Physician burnout affects over half of US physicians, impacting clinical performance, quality of care, and staff turnover. Mayo Clinic's nine-point plan addresses the issue through organizational changes, targeted interventions, and promoting flexibility and work-life balance.
Researchers at Mayo Clinic are developing a universal shear-thinning biomaterial that can be injected through an endovascular catheter, creating an impenetrable cast of the vessel and preventing further bleeding. This alternative to metallic coils may improve treatment outcomes for patients undergoing coil embolization.
Researchers from Mayo Clinic identified a new biomarker for brain and spinal cord inflammation, allowing for faster diagnosis and treatment of patients with autoimmune meningoencephalomyelitis. The biomarker, an antibody targeting glial fibrillary acidic protein, helps diagnose the disease earlier and promotes more effective therapy.
A Mayo Clinic study found that type 1 interferon beta levels are associated with poor response to tumor necrosis factor inhibitors in rheumatoid arthritis patients. This discovery may lead to more personalized treatment approaches based on individual patient biology.
A new study published in Neurology suggests that a lack of hippocampus shrinkage may indicate an increased risk of developing dementia with Lewy bodies. The study found that individuals with normal hippocampus volume were 5.8 times more likely to develop probable dementia with Lewy bodies than those with atrophy.
A study published in Mayo Clinic Proceedings found a persistent decline in kidney function after an individual's first case of kidney stones. This decline was linked to higher levels of cystatin C and urine protein, both associated with increased risk of chronic kidney disease.
A collaboration of 32 researchers found a genetic mutation in the PINK1 gene that confers a risk for developing Parkinson's disease earlier than expected. The study showed that a specific mutation impairs the PINK1-PARKIN pathway, leading to damaged mitochondria accumulation and neurodegeneration.
A genetic testing error led to the misdiagnosis of long QT syndrome in over 20 family members, resulting in one tragic death. The case highlights the importance of accurate interpretation and careful use of genetic testing to avoid such mistakes.
Senescent cells drive the formation of fatty streaks in animal models of atherosclerosis. These lesions progress to larger plaques through the recruitment of immune cells, ultimately leading to unstable plaques prone to rupture. Eliminating senescent cells selectively can reduce plaque size and preserve cap integrity.
A Mayo Clinic study found that patients with multiple myeloma treated at centers seeing more cases of the disease live longer. The researchers analyzed data from over 94,000 patients and discovered a significant correlation between treatment center volume and patient outcomes.
A Mayo Clinic study found that pregabalin, a neuro-pain inhibitor, may alleviate abdominal pain in patients with irritable bowel syndrome (IBS). The 12-week study showed significant improvement in pain management for those taking pregabalin compared to placebo.
Researchers aim to learn about physical parameters limiting drug delivery into brain tumors to improve treatment selection for unique tumors.
Researchers mapped patterns of prostate cancer recurrence using C-11 choline PET imaging and multiparametric MRI, identifying sites of recurrence that can be targeted for radiation therapy. Nearly two-thirds of men had recurrence limited to the pelvis, a potentially treatable area.
Researchers identified individual strategies like mindfulness training and organizational changes such as limiting duty hours, which are effective in reducing physician burnout. The study's findings suggest that a combination of interventions may be needed for long-term benefits.
A Mayo Clinic study found that NOACs dabigatran, rivaroxaban, and apixaban are at least as effective as warfarin in preventing stroke in atrial fibrillation patients. However, apixaban was associated with lower major bleeding rates, while rivaroxaban had a higher risk of serious bleeding.
A Mayo Clinic study found a significant relationship between stress levels and poor quality of life in medical center employees. The researchers emphasize the importance of engaging employees into wellness programs to reduce burnout and improve overall well-being.
A recent study at Mayo Clinic and other academic medical centers identified common conditions mistaken for multiple sclerosis, revealing potential risks of misdiagnosis. The research highlights the need for better clinician education on using diagnostic criteria to avoid premature or incorrect MS diagnoses.
