Burnout among US resident physicians is widespread, with high rates in urology, neurology, and emergency medicine. High levels of anxiety during medical school are associated with burnout symptoms during residency.
Researchers at Mayo Clinic have discovered that a dietary supplement called cyclocreatine may block the growth of HER2 positive breast cancer. The study found that cyclocreatine effectively targets mitochondrial creatine kinase 1 enzyme and reduces cancer growth without toxicity.
Researchers at Mayo Clinic and Arizona State University have discovered that a type of clay can kill certain bacteria causing infections in wounds. The clay's antibacterial properties were tested against various bacterial strains, including those resistant to antibiotics.
A Mayo Clinic research team has identified specific genes associated with an increased risk for developing triple-negative breast cancer. Alternations in BARD1, BRCA1, BRCA2, PALB2 and RAD51D genes were linked to a high risk for this subtype of breast cancer, while mutations in BRIP1 and RAD51C genes showed a moderate risk.
A Mayo Clinic study found that specific gut bacteria, such as Phascolarctobacterium and Dialister, are associated with weight loss success and failure, respectively. The research suggests that individualized strategies may be needed to address the unique metabolic needs of each person.
Researchers found that opioid prescription rates have remained flat for commercially insured patients over the past decade, but rates for some Medicare patients are leveling off. The study of 48 million U.S. patients showed high rates of opioid use among disabled Medicare Advantage recipients.
A new Mayo Clinic research study found that general anesthesia and surgery are associated with a subtle decline in memory and thinking skills in adults over 70. The study analyzed nearly 2,000 participants and found that exposure to anesthesia after age 70 was linked to long-term changes in brain function.
Researchers at Mayo Clinic have identified a neurological cause for the yips in golfers, which can be measured using quantitative methods. The study found that five out of 27 golfers had a neurologic cause for their condition, with greater acceleration of wrist and arm movement and more variability in wrist acceleration and rotation.
Researchers at Mayo Clinic found that senolytic drugs can significantly improve health span and life span in elderly mice by removing senescent cells. The study showed that administering senolytics orally improved physical function, increased daily activity, and extended remaining life span by 36 percent.
Researchers used precision genomics to identify new genetic abnormalities associated with short telomeres, which can cause premature aging. The study aimed to find better ways to screen, diagnose, and treat patients with these rare conditions.
Researchers at Mayo Clinic have discovered how the DNA repair protein 53BP1 relocates to chromosomes to fix damage, using RNA molecules as an off/on switch. This finding could lead to new therapies for ovarian cancer by targeting a specific protein called TIRR.
Researchers have discovered a potential diagnostic method for pancreatic cancer in patients with early onset diabetes by analyzing blood sugar levels over time. The ENDPAC score model identifies patients at high risk of developing pancreatic cancer, providing a new way to diagnose the disease at an earlier stage.
Researchers found six genes with mutations that substantially increase a person's risk for pancreatic cancer, even in those without family history. The study recommends genetic testing for all pancreatic cancer patients as the new standard of care.
Researchers at the Mayo Clinic have discovered genetically engineered bacteria that produce tryptamine, which helps food pass through the intestines with potentially less risk of side effects. This finding is significant as there are few approved constipation remedies on the market and traditional probiotics don't work for everyone.
Researchers at Mayo Clinic have developed a DNA test that can detect liver cancer with high accuracy, outperforming current methods. The test uses abnormal DNA markers found in liver cancer tissues and has been shown to detect over 90% of patients with curable stage tumors.
A new study found that hot flashes and night sweats can persist well into women's 60s, 70s, and 80s. Researchers suggest that women with these symptoms should discuss treatment options with their healthcare providers.
A study found that closing the left atrial appendage during coronary artery bypass or heart valve surgery reduces stroke and mortality risks, especially for patients with pre-existing atrial fibrillation. However, this procedure may increase risk in patients without prior atrial fibrillation.
A recent study by Mayo Clinic researchers found that the FDA-approved drug decitabine may be effective in treating triple-negative breast cancer. The study identified a subset of patients who could benefit from this therapy based on the presence of certain critical proteins.
Researchers developed an algorithm to predict treatment effectiveness in individual patients using a molecular communication pathway. The study found that repurposing ruxolitinib, a drug approved for malignant blood disorders, can overcome resistance to measles virotherapy by increasing its effectiveness by a factor of 1,000.
A team of researchers from Mayo Clinic identified a technology to address false positives in CT-based lung cancer screening, analyzing CT images and identifying disease characteristics. The findings show that a set of 57 variables can distinguish benign nodules from cancerous ones, reducing patient anxiety and unnecessary testing.
A Mayo Clinic survey found that nearly a third of patients did not use any opioids prescribed after surgery, with only 8% disposing of their remaining medications. The study suggests that patient factors such as age and pain score can influence opioid use, highlighting the need for tailored prescribing guidelines.
A Mayo Clinic study found that anesthesia exposure before the third birthday has no significant impact on intelligence, but may affect fine motor skills and behavior. Children with multiple anesthetic exposures showed modest declines in these areas, as well as increased learning and behavioral problems.
A new Mayo Clinic study reveals that transplanted livers regulate the host's immune responses and have a protective effect on other organs. This finding may pave the way for reduced immunosuppression needs in transplant patients.
New Mayo Clinic research reveals a disconnect between online physician reviews and patient satisfaction survey scores. While physicians with negative reviews do not score lower on patient interactions, they do receive lower ratings for factors beyond their control, such as waiting times and billing.
The Mayo Clinic has published a 'Charter on Physician Well-Being' to minimize and manage physician burnout, promoting a positive workplace culture. The charter calls for adequate support systems, wellness programs, and organizational changes to address stress, overwork, and mental health issues.
