A Mayo Clinic study found that consuming a single 16-ounce energy drink can significantly increase blood pressure and stress hormone responses, potentially increasing the risk of cardiovascular events. The study also showed increases in norepinephrine levels and systolic blood pressure after energy drink consumption.
Deaths from cardiovascular disease among people with rheumatoid arthritis are declining, according to a new study. Researchers found that efforts to prevent and diagnose heart problems may be paying off for patients with the chronic condition.
A recent study by Mayo Clinic reveals that only one in five US pancreatic cancer patients receive the CA 19-9 tumor marker test at diagnosis, which can help predict treatment outcomes and guide personalized treatment. The test eliminates negative effects on survival when chemotherapy is administered before surgery.
Researchers found that Janus kinase inhibitors decreased factors released by human senescent cells and reduced inflammatory mediators in mice. The treatment improved physical function, including grip strength, endurance, and physical activity, in aged mice over two months.
A new stool DNA test has been found accurate in screening for colorectal cancer among Alaska Native people, a population with one of the world's highest rates of the disease. The test detected significantly more screen-relevant neoplasms than traditional fecal occult blood testing methods.
A new consensus guideline recommends that researchers share genomic findings with family members when necessary to avert imminent harm. The guidelines also emphasize the importance of protecting participant privacy and involving relatives in decision-making.
A Mayo Clinic study found stepping down daily asthma medicines can be done safely and at less cost for patients with stable asthma. Patients who stepped down their medicines saved an average of $34 per month compared to those who maintained the same level, without increased costs or reduced quality of life.
Researchers at Mayo Clinic have discovered a specific protein in the blood that can serve as an early indicator of end-stage renal disease and death in people with hypertension. This finding may enable doctors to intervene more effectively, potentially improving patients' quality and quantity of life.
A Mayo Clinic study found that genetic differences among races affect colon cancer recurrence. Tumors from whites were twice as likely to have BRAF mutations, while black tumors had the highest frequency of KRAS mutations, leading to a higher risk of recurrence among young blacks.
A Mayo Clinic study found that nearly three-quarters of patients with autoimmune cerebellar ataxia were women. The median duration from symptom onset to last follow-up was 25 months, with 51 patients experiencing physician-reported neurologic improvement with immunotherapy and cancer therapy.
A new study from Mayo Clinic shows that simple conversation cards can dramatically improve patients' and clinicians' satisfaction with antidepressant discussions. The tool increased patients' comfort in making decisions by 5 points and their satisfaction likelihood by 2.4-fold, while also improving physicians' decision-making comfort a...
A recent study by Mayo Clinic Children's Research Center found that kids with asthma who are exposed to secondhand smoke are twice as likely to be hospitalized for an asthma flare. The study analyzed data from over 430,000 children and strengthens the link between secondhand smoke exposure and increased asthma symptoms.
A Mayo Clinic study examines the adoption and cessation of calcium magnesium (CaMg) use for oxaliplatin-induced neuropathy, highlighting the challenges of translating research into clinical practice. The study reveals a decade-long cycle of rapid changes in treatment, driven by emerging evidence and public perception.
Individualized medicine is revolutionizing patient care through precision diagnostics, such as preventing drug-related adverse effects and identifying disease susceptibility. Whole exome sequencing is also offering new diagnoses for patients with undiagnosed diseases.
Researchers have identified the protein marker Bim as a potential predictor for patient response to PD-1 immunotherapy for melanoma. Patients with high levels of Bim and soluble PD-L1 are more likely to respond to treatment, suggesting that this biomarker may help clinicians predict which patients will benefit from PD-1 blockade.
Researchers at Mayo Clinic's Florida campus have been awarded a $13.3 million grant to conduct a national, phase II clinical trial testing the ability of a folate receptor alpha vaccine to prevent recurrence of triple-negative breast cancer following initial treatment. The vaccine was designed by Dr. Keith Knutson and exploits the need...
