The work group reframed what is clinically meaningful to slow Alzheimer's disease progression, including the need for combination therapies and realistic expectations of benefits and risks. Slowing brain deterioration by four to six months in early stages may preserve function, leading to meaningful outcomes for patients and families.
A new study led by Mayo Clinic researchers found that women carrying specific genetic changes, such as BRCA1 and BRCA2, have a twofold increased risk of developing contralateral breast cancer. Premenopausal women with these mutations are more likely to develop cancer in both breasts.
A study by Mayo Clinic researchers found a specific colonization of microbes in the reproductive tract is commonly found in women with ovarian cancer. The discovery strengthens evidence that the bacterial component of the microbiome is an important indicator for early detection, diagnosis, and prognosis of ovarian cancer.
Researchers at Mayo Clinic developed an AI algorithm that accurately detects weak heart pumps using single-lead Apple Watch ECGs. The system has shown promising results, rivaling medical treadmill diagnostic tests in accuracy, and holds potential for scalable screening and prevention of heart failure.
A Mayo Clinic study found that clinicians who were high adopters of an AI-enabled clinical decision support tool were twice as likely to diagnose low left ventricular ejection fraction as those who were low adopters. The tool's accuracy was critical in detecting serious health conditions before symptoms appeared.
Researchers discovered that animal models with germline alteration rs55705857 developed gliomas significantly faster than those without the alteration. The study offers new insights into tumor formation and may lead to novel therapies targeting this specific change.
Researchers used multi-omics technologies to analyze samples from 350 patients with major depressive disorder, finding distinct blood-based signatures between those with and without a history of attempted suicide. Variations in genes CLOCK and ARNTL were associated with lower antidepressant response rates.
Researchers at Mayo Clinic used AI to evaluate patients' ECGs, identifying new cases of atrial fibrillation that would not have been detected through routine care. The study showed that AI can target screening to high-risk patients, potentially reducing undiagnosed strokes and deaths worldwide.
Mayo Clinic researchers identified critical genomic changes associated with abiraterone acetate/prednisone resistance in advanced prostate cancer. An 11-gene drug panel predicted a worse prognosis for a subset of patients, and whole-exome sequencing data revealed mechanisms of acquired resistance.
Researchers at Mayo Clinic Comprehensive Cancer Center have identified a gene marker that may lead to more effective precision treatment for pancreatic ductal adenocarcinoma. The protein METTL16 is correlated with accumulated DNA damage and suppresses DNA repair, suggesting it as a potential biomarker for PARPi treatment.
Researchers used data from over 66,000 deliveries to create a prediction model that analyzes patterns of changes in women in labor. The algorithm aims to reduce cesarean delivery rates and maternal/neonatal complications by providing real-time risk predictions.
A new type of extravascular ICD using a lead placed behind the sternum effectively terminated acute and chronic life-threatening ventricular arrhythmias. The device delivered anti-tachycardia pacing to terminate 70% of ventricular tachycardia episodes, with a defibrillation success rate of 98.7%.
Researchers developed an algorithm to identify different regions within tumors using nearly 6,500 digital slide images. The algorithm can predict recurrence-free survival and help guide therapy for patients with colon cancer.
A research study of African Americans with cardiovascular disease found that higher levels of religious practices and spirituality are associated with greater likelihood of intermediate or ideal levels of heart health. Specifically, private prayer was linked to better diet and smoking habits, while nontheistic spirituality was associat...
Researchers tested a new needle ablation technique called SERF to treat ventricular tachycardia in patients who had not responded to other treatments. The study found that 31 of 32 patients experienced eliminated clinical ventricular tachycardia, with device therapies reduced by 89% during follow-up.
Researchers found that using the drug erlotinib, which blocks a specific cancer pathway, led to a 30 percent reduction in polyps formed in patients with FAP. The study's findings suggest potential ways to prevent colorectal cancer in the general population at an earlier stage.
Researchers found higher levels of brain cell damage and inflammation markers in women with severe preeclampsia compared to those with uncomplicated pregnancies. The study used health record data from the Rochester Epidemiology Project and explored extracellular vesicles as potential early risk indicators.
