Researchers found that treating subclinical hypothyroidism in pregnancy can reduce pregnancy loss, especially for those with higher TSH levels. However, treated women were more likely to experience preterm delivery and gestational diabetes.
Researchers at Mayo Clinic identified Ect2 as a genetic promoter of lung cancer, driving tumor formation through increased ribosome production. The study found that Ect2 supports tumor cell growth by stimulating ribosome biogenesis.
Researchers at Mayo Clinic found that two common cancer-fighting drugs sparked significant weight loss in morbidly obese mice despite a high-fat diet. The study suggests that these drugs can induce the liver to burn off excess fat, reducing obesity. Further research is needed to explore this potential approach for treating morbid obesity.
Researchers at Mayo Clinic have identified a key drug target, CDK4/6, which regulates the spread of triple-negative breast cancer. The study found that inhibiting this protein with CDK 4/6 inhibitors can prevent the metastasis of triple-negative breast cancer to distant organs.
A Mayo Clinic study finds that vaginal microbes are distinct in women with endometrial cancer compared to those without the disease. Researchers hope to use vaginal swabs as an early screening tool and investigate the role of the microbiome in preventing endometrial cancer.
A Mayo Clinic study found significant discrepancies in reporting postoperative infection complications between hospital-based administrative data and clinical registry data. The analysis of four common complications revealed that the two approaches yielded vastly different assessments, with rates varying up to fivefold.
Research suggests that nonsteroidal anti-inflammatory drugs (NSAIDs) can prevent the recurrence of advanced neoplasia after polyp removal, with ibuprofen showing superior benefits over aspirin or supplements. However, the choice of NSAID should be individualized based on patient risk factors and health considerations.
Researchers at Mayo Clinic have identified a key protein, Rab10, that helps hungry liver cells locate and break down fat for energy. This discovery could lead to new treatments for fatty liver disease.
Researchers identified four new markers of primary sclerosing cholangitis risk on the human genome, bringing the total number of known predisposing locations to 20. The study also shed light on the genetic relationship between primary sclerosing cholangitis and inflammatory bowel disease.
A Mayo Clinic study found that high school football players did not experience an increase in degenerative brain diseases, contrary to previous findings. Researchers compared the medical records of over 300 football players with those of non-football athletes, and found a higher incidence of head trauma among football players.
A recent study published in Genes & Development reveals an enzyme called UCHL3 that plays a crucial role in regulating the BRCA2 pathway. This research suggests that UCHL3 could be used as a potential therapeutic target to overcome chemotherapy resistance in breast and ovarian cancer cells.
Researchers at Mayo Clinic found that inherited pathogenic variants in genes BARD1 and RAD51D increase a woman's likelihood of developing breast cancer. The study also confirmed the involvement of other genes such as ATM, CHEK2 and PALB2 in breast cancer risk.
Using a one-minute shared decision-making aid can reduce unnecessary hospitalization and advanced cardiac testing for patients with low-risk chest pain. The study found that the aid resulted in greater patient knowledge, increased patient involvement in decision-making, and reduced admissions for observation.
Patients with a history of cancer who experience severe heart attacks have a three times higher risk of noncardiac death but not higher cardiac death rates. They also face increased risks of cardiogenic shock and need more intensive treatment.
A Mayo Clinic study comparing thousands of overlapping and non-overlapping surgeries found no difference in postoperative complications or deaths within a month. Overlapping surgeries provide greater access to qualified surgeons and more efficient use of operating rooms.
Researchers found that myocarditis is affecting both children and adults worldwide, with men being twice as likely as women to develop severe reactions. Early diagnosis is key to preventing long-term heart damage, and new investigational therapies are soon to be tested.
Researchers have pinpointed a cause and potential treatment for inflammatory myofibroblastic tumors, a rare form of sarcoma that does not respond to radiation or chemotherapy. The drug ceritinib shows promise as a new treatment option.
