Researchers at Mayo Clinic Cancer Center found that remote patient monitoring reduced the risk of hospitalization for cancer patients with COVID-19 by 78%. The program used in-home technology to monitor oxygen levels and vital signs, resulting in fewer hospitalizations and ICU admissions.
The study found that rivaroxaban is safe for patients with luminal gastrointestinal cancer, while apixaban should be used cautiously due to higher bleeding risk. DOACs can also be used in non-luminal GI cancers like pancreatic and hepatobiliary cancers.
Researchers found that a significant gap between numerical age and biological age, as predicted by AI-enabled EKGs, is associated with increased risk of death from heart disease. The study validated the use of AI-aged EKGs in predicting mortality rates.
A Mayo Clinic study reports on the first 100 patients with post-COVID-19 syndrome, experiencing symptoms like fatigue, respiratory complaints, and neurologic issues. The study highlights the need for healthcare providers to prepare for prolonged symptoms and provide effective treatment, including psychosocial support.
A new AI-powered ECG screening tool detected asymptomatic low ejection fraction in patients with improved diagnosis rates. The study found that the AI intervention increased the diagnosis of low ejection fraction by 32% relative to usual care.
A high rate of vaccination is vital to reducing COVID-19 cases and controlling the pandemic, according to new research from the Mayo Clinic. If Minnesota had achieved a 75% vaccination rate by early April, case numbers and hospitalizations would plummet by July.
Researchers developed an acellular product, PEP, derived from platelets that heals ischemic wounds by delivering healing messages to cells. The study demonstrates restoration of skin integrity and function in preclinical animal models.
A small study from Mayo Clinic researchers raises concerns that some transplant patients may have a limited immune response after receiving an mRNA COVID-19 vaccine. The study found that infected vaccinated solid organ transplant recipients had a 10 times higher infection rate compared to the general population.
Researchers analyzed tissue samples from 385 brains with Alzheimer's disease, identifying the SERPINA5 gene as strongly associated with tau protein tangle progression. The study aimed to clarify the relevance of gene expression changes in Alzheimer's disease and provide new targets for treatment.
A Mayo Clinic study found that 15.5% of patients with colorectal cancer had inherited gene mutations, which can be detected through universal testing and broader gene panels. This discovery has the potential to lead to targeted cancer therapies and earlier disease detection in families.
A Mayo Clinic study found that pregnancy significantly increases the risk of a first-time symptomatic kidney stone. The risk peaks close to delivery and improves by one year after delivery.
A new surgical approach at Mayo Clinic has shown promising results in reducing antibody-mediated rejection in highly sensitized patients. The reverse-order heart-liver transplant procedure involves transplanting the liver first, followed by the heart, and has been successful in all seven patients who underwent the procedure.
A new Mayo Clinic research found that tumor mutation burden is significantly inflated in Black patients with cancer compared to White patients, affecting therapy selection. The study suggests that accurate tumor mutational burden is crucial for predicting optimal treatment for patients with diverse ancestral backgrounds.
A Mayo Clinic study found that vaccinated patients without symptoms had an 80% lower adjusted risk of testing positive for COVID-19 after their last dose. The Pfizer-BioNTech and Moderna messenger RNA vaccines showed efficacy in limiting the spread of COVID-19 among asymptomatic individuals.
The study found a significant increase in loneliness and a decrease in feelings of friendship during the pandemic. Women reported higher levels of loneliness compared to men, while those with poorer health experienced decreased emotional support.
Researchers at Mayo Clinic have combined a functional test with clinical information to determine the clinical importance of BRCA2 gene variants of uncertain significance. The findings improved reclassification rates for VUS from 10% to 86%, enabling more accurate patient care and targeted therapy options.
Researchers at Mayo Clinic have developed LEAP, a proton therapy technique that targets cancer cells with defects in the ATM-BRCA1-BRCA2 DNA repair pathway, sparing surrounding normal tissues. The technique uses concentrated proton energy deposition to induce biologic responses in treatment-resistant cancers.
