Researchers analyzed data from patients undergoing stage IV colorectal cancer surgery to identify benchmarks for surgical practice. They found that major complications vary depending on the extent of liver resection and type of colorectal surgery performed.
The Mayo Clinic Cancer Center has been awarded a Specialized Program of Research Excellence (SPORE) grant to study the genetic basis of multiple myeloma and develop novel therapies.
Researchers at Mayo Clinic have discovered a way to potentially reprogram cancer cells back to normalcy by restoring the expression of specific microRNAs. This finding represents an unexpected new biology that provides the code for turning off cancer, offering a potential strategy for cancer therapy.
A Mayo Clinic study published in Pediatric Obesity found that excessive vitamin D supplementation in obese teenagers showed no benefits for their heart health or diabetes risk. The study, led by Dr. Seema Kumar, also found increased cholesterol and triglyceride levels in the teens during supplementation.
A Mayo Clinic-led study has validated the National Cancer Institute's Patient Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE), a tool used to track side effects in cancer clinical trials. The study found that PRO-CTCAE was accurate, reliable and responsive compared to other measures.
Mayo researchers found that class II HDAC inhibitors signal through a newly discovered pathway to promote synergy with chemotherapy treatment in anaplastic thyroid cancer. The study identified vorinostat and belinostat as effective agents, which can increase activity of RhoB, a tumor suppressor and stimulate cell death.
Leading cancer experts recommend several measures to reduce high cancer drug prices, including a post-approval price review mechanism and Medicare negotiations. The recommendations aim to improve patient care and alleviate the financial burden on those affected by high cancer drug costs.
A Mayo Clinic study has identified abnormalities in the levels and processing of ribonucleic acids (RNA) in patients with sporadic and genetic forms of ALS. The findings, published in Nature Neuroscience, suggest that different factors may contribute to the development of ALS and highlight the need for tailored therapies.
The Lymphoma Epidemiology of Outcomes Cohort Study will enroll 12,000 NHL patients and follow them for long-term prognosis and survivorship. The grant aims to improve the length and quality of life for NHL survivors.
Researchers identified nicotine use and substance abuse as top risk factors for long-term opioid use. Patients with these histories should proceed with caution when offered opioid prescriptions, says lead author W. Michael Hooten.
Researchers found that dasatinib inhibits proteins promoting cancer growth but also suppresses those protecting against it. The study suggests pretesting patient biopsies can help identify patients who may respond to dasatinib and those who should avoid it.
Researchers at Mayo Clinic have identified a new epigenomic block that could help stop the progression of many late-stage cancers. This discovery has the potential to improve diagnosis and treatment of advanced disease across various cancer types.
Researchers at Mayo Clinic have developed a new molecular classification system for gliomas, which could lead to more accurate diagnoses and personalized treatments. The system categorizes tumors based on three genetic alterations, allowing clinicians to predict patient outcomes and tailor treatment plans accordingly.
Mayo Clinic researchers identified 69 never events among 1.5 million invasive procedures, with 628 human factors contributing to the errors. Four to nine factors contributed to each event, including environmental, organizational, job and individual characteristics.
A recent Mayo Clinic study found that combining the targeted drug ibrutinib with standard chemotherapy significantly reduces the risk of death or cancer progression in patients with relapsed CLL or SLL. The treatment results in a nearly 80% reduction in mortality, offering new hope for longer disease control and decreased risk of relapse.
Pacritinib significantly reduced severe spleen enlargement and debilitating side effects in over 20% and 46% of patients, respectively. The therapy also showed promise in treating thrombocytopenia, a life-threatening condition often associated with myelofibrosis.
For individuals over 75, taking newer anticoagulant medications dabigatran or rivaroxaban increases the risk of gastrointestinal (GI) bleeding by 3-5 times compared to warfarin. The study found that younger patients have a lower risk of GI bleeding with these medications.
A study published in Journal of Pediatric Surgery highlights the risks of dog bites, particularly from family dogs. The research found that over 50% of dog bite injuries treated at a children's hospital came from immediate family members.
Patients with liver cancer can be cured with a liver transplant using organs from donors who died of cardiac death, according to the largest study of its kind. The study found no difference in liver cancer recurrence between livers donated after cardiac death and those obtained from brain-dead donors.
Researchers discover a minimally invasive method to remove genitourinary mesh implants without major surgery, improving symptoms for some patients. Mayo Clinic also reports promising outcomes for octogenarians undergoing artificial urinary sphincter operations and children with ADHD who receive sacral neuromodulation therapy
Researchers at Mayo Clinic developed a mouse model exhibiting neuropathological and behavioral features associated with C9ORF72 mutation. The study suggests a link between the repeat expansion in C9ORF72 and TDP-43 pathology, potentially leading to therapeutic agents targeting RNA foci and c9RAN proteins.
The Mayo Clinic is launching a study of 10,000 patients to examine the potential risks of drug reactions based on individual genome variations. Researchers will analyze DNA sequencing data from 69 genes influencing drug metabolism, aiming to identify 'early warning systems' for adverse reactions and ineffective treatments.
Researchers at Mayo Clinic analyzed data from over 20,000 patients and found that toxic levels are rare among those taking supplements. High levels above 50 ng/mL were associated with increased risk of kidney stones and other complications in women over age 65.
A Mayo Clinic-led research team has identified a molecular switch in the HER2 protein that sets off a cascade of events leading to cancer. Disrupting this site can stem the growth of breast cancer cells more effectively than current treatments.
Women with uterine fibroids have several treatment options, including medical and interventional therapies. Alternative treatment options include tranexamic acid, levonorgestrel-releasing IUDs, hysteroscopic myomectomy, endometrial ablation, gonadotropin-releasing hormone agonists, and more.
