The Mayo Venture Partner (MVP) program aims to create groundbreaking technologies, co-invest in aligned companies, and build new ventures from the ground up. Industry veterans will leverage Mayo Clinic's world-class research and clinical expertise to drive innovation.
Researchers from Mayo Clinic Comprehensive Cancer Center will present practice-changing studies on chemotherapy approaches, AI applications in oncology, and new therapies for breast and melanoma. The event will feature 59 abstracts highlighting advancements in cancer care.
The new office staff will assist patients making appointments at Mayo Clinic in Minnesota, Arizona, Florida, and London, as well as help with travel arrangements and billing. The services are free of charge and include interpreter support for non-English speakers.
The Mayo Clinic has established the world's first biobank of human salivary gland tissue-organoids, which can help researchers find a cure for chronic dry mouth. The biobank contains specimens from 208 donors and has already identified biomarkers for mature, saliva-producing cells.
Researchers identified a biological process causing donor heart damage during cold storage and found that a drug can prevent this damage. Treatment with the drug nearly tripled pumping strength in human donor hearts, improving blood flow and reducing cell injury.
Mayo Clinic is expanding its patient information office in Guatemala City to provide more assistance to patients, including travel arrangements, billing, and insurance. The office staff will also facilitate coordination of care for patients visiting Mayo Clinic locations around the world.
A recent study published in the Journal of Hepatology has shown that simultaneous bariatric surgery and liver transplant is safe and improves long-term health outcomes for severely obese patients. The combined approach resulted in sustained weight loss, reduced risk of type 2 diabetes, and lower risk of fatty liver disease recurrence.
Researchers at Mayo Clinic developed AI-ECG tools that can detect heart muscle weakness in women of childbearing age, allowing for earlier identification and management. The tools demonstrated high diagnostic performance, with an area under the curve of .94 for AI-ECG and .98 for AI digital stethoscope.
Researchers at Mayo Clinic have identified a potential new way to monitor the progression of high-grade gliomas by developing a personalized blood test tailored to each patient's tumor DNA. The study suggests that this approach may provide a clearer picture of disease progression and enable clinicians to make more informed treatment de...
Researchers at Mayo Clinic discovered a rare genetic variant that can directly cause metabolic dysfunction-associated steatotic liver disease. The MET gene malfunction leads to fat accumulation, inflammation, and scarring, potentially progressing to cirrhosis or liver cancer.
Researchers found people with Tourette syndrome have 50% fewer interneurons, which calm excess movement signals, and stress responses in other brain cells. This deficit may contribute to the disorder's symptoms.
Researchers at Mayo Clinic developed a personalized deep brain stimulation platform to treat drug-resistant epilepsy. The study found that this approach reduced seizures while also improving memory and sleep in patients with temporal lobe epilepsy.
Researchers at Mayo Clinic are conducting a study to understand the factors that contribute to rapid progression of dementia in patients with Alzheimer's disease and Related Dementias. The team aims to identify biomarkers and disease-modifying targets that can improve diagnosis and treatment outcomes for these patients.
Researchers found that detectable mutant KRAS circulating tumor DNA (ctDNA) indicates a higher risk of cancer spread and worse survival rates for patients with pancreatic ductal adenocarcinoma. The study suggests that ctDNA assays should be performed prior to treatment to have the highest yield.
Mayo Clinic researchers have developed a new way to more precisely detect and monitor brain cell activity during deep brain stimulation, a common treatment for movement disorders. The study uses custom algorithms to record broadband signals associated with hand movement in patients undergoing awake DBS surgery.
Researchers identified fibronectin and smooth muscle actin as associated with resistance to immunotherapy treatment. Cancer-associated fibroblasts produce these proteins, which contribute to the suppression of the anti-tumor immune response.
Mayo Clinic is investing $1.9 billion in its Arizona campus, expanding clinical space by nearly 60% to care for more patients with complex medical conditions. The new facility will feature innovative care concepts, integrated technologies, and a better workplace for staff.
Mayo Clinic has been recognized as the world's best hospital for the seventh straight year by Newsweek, with a focus on delivering compassionate care to patients. The institution prioritizes innovation in clinical practice, education, and research to transform healthcare.
Researchers explore ataciguat to manage aortic valve stenosis, showing potential to significantly slow disease progression. The drug may enable a once-in-a-lifetime procedure by delaying valve replacement surgery.
Researchers discovered noncoding cryptic peptides as an alternative source of target antigens for ovarian cancer. The findings could improve treatment approaches by mobilizing the immune system to attack tumor cells.
A study published in Mayo Clinic Proceedings suggests that virtual reality can reduce preoperative anxiety in older patients undergoing open-heart surgery. The research found that immersive VR was effective and well-tolerated, leading to reduced anxiety scores and improved mood.
The OmicsFootPrint tool uses AI to convert complex biological data into circular images, helping researchers visualize disease patterns and identify personalized therapies. The tool demonstrated high accuracy in distinguishing between different cancer types and has potential for studying neurological disorders.
Researchers have identified a targeted therapy that could bring relief to people living with lichen planus, a chronic inflammatory skin condition. The treatment, baricitinib, selectively blocks specific inflammatory pathways, reducing inflammation and suppressing the overactive immune response that contributes to the disease.
Researchers at Mayo Clinic developed patient-derived organoid models to study uveal melanoma, a common type of eye cancer. These 3D models accurately represent the disease's genetic and biological characteristics, enabling better understanding and treatment development.
Mayo Clinic is developing foundation models with Microsoft Research and Cerebras Systems to personalize patient care, accelerating diagnostic time and improving accuracy. These multimodal models integrate radiology images and genomic sequencing data to transform clinical diagnosis and treatment.
Mayo Clinic's Digital Pathology platform is transforming pathology by leveraging large datasets and AI models for faster, more accurate diagnoses. The partnership with NVIDIA and Aignostics aims to improve patient care and accelerate medical breakthroughs.
A multi-institutional study led by Mayo Clinic researchers has improved the accuracy of genetic testing for BRCA2 variants, enabling precise risk assessments and personalized treatment plans. The findings will aid in identifying patients who may benefit from targeted therapies such as PARP inhibitors.
A phase 2 study conducted by Mayo Clinic found that 56% of participants were alive after 12 months, with a median overall survival of 13.1 months. The treatment, which combines short-course hypofractionated proton beam therapy with advanced imaging techniques, was more effective in patients over 65 with favorable tumor genetics.
A Mayo Clinic study found a widening global gap between lifespan and healthspan, with the US and women experiencing the largest disparities. The research suggests that while people are living longer, they are not necessarily living healthier lives.
A new treatment shows promise for people with high-risk smoldering multiple myeloma, delaying cancer progression and improving overall survival. Daratumumab significantly reduces risk of progression to active disease and improves patient outcomes.
A phase 3 study demonstrated nearly 75% complete cancer remission in patients with high-risk bladder cancer unresponsive to BCG therapy. The novel treatment, cretostimogene grenadenorepvec, was well-tolerated and did not require bladder removal surgery.
A new study suggests that using AI-ECG tools to screen patients for low ejection fraction is cost-effective in the long term, especially in outpatient settings. The study found a cost-effectiveness ratio of $1,651 per quality-adjusted life year, indicating that the program can reduce costs over time.
The study analyzed DNA from over 100,000 participants and found that nearly 2,000 carried at least one genetic variant linked to these diseases. The findings have led to life-changing discoveries and new insights into personalized medicine.
A new hourglass-shaped stent could improve blood flow and alleviate severe chest pain in people with microvascular disease. The study found that 76% of participants experienced improvement in their daily activities, including walking and climbing stairs without pain.
Researchers at Mayo Clinic recommend minimally invasive treatment alternatives to hysterectomy for uterine fibroids, which can help women recover faster and reduce long-term risks. Early detection and treatment are key in reducing health disparities among Black women.
Researchers found that microgravity can strengthen the regenerative potential of cells, leading to improved growth and function. This discovery has potential clinical applications for treating age-related conditions such as stroke, dementia, neurodegenerative diseases, and cancer.
Doctors at Mayo Clinic used a new catheter-based approach to draw out resistant pockets of infection in the heart without surgery. Over 90% of participants had their infection cleared, with lower in-hospital mortality compared to those whose infections remained.
A Mayo Clinic study found that standing on one leg shows the highest rate of decline with age, indicating balance as a crucial aging indicator. The research suggests people can train their balance without special equipment to maintain independence and well-being.
Mayo Clinic scientists created mini brain models in a dish that closely match key features seen in the brains of patients with Lewy body dementia. The team identified four potential drug compounds that may offer approaches to treating the disease.
Researchers have identified eight novel genetic mutations in patients with CSF1R-Related Disorder worldwide, highlighting the prevalence of the disease and paving the way for future individualized treatment. The discovery also suggests that genetic and environmental factors may influence the disease.
CAR-T cell therapy, a regenerative immunotherapy, has shown promise in treating blood cancers but struggles with T-cell exhaustion. Researchers have discovered that overproduction of the IL-4 protein causes this exhaustion and used CRISPR gene-editing technology to remove it, improving CAR-T cell therapy outcomes.
A Mayo Clinic study found that people with monoclonal B-cell lymphocytosis (MBL) have a 92% elevated risk of developing melanoma. MBL is a precursor to chronic lymphocytic leukemia and also increases the risk of cancers originating in the lymphatic system and serious infections.
A study at the European Society of Cardiology Congress found that an AI-enabled digital stethoscope helped doctors identify twice as many cases of pregnancy-related heart failure compared to a control group. The tool was 12 times more likely to flag heart pump weakness, leading to better diagnosis and potentially life-saving treatment.
A Mayo Clinic team developed a computational tool that analyzes the gut microbiome with at least 80% accuracy. The Gut Microbiome Wellness Index 2 identifies subtle changes in gut health, enabling proactive health indicators and potential prevention of chronic diseases.
Researchers at Mayo Clinic used AI to analyze electroencephalogram (EEG) tests, identifying subtle brain wave patterns characteristic of cognitive problems like Alzheimer's disease. This technology has the potential to provide healthcare professionals with a more accessible tool for early diagnosis in communities without easy access to...
Researchers at the Mayo Clinic Comprehensive Cancer Center discovered a new treatment approach that improved survival rates for patients with B-cell precursor leukemia by nearly 60%. The study found that adding blinatumomab to chemotherapy reduced the risk of leukemia recurrence and death.
A Mayo Clinic study reveals that current genetic screening protocols fail to detect notable numbers of people carrying hereditary breast and ovarian cancer syndrome and Lynch syndrome mutations. The study identified 550 carriers of these mutations, with half being previously unaware of their risk.
Mayo Clinic scientists have established criteria for a memory-loss syndrome in older adults that specifically impