Scientists analyzed DNA sequence data from nearly 71,000 people worldwide and identified mutations in ACE2 and TMPRSS2 genes that affect protein expression, influencing COVID-19 susceptibility and severity. The study suggests a potential new diagnostic method based on host cell variation rather than the evolving virus.
A Mayo Clinic study found that a culturally relevant mobile app improved overall heart health scores and behaviors related to diet and physical activity among African American participants. The app, part of the FAITH! program, was designed in collaboration with community partners and showed significant results in a 10-week clinical trial.
Researchers from Mayo Clinic Comprehensive Cancer Center found that adding brentuximab vedotin to standard chemotherapy treatment improves overall survival in patients with Hodgkin Lymphoma. The study showed that the drug has a positive impact on overall survival, regardless of other treatments administered later in the course of care.
Researchers used radiomics-based machine learning models to detect pancreatic cancer on prediagnostic CT scans, identifying it up to 386 days before clinical diagnosis. The AI model showed high accuracy and specificity, with a range of 94-98%, and was unaffected by image variations.
Researchers developed machine-learning algorithms to distinguish between alcohol-associated hepatitis and acute cholangitis using routinely available lab values. The algorithms demonstrated excellent performances for discriminating the two conditions, with over 93% accuracy.
A Mayo Clinic study found that patients with severe brachial plexus injuries who undergo amputation experience reduced mechanical shoulder pain and higher employment rates. The study also showed improved prosthetic use among patients with myoelectric prostheses, suggesting a potential benefit to amputation for some individuals.
A Mayo Clinic study of 10,775 high-risk adult patients during the COVID-19 delta surge found that treatment with anti-spike neutralizing monoclonal antibodies led to low rates of severe disease, hospitalization, and mortality. The rates were lowest for patients treated with sotrovimab, with only 1.2% developing severe disease.
A collaborative team of scientists has discovered 15 additional genetic mutations in the KCNK9 gene that cause a neurodevelopmental syndrome. The study provides definitive diagnoses to 21 families worldwide, offering new insights into the disorder's symptoms and treatment options.
A Mayo Clinic study found that Paxlovid treatment benefited almost all high-risk COVID-19 patients, with only a handful experiencing mild rebound symptoms. Researchers suggest comorbidities and secondary immune responses may be factors behind the rare rebound phenomenon.
A Mayo Clinic study found that disparities in opioid treatment access persist among women, Black and Hispanic populations. Despite increased access, these groups continue to face systemic barriers, including racism, mistrust of healthcare professionals, and lack of clinicians able to prescribe buprenorphine.
A Mayo Clinic study found that nearly one-quarter of over 24,000 patients had mitral annulus calcification, a chronic degeneration of tissue at the base of the heart's mitral valve. This condition is associated with higher mortality rates and increased risk of cardiovascular disease.
A clinical trial found that adding immunotherapy to standard treatment increased the likelihood of complete tumor eradication in patients with high PD-L1 expression. The combination could become a new standard of care if confirmed in larger trials.
A study published by Mayo Clinic Cancer Center investigates the reasons for decreasing remission rates for patients with non-Hodgkin lymphoma treated with CAR-T cell therapy. The team found that a gene called TIGIT drives CAR-T cell exhaustion and dysfunction, suggesting its blocking strategy may improve treatment efficacy.
Researchers developed an AI algorithm that can detect weak heart pumps in patients using single-lead Apple Watch ECGs. The study found high participation rates and high-quality data from over 46 states and 11 countries, demonstrating the potential for this tool to be widely used.
A new study from Mayo Clinic suggests that AI-enabled electrocardiograms (ECGs) can predict atrial fibrillation, a cardiac rhythm abnormality linked to one-third of ischemic strokes. The algorithm also detects other cardiac disease markers and correlates with small vessel cerebrovascular disease and cognitive decline.
A review by Mayo Clinic researchers highlights the increasing trend of early onset colorectal cancer, defined as being diagnosed at age 50 or younger. Dr. Sinicrope emphasizes the need for public health measures to address risk factors such as poor diet and physical inactivity.
