Researchers at Mayo Clinic have developed a new method to accurately measure GDF11, a circulating factor associated with advanced biological age and chronic disease. Higher levels of GDF11 were found in older adults with frailty, diabetes, or prior cardiac conditions.
Researchers at Mayo Clinic have identified CD38 as the key enzyme responsible for decreased nicotinamide adenine dinucleotide (NAD) levels during aging. This decline is associated with age-related metabolic decline and conditions like obesity and diabetes. Increasing NAD levels may be achieved by inhibiting CD38 function.
A new study found that intensive glucose treatment can nearly double the risk of severe hypoglycemia in older patients and those with serious chronic conditions. Patients taking multiple medications to lower HbA1C levels were at higher risk of experiencing severe low blood sugar episodes.
Researchers discovered that Pten's phosphatase activity counteracts PI3 kinase activity, leading to uncontrolled cell proliferation and survival. Mutant mice lacking critical amino acids form tumors at high frequency, making them susceptible to targeted cancer therapy.
A Mayo Clinic study analyzed 55 cancer drugs approved using surrogate endpoints, finding that many lacked formal empirical verification. The FDA's reliance on these surrogates may compromise patient outcomes and drug safety.
A Mayo Clinic-led study discovered that obese teenagers have lower levels of the hormone spexin, which may play a role in weight gain. The study suggests that spexin could be involved in childhood obesity and potentially used to treat or manage the condition.
A crowdsourcing contest analyzing brain data from humans and dogs improved epileptic seizure forecasting. Over half of algorithms performed better than random predictions, accurately predicting more than 70% of seizures.
Mayo Clinic researchers found that a combination of chemotherapy, radiation, and surgery can significantly improve survival rates for pancreatic cancer patients. Patients who received chemotherapy and/or radiation before surgery had better long-term outcomes than those who did not, with median survival times approaching four years.
A Mayo Clinic study found that endoscopists with knowledge of a positive Cologuard test detected polyps or hemorrhagic lesions 83% of the time, compared to 68% without this information. This increased detection led to more true-positive results and fewer false-negative results.
A study published in the Journal of Neurology found that brain scans of dementia patients with coprophagia showed significant neurodegeneration, particularly in the medial temporal lobe and amygdala. The researchers also noted that behavioral modifications and antipsychotic medication were effective in treating the behavior.
A Mayo Clinic study found that sending children home with catheters infusing a non-narcotic nerve-blocking drug reduces opioid painkiller use and shortens hospital stays. The procedure is effective in controlling pain after the Nuss procedure, which reshapes the chest wall to correct pectus excavatum.
Mayo Clinic's OB Nest study found that patient satisfaction improved with fewer office visits, empowering expectant women to take control of their care. The program provided personalized nursing care and home monitoring equipment, resulting in reduced patient burden and healthcare provider resources.
Researchers identified predictors of postoperative complications after partial nephrectomy and found a significant reduction in perioperative blood transfusions with the use of tranexamic acid. Additionally, men who underwent primary artificial urinary sphincter implantation for stress incontinence had improved long-term outcomes.
A Mayo Clinic study found that metformin does not limit the action of hormone glucagon, which may mitigate its ability to lower glucose production in the liver. The researchers discovered a compensatory increase of glucagon in prediabetic individuals taking metformin.
Researchers at Mayo Clinic discovered a link between the protein Bim and predicting patient responses to immunotherapy for metastatic melanoma. They found that patients with higher levels of Bim were more likely to respond to immunotherapy, offering hope for better treatment outcomes.
A Mayo-led study found that aspirin use is associated with a significantly reduced risk of developing bile duct cancer. The study showed that individuals who took aspirin had a more than two-and-a-half to three-and-a-half-fold lesser chance of developing the disease compared to those who did not take aspirin.
A new study from Mayo Clinic found that patients with high and low levels of donor-specific alloantibodies who received simultaneous liver-kidney transplants showed a lower incidence of cellular and antibody-mediated rejection, chronic injury to the kidney, and better overall kidney function compared to those who received a kidney tran...
A multi-institution study found that nipple-sparing mastectomies are as effective as traditional mastectomy in preventing breast cancer in women with a genetic mutation called BRCA. The procedure, which preserves the nipple and surrounding skin, was found to be safe and effective in reducing breast cancer risk.
Patients with grade 2 glioma who received radiation therapy plus PCV chemotherapy experienced longer progression-free and overall survival times compared to those who received radiation therapy alone. The treatment combination improved survival rates by up to 10 years.
Patients who received a physician discussion using Chest Pain Choice increased their knowledge about their risk and options, answering 53% of questions correctly. The study also found that patients who used the tool were more likely to recommend discussing their care with their physicians, 68.9% compared to 61.2%.
A Mayo Clinic study found a strong association between physician burnout and reducing clinical practice hours, particularly among primary care specialties. The research suggests that increased emotional exhaustion predicts physicians cutting back on work hours, exacerbating the existing US physician shortage.
A new study found that prostate-specific antigen screening publications led to a decrease in biopsy rates by one-third, while also increasing the relative risk of post-biopsy complications. The researchers identified factors that put patients at higher risk, such as age and prior cancer diagnosis.
Researchers found that a poor diet and lack of exercise accelerate cellular senescence and age-related conditions in mice. Exercise was shown to prevent premature senescent cell accumulation and protect against unhealthy diet-induced damage.
A study by Mayo Clinic researchers found that medical students are more prone to alcohol abuse, with one-third experiencing clinical problems. The causes include burnout, being young and unmarried, and substantial educational debt. The authors recommend wellness curricula for medical schools to address these issues.
