Mayo Clinic researchers discovered subtle structural features in living donor kidneys that can predict transplant failure in recipients. These features include minimal scarring, hardening of vessels, and enlarged nephrons.
New study finds liver mesenchymal stromal cells have immunoregulatory qualities making them more effective than similar cells derived from bone marrow and fat tissue. The discovery could lead to better treatment options for diseases like organ rejection, inflammatory bowel disease, and autoimmune disorders.
Researchers identify Protease Activated Receptor 1 (PAR1) as a molecular switch that promotes myelin regeneration, potentially improving function in neurological disorders. The study's findings suggest new strategies for treating diseases of the central nervous system.
Researchers used genetic testing to identify a common genetic factor among affected families, revealing a homozygous multiexon duplication in RYR2 gene. Genetic testing confirmed the same gene duplication in two unrelated Amish families, allowing for potential lifesaving premarital counseling and reproductive planning
A new study found that cardiorespiratory exercise is associated with increased gray matter volume and decelerated cognitive decline. Regular exercise of moderate intensity, such as walking or biking, may contribute to improved brain health.
A Mayo Clinic study assesses its own compensation model and finds 96% of physicians adhere to pay equity guidelines. The study's results demonstrate the effectiveness of a structured compensation system in promoting pay equity, with no correlation between compensation disparities and gender, race, or ethnicity.
A population study found that diabetes is an independent risk factor for heart failure, with 21% of diabetic patients developing heart failure over a 10-year period. This study supports the concept of diabetic cardiomyopathy and highlights the need for further research into this association.
Researchers found that younger patients with stomach cancer often present with more aggressive disease, a worse prognosis, and reduced effectiveness of traditional chemotherapy treatments. The study highlights the importance of increased awareness and early detection for this increasingly prevalent form of stomach cancer.
A Mayo Clinic study of 5,540 patients with metastatic colorectal cancer found that maintenance chemotherapy after initial treatment is more beneficial for patients whose disease is under control. The preferred regimen is fluoropyrimidine with or without bevacizumab, according to the analysis.
Researchers found a microbiome signature associated with endometrial cancer risk, particularly in postmenopausal women, and verified established risk factors including obesity and high vaginal pH. The study aims to develop a screening tool for early detection of endometrial cancer.
Researchers found that women who used ibuprofen or naproxen had a 40% reduced breast cancer risk, while aspirin use offered no benefit. Young women with HER2-positive breast cancer may preserve fertility by choosing less intensive chemotherapy regimens.
A Mayo Clinic study found a statistically insignificant increase in injury rate among participants in a six-week high-intensity functional training program. The study reported an injury rate of 9 injuries per 1,000 training hours during the six-week training, compared to 5 injuries per 1,000 training hours before enrollment.
A clinical trial enrolled 10 adults with traumatic spinal cord injuries to receive stem cell injections, with the first patient demonstrating significant improvement in motor and sensory functions. The study's early findings suggest that patient response varies, but the treatment may offer a new option for improving physical function a...
A Mayo Clinic-led study found that people with inflammatory bowel disease, Type 1 diabetes or blood clots may be at increased risk of developing rheumatoid arthritis. Comorbidities are linked to poorer outcomes for patients with rheumatoid arthritis, including worsened physical disability and increased mortality.
The ORION-10 trial shows inclisiran significantly lowers LDL cholesterol in patients taking statin drugs, reducing heart attack and stroke risk. The medication's excellent safety profile and convenient dosing schedule make it a promising treatment option.
A Mayo Clinic study found that men reported higher levels of physical activity and greater confidence in maintaining good health habits compared to women. Women, however, had lower self-reported levels of physical activity and lower confidence in their ability to maintain it.
A Mayo Clinic-led study found that microvascular endothelial dysfunction is associated with a greater than twofold risk of cancer. The condition, which affects the heart's small arteries, may be a useful marker for predicting cancer risk.