A new study by the Mayo Clinic confirms that living kidney donor surgery via laparoscopic surgery is low-risk for most patients, with only 2.5% experiencing major complications. The study tracked over 3,000 donors and found that most complications occurred after discharge.
Researchers found plasma neurofilament light levels were elevated in all types of frontotemporal dementia, and in people who had mutations but hadn't shown symptoms yet. Higher levels of the protein were associated with greater disease severity and increased just before symptom onset.
A study published in Gastroenterology found that artificial intelligence reduced the rate of missed precancerous polyps in colorectal cancer screening by twofold compared to standard colonoscopy. The AI detection method identified smaller, flatter polyps and improved false negative rates.
Researchers load CAR-T cells with an oncolytic virus to target and kill solid cancer tumors, providing a potent immune response. The combination approach overcomes challenges in treating solid tumors with CAR-T cell therapy alone.
A randomized controlled study found that lack of sufficient sleep increased calorie intake and visceral fat area by 9% and 11%, respectively. The study suggests that inadequate sleep is a previously unrecognized trigger for visceral fat deposition, potentially contributing to obesity and metabolic diseases.
Mayo Clinic researchers propose a novel computational model that links Alzheimer's disease symptoms to brain anatomy, revealing a complex relationship between mental processing and brain function. The model uses machine learning to analyze patient brain imaging data and compresses complex brain anatomy into a conceptual framework.
Researchers at Mayo Clinic have developed a new antibody test to diagnose multiple sclerosis (MS), a potentially disabling disease of the brain and spinal cord. The validated test measures kappa immunoglobulin free light chains in cerebrospinal fluid, offering a faster and more cost-effective alternative to existing tests.
A Mayo Clinic study of 106,349 primary care patients found that hospitalization rates for breakthrough COVID-19 were extremely low, even among those previously infected or vaccinated. The study supports previous findings that vaccination is the best way to prevent severe COVID-19 infection and hospitalization.
A new study from Mayo Clinic and Baylor College of Medicine found that targeted genomic information can significantly impact drug prescribing practices. By applying drug-gene testing, clinicians can identify nearly every patient as a potential candidate for preemptive testing, particularly for drugs with unknown genetic influences.
Researchers found epigenetic changes that activate harmful genes and cause cancer to grow faster in patients with ASXL1-mutations. The study provides a new therapeutic strategy and adds to the knowledge of ASXL1 gene expression, suggesting potential individualized therapeutic targets.
Researchers found lower quality genomic sequencing data in self-reported Black patients and patients of African ancestry, highlighting the need for equitable data quality across racial groups. This disparity affects patient care, personalized therapies, and clinical outcomes.
Researchers found that accounting for six messenger RNA molecules in blood plasma improves ability to accurately identify participants with an Alzheimer's diagnosis by 8%. This discovery could lead to more accurate screening options for the population at greatest risk, including African Americans.
Mayo Clinic researchers used AI to predict antidepressant outcomes in children and adolescents with major depressive disorder. They identified six depressive symptoms and assessed them using the Children's Depression Rating Scale-Revised to predict treatment outcomes.
Mayo Clinic researchers found that senolytic drugs increase the production of protective protein a-klotho in mice and human studies, potentially boosting health against aspects of aging and disease. The study demonstrates an orally active approach to increase this beneficial protein.
A recent Mayo Clinic study found that community-based support can prevent and reverse weight gain, even during the COVID-19 pandemic. Participants who received peer-led intervention lost an average of 2% of their body weight while improving cardiovascular health measures.
Researchers have discovered that messenger RNA can be used to regenerate bone at low doses, producing high-quality tissue with no side effects. The new method is superior to existing treatments and may not require repeat doses.
A team of Mayo Clinic medical experts and community leaders developed a playbook to reduce health disparities related to COVID-19. The approach focused on communication gaps, community priorities, and access to resources, resulting in beneficial systems and policy changes that improved health equity for immigrant and refugee populations.