A study by Mayo Clinic researchers has identified USP24 as a frequently missing gene in pediatric patients with neuroblastoma, an aggressive form of childhood cancer. The gene plays a crucial role in protecting cells against errors during cell division and its loss may contribute to the development of aggressive tumors.
A Mayo Clinic team developed an ionic liquid formulation that killed cancer cells and allowed for uniform distribution of a chemotherapy drug into liver tumors and other solid tumors. This discovery could solve challenges in drug delivery to tumors, particularly for patients with liver cancer awaiting a transplant.
A study by Mayo Clinic researchers found that certain biomarkers can help diagnose acute kidney inflammation in cancer patients treated with immune checkpoint inhibitors. These biomarkers, such as serum creatinine and C-reactive protein, may aid in distinguishing treatment-associated kidney injury from other causes.
Researchers at Mayo Clinic have developed an AI-powered mobile EKG device that can rapidly and accurately determine a patient's QTc, identifying those at risk of sudden cardiac death from congenital long QT syndrome or drug-induced QT prolongation. The device achieved high sensitivity and specificity in detecting clinically meaningful ...
Researchers at Mayo Clinic have developed the first hybrid gene therapy for treating long QT syndrome, a genetic heart rhythm condition. The therapy targets the KCNQ1 gene and has shown potential therapeutic efficacy in two in vitro model systems using beating heart cells reengineered from patient blood samples.
A new multi-institution study provides more accurate estimates of breast cancer risk for US women with inherited mutations in breast cancer predisposition genes. The findings may allow healthcare providers to better assess the risk of breast cancer and provide more appropriate risk management strategies.
A Mayo Clinic study found that age influences sex-related outcomes after a heart attack, with younger women being more likely to experience vascular complications and major bleeds. The study analyzed over 6.7 million hospitalization records and showed distinct differences in risk profiles for heart disease between men and women.
A retrospective study of 7,891 patients with COVID-19 treated at Mayo Clinic found lower mortality rates compared to national and international averages. The team-based approach, leveraging clinical trials and available therapies, and remote monitoring tools contributed to these favorable outcomes.
Researchers found that Black churches are trusted messengers of COVID-19 information, with high levels of community engagement and positive feedback. The FAITH! program helped establish emergency preparedness teams and culturally relevant messaging channels within participating churches.
A recent study found that only about 60% of patients with coronary artery disease, stroke, or peripheral artery disease receive the recommended statin therapy. Despite a decrease in drug cost, disparities persist in statin use among different age groups, genders, and racial backgrounds.
A recent study by Mayo Clinic researchers found significant changes in substance use among young adults during the COVID-19 pandemic. Nearly 70% of respondents increased alcohol consumption, while vaping decreased in 44% of people. The study suggests that loneliness, anxiety, and depression may fuel increases in substance use.
A new study found a correlation between RNA-binding protein clumping and protein aggregates in the hearts of patients with RBM20 dilated cardiomyopathy. This discovery suggests that RBM20 is an RNA-binding protein granule disease similar to Lou Gehrig's disease and Alzheimer's disease.
Researchers found that children who received antibiotics before age 2 were more likely to develop multiple illnesses or conditions later in childhood. These include allergic rhinitis, food allergies, attention deficit hyperactivity disorder, celiac disease, and atopic dermatitis.
Researchers found that neurofilament light protein levels in the blood can predict stroke severity and prognosis, as well as anticipate future recovery. Higher NFL levels forecast worse functional outcomes and shorter survival time after a stroke. This discovery establishes NFL as a promising prognostic biomarker for stroke.
A Mayo Clinic study found that 13.5% of cancer patients had inherited genetic mutations associated with their cancer development. The discovery could lead to targeted cancer therapies and improved survival rates for patients with these high-risk mutations.
A Mayo Clinic study analyzed Google web searches for keywords related to COVID-19, finding strong correlations with outbreaks in parts of the US up to 16 days prior. The study's findings suggest that analyzing internet surveillance data can help predict and respond to hot spots in a pandemic.
Researchers at Mayo Clinic have developed a potential test for Machado-Joseph disease, a rare neurodegenerative disorder with no cure. The new test can quantify mutant protein levels in human biofluids, which may help evaluate the effectiveness of therapies aimed at reducing protein accumulation.