A recent Mayo Clinic study found that the number of new thyroid cancer cases is doubling, driven by the detection of previously undiagnosed low-risk tumors. These silent cancers often require unnecessary treatments, leading to financial and physical hardship for patients.
Imetelstat, a novel telomerase targeting drug, demonstrates potential value in treating patients with myelofibrosis by inducing morphologic and molecular remissions in some patients. The study shows selective anti-clonal activity, inhibiting the growth of cancer cells.
Researchers analyzed data from patients undergoing stage IV colorectal cancer surgery to identify benchmarks for surgical practice. They found that major complications vary depending on the extent of liver resection and type of colorectal surgery performed.
The Mayo Clinic Cancer Center has been awarded a Specialized Program of Research Excellence (SPORE) grant to study the genetic basis of multiple myeloma and develop novel therapies.
Researchers at Mayo Clinic have discovered a way to potentially reprogram cancer cells back to normalcy by restoring the expression of specific microRNAs. This finding represents an unexpected new biology that provides the code for turning off cancer, offering a potential strategy for cancer therapy.
A Mayo Clinic study published in Pediatric Obesity found that excessive vitamin D supplementation in obese teenagers showed no benefits for their heart health or diabetes risk. The study, led by Dr. Seema Kumar, also found increased cholesterol and triglyceride levels in the teens during supplementation.
A Mayo Clinic-led study has validated the National Cancer Institute's Patient Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE), a tool used to track side effects in cancer clinical trials. The study found that PRO-CTCAE was accurate, reliable and responsive compared to other measures.
Mayo researchers found that class II HDAC inhibitors signal through a newly discovered pathway to promote synergy with chemotherapy treatment in anaplastic thyroid cancer. The study identified vorinostat and belinostat as effective agents, which can increase activity of RhoB, a tumor suppressor and stimulate cell death.
Leading cancer experts recommend several measures to reduce high cancer drug prices, including a post-approval price review mechanism and Medicare negotiations. The recommendations aim to improve patient care and alleviate the financial burden on those affected by high cancer drug costs.
A Mayo Clinic study has identified abnormalities in the levels and processing of ribonucleic acids (RNA) in patients with sporadic and genetic forms of ALS. The findings, published in Nature Neuroscience, suggest that different factors may contribute to the development of ALS and highlight the need for tailored therapies.
The Lymphoma Epidemiology of Outcomes Cohort Study will enroll 12,000 NHL patients and follow them for long-term prognosis and survivorship. The grant aims to improve the length and quality of life for NHL survivors.
Researchers identified nicotine use and substance abuse as top risk factors for long-term opioid use. Patients with these histories should proceed with caution when offered opioid prescriptions, says lead author W. Michael Hooten.
Researchers found that dasatinib inhibits proteins promoting cancer growth but also suppresses those protecting against it. The study suggests pretesting patient biopsies can help identify patients who may respond to dasatinib and those who should avoid it.
Researchers at Mayo Clinic have identified a new epigenomic block that could help stop the progression of many late-stage cancers. This discovery has the potential to improve diagnosis and treatment of advanced disease across various cancer types.
Researchers at Mayo Clinic have developed a new molecular classification system for gliomas, which could lead to more accurate diagnoses and personalized treatments. The system categorizes tumors based on three genetic alterations, allowing clinicians to predict patient outcomes and tailor treatment plans accordingly.
Mayo Clinic researchers identified 69 never events among 1.5 million invasive procedures, with 628 human factors contributing to the errors. Four to nine factors contributed to each event, including environmental, organizational, job and individual characteristics.
A recent Mayo Clinic study found that combining the targeted drug ibrutinib with standard chemotherapy significantly reduces the risk of death or cancer progression in patients with relapsed CLL or SLL. The treatment results in a nearly 80% reduction in mortality, offering new hope for longer disease control and decreased risk of relapse.
Pacritinib significantly reduced severe spleen enlargement and debilitating side effects in over 20% and 46% of patients, respectively. The therapy also showed promise in treating thrombocytopenia, a life-threatening condition often associated with myelofibrosis.
