Mayo Clinic researchers have discovered an enzyme, Rac1b, that is tightly linked to the development of aggressive pancreatic cancer. The study provides key insights into the most aggressive form of the disease and offers a potential way to gauge outcome in individual patients.
A Mayo Clinic review of 47 studies found that complex, patient-centered interventions can reduce 30-day readmissions by almost 40%. These interventions include in-person visits to patients' homes after discharge to assess their living environment and needs.
A Mayo Clinic study finds that implementing a uniform method to care for lower-risk cardiac surgical patients reduces hospital time by 15% and lowers overall costs by 15%. The new model sets clear expectations for hospital care, improves patient experiences, and reduces variability in costs and outcomes.
A recent Mayo Clinic study found that nerve damage after hip surgery may be caused by inflammation, rather than mechanical factors. The study identified key signs for physicians to look out for, including delayed onset of neuropathy and severe pain.
Mayo Clinic researchers define a new subtype of Alzheimer's disease that produces different symptoms and affects the brain in unique ways. This subtype, called hippocampal sparing AD, may be misdiagnosed as other conditions, but could be treated with current medications.
A Mayo Clinic study found that ultrasound images of underarm lymph nodes are more accurate in overweight and obese breast cancer patients than in those with a normal body mass index. The research suggests that soft fatty tissue can be compressed during ultrasounds, leading to better specificity and accuracy for these patients.
A recent Mayo Clinic study discovered that individuals with mild cognitive impairment (MCI) tend to die at a higher rate than those without the condition. People with MCI experience an 80% increased risk of death over nearly six years.
A Mayo Clinic-led study found nine independent risk factors for acute respiratory distress syndrome in surgical patients, including sepsis and high-risk cardiac surgery. The findings may lead to better identification of high-risk patients before surgery and inform changes in care to prevent the condition.
Researchers found that rheumatoid arthritis patients have a 1 in 4 chance of developing chronic kidney disease over a 20-year period, compared to the general population's 1-in-5 risk. Patients should work to keep blood pressure under control and avoid medications damaging to the kidneys.
The Mayo Clinic uses frozen section analysis during breast cancer lumpectomies, sparing patients the need for repeat surgeries in 96% of cases. This technique significantly lowers the 30-day reoperation rate from 13.2% nationally to 3.6% at Mayo.
A new study by Mayo Clinic reveals that CT scans are effective in detecting uric acid crystals around joints, particularly in patients with multiple gout-like flares. Accurate diagnosis is crucial as gout patients require different medication than those with other forms of inflammatory arthritis.
Researchers at Mayo Clinic have discovered a specific genetic defect in the SCN5A gene that causes disruption in bowel function, leading to irritable bowel syndrome. This breakthrough finding has given researchers hope of developing disease-modifying agents to treat IBS.
Cologuard detects precancer and cancer with high sensitivity rates, surpassing existing non-invasive tests, offering a user-friendly approach to expand screening effectiveness and curb colorectal cancer rates. The test's accuracy has transformed how we think about colorectal cancer screening.
A large waist circumference is associated with increased mortality risk, even among individuals with a healthy body mass index (BMI). Men and women with larger waists are more likely to die younger and die from illnesses such as heart disease and cancer. Researchers recommend considering both BMI and waist circumference in risk assessm...
A new approach to breast reconstruction surgery, known as an enhanced recovery pathway, has been shown to reduce opioid painkiller use in patients by 50% and decrease hospital stays by a day on average. The method includes preoperative analgesics, nonsteroidal anti-inflammatories, and resuming food and walking soon after surgery.
A study by Mayo Clinic researchers found that patients who had troublesome teeth extracted before heart surgery were at a higher risk of poor outcomes, including death. The study suggested that physicians should evaluate each patient individually to weigh the benefits and risks of tooth extraction before cardiac surgery.
A new study by Mayo Clinic reveals that African-American individuals develop twice the antibody response to the rubella vaccine compared to Caucasians. This finding may enable the creation of vaccines tailored to specific ethnic groups or individuals, offering a more effective approach to immunization.
A Mayo Clinic study found that blacks are twice as likely to develop multiple myeloma because they are more likely to have monoclonal gammopathy of undetermined significance (MGUS). The study also showed that the type of MGUS in blacks is associated with a higher risk of progression to full-blown multiple myeloma.
Researchers discovered a protein responsible for gas exchanges in zebrafish gills, which may mimic human kidney function. NHE3 protein controls sodium and hydrogen ions, aiding in energy-saving balance and waste removal.
Researchers discovered that SPOP protein selectively destroys androgen receptor, a master regulator of prostate cancer cell growth. This finding sheds light on a new mechanism by which prostate cancer develops.
A study found that patients undergoing PCI have a higher risk of dying from non-cardiac diseases than heart disease, with only 37% of deaths being cardiac-related. The researchers attribute this to improved cardiac therapies, such as medication and catheterization laboratory technologies.
A Mayo Clinic study found a significant rise in skin cancer among middle-aged adults, with incidence increasing nearly eightfold between 1970 and 2009. Women between 40 and 50 showed the highest rates of increase, while men were more likely to have deeper lesions.
The new cholesterol guidelines suggest that caregivers prescribe statins to healthy patients if their 10-year cardiovascular risk is 7.5 percent or higher. A decision-making tool can help patients and clinicians weigh the benefits and harms of treatment, making a personalized choice based on individual values and context.
A Mayo Clinic study found that using a standardized medical management protocol and surgery can improve life expectancy for stroke patients. The treatment, which involves decompressing brain swelling, reduces pressure in the head and risk of death by about 50 percent.