A clinical study from Mayo Clinic found whole-exome sequencing to be a viable diagnostic approach for identifying rare genetic conditions, resolving diagnostic odysseys and improving patient management. The study reported a success rate of 29%, twice that of conventional genetic evaluations, with insurance coverage existing for the test.
A recent study published in Neurology found that maintaining mental activity can slow the onset of Alzheimer's symptoms in people without a family history of the disease. For those with the APOE4 gene, continued learning and intellectual activity in middle age can lower amyloid plaque levels.
Mayo Clinic researchers found that using frozen section analysis during lumpectomies can reduce the need for second operations by 95%, saving patients time and financial burdens. The study estimates annual cost savings of $90.9 million to payers and $1.8 million to providers.
A 10-year clinical trial found that both surgery and stenting reduce the risk of stroke by about 7%, with low rates of restenosis over time. The procedures are safe and durable for preventing stroke in various patient groups.
Researchers at Mayo Clinic have discovered that apraxia of speech can evolve into a neurodegenerative disease, causing significant difficulties with speech, movement, and daily activities. Early diagnosis and therapy are crucial to develop compensations for producing sounds and improving communication.
Researchers at Mayo Clinic have demonstrated significant health improvements in the vascular system of mice following repeated treatments to remove senescent cells. The study shows that regular clearance of senescent cells can improve age-related vascular conditions and may be a viable approach to reduce cardiovascular disease and death.
Researchers have discovered a new bacterial species, B. mayonii, that causes Lyme disease in people in the upper Midwestern US. The species was previously unknown and has been identified through PCR testing of patient samples.
A new study by Mayo Clinic reveals that only one-third of patients receive preemptive or early living donor kidney transplants, despite research suggesting improved patient outcomes. The study highlights the need for education and access to information about living donor kidney transplantation to improve long-term outcomes.
Researchers found that females with childhood ADHD are at a two-fold greater risk of developing obesity during childhood and adulthood. Obesity is not associated with stimulant treatment among childhood ADHD cases.
Researchers argue for greater support and research to help women make informed decisions about preventive mastectomies and ovary removal. The procedures can significantly reduce cancer risk but also carry risks and emotional challenges.
Researchers at Mayo Clinic have found that eliminating senescent cells in mice can delay tumor formation, preserve tissue function, and increase lifespan. The study's results suggest that targeting these cells could lead to new therapies against age-related disabilities and diseases.
Researchers at Mayo Clinic have developed a saliva gland test that can detect early Parkinson's disease. The test involves taking a biopsy of the submandibular gland, which has been shown to be effective in detecting the abnormal protein associated with the disease in 14 out of 19 patients.
A study by Mayo Clinic researchers found that people who quit smoking for over 15 years are still at a higher risk of developing lung cancer. Expanding lung cancer screening to include this group could detect more cases and further reduce mortality.
A Mayo Clinic study found no association between surgical anesthesia and development of mild cognitive impairment in people aged 40 and older. Researchers evaluated over 1,700 participants and found that exposure to anesthesia did not increase the risk of mild cognitive impairment.
Ongoing aerobic exercise has been shown to enhance factors that potentially have a protective effect on the brain, counteracting brain shrinkage and improving connections in individuals with Parkinson's disease. Aerobic exercise can also help manage symptoms such as rigid muscles, slowed movement, and impaired posture and balance.
A population-based study published in JACI found that adults with asthma are at a 70% greater risk of developing shingles compared to those without asthma. Additionally, individuals with atopic dermatitis also showed a higher risk of shingles, even when other factors were accounted for.
A Mayo Clinic study of 102 lung transplant patients found that those who were frail before surgery had lower survival rates at one and three years post-transplant. Frailty was associated with decreased survival and poorer outcomes.
Researchers have discovered proteins that could serve as diagnostic markers for bipolar I disorder, differentiating it from other mood disorders and potentially guiding treatment choices.
A Mayo Clinic study reveals that adults with type 2 diabetes are often tested more frequently than needed, resulting in unnecessary costs and time burden. The researchers found that excessive testing increases the odds of overtreatment with hypoglycemic drugs.
Researchers at Mayo Clinic found significant evidence of chronic traumatic encephalopathy (CTE) in males who participated in amateur contact sports, including football, wrestling, and rugby. The study suggests that these sports may increase the risk of developing CTE, a progressive degenerative disease caused by repetitive brain trauma.
Burnout among U.S. physicians has increased by 10% over three years, with nearly all specialties affected. The study highlights the need for healthcare organizations to improve practice environments, reduce clerical burden, and provide greater flexibility for doctors.
A consensus report by Mayo Clinic researchers provides a standardized approach to diagnosing glomerulonephritis based on the underlying cause of the disease. This new method aims to improve personalized diagnosis and targeted treatment for patients with kidney disease.
Researchers discovered that the TCF7L2 gene variant impairs glucose balance by suppressing glucagon, raising blood sugar levels. This finding sheds light on the novel mechanism of predisposition to diabetes and may lead to new therapies.
A study by Mayo Clinic researchers found that women with a history of oral contraceptive use have improved progression-free survival and overall survival rates compared to those who did not use the pill. The study suggests that oral contraceptives may reduce DNA mutations, leading to less aggressive ovarian cancer at a later date.
A study found that isosorbide mononitrate, a common medication for heart failure with preserved ejection fraction (HFpEF), did not improve exercise tolerance or daily activity levels in patients. The drug actually decreased daily activity by 18 minutes per day at the highest dose.
Disclosing genetic risk information for coronary heart disease results in lower low-density lipoprotein (bad) cholesterol levels. Participants who received genetic risk information showed nearly 10 milligrams per deciliter of blood lower LDL levels six months after risk disclosure.