The Mayo Clinic has provided guidance on how to use ECGs to monitor patients at risk of drug-induced sudden cardiac death due to COVID-19. The guidelines aim to minimize the chance of fatal arrhythmias, particularly for patients taking antimalarial drugs like hydroxychloroquine.
A study published in Mayo Clinic Proceedings found that homeless patients admitted with a heart attack often received less treatment, had longer hospital stays, and were more likely to be readmitted. These patients also faced unique challenges due to high rates of mental illness, substance abuse, and HIV infections.
Researchers have uncovered mechanisms of healing after a heart attack using human cardiopoietic cells, which restored cardiac muscle to its pre-attack state. The study found that these cells reversed two-thirds of the changes caused by a heart attack, with 85% of cellular functional categories responding favorably to treatment.
A new Mayo Clinic study found no link between surgery with general anesthesia and the indicator of Alzheimer's disease. Cortical thinning in cerebral areas was observed, but no significant evidence of amyloid protein deposits, a hallmark of Alzheimer's, was detected.
A Mayo Clinic-led study reveals that rapid fat degradation occurs in acute pancreatitis, triggered by PNLIP enzyme, and worsens disease outcomes. Obesity exacerbates pancreatitis risk, while unsaturated fats increase organ failure risk.
A new study by Mayo Clinic researchers found that catheter ablation reduced the risk of death or hospitalization due to worsening heart failure in patients with both conditions. The study analyzed data from over 289,000 patients and showed an 18% reduction in risk for those who received ablation.
Researchers discovered that a Mx protein, called MxB, helps cells fight viral infections by supporting mitochondrial function and integrity. The study provides new insights into the role of MxB in cellular defense against viral infections.
A Mayo Clinic study found that genetic variants on chromosomes 1 and 5 were linked to higher tau levels in older adults. Participants with these variants had about 10% higher tau levels than those without them. The research suggests that genes previously linked to Alzheimer's risk may not be associated with tau accumulation.
A new framework for managing chronic pain in older adults emphasizes the importance of combining pharmacologic strategies with nondrug therapies. The 'start low, go slow' approach suggests beginning with low-risk, noninvasive options that involve patients in their own care, while judiciously using higher-risk treatments as needed.
Researchers at Mayo Clinic have found that combining density of immune cells with analysis of tumor budding can improve accuracy in predicting patient survival for patients with stage III colon cancer. This method provides important data on patient survival and may lead to personalized treatment recommendations.
A study by Mayo Clinic researchers suggests that all women with a breast cancer diagnosis under the age of 66 be offered germline genetic testing. This approach would identify 98% of women with BRCA1 and BRCA2 mutations, while avoiding testing of 20% of all breast cancers.
A new study found that people with Type 2 diabetes in the US often receive treatment that is too aggressive or not aggressive enough, with those who are most likely to benefit from intensive therapy being underserved. The study suggests a fine line between effective treatment and increased risk of hypoglycemia.
Researchers at Mayo Clinic have created an artificial intelligence (AI) algorithm that can detect unseen characteristics of hypertrophic cardiomyopathy using standard EKGs. The AI's ability to diagnose the disease was found to be highly accurate, with an area under the curve of 0.96, outperforming traditional tests.
The study evaluated nationwide data from 2003 to 2016, assessing changes in the risk profiles and number of patients undergoing revascularization. It found an increase in elderly patients, racial minorities, and those with lower income, as well as a decrease in the use of coronary artery bypass grafting.
Researchers at Mayo Clinic have discovered a method to make tumor cells more responsive to immunotherapy. By promoting genetic mutations in tumor cells, they found that these cells become vulnerable to immune system attacks. The approach showed promise across different types of tumors and patient genomes.
Researchers propose evaluating vascular function in women starting in middle age to detect early signs of vascular aging and reduce heart disease risk. This approach could help establish a baseline of vascular health, measure effectiveness of lifestyle changes and clinical treatment for cardiovascular disease.