Researchers at Mayo Clinic, along with the Geroscience Network, published six manuscripts mapping strategies for new drugs targeting aging processes. The goal is to treat multiple age-related diseases and disabilities, reducing healthcare costs by delaying or preventing conditions like stroke, heart disease, and dementia.
The Mayo Clinic and ASU Team Science Grants will fund projects in Biomedical Sensing, Functional Restoration, and Biomedical Imaging/Informatics. Three collaborative teams were chosen, with each project receiving up to $900,000 in award funding.
Researchers at Mayo Clinic found bacterial DNA in breast tissue, even when sterile conditions are maintained. The team discovered significant differences in the breast tissue microbiome of women with and without cancer, suggesting a distinct role for the microbiome in breast cancer development.
The TAILOR-PCI Study aims to determine whether prescribing antiplatelet therapy based on a patient's CYP2C19 genotype can prevent heart attack, stroke, and cardiovascular death. The study, which began in 2013, plans to enroll 5,270 patients and investigate the effects of genomics on treatment outcomes.
Changes to HER2 testing guidelines have led to a doubling of HER2-positive breast cancers in women, resulting in additional testing and more women being labeled as HER2-positive. However, the effectiveness of targeted therapies like Herceptin is still uncertain, highlighting the need for accurate determination of HER2 status.
A new gene therapy approach has shown promising results in treating hereditary tyrosinemia type 1 (HT1), a metabolic disorder characterized by progressive liver disease. The treatment involves transplanting corrected liver cells into the diseased liver, resulting in enzyme production and preventing liver failure.
Patients with three or fewer metastatic brain tumors who received stereotactic radiosurgery (SRS) alone had less cognitive deterioration and improved quality of life compared to those who received SRS combined with whole brain radiation therapy (WBRT). The study, published in the Journal of the American Medical Association, found that ...
Researchers at Mayo Clinic developed a new method to detect ovarian cancer recurrence using liquid biopsies from blood tests and DNA sequencing. This approach allows for earlier intervention and more effective individualized treatment by monitoring genetic changes in circulating cell-free DNA.
A Mayo Clinic study reveals a drug combination of TLR agonists and cyclophosphamide to effectively treat advanced and metastatic cancers in mice. The treatment promotes the destruction of cancer cells and activates immune responses without toxicity.
A recent study found that estrogen therapy via skin patch reduced beta-amyloid deposits in the brains of newly postmenopausal women, potentially decreasing Alzheimer's disease risk. Women with a greater genetic risk for Alzheimer's, such as those with the APOE e4 genotype, particularly benefited from this therapy.
Researchers at Mayo Clinic have identified intestinal bacteria as a possible cause of rheumatoid arthritis and found a link between specific microbiota and the disease. Testing for certain gut bacteria may help predict and prevent rheumatoid arthritis, with potential applications in personalized treatment.
Researchers have successfully combined everolimus with the standard R-CHOP regimen for new, untreated diffuse large B-cell lymphoma patients. The treatment achieved a 96% overall response rate and no dose-limiting toxicity was observed, indicating potential benefits in increasing cure rates and improving patient outcomes.
A national study of US physicians reveals that the use of electronic health records and computerized physician order entry leads to lower satisfaction and higher rates of professional burnout. The findings highlight the need to find ways to incorporate these tools without increasing clerical burden or reducing efficiency for physicians.
Researchers at Mayo Clinic are exploring the potential of genetic testing and electronic health records to tailor antidepressant treatment. The study finds that genetic variation can affect patient reactions to drugs, offering a unique opportunity to develop pharmacogenetic guidelines.
The study found a significant increase in Parkinson's disease incidence, particularly among men aged 70 and older. Environmental and lifestyle factors may contribute to this trend, warranting further research to identify potential causes.
Researchers at Mayo Clinic have developed a new method to accurately measure GDF11, a circulating factor associated with advanced biological age and chronic disease. Higher levels of GDF11 were found in older adults with frailty, diabetes, or prior cardiac conditions.
Researchers at Mayo Clinic have identified CD38 as the key enzyme responsible for decreased nicotinamide adenine dinucleotide (NAD) levels during aging. This decline is associated with age-related metabolic decline and conditions like obesity and diabetes. Increasing NAD levels may be achieved by inhibiting CD38 function.
A new study found that intensive glucose treatment can nearly double the risk of severe hypoglycemia in older patients and those with serious chronic conditions. Patients taking multiple medications to lower HbA1C levels were at higher risk of experiencing severe low blood sugar episodes.
Researchers discovered that Pten's phosphatase activity counteracts PI3 kinase activity, leading to uncontrolled cell proliferation and survival. Mutant mice lacking critical amino acids form tumors at high frequency, making them susceptible to targeted cancer therapy.
A Mayo Clinic study analyzed 55 cancer drugs approved using surrogate endpoints, finding that many lacked formal empirical verification. The FDA's reliance on these surrogates may compromise patient outcomes and drug safety.
A Mayo Clinic-led study discovered that obese teenagers have lower levels of the hormone spexin, which may play a role in weight gain. The study suggests that spexin could be involved in childhood obesity and potentially used to treat or manage the condition.
A crowdsourcing contest analyzing brain data from humans and dogs improved epileptic seizure forecasting. Over half of algorithms performed better than random predictions, accurately predicting more than 70% of seizures.
Mayo Clinic researchers found that a combination of chemotherapy, radiation, and surgery can significantly improve survival rates for pancreatic cancer patients. Patients who received chemotherapy and/or radiation before surgery had better long-term outcomes than those who did not, with median survival times approaching four years.
A Mayo Clinic study found that endoscopists with knowledge of a positive Cologuard test detected polyps or hemorrhagic lesions 83% of the time, compared to 68% without this information. This increased detection led to more true-positive results and fewer false-negative results.
A study published in the Journal of Neurology found that brain scans of dementia patients with coprophagia showed significant neurodegeneration, particularly in the medial temporal lobe and amygdala. The researchers also noted that behavioral modifications and antipsychotic medication were effective in treating the behavior.
A Mayo Clinic study found that sending children home with catheters infusing a non-narcotic nerve-blocking drug reduces opioid painkiller use and shortens hospital stays. The procedure is effective in controlling pain after the Nuss procedure, which reshapes the chest wall to correct pectus excavatum.
Mayo Clinic's OB Nest study found that patient satisfaction improved with fewer office visits, empowering expectant women to take control of their care. The program provided personalized nursing care and home monitoring equipment, resulting in reduced patient burden and healthcare provider resources.
Researchers identified predictors of postoperative complications after partial nephrectomy and found a significant reduction in perioperative blood transfusions with the use of tranexamic acid. Additionally, men who underwent primary artificial urinary sphincter implantation for stress incontinence had improved long-term outcomes.
A Mayo Clinic study found that metformin does not limit the action of hormone glucagon, which may mitigate its ability to lower glucose production in the liver. The researchers discovered a compensatory increase of glucagon in prediabetic individuals taking metformin.
Researchers at Mayo Clinic discovered a link between the protein Bim and predicting patient responses to immunotherapy for metastatic melanoma. They found that patients with higher levels of Bim were more likely to respond to immunotherapy, offering hope for better treatment outcomes.
A Mayo-led study found that aspirin use is associated with a significantly reduced risk of developing bile duct cancer. The study showed that individuals who took aspirin had a more than two-and-a-half to three-and-a-half-fold lesser chance of developing the disease compared to those who did not take aspirin.
A new study from Mayo Clinic found that patients with high and low levels of donor-specific alloantibodies who received simultaneous liver-kidney transplants showed a lower incidence of cellular and antibody-mediated rejection, chronic injury to the kidney, and better overall kidney function compared to those who received a kidney tran...
A multi-institution study found that nipple-sparing mastectomies are as effective as traditional mastectomy in preventing breast cancer in women with a genetic mutation called BRCA. The procedure, which preserves the nipple and surrounding skin, was found to be safe and effective in reducing breast cancer risk.