Researchers developed an algorithm to predict treatment effectiveness in individual patients using a molecular communication pathway. The study found that repurposing ruxolitinib, a drug approved for malignant blood disorders, can overcome resistance to measles virotherapy by increasing its effectiveness by a factor of 1,000.
A team of researchers from Mayo Clinic identified a technology to address false positives in CT-based lung cancer screening, analyzing CT images and identifying disease characteristics. The findings show that a set of 57 variables can distinguish benign nodules from cancerous ones, reducing patient anxiety and unnecessary testing.
A Mayo Clinic survey found that nearly a third of patients did not use any opioids prescribed after surgery, with only 8% disposing of their remaining medications. The study suggests that patient factors such as age and pain score can influence opioid use, highlighting the need for tailored prescribing guidelines.
A Mayo Clinic study found that anesthesia exposure before the third birthday has no significant impact on intelligence, but may affect fine motor skills and behavior. Children with multiple anesthetic exposures showed modest declines in these areas, as well as increased learning and behavioral problems.
A new Mayo Clinic study reveals that transplanted livers regulate the host's immune responses and have a protective effect on other organs. This finding may pave the way for reduced immunosuppression needs in transplant patients.
New Mayo Clinic research reveals a disconnect between online physician reviews and patient satisfaction survey scores. While physicians with negative reviews do not score lower on patient interactions, they do receive lower ratings for factors beyond their control, such as waiting times and billing.
The Mayo Clinic has published a 'Charter on Physician Well-Being' to minimize and manage physician burnout, promoting a positive workplace culture. The charter calls for adequate support systems, wellness programs, and organizational changes to address stress, overwork, and mental health issues.
A new study published in Cephalalgia found that a single-pulse transcranial magnetic stimulation device can reduce the frequency of headache days by about three days per month. The device, called Spring TMS, was safe and easy to use, with 46% of patients experiencing at least 50% or less migraine attacks per month.
A new study by Mayo Clinic and international researchers found that genetic mutations associated with heart disease account for approximately 5% of SIDS deaths. The findings contradict previous estimates suggesting a higher prevalence of these genetic mutations in SIDS cases.
New Mayo Clinic research reveals that a significant majority of patients are receptive to asking about sexual orientation and gender identity, dispelling long-held concerns among healthcare providers. The study aims to improve health disparities among LGBTI patients by encouraging providers to ask these questions.
Research reveals that breast cancer and lymphoma patients are at increased risk of developing congestive heart failure, with a threefold higher risk compared to non-cancer patients. Periodic cardiac imaging and lifestyle changes may help mitigate this risk.
A new scientific statement by a Mayo Clinic led team suggests that conservative treatment may be more effective for women with SCAD. The average age of women with SCAD ranges from 45 to 53 years, and it is the No. 1 cause of heart attack during pregnancy and in the period right after giving birth.
A new study published in Mayo Clinic Proceedings found that up to 37 percent of studies on clinical trials show grossly exaggerated early results. The researchers emphasized the need for physicians and patients to be cautious when considering new or early trial evidence, as it may not accurately reflect real-world outcomes.
A Mayo Clinic study found a steady increase in kidney stone formers, particularly among women aged 18-39. Improved imaging technology allowed for better diagnosis and classification of stones, leading to more symptomatic cases being detected.
The Clinical Pharmacogenetics Implementation Consortium has published the first-ever clinical practice guideline for using CYP2D6 genotype to guide tamoxifen therapy in women with early-stage estrogen receptor-positive breast cancer. The guidelines recommend alternative hormonal therapies based on CYP2D6 genotype, aiming to improve tre...
A new study published in the European Journal of Preventive Cardiology found that standing burns more calories than sitting. By substituting standing for sitting for six hours a day, adults can expend an extra 54 calories, equivalent to 5.5 pounds in one year.
Researchers at Mayo Clinic discovered that electrical stimulation of the lateral temporal cortex enhances word recall, making it easier for patients to remember previously viewed words. The study suggests potential new treatment devices for memory and cognitive deficits.