For individuals over 75, taking newer anticoagulant medications dabigatran or rivaroxaban increases the risk of gastrointestinal (GI) bleeding by 3-5 times compared to warfarin. The study found that younger patients have a lower risk of GI bleeding with these medications.
A study published in Journal of Pediatric Surgery highlights the risks of dog bites, particularly from family dogs. The research found that over 50% of dog bite injuries treated at a children's hospital came from immediate family members.
Patients with liver cancer can be cured with a liver transplant using organs from donors who died of cardiac death, according to the largest study of its kind. The study found no difference in liver cancer recurrence between livers donated after cardiac death and those obtained from brain-dead donors.
Researchers discover a minimally invasive method to remove genitourinary mesh implants without major surgery, improving symptoms for some patients. Mayo Clinic also reports promising outcomes for octogenarians undergoing artificial urinary sphincter operations and children with ADHD who receive sacral neuromodulation therapy
Researchers at Mayo Clinic developed a mouse model exhibiting neuropathological and behavioral features associated with C9ORF72 mutation. The study suggests a link between the repeat expansion in C9ORF72 and TDP-43 pathology, potentially leading to therapeutic agents targeting RNA foci and c9RAN proteins.
The Mayo Clinic is launching a study of 10,000 patients to examine the potential risks of drug reactions based on individual genome variations. Researchers will analyze DNA sequencing data from 69 genes influencing drug metabolism, aiming to identify 'early warning systems' for adverse reactions and ineffective treatments.
Researchers at Mayo Clinic analyzed data from over 20,000 patients and found that toxic levels are rare among those taking supplements. High levels above 50 ng/mL were associated with increased risk of kidney stones and other complications in women over age 65.
A Mayo Clinic-led research team has identified a molecular switch in the HER2 protein that sets off a cascade of events leading to cancer. Disrupting this site can stem the growth of breast cancer cells more effectively than current treatments.
Women with uterine fibroids have several treatment options, including medical and interventional therapies. Alternative treatment options include tranexamic acid, levonorgestrel-releasing IUDs, hysteroscopic myomectomy, endometrial ablation, gonadotropin-releasing hormone agonists, and more.
Researchers have identified methylated DNA markers in blood samples with 80% accuracy, enabling potential non-invasive screening for cancer. The discovery could lead to earlier diagnosis and improved patient outcomes for rare cancers like pancreatic cancer.
Researchers at Mayo Clinic have developed a profile to identify patients most at risk of developing pancreatic cancer. The study analyzed data from 1,126 patients and found that factors such as history of smoking, obesity, jaundice, and cyst size on imaging scans are associated with high risk.
A Mayo Clinic-led team has combined 77 common genetic variants into a polygenic risk score to improve breast cancer identification. The score is associated with a higher or lower risk of developing breast cancer, and can be used in conjunction with traditional predictors to personalize estimates.
Researchers found that transplant outcomes using kidneys from deceased donors with AKI were no different between the AKI and non-AKI groups at both 1 and 3 years post-transplant. The study results suggest that acutely injured kidneys can be considered for transplantation, potentially alleviating the US kidney shortage.
A Mayo Clinic study found that frequent attendance at work site wellness centers led to significant weight loss and healthcare cost savings. Members who visited the Dan Abraham Healthy Living Center (DAHLC) more than 360 times were 72% more likely to experience weight loss, with corresponding reductions in healthcare costs.
A Mayo Clinic study of over 3,600 postmortem brains reveals that tau protein is the primary driver of cognitive decline and memory loss in Alzheimer's disease. Amyloid buildup, while toxic, does not play a major role in disease progression, according to researchers.
Researchers at Mayo Clinic have discovered that it is possible to detect endometrial cancer using tumor DNA picked up by ordinary tampons. The study found higher methylation levels in vaginal secretions from women with endometrial cancer, suggesting a potential tool for early detection.