A Mayo Clinic study found that diets rich in calcium and potassium can help prevent recurrent symptomatic kidney stones. Patients who experienced a first-time stone were more likely to experience recurrence if their diet was low in these nutrients.
Scientists analyzed DNA sequence data from nearly 71,000 people worldwide and identified mutations in ACE2 and TMPRSS2 genes that affect protein expression, influencing COVID-19 susceptibility and severity. The study suggests a potential new diagnostic method based on host cell variation rather than the evolving virus.
A Mayo Clinic study found that a culturally relevant mobile app improved overall heart health scores and behaviors related to diet and physical activity among African American participants. The app, part of the FAITH! program, was designed in collaboration with community partners and showed significant results in a 10-week clinical trial.
Researchers from Mayo Clinic Comprehensive Cancer Center found that adding brentuximab vedotin to standard chemotherapy treatment improves overall survival in patients with Hodgkin Lymphoma. The study showed that the drug has a positive impact on overall survival, regardless of other treatments administered later in the course of care.
Researchers used radiomics-based machine learning models to detect pancreatic cancer on prediagnostic CT scans, identifying it up to 386 days before clinical diagnosis. The AI model showed high accuracy and specificity, with a range of 94-98%, and was unaffected by image variations.
Researchers developed machine-learning algorithms to distinguish between alcohol-associated hepatitis and acute cholangitis using routinely available lab values. The algorithms demonstrated excellent performances for discriminating the two conditions, with over 93% accuracy.
A Mayo Clinic study found that patients with severe brachial plexus injuries who undergo amputation experience reduced mechanical shoulder pain and higher employment rates. The study also showed improved prosthetic use among patients with myoelectric prostheses, suggesting a potential benefit to amputation for some individuals.
A Mayo Clinic study of 10,775 high-risk adult patients during the COVID-19 delta surge found that treatment with anti-spike neutralizing monoclonal antibodies led to low rates of severe disease, hospitalization, and mortality. The rates were lowest for patients treated with sotrovimab, with only 1.2% developing severe disease.
A collaborative team of scientists has discovered 15 additional genetic mutations in the KCNK9 gene that cause a neurodevelopmental syndrome. The study provides definitive diagnoses to 21 families worldwide, offering new insights into the disorder's symptoms and treatment options.
A Mayo Clinic study found that Paxlovid treatment benefited almost all high-risk COVID-19 patients, with only a handful experiencing mild rebound symptoms. Researchers suggest comorbidities and secondary immune responses may be factors behind the rare rebound phenomenon.
A Mayo Clinic study found that disparities in opioid treatment access persist among women, Black and Hispanic populations. Despite increased access, these groups continue to face systemic barriers, including racism, mistrust of healthcare professionals, and lack of clinicians able to prescribe buprenorphine.
A Mayo Clinic study found that nearly one-quarter of over 24,000 patients had mitral annulus calcification, a chronic degeneration of tissue at the base of the heart's mitral valve. This condition is associated with higher mortality rates and increased risk of cardiovascular disease.
A clinical trial found that adding immunotherapy to standard treatment increased the likelihood of complete tumor eradication in patients with high PD-L1 expression. The combination could become a new standard of care if confirmed in larger trials.
A study published by Mayo Clinic Cancer Center investigates the reasons for decreasing remission rates for patients with non-Hodgkin lymphoma treated with CAR-T cell therapy. The team found that a gene called TIGIT drives CAR-T cell exhaustion and dysfunction, suggesting its blocking strategy may improve treatment efficacy.
Researchers developed an AI algorithm that can detect weak heart pumps in patients using single-lead Apple Watch ECGs. The study found high participation rates and high-quality data from over 46 states and 11 countries, demonstrating the potential for this tool to be widely used.
A new study from Mayo Clinic suggests that AI-enabled electrocardiograms (ECGs) can predict atrial fibrillation, a cardiac rhythm abnormality linked to one-third of ischemic strokes. The algorithm also detects other cardiac disease markers and correlates with small vessel cerebrovascular disease and cognitive decline.
