD-L1 are more likely to respond to treatment, suggesting that this biomarker may help clinicians predict which patients will benefit from PD-1 blockade.
Researchers at Mayo Clinic's Florida campus have been awarded a $13.3 million grant to conduct a national, phase II clinical trial testing the ability of a folate receptor alpha vaccine to prevent recurrence of triple-negative breast cancer following initial treatment. The vaccine was designed by Dr. Keith Knutson and exploits the need...
A recent Mayo Clinic study found that the number of new thyroid cancer cases is doubling, driven by the detection of previously undiagnosed low-risk tumors. These silent cancers often require unnecessary treatments, leading to financial and physical hardship for patients.
Imetelstat, a novel telomerase targeting drug, demonstrates potential value in treating patients with myelofibrosis by inducing morphologic and molecular remissions in some patients. The study shows selective anti-clonal activity, inhibiting the growth of cancer cells.