Glaucoma blindness risk has dropped by half in the last generation, according to Mayo Clinic research. The study found a significant decrease in the probability of going blind in at least one eye due to glaucoma.
Researchers have found that trastuzumab can improve outcomes for bladder cancer patients with HER2 amplification, a known driver of aggressive tumors. The study identified 15% of MPUC patients had HER2 amplification, leading to faster growth and higher recurrence rates.
A study published in Mayo Clinic Proceedings reveals that most guidelines are based on lower-quality evidence and fail to disclose authors' conflicts of interest. The study highlights the need for more concise and transparent guideline development processes.
A Mayo Clinic study found that nearly all patients with intact rotator cuffs experience improved function and pain relief after shoulder replacement surgery. The procedure improves range of motion and reduces pain in nearly all cases, especially for those with rheumatoid arthritis.
A recent study at Mayo Clinic suggests that certain types of fractures in children may be linked to lower bone strength and a higher risk of osteoporotic fractures later in life. The study found that children with mild-trauma distal forearm fractures had weaker bones compared to those with moderate trauma or no fractures.
Combining varenicline and bupropion for smoking cessation showed increased quit rates in heavier and more dependent smokers. However, the effects were similar in lighter smokers using varenicline alone.
Mayo Clinic researcher Abba Zubair is sending human stem cells into space to see if they grow more rapidly than on Earth. The experiment aims to expand the population of stem cells that can induce regeneration of neurons and blood vessels in patients who have suffered a hemorrhagic stroke.
A Mayo Clinic-led study found that pain drugs used in prostate gland removal may be linked to cancer outcomes, as they can suppress the immune system's ability to fight cancer cells. The research suggests that a specific technique using opioids may reduce the risk of cancer recurrence and mortality.
A Mayo Clinic review article highlights the risks associated with elective early-term deliveries, including morbidity in newborns and maternal health concerns. The study calls for increased patient awareness and public education to promote safe term pregnancies.
A Mayo Clinic study found that endoxifen, an active metabolite of tamoxifen, is safe and shows anti-tumor activity in early-stage trials. The findings suggest a potential new treatment for estrogen-positive breast cancer patients who don't respond to standard hormonal therapies.
Researchers discovered imetelstat, a telomerase inhibitor, induces morphologic, molecular and clinical remissions in some patients with myelofibrosis. The study showed five patients achieved complete or partial remissions, including reversal of bone marrow fibrosis.
Mayo Clinic researchers found that improved mood is associated with increased participation in daily activities and independent living after brain injury rehabilitation. The study suggests a holistic approach to care can address both physical and personal problems, leading to better outcomes for patients.
A Mayo Clinic-led study has found that two commonly used drugs, low-dose dopamine and low-dose nesiritide, do not improve kidney function in hospitalized acute heart failure patients. The study analyzed data from 360 patients with kidney dysfunction and showed no significant improvement in urine volume or serum cystatin-C levels.
Researchers are exploring the role of innate immunity in Alzheimer's disease, hoping to identify novel therapies. By analyzing gene expression and RNA transcripts, they aim to understand the immune response's impact on the disease.
A Mayo Clinic study published in the Journal of Bone and Mineral Research found that patients with type 2 diabetes have lower bone material strength, highlighting the need for conventional measurements to be reevaluated. The research suggests potential detrimental effects of poor glucose control on bone quality.
Elderly patients who start dialysis after age 75 have a high mortality rate, with half dying within one year. Healthier elderly patients do better than those with declining health.
Researchers found that Cul4 modifies histone proteins to weaken their interaction with chaperones, leading to genomic instability and tumor formation. The study suggests that cancer cells may have evolved mechanisms to disrupt proper nucleosome assembly, affecting genome stability.
A minimally invasive endoscopic procedure to remove superficial, early stage esophageal cancer is as effective as surgery that takes out and rebuilds the esophagus, according to a Mayo Clinic study. The research found that patients treated by endoscopy had similar overall survival times compared to surgery.
Fibromyalgia symptoms worsen with age, according to a Mayo Clinic study. Young and middle-aged patients experience more severe physical health problems and lower quality of life compared to their older counterparts.
A new Mayo Clinic study finds that young and middle-aged fibromyalgia patients experience more severe symptoms and poorer quality of life compared to their older counterparts. The research also highlights the importance of considering age as a factor in understanding the disorder's impact on physical and mental health.
Mayo Clinic studies reveal that patients with rheumatoid arthritis are at increased risk of heart disease, with early menopause and a strong immune response to certain viruses being major contributors. The research also identifies specific biomarkers and blood test results that may indicate cardiovascular complications.
A recent Mayo Clinic survey found that uterine fibroids significantly impact the quality of life and workplace performance of women, with African-American women experiencing more severe symptoms and delayed diagnosis. The study highlights the need for better treatment options and increased awareness about this common public health issue.
Many parents believe the HPV vaccine is unnecessary or unsafe, which poses a barrier to its success. Experts argue that clinicians must engage with parents and address their concerns through open conversations and science-based information. Social media may also play a role in future HPV vaccination programs.
A Mayo Clinic psychiatrist argues that mass shootings are carefully planned and can be executed within a short time frame, making it difficult to restrict access to firearms for the mentally ill. The expert suggests that gun restriction among suicidal people works, but not necessarily in cases of mass shootings.
A Mayo Clinic study reveals that individuals with speech and language disorders are 3.5 times more likely to be teachers, highlighting an occupational hazard for educators. The researchers also found no such correlation between other occupations and the development of these disorders.
A Mayo Clinic study found that cataract surgery rates are rising across all age groups, with a significant increase among 70- and 80-year-olds. The demand is expected to continue, highlighting the need to manage costs and ensure access to treatment.