A review by Mayo Clinic researchers highlights the increasing trend of early onset colorectal cancer, defined as being diagnosed at age 50 or younger. Dr. Sinicrope emphasizes the need for public health measures to address risk factors such as poor diet and physical inactivity.
A new study by the Mayo Clinic confirms that living kidney donor surgery via laparoscopic surgery is low-risk for most patients, with only 2.5% experiencing major complications. The study tracked over 3,000 donors and found that most complications occurred after discharge.
Researchers found plasma neurofilament light levels were elevated in all types of frontotemporal dementia, and in people who had mutations but hadn't shown symptoms yet. Higher levels of the protein were associated with greater disease severity and increased just before symptom onset.
A study published in Gastroenterology found that artificial intelligence reduced the rate of missed precancerous polyps in colorectal cancer screening by twofold compared to standard colonoscopy. The AI detection method identified smaller, flatter polyps and improved false negative rates.
Researchers load CAR-T cells with an oncolytic virus to target and kill solid cancer tumors, providing a potent immune response. The combination approach overcomes challenges in treating solid tumors with CAR-T cell therapy alone.
A randomized controlled study found that lack of sufficient sleep increased calorie intake and visceral fat area by 9% and 11%, respectively. The study suggests that inadequate sleep is a previously unrecognized trigger for visceral fat deposition, potentially contributing to obesity and metabolic diseases.
Mayo Clinic researchers propose a novel computational model that links Alzheimer's disease symptoms to brain anatomy, revealing a complex relationship between mental processing and brain function. The model uses machine learning to analyze patient brain imaging data and compresses complex brain anatomy into a conceptual framework.
Researchers at Mayo Clinic have developed a new antibody test to diagnose multiple sclerosis (MS), a potentially disabling disease of the brain and spinal cord. The validated test measures kappa immunoglobulin free light chains in cerebrospinal fluid, offering a faster and more cost-effective alternative to existing tests.
A Mayo Clinic study of 106,349 primary care patients found that hospitalization rates for breakthrough COVID-19 were extremely low, even among those previously infected or vaccinated. The study supports previous findings that vaccination is the best way to prevent severe COVID-19 infection and hospitalization.
A new study from Mayo Clinic and Baylor College of Medicine found that targeted genomic information can significantly impact drug prescribing practices. By applying drug-gene testing, clinicians can identify nearly every patient as a potential candidate for preemptive testing, particularly for drugs with unknown genetic influences.
Researchers found epigenetic changes that activate harmful genes and cause cancer to grow faster in patients with ASXL1-mutations. The study provides a new therapeutic strategy and adds to the knowledge of ASXL1 gene expression, suggesting potential individualized therapeutic targets.
Researchers found lower quality genomic sequencing data in self-reported Black patients and patients of African ancestry, highlighting the need for equitable data quality across racial groups. This disparity affects patient care, personalized therapies, and clinical outcomes.
Researchers found that accounting for six messenger RNA molecules in blood plasma improves ability to accurately identify participants with an Alzheimer's diagnosis by 8%. This discovery could lead to more accurate screening options for the population at greatest risk, including African Americans.
Mayo Clinic researchers used AI to predict antidepressant outcomes in children and adolescents with major depressive disorder. They identified six depressive symptoms and assessed them using the Children's Depression Rating Scale-Revised to predict treatment outcomes.
Mayo Clinic researchers found that senolytic drugs increase the production of protective protein a-klotho in mice and human studies, potentially boosting health against aspects of aging and disease. The study demonstrates an orally active approach to increase this beneficial protein.
A recent Mayo Clinic study found that community-based support can prevent and reverse weight gain, even during the COVID-19 pandemic. Participants who received peer-led intervention lost an average of 2% of their body weight while improving cardiovascular health measures.
Researchers have discovered that messenger RNA can be used to regenerate bone at low doses, producing high-quality tissue with no side effects. The new method is superior to existing treatments and may not require repeat doses.