Researchers at Mayo Clinic have identified a way to slow and reverse fibrosis by targeting a dopamine receptor, which blocks the growth of scar-forming cells. The approach reversed fibrotic processes in lung and liver models, offering a new treatment concept for fibrotic diseases.
Researchers at Mayo Clinic identified distinct patterns of brain damage associated with different Alzheimer's subtypes and age of onset. These findings suggest that available therapies will be most effective for patients with the hippocampal-sparing subtype and young-onset form of the disease.
A study by the Eastern Cooperative Oncology Group found that lenalidomide delayed disease progression and improved overall survival in high-risk smoldering multiple myeloma patients. The treatment reduced serious adverse events, but it is unclear if it affects overall survival.
Chronic kidney disease patients are at an increased risk of heart attacks, congestive heart failure, stroke, and other adverse cardiovascular events. The study found that chronic kidney disease is associated with a 95% higher risk of heart attack during the follow-up period.
A Mayo Clinic study reveals that commercial facial recognition software can accurately identify people from brain MRI scans, even with image face removal. The study found an 83% success rate in identifying participants using publicly available facial recognition software.
Researchers have found no evidence of lipid accumulation as the cause of vaping-related lung injuries, suggesting a direct chemical injury from noxious fumes instead. The study's findings support concerns about the risks of vaping and call for better regulation and education.
A review of medical data on opioid addiction in the US found that medication-assisted treatment with naltrexone, buprenorphine and methadone is effective in treating opioid use disorder. The three drugs have different strengths and weaknesses, and their optimal approach should be discussed with each patient.
In a small clinical trial, Mayo Clinic researchers showed that senolytic drugs can significantly decrease senescent cell burden in humans. The study found that the combination of dasatinab and quercetin reduced senescent cells in blood, skin, and fat tissue for at least 11 days.
Researchers at Mayo Clinic discovered that inhibiting GSK-3 enzyme sensitizes pancreatic cancer cells to gemcitabine, a commonly used chemotherapy. This new approach may overcome resistance to chemotherapy and improve treatment outcomes for patients with pancreatic cancer.
Researchers at Mayo Clinic found that increasing PD-L1 expression in colorectal cancer cells can improve chemotherapy effectiveness. This discovery suggests a potential strategy to enhance treatment outcomes for patients with resistant colon cancer.
A recent study published in Mayo Clinic Proceedings found that dog owners had lower cardiovascular disease risk factors and healthier cardiovascular profiles compared to non-pet owners. The study discovered that the benefits of dog ownership on heart health were most pronounced for those who owned a dog, regardless of age, sex, or educ...
A Mayo Clinic study found that 44% of screened first-degree relatives had celiac disease, with 94% displaying no classic symptoms. The study advocates for proactive screening among family members to prevent malabsorption, nutritional deficiencies and autoimmune conditions.
CBD oils may have anti-inflammatory effects and improve sleep and anxiety, but human trials are limited due to concerns over liver injury. Physicians need to become better informed about CBD products to provide effective treatment options for chronic pain management.
A recent study by Mayo Clinic researchers found that over 2.3 million adult patients in the US are likely treated too intensively for their blood sugar levels, resulting in thousands of preventable hospitalizations and emergency department visits. This excessive treatment is linked to increased risk of hypoglycemia and other complicati...
A study by Mayo Clinic researchers found that external professional coaching can alleviate burnout symptoms in physicians. The coaching focused on goal setting, work choices, and influencing change at work, leading to reduced burnout and improved quality of life among participants.
Researchers trained AI to identify subtle differences in normal EKGs that indicate changes caused by atrial fibrillation. The AI-enabled EKG correctly identified the condition with 90% accuracy, improving treatment options and efficiency of heart disease screening.
Researchers at Mayo Clinic have identified two distinct pathways for lung adenocarcinoma development, which can inform treatment strategies and predict patient response. The study's findings suggest that targeting specific pathways may provide alternative treatment options for patients with limited response to traditional therapies.