In a new study, Mayo Clinic researchers discovered that in-home bilevel positive airway pressure (BiPAP) therapy can significantly improve COPD patient outcomes, including reduced mortality rates and fewer hospital admissions. The treatment helps alleviate shortness of breath and reduces the risk of intubation.
A Mayo Clinic medical student has developed a curriculum to train fellow students to identify and provide resources to potential human trafficking victims. The study highlights the need for standardized training resources in medical schools to recognize the signs of trafficking and care for these patients.
Mayo Clinic researchers discovered subtle structural features in living donor kidneys that can predict transplant failure in recipients. These features include minimal scarring, hardening of vessels, and enlarged nephrons.
New study finds liver mesenchymal stromal cells have immunoregulatory qualities making them more effective than similar cells derived from bone marrow and fat tissue. The discovery could lead to better treatment options for diseases like organ rejection, inflammatory bowel disease, and autoimmune disorders.
Researchers identify Protease Activated Receptor 1 (PAR1) as a molecular switch that promotes myelin regeneration, potentially improving function in neurological disorders. The study's findings suggest new strategies for treating diseases of the central nervous system.
Researchers used genetic testing to identify a common genetic factor among affected families, revealing a homozygous multiexon duplication in RYR2 gene. Genetic testing confirmed the same gene duplication in two unrelated Amish families, allowing for potential lifesaving premarital counseling and reproductive planning
A new study found that cardiorespiratory exercise is associated with increased gray matter volume and decelerated cognitive decline. Regular exercise of moderate intensity, such as walking or biking, may contribute to improved brain health.
A Mayo Clinic study assesses its own compensation model and finds 96% of physicians adhere to pay equity guidelines. The study's results demonstrate the effectiveness of a structured compensation system in promoting pay equity, with no correlation between compensation disparities and gender, race, or ethnicity.
A population study found that diabetes is an independent risk factor for heart failure, with 21% of diabetic patients developing heart failure over a 10-year period. This study supports the concept of diabetic cardiomyopathy and highlights the need for further research into this association.
Researchers found that younger patients with stomach cancer often present with more aggressive disease, a worse prognosis, and reduced effectiveness of traditional chemotherapy treatments. The study highlights the importance of increased awareness and early detection for this increasingly prevalent form of stomach cancer.
A Mayo Clinic study of 5,540 patients with metastatic colorectal cancer found that maintenance chemotherapy after initial treatment is more beneficial for patients whose disease is under control. The preferred regimen is fluoropyrimidine with or without bevacizumab, according to the analysis.
Researchers found a microbiome signature associated with endometrial cancer risk, particularly in postmenopausal women, and verified established risk factors including obesity and high vaginal pH. The study aims to develop a screening tool for early detection of endometrial cancer.
Researchers found that women who used ibuprofen or naproxen had a 40% reduced breast cancer risk, while aspirin use offered no benefit. Young women with HER2-positive breast cancer may preserve fertility by choosing less intensive chemotherapy regimens.
A Mayo Clinic study found a statistically insignificant increase in injury rate among participants in a six-week high-intensity functional training program. The study reported an injury rate of 9 injuries per 1,000 training hours during the six-week training, compared to 5 injuries per 1,000 training hours before enrollment.
A clinical trial enrolled 10 adults with traumatic spinal cord injuries to receive stem cell injections, with the first patient demonstrating significant improvement in motor and sensory functions. The study's early findings suggest that patient response varies, but the treatment may offer a new option for improving physical function a...
A Mayo Clinic-led study found that people with inflammatory bowel disease, Type 1 diabetes or blood clots may be at increased risk of developing rheumatoid arthritis. Comorbidities are linked to poorer outcomes for patients with rheumatoid arthritis, including worsened physical disability and increased mortality.
The ORION-10 trial shows inclisiran significantly lowers LDL cholesterol in patients taking statin drugs, reducing heart attack and stroke risk. The medication's excellent safety profile and convenient dosing schedule make it a promising treatment option.