A study published in Mayo Clinic Proceedings found that newborn telemedicine consultations can positively impact patient care by providing enhanced access to neonatologists. This resulted in one-third of babies being able to stay with their families in the local hospital, increasing the value of care and potential cost savings.
Physician burnout affects over half of US physicians, impacting clinical performance, quality of care, and staff turnover. Mayo Clinic's nine-point plan addresses the issue through organizational changes, targeted interventions, and promoting flexibility and work-life balance.
Researchers at Mayo Clinic are developing a universal shear-thinning biomaterial that can be injected through an endovascular catheter, creating an impenetrable cast of the vessel and preventing further bleeding. This alternative to metallic coils may improve treatment outcomes for patients undergoing coil embolization.
Researchers from Mayo Clinic identified a new biomarker for brain and spinal cord inflammation, allowing for faster diagnosis and treatment of patients with autoimmune meningoencephalomyelitis. The biomarker, an antibody targeting glial fibrillary acidic protein, helps diagnose the disease earlier and promotes more effective therapy.
A Mayo Clinic study found that type 1 interferon beta levels are associated with poor response to tumor necrosis factor inhibitors in rheumatoid arthritis patients. This discovery may lead to more personalized treatment approaches based on individual patient biology.
A new study published in Neurology suggests that a lack of hippocampus shrinkage may indicate an increased risk of developing dementia with Lewy bodies. The study found that individuals with normal hippocampus volume were 5.8 times more likely to develop probable dementia with Lewy bodies than those with atrophy.
A study published in Mayo Clinic Proceedings found a persistent decline in kidney function after an individual's first case of kidney stones. This decline was linked to higher levels of cystatin C and urine protein, both associated with increased risk of chronic kidney disease.
A collaboration of 32 researchers found a genetic mutation in the PINK1 gene that confers a risk for developing Parkinson's disease earlier than expected. The study showed that a specific mutation impairs the PINK1-PARKIN pathway, leading to damaged mitochondria accumulation and neurodegeneration.
A genetic testing error led to the misdiagnosis of long QT syndrome in over 20 family members, resulting in one tragic death. The case highlights the importance of accurate interpretation and careful use of genetic testing to avoid such mistakes.
Senescent cells drive the formation of fatty streaks in animal models of atherosclerosis. These lesions progress to larger plaques through the recruitment of immune cells, ultimately leading to unstable plaques prone to rupture. Eliminating senescent cells selectively can reduce plaque size and preserve cap integrity.
A Mayo Clinic study found that patients with multiple myeloma treated at centers seeing more cases of the disease live longer. The researchers analyzed data from over 94,000 patients and discovered a significant correlation between treatment center volume and patient outcomes.
A Mayo Clinic study found that pregabalin, a neuro-pain inhibitor, may alleviate abdominal pain in patients with irritable bowel syndrome (IBS). The 12-week study showed significant improvement in pain management for those taking pregabalin compared to placebo.
Researchers aim to learn about physical parameters limiting drug delivery into brain tumors to improve treatment selection for unique tumors.
Researchers mapped patterns of prostate cancer recurrence using C-11 choline PET imaging and multiparametric MRI, identifying sites of recurrence that can be targeted for radiation therapy. Nearly two-thirds of men had recurrence limited to the pelvis, a potentially treatable area.
Researchers identified individual strategies like mindfulness training and organizational changes such as limiting duty hours, which are effective in reducing physician burnout. The study's findings suggest that a combination of interventions may be needed for long-term benefits.
A Mayo Clinic study found that NOACs dabigatran, rivaroxaban, and apixaban are at least as effective as warfarin in preventing stroke in atrial fibrillation patients. However, apixaban was associated with lower major bleeding rates, while rivaroxaban had a higher risk of serious bleeding.
A Mayo Clinic study found a significant relationship between stress levels and poor quality of life in medical center employees. The researchers emphasize the importance of engaging employees into wellness programs to reduce burnout and improve overall well-being.