A longitudinal study of 3,756 U.S. medical students found that racism in medical school was associated with graduating students' decisions to provide care in high-need communities. Strategies such as service learning experiences and a curriculum focused on minority health can increase intention to practice in underserved areas.
A recent study by Mayo Clinic researchers found an association between increased symptoms of burnout and heightened racial bias in medical residents. Physicians experiencing high symptoms of burnout tended to exhibit more racial bias, both explicit and implicit, but recoveries from burnout were linked to reductions in bias.
A phase I clinical trial demonstrates the potential of regenerative therapy for hypoplastic left heart syndrome through collecting, processing and injecting an infant's own stem cells directly into the heart at the time of surgery. The study showed no deaths or significant safety concerns over six months following surgery.
A study of over 1,800 cases found that the need for additional surgery was twice as high after transobturator sling surgery compared to retropubic sling. The study also revealed lower reoperation rates and fewer complications with the retropubic procedure.
A study by Mayo Clinic researchers found that micronutrient deficiencies are common in adults diagnosed with celiac disease. The most frequent deficiency was zinc, observed in 59.4% of patients, while vitamin D, iron, copper, vitamin B12, and folate were also prevalent.
A recent study found that only 5.5% of glioblastoma patients survive five years after diagnosis, highlighting the need for more aggressive treatments to improve long-term survival. The research analyzed 48,652 cases and identified factors associated with five-year survival, including age, race, gender, and treatment with radiotherapy.
A new study by Mayo Clinic researchers found that generic and brand-name levothyroxine therapy are similar in terms of cardiovascular event rates, with lower pharmacy costs for the generic drug. The analysis used deidentified claims data from a large private health plan and included over 87,000 patients.
A Mayo Clinic study of 444,764 patients found that tramadol was more likely than other opioids to result in prolonged use, challenging its classification as a lower-risk medication. The researchers used de-identified data from the OptumLabs Data Warehouse to examine prescription fills after surgery.
A randomized, double-blind, placebo-controlled study found that eculizumab significantly reduced the risk of relapse in patients with neuromyelitis optica spectrum disorder. Nearly 98% of patients treated with eculizumab had not relapsed after 48 weeks, compared to 63% for those on the placebo.
A Mayo Clinic study shows that less-invasive mastectomy is a safe option for more patients, including those with locally advanced cancer or surgical complication risk factors. The procedure's complications declined significantly between 2009 and 2017, and reconstruction success rates were high at one year after surgery.
Research suggests that daily activities such as eating and walking are affected early in the course of rheumatoid arthritis, with most patients experiencing functional disabilities. The study also found that persistent excess in functional disability continued even after diagnosis and treatment.
A new report calls for increased research into 'limbic-predominant age-related TDP-43 encephalopathy,' or LATE, a degenerative brain disease that affects the elderly and mimics Alzheimer's. Researchers aim to improve prevention, diagnosis, and treatment through better understanding of the condition.
Cancer cells use PD-L1 to evade immune surveillance and resist chemotherapy and radiation therapy. Researchers propose using an antibody that disrupts PD-L1's internal function to make cancer cells more sensitive to treatment.
A majority of US states restrict decision-making for incapacitated pregnant women, with 25 laws invalidating advance directives during pregnancy. Thirty-eight states have laws that identify pregnancy as a condition affecting decisions for incapacitated women, but these laws vary widely in content.
A recent study published in JAMA found that magic mouthwash significantly reduced pain from oral mucositis, a common side effect of radiation therapy for head and neck cancers. The treatment, which contains diphenhydramine, lidocaine, and antacids, was well-tolerated by patients and outperformed placebo.
A telerehabilitation program has been shown to improve the physical function, pain, and quality of life of patients with late-stage cancers. The study found that these patients who received remotely delivered rehabilitation services had fewer hospital and nursing home stays.