A new scoring system, MIAAH, accurately identifies patients at highest risk of death and those likely to survive from alcohol-associated hepatitis. The tool incorporates laboratory variables and demographic data, offering a valuable prognostic model for clinicians.
Researchers at Mayo Clinic Cancer Center developed a machine learning algorithm that integrates genetic data from over 5,000 patients to predict patient benefit from chemotherapy and immunotherapy. A 32-gene molecular signature was identified, providing prognostic information and predicting patient response to immunotherapy.
Researchers at Mayo Clinic developed a non-opioid pain management approach that provides equivalent or better pain control and patient satisfaction compared to traditional opioid regimens. This approach eliminates opioids after common sports surgeries, such as knee and shoulder procedures.
A recent study found that individuals with an accurate self-assessment of their skin cancer risk are less likely to use tanning beds within the next year. This association was observed even among those who perceived a high risk of skin cancer development.
A new study published in Mayo Clinic Proceedings found that patients with alcohol-associated cirrhosis had significantly higher post-ICU death rates and mortality at 30 days after ICU discharge compared to those with cirrhosis attributed to other causes. The study, which analyzed case files of 1,174 patients, suggests that early diagno...
A study by Mayo Clinic researchers found that cancer patients receiving chemotherapy and targeted therapies may mount inadequate immune responses to COVID-19 vaccination. The authors recommend antibody level testing and booster vaccinations for these patients.
A new study published in Mayo Clinic Proceedings found that direct oral anticoagulants significantly decrease cancer-associated venous thrombosis recurrence without increasing bleeding. The study involved 2,894 patients and showed a 41% decrease in thrombosis recurrence with direct oral anticoagulants compared to parenteral dalteparin.
A recent study published in Transplantation Direct highlights the increased risk of death from cancer and infection for kidney transplant patients. Focusing on lifestyle changes such as weight loss, exercise, and diabetes management can improve long-term outcomes for these patients.
A new study from the Mayo Clinic finds that people who vape and test positive for COVID-19 are more likely to experience common symptoms such as headaches, muscle aches, and chest pain. The study also shows that those who vape and smoke tobacco have labored breathing and more frequent emergency department visits compared to non-vapers.
A Mayo Clinic study reveals that cardiovascular risks, including coronary artery disease and diabetes, have a stronger association with memory and thinking skills decline in middle-aged women. The research found that women with these conditions experience an annual decline in global cognition more than two times greater than men.
African American adults in Minnesota have nearly double the rate of death from cardiovascular disease compared to their white counterparts. The study found that basic health beliefs and demographics are associated with risk factors for cardiovascular disease, including hypertension, hyperlipidemia, and diabetes.
A global study published in JAMA Network Open found that patients hospitalized with COVID-19 who have metabolic syndrome are at a higher risk of developing acute respiratory distress syndrome and dying. The study examined records of over 46,000 patients across 26 countries and found that those with metabolic syndrome were 36% more like...
Researchers used AI and genomic data to predict which patients with early-stage rheumatoid arthritis are most likely to benefit from methotrexate treatment within the first three months. The study identified potential personalized medicine approaches for rheumatoid arthritis treatment, paving the way for further research.
Researchers at Mayo Clinic found that mRNA therapy improves the response of patients who weren't responding to cancer immunotherapy. The study identified a weak spot in T cells, white blood cells crucial for fighting cancer, and developed an mRNA-based strategy to enhance their response.
A study found that primary care clinicians prefer noninvasive options for patients who are unwilling to undergo invasive procedures, concerned about work time, or unconvinced of the need for screening. The researchers suggest tailoring recommendations to patient preferences to improve adherence to colorectal cancer screening.
A Mayo Clinic study reveals sex and race disparities in the management of patients with hypertrophic cardiomyopathy, with women and patients of color receiving ICDs less frequently. Regional variations in ICD use were also observed, with underuse in some areas and overuse in others.
A novel AI algorithm developed at Mayo Clinic can predict long-term patient survival after cardiac surgery using a single-lead EKG. The study found a clear correlation between long-term mortality and a positive AI ECG screen for reduced left ventricular ejection fraction among patients without apparent severe cardiomyopathy.