A recent study at Mayo Clinic and other academic medical centers identified common conditions mistaken for multiple sclerosis, revealing potential risks of misdiagnosis. The research highlights the need for better clinician education on using diagnostic criteria to avoid premature or incorrect MS diagnoses.
Researchers at Mayo Clinic, along with the Geroscience Network, published six manuscripts mapping strategies for new drugs targeting aging processes. The goal is to treat multiple age-related diseases and disabilities, reducing healthcare costs by delaying or preventing conditions like stroke, heart disease, and dementia.
The Mayo Clinic and ASU Team Science Grants will fund projects in Biomedical Sensing, Functional Restoration, and Biomedical Imaging/Informatics. Three collaborative teams were chosen, with each project receiving up to $900,000 in award funding.
Researchers at Mayo Clinic found bacterial DNA in breast tissue, even when sterile conditions are maintained. The team discovered significant differences in the breast tissue microbiome of women with and without cancer, suggesting a distinct role for the microbiome in breast cancer development.
The TAILOR-PCI Study aims to determine whether prescribing antiplatelet therapy based on a patient's CYP2C19 genotype can prevent heart attack, stroke, and cardiovascular death. The study, which began in 2013, plans to enroll 5,270 patients and investigate the effects of genomics on treatment outcomes.
Changes to HER2 testing guidelines have led to a doubling of HER2-positive breast cancers in women, resulting in additional testing and more women being labeled as HER2-positive. However, the effectiveness of targeted therapies like Herceptin is still uncertain, highlighting the need for accurate determination of HER2 status.
A new gene therapy approach has shown promising results in treating hereditary tyrosinemia type 1 (HT1), a metabolic disorder characterized by progressive liver disease. The treatment involves transplanting corrected liver cells into the diseased liver, resulting in enzyme production and preventing liver failure.
Patients with three or fewer metastatic brain tumors who received stereotactic radiosurgery (SRS) alone had less cognitive deterioration and improved quality of life compared to those who received SRS combined with whole brain radiation therapy (WBRT). The study, published in the Journal of the American Medical Association, found that ...
Researchers at Mayo Clinic developed a new method to detect ovarian cancer recurrence using liquid biopsies from blood tests and DNA sequencing. This approach allows for earlier intervention and more effective individualized treatment by monitoring genetic changes in circulating cell-free DNA.
A Mayo Clinic study reveals a drug combination of TLR agonists and cyclophosphamide to effectively treat advanced and metastatic cancers in mice. The treatment promotes the destruction of cancer cells and activates immune responses without toxicity.
A recent study found that estrogen therapy via skin patch reduced beta-amyloid deposits in the brains of newly postmenopausal women, potentially decreasing Alzheimer's disease risk. Women with a greater genetic risk for Alzheimer's, such as those with the APOE e4 genotype, particularly benefited from this therapy.
Researchers at Mayo Clinic have identified intestinal bacteria as a possible cause of rheumatoid arthritis and found a link between specific microbiota and the disease. Testing for certain gut bacteria may help predict and prevent rheumatoid arthritis, with potential applications in personalized treatment.
Researchers have successfully combined everolimus with the standard R-CHOP regimen for new, untreated diffuse large B-cell lymphoma patients. The treatment achieved a 96% overall response rate and no dose-limiting toxicity was observed, indicating potential benefits in increasing cure rates and improving patient outcomes.
A national study of US physicians reveals that the use of electronic health records and computerized physician order entry leads to lower satisfaction and higher rates of professional burnout. The findings highlight the need to find ways to incorporate these tools without increasing clerical burden or reducing efficiency for physicians.
Researchers at Mayo Clinic are exploring the potential of genetic testing and electronic health records to tailor antidepressant treatment. The study finds that genetic variation can affect patient reactions to drugs, offering a unique opportunity to develop pharmacogenetic guidelines.
The study found a significant increase in Parkinson's disease incidence, particularly among men aged 70 and older. Environmental and lifestyle factors may contribute to this trend, warranting further research to identify potential causes.