A Mayo Clinic study found that men reported higher levels of physical activity and greater confidence in maintaining good health habits compared to women. Women, however, had lower self-reported levels of physical activity and lower confidence in their ability to maintain it.
A Mayo Clinic-led study found that microvascular endothelial dysfunction is associated with a greater than twofold risk of cancer. The condition, which affects the heart's small arteries, may be a useful marker for predicting cancer risk.
Researchers at Mayo Clinic have identified a way to slow and reverse fibrosis by targeting a dopamine receptor, which blocks the growth of scar-forming cells. The approach reversed fibrotic processes in lung and liver models, offering a new treatment concept for fibrotic diseases.
Researchers at Mayo Clinic identified distinct patterns of brain damage associated with different Alzheimer's subtypes and age of onset. These findings suggest that available therapies will be most effective for patients with the hippocampal-sparing subtype and young-onset form of the disease.
A study by the Eastern Cooperative Oncology Group found that lenalidomide delayed disease progression and improved overall survival in high-risk smoldering multiple myeloma patients. The treatment reduced serious adverse events, but it is unclear if it affects overall survival.
Chronic kidney disease patients are at an increased risk of heart attacks, congestive heart failure, stroke, and other adverse cardiovascular events. The study found that chronic kidney disease is associated with a 95% higher risk of heart attack during the follow-up period.
A Mayo Clinic study reveals that commercial facial recognition software can accurately identify people from brain MRI scans, even with image face removal. The study found an 83% success rate in identifying participants using publicly available facial recognition software.
Researchers have found no evidence of lipid accumulation as the cause of vaping-related lung injuries, suggesting a direct chemical injury from noxious fumes instead. The study's findings support concerns about the risks of vaping and call for better regulation and education.
A review of medical data on opioid addiction in the US found that medication-assisted treatment with naltrexone, buprenorphine and methadone is effective in treating opioid use disorder. The three drugs have different strengths and weaknesses, and their optimal approach should be discussed with each patient.
In a small clinical trial, Mayo Clinic researchers showed that senolytic drugs can significantly decrease senescent cell burden in humans. The study found that the combination of dasatinab and quercetin reduced senescent cells in blood, skin, and fat tissue for at least 11 days.
Researchers at Mayo Clinic discovered that inhibiting GSK-3 enzyme sensitizes pancreatic cancer cells to gemcitabine, a commonly used chemotherapy. This new approach may overcome resistance to chemotherapy and improve treatment outcomes for patients with pancreatic cancer.
Researchers at Mayo Clinic found that increasing PD-L1 expression in colorectal cancer cells can improve chemotherapy effectiveness. This discovery suggests a potential strategy to enhance treatment outcomes for patients with resistant colon cancer.
A recent study published in Mayo Clinic Proceedings found that dog owners had lower cardiovascular disease risk factors and healthier cardiovascular profiles compared to non-pet owners. The study discovered that the benefits of dog ownership on heart health were most pronounced for those who owned a dog, regardless of age, sex, or educ...
A Mayo Clinic study found that 44% of screened first-degree relatives had celiac disease, with 94% displaying no classic symptoms. The study advocates for proactive screening among family members to prevent malabsorption, nutritional deficiencies and autoimmune conditions.
CBD oils may have anti-inflammatory effects and improve sleep and anxiety, but human trials are limited due to concerns over liver injury. Physicians need to become better informed about CBD products to provide effective treatment options for chronic pain management.
A recent study by Mayo Clinic researchers found that over 2.3 million adult patients in the US are likely treated too intensively for their blood sugar levels, resulting in thousands of preventable hospitalizations and emergency department visits. This excessive treatment is linked to increased risk of hypoglycemia and other complicati...
A study by Mayo Clinic researchers found that external professional coaching can alleviate burnout symptoms in physicians. The coaching focused on goal setting, work choices, and influencing change at work, leading to reduced burnout and improved quality of life among participants.