Researchers at Mayo Clinic developed a new test that can establish which inherited BRCA2 gene mutations increase the risk of breast or ovarian cancer. The study identified 54 pathogenic mutations and expanded the list of neutral mutations, providing better decision-making options for patients with genetic testing results.
The Harry T. Mangurian Jr. Foundation has donated $20 million to Mayo Clinic to name a new medical building for cancer and neurologic care. The building will double the size of existing departments and support increased staff and research.
A Mayo Clinic study published in the New England Journal of Medicine found that patients with monoclonal gammopathy of undetermined significance are at risk of progressing to multiple myeloma or a related cancer even after 30 years. The overall risk of progression is relatively small, but it persists indefinitely.
A recent study by Mayo Clinic researchers found that most patients with suspected spinal cord inflammation of unknown cause were later diagnosed with a specific condition. The study revealed that nearly 70% of patients received an alternative diagnosis, including multiple sclerosis and vascular strokes of the spinal cord.
A Mayo Clinic study reveals that hysterectomy alone is associated with a significantly increased risk of cardiovascular diseases and metabolic conditions. Women under 35 had a high risk of congestive heart failure and coronary artery disease.
A new guideline from Mayo Clinic suggests that exercise can help people with mild cognitive impairment, which is an intermediate stage between normal aging and dementia. Twice-weekly workouts of 30 minutes or less may slow down the progression of symptoms.
A Mayo Clinic study found that high school athletes are more likely to correctly identify a concussion as a brain injury than their parents and coaches. Athletes were also better at identifying typical symptoms of concussion but struggled with understanding how the injury occurs and criteria for returning to play.
Researchers found that socio-demographic factors such as income level, education, and insurance status significantly impact access to stem cell transplants for patients with multiple myeloma. Higher-income Whites and Blacks, and those with private insurance, were more likely to receive the treatment.
Researchers found that higher physical activity prior to diagnosis and increased activity after diagnosis significantly improved overall and lymphoma-specific survival. Decreased perception of physical activity also led to poorer outcomes.
Researchers found that Apple Watch activity data correlated with standard patient-reported outcome measures, including physical function and quality of life. The study used emojis to measure quality of life, which showed significant associations with traditional scales.
Researchers developed a genetic model that predicts outcomes in primary myelofibrosis patients under 70 using gene mutations and clinical variables. The model improves on previous predictive models, which only used clinical variables.
Researchers found that contrast-enhanced digital mammography (CEDM) is comparable to breast MRI in evaluating residual breast cancer after neoadjuvant endocrine therapy or chemotherapy. CEDM may be a more accessible and cost-effective alternative to breast MRI, with fewer anxiety-provoking effects for patients.
A new article reviews options for treating genitourinary syndrome of menopause, including low-dose vaginal estrogen therapy and pelvic floor physical therapy. Despite the availability of effective treatments, lack of awareness among healthcare providers and patients hinders reaching women with this condition.
Researchers found that non-vitamin K antagonist oral anticoagulants are associated with reduced risk of adverse kidney outcomes in patients with atrial fibrillation. The study, published in the Journal of the American College of Cardiology, showed that about 1 in 4 patients taking these medications experienced significant kidney functi...
A Mayo Clinic study surveyed neurosurgeons on their attitudes toward ceasing practice and testing in late career. Most disagreed with an absolute age cutoff, while half favored additional testing for neurosurgeons 65 and older. The study highlights the need to focus on patient safety and assess a surgeon's capacity over time.
A phase 3 trial found tolvaptan slows the rate of decline in kidney function in patients with autosomal dominant polycystic kidney disease. The condition affects millions in the US and has no cure. The drug targets a mechanism contributing to cyst growth, potentially delaying transplant or dialysis need.
A study published in Annals of Oncology has identified genetic markers that may predict resistance to a specific therapy used for treating advanced prostate cancer. The researchers found that understanding the genetic markers of tumors can help healthcare providers match a therapy that is likely to succeed on the first try.