A new study published in Cephalalgia found that a single-pulse transcranial magnetic stimulation device can reduce the frequency of headache days by about three days per month. The device, called Spring TMS, was safe and easy to use, with 46% of patients experiencing at least 50% or less migraine attacks per month.
A new study by Mayo Clinic and international researchers found that genetic mutations associated with heart disease account for approximately 5% of SIDS deaths. The findings contradict previous estimates suggesting a higher prevalence of these genetic mutations in SIDS cases.
New Mayo Clinic research reveals that a significant majority of patients are receptive to asking about sexual orientation and gender identity, dispelling long-held concerns among healthcare providers. The study aims to improve health disparities among LGBTI patients by encouraging providers to ask these questions.
Research reveals that breast cancer and lymphoma patients are at increased risk of developing congestive heart failure, with a threefold higher risk compared to non-cancer patients. Periodic cardiac imaging and lifestyle changes may help mitigate this risk.
A new scientific statement by a Mayo Clinic led team suggests that conservative treatment may be more effective for women with SCAD. The average age of women with SCAD ranges from 45 to 53 years, and it is the No. 1 cause of heart attack during pregnancy and in the period right after giving birth.
A new study published in Mayo Clinic Proceedings found that up to 37 percent of studies on clinical trials show grossly exaggerated early results. The researchers emphasized the need for physicians and patients to be cautious when considering new or early trial evidence, as it may not accurately reflect real-world outcomes.
A Mayo Clinic study found a steady increase in kidney stone formers, particularly among women aged 18-39. Improved imaging technology allowed for better diagnosis and classification of stones, leading to more symptomatic cases being detected.
The Clinical Pharmacogenetics Implementation Consortium has published the first-ever clinical practice guideline for using CYP2D6 genotype to guide tamoxifen therapy in women with early-stage estrogen receptor-positive breast cancer. The guidelines recommend alternative hormonal therapies based on CYP2D6 genotype, aiming to improve tre...
A new study published in the European Journal of Preventive Cardiology found that standing burns more calories than sitting. By substituting standing for sitting for six hours a day, adults can expend an extra 54 calories, equivalent to 5.5 pounds in one year.
Researchers at Mayo Clinic discovered that electrical stimulation of the lateral temporal cortex enhances word recall, making it easier for patients to remember previously viewed words. The study suggests potential new treatment devices for memory and cognitive deficits.
Researchers at Mayo Clinic developed a new test that can establish which inherited BRCA2 gene mutations increase the risk of breast or ovarian cancer. The study identified 54 pathogenic mutations and expanded the list of neutral mutations, providing better decision-making options for patients with genetic testing results.
The Harry T. Mangurian Jr. Foundation has donated $20 million to Mayo Clinic to name a new medical building for cancer and neurologic care. The building will double the size of existing departments and support increased staff and research.
A Mayo Clinic study published in the New England Journal of Medicine found that patients with monoclonal gammopathy of undetermined significance are at risk of progressing to multiple myeloma or a related cancer even after 30 years. The overall risk of progression is relatively small, but it persists indefinitely.
A recent study by Mayo Clinic researchers found that most patients with suspected spinal cord inflammation of unknown cause were later diagnosed with a specific condition. The study revealed that nearly 70% of patients received an alternative diagnosis, including multiple sclerosis and vascular strokes of the spinal cord.
A Mayo Clinic study reveals that hysterectomy alone is associated with a significantly increased risk of cardiovascular diseases and metabolic conditions. Women under 35 had a high risk of congestive heart failure and coronary artery disease.
A new guideline from Mayo Clinic suggests that exercise can help people with mild cognitive impairment, which is an intermediate stage between normal aging and dementia. Twice-weekly workouts of 30 minutes or less may slow down the progression of symptoms.
A Mayo Clinic study found that high school athletes are more likely to correctly identify a concussion as a brain injury than their parents and coaches. Athletes were also better at identifying typical symptoms of concussion but struggled with understanding how the injury occurs and criteria for returning to play.
Researchers found that socio-demographic factors such as income level, education, and insurance status significantly impact access to stem cell transplants for patients with multiple myeloma. Higher-income Whites and Blacks, and those with private insurance, were more likely to receive the treatment.
Researchers found that higher physical activity prior to diagnosis and increased activity after diagnosis significantly improved overall and lymphoma-specific survival. Decreased perception of physical activity also led to poorer outcomes.
Researchers found that Apple Watch activity data correlated with standard patient-reported outcome measures, including physical function and quality of life. The study used emojis to measure quality of life, which showed significant associations with traditional scales.
Researchers developed a genetic model that predicts outcomes in primary myelofibrosis patients under 70 using gene mutations and clinical variables. The model improves on previous predictive models, which only used clinical variables.
Researchers found that contrast-enhanced digital mammography (CEDM) is comparable to breast MRI in evaluating residual breast cancer after neoadjuvant endocrine therapy or chemotherapy. CEDM may be a more accessible and cost-effective alternative to breast MRI, with fewer anxiety-provoking effects for patients.
A new article reviews options for treating genitourinary syndrome of menopause, including low-dose vaginal estrogen therapy and pelvic floor physical therapy. Despite the availability of effective treatments, lack of awareness among healthcare providers and patients hinders reaching women with this condition.
Researchers found that non-vitamin K antagonist oral anticoagulants are associated with reduced risk of adverse kidney outcomes in patients with atrial fibrillation. The study, published in the Journal of the American College of Cardiology, showed that about 1 in 4 patients taking these medications experienced significant kidney functi...
A Mayo Clinic study surveyed neurosurgeons on their attitudes toward ceasing practice and testing in late career. Most disagreed with an absolute age cutoff, while half favored additional testing for neurosurgeons 65 and older. The study highlights the need to focus on patient safety and assess a surgeon's capacity over time.