Researchers have identified methylated DNA markers in blood samples with 80% accuracy, enabling potential non-invasive screening for cancer. The discovery could lead to earlier diagnosis and improved patient outcomes for rare cancers like pancreatic cancer.
Researchers at Mayo Clinic have developed a profile to identify patients most at risk of developing pancreatic cancer. The study analyzed data from 1,126 patients and found that factors such as history of smoking, obesity, jaundice, and cyst size on imaging scans are associated with high risk.
A Mayo Clinic-led team has combined 77 common genetic variants into a polygenic risk score to improve breast cancer identification. The score is associated with a higher or lower risk of developing breast cancer, and can be used in conjunction with traditional predictors to personalize estimates.
Researchers found that transplant outcomes using kidneys from deceased donors with AKI were no different between the AKI and non-AKI groups at both 1 and 3 years post-transplant. The study results suggest that acutely injured kidneys can be considered for transplantation, potentially alleviating the US kidney shortage.
A Mayo Clinic study found that frequent attendance at work site wellness centers led to significant weight loss and healthcare cost savings. Members who visited the Dan Abraham Healthy Living Center (DAHLC) more than 360 times were 72% more likely to experience weight loss, with corresponding reductions in healthcare costs.
A Mayo Clinic study of over 3,600 postmortem brains reveals that tau protein is the primary driver of cognitive decline and memory loss in Alzheimer's disease. Amyloid buildup, while toxic, does not play a major role in disease progression, according to researchers.
Researchers at Mayo Clinic have discovered that it is possible to detect endometrial cancer using tumor DNA picked up by ordinary tampons. The study found higher methylation levels in vaginal secretions from women with endometrial cancer, suggesting a potential tool for early detection.
Researchers identified five familial cases of spontaneous coronary artery dissection (SCAD), a condition where a tear occurs inside an artery leading to a heart attack. The study suggests that SCAD may be inherited, with implications for at-risk family members and a better understanding of the condition.
Researchers at Mayo Clinic developed a new scoring system to identify individuals at high risk of developing dementia. The study found that variables such as age, diabetes, heart health risk factors, slow gate, depression, and anxiety disorders are key contributors to the risk score.
A study by Mayo Clinic Cancer Center reveals the average price of cancer drugs in the US has increased significantly over the years, affecting patient care. The authors recommend six potential solutions to control high drug costs, including allowing Medicare to negotiate prices and implementing value-based pricing.
Researchers identified patients who donated their body to medical research and had undergone multiple MRI exams. Brain tissue samples showed measurable quantities of gadolinium deposited in the brain tissue of exposed patients, but no specific symptoms or diseases were linked to this finding.
A study by Mayo Clinic researchers found that energy drinks increase resting blood pressure, particularly in caffeine-naive individuals, doubling their blood pressure compared to a placebo.
Researchers found significant increases in blood pressure during nighttime hours among participants exposed to prolonged periods of shortened sleep. The study, conducted at Mayo Clinic, used a controlled protocol to mimic the effects of sleep loss on the body.
A study of over 12,000 TAVR patients in the US found a one-year death rate of 23.7% and a stroke rate of 4.1%. The median age of patients was 84 years old, with 52% female.
Researchers at Mayo Clinic and collaborators have identified a new class of senolytic drugs that clearly reduce health problems in mice by targeting senescent cells. These treatments aim to limit the effects of aging and extend patient healthspan.
A study published in Pediatrics found that the rate of inhaled nitric oxide (iNO) utilization in American NICUs increased by 23% between 2009 and 2013, with nearly half of all iNO users being preterm neonates. This trend has significant economic implications, estimated to be $153 million in 2013.
A Mayo Clinic study found that US women's awareness of breast density varies significantly by race, ethnicity, household income, education level, and healthcare experiences. More than half of women reported having heard of breast density, but only 53% knew it was associated with cancer risk.
Research at Mayo Clinic found that a decline in smoking rates may lead to fewer people qualifying for early detection of lung cancer through low-dose CT scans. As smokers quit earlier, more patients are diagnosed at a later stage, increasing mortality.
Researchers at Mayo Clinic and the University of Oslo have identified a molecule that transforms normal pancreatic cells into duct-like structures, which can become cancerous. Inhibiting this gene, PKD1, may halt progression and spread of pancreatic cancer.
A study of over 1,500 cigarette smokers found that combining varenicline with cutting back on cigarette consumption increased long-term success in quitting. Smokers who reduced their smoking rate before attempting to quit were four times more likely to succeed at six months and two times more likely to quit at 12 months.
Researchers at Mayo Clinic have identified Stearoyl-CoA desaturase 1 as an oncogenic enzyme crucial to the survival of anaplastic thyroid carcinoma cells. Inhibiting this molecule has been shown to effectively shut down ATC cell growth and induce cell death.
A Mayo Clinic study analyzed over 345,000 patients' surgical outcomes between 2009 and 2013, finding no association between NSQIP hospital participation and improved postoperative outcomes. The study suggests that surgical outcomes reporting systems do not provide a clear mechanism for quality improvement.
A genomic test helped doctors solve a medical mystery for a boy with painful spasms. Whole exome sequencing identified the rare condition Episodic ataxia type 1, allowing for targeted treatment and symptom relief. The patient's motor and cognitive functioning have improved since medication was started.
A new study published in Journal of Clinical Oncology finds that ultrasound can help surgeons decide whether to remove only a few or all underarm lymph nodes from breast cancer patients who have received chemotherapy, reducing the risk of complications and saving healthcare costs.
The Mayo Clinic has established a new program dedicated to finding answers and treatments for Lewy body dementia, a deadly disease causing progressive decline in mental and physical abilities. The program builds on previous research discoveries, including a genetic risk factor and severe sleep disorder linked to the disease.