A study found that proton beam therapy in combination with chemotherapy prior to surgery reduces postoperative heart and lung problems and mortality rates in elderly patients. Researchers followed 571 patients treated with traditional radiation therapy and chemotherapy followed by surgery at Mayo Clinic Cancer Center.
A recent study led by Mayo Clinic researchers found that tumor-infiltrating lymphocytes present in high-grade ovarian cancer tumors can predict patient survival. The study analyzed over 5,500 patients from nine countries and discovered that higher levels of these immune cells were associated with better outcomes.
Midlife women experience significant weight gain, mainly in the midsection, increasing cardiovascular disease risk. Researchers recommend primary care providers screen for overweight and establish behavioral interventions, including psychological support and physical activity.
A recent study by Mayo Clinic found that nearly 40% of physicians hesitate to seek mental health care due to concerns about their medical license. The researchers discovered that states with licensing requirements asking about past mental health conditions have more reluctant physicians.
Researchers found that patients with pre-existing psychiatric diagnoses had higher acute and follow-up costs, particularly in emergency department and hospital outpatient costs. Addressing psychiatric comorbidities proactively may mitigate cost differences for these patients.
Researchers found ED opioid prescriptions were 44% less likely to exceed a three-day supply and 46% less likely to progress to long-term use. Patients in non-ED settings received higher doses, with one in five exceeding CDC guidelines, leading to a higher risk of long-term use.
Mayo Clinic researchers found that reducing radiation therapy intensity by 50% resulted in fewer side effects without compromising survival or cure rates. The study followed 80 patients with HPV-related throat cancer and reported a 95% tumor control rate at two years, with only one regional recurrence.
A Mayo Clinic study found that Liraglutide slowed stomach emptying and led to significant weight loss in treated patients. The degree of stomach emptying delay was associated with the degree of weight loss, suggesting a potential biomarker for individualizing obesity treatment.
A new Mayo Clinic study found that sleeping with dogs can help people sleep better, but only if they're in the bedroom, not in bed. The study of 40 healthy adults and their dogs over five months showed that having pets nearby can provide comfort and security.
Senolytic agents target senescent cells, which accumulate with age and contribute to chronic conditions like diabetes, cardiovascular disease, and cancer. Mayo Clinic researchers have identified new screening platforms to find additional senolytic drugs, potentially leading to transformative treatments for aging-related diseases.
Researchers have identified two key genes that contribute to the aggressive spread of neuroblastomas. The study found that high levels of LMO1 expression promote metastasis in MYCN-induced neuroblastoma by dysregulating extracellular matrix genes, paving the way for new therapies.
Researchers found that Z-endoxifen provided substantial drug exposure, acceptable toxicity, and promising anti-tumor activity in patients with metastatic breast cancer who had progressed on standard anti-estrogen treatments. The treatment resulted in tumor shrinkage, with some cases lasting over two years without disease progression.
A new study from Mayo Clinic researchers found that women with a history of pre-eclampsia are more likely to experience atherosclerosis, hardening and narrowing of the arteries, decades after their pregnancy. This condition can pose a risk to the mother's cardiovascular health even after menopause.
Researchers discovered a causal link between senescent cells and age-related bone loss in mice. Targeting these cells increased bone mass and strength. The study's findings suggest that senolytic drugs may have widespread application in treating multiple chronic diseases, including osteoporosis.
Researchers at Mayo Clinic have identified a link between SPOP gene mutations and treatment resistance in prostate cancer. The discovery suggests ways to improve therapy by using these mutations as biomarkers. This breakthrough could lead to more effective treatments for this common and deadly form of cancer.
Researchers at Mayo Clinic and University of Iowa found a human gut microbe, Prevotella histicola, that effectively suppresses immune disease in a mouse model of MS. The study suggests that this microbe may play a role in treating MS, an autoimmune disease caused by the immune system's attack on the myelin sheath.