A Mayo Clinic study found that patients with large polycystic kidneys can have their diseased kidneys removed laparoscopically at the same time as a kidney transplant, without compromising kidney function. The dual surgery approach has been shown to be a safe and viable option for these patients.
A Mayo Clinic study reveals that lung transplant patients who receive antifungal preventive medications have a significantly lower risk of death within the first year posttransplant. The study analyzed data from 667 patients and found that mortality risk was about twice as high in those not receiving treatment.
A new Mayo Clinic study found that clinical oncologists are less informed about the federal Right to Try (RTT) law, citing concerns over patient safety and regulatory burden. The study also revealed that most oncologists had limited familiarity with RTT despite having experience with FDA's Expanded Access Programs.
Researchers created an index that distinguishes between healthy and diseased gut microbiomes based on a biologically-interpretable mathematical formula. The Gut Microbiome Health Index predicts the likelihood of having a disease independent of clinical diagnosis, with high accuracy rates.
A new clinical trial, TAILOR-PCI, found that genetic testing can identify patients who may benefit from alternative antiplatelet therapy. The study showed a statistically significant 40% reduction in blood clotting events in patients with the CYP2C19 gene variation who received genotype-guided treatment.
A study by Mayo Clinic researchers found that online searches for 'chest pain' increased by at least 34% during the COVID-19 pandemic, while emergency visits for heart attacks dropped. This suggests that people may be misconstruing chest pain as an infectious symptom or avoiding medical care due to pandemic concerns.
A study published in Menopause: The Journal of the North American Menopause Society found that women with a history of high blood pressure disorders during pregnancy reported more bothersome menopausal symptoms. Women using hormone therapy also experienced more severe symptoms compared to those without a high blood pressure history.
A study by Mayo Clinic researchers found that emergency department visits declined by 42-64% during the four-month period, with largest declines seen in areas with high COVID-19 cases. Hospital admissions remained relatively stable until local increases in COVID-19 cases led to dramatic upticks.
A new study published in Clinical Infectious Diseases suggests that phage therapy could be a game-changer in treating complex bacterial infections in prosthetic joints. The treatment has shown promising results in patients with biofilm-related infections, which are notoriously difficult to eradicate with antibiotics.
Researchers at Mayo Clinic have found that investigational convalescent plasma is safe to use in a diverse group of 20,000 patients, with a significant decline in seven-day mortality rates compared to previous studies. The study also found lower serious adverse events and a more rapid availability of plasma for treatment.
A clinical trial found that olanzapine significantly improved patient quality of life by reducing nausea and vomiting scores. The study showed that patients who received olanzapine reported less vomiting, better appetite, and better well-being compared to those who received a placebo.
Researchers at Mayo Clinic have discovered a potential link between heart disease and worse COVID-19 outcomes. The study found that patients with obstructive hypertrophic cardiomyopathy had elevated levels of the ACE2 protein, which the SARS-CoV-2 virus uses to gain entry into cells.
A study published in JAMA Network Open found that more than half of Americans starting highly regulated opioids may be receiving inappropriate treatment. The research team used pharmacy and medical claims data to identify nearly 300,000 instances of prescriptions for medications reserved for people with opioid tolerance. However, less ...
The article proposes algorithms for evaluating patients with suspected or confirmed COVID-19 and signs of acute heart attack, guiding triage and treatment. Mayo Clinic cardiologists and radiologists emphasize the importance of immediate and appropriate treatment to minimize risks for both patients and medical staff.
A Mayo Clinic article highlights the risks of relying on COVID-19 testing, citing the high sensitivity of reverse transcriptase-polymerase chain reaction (RT-PCR) testing and its limitations in ruling out the disease. Health care officials are advised to consider patient characteristics and exposure when interpreting test results.
Researchers at Mayo Clinic discovered that fetal surgery to correct congenital spinal cord defects is more effective at healing neurological structure than surgery after birth. The procedure led to improved brain structure and anatomy in three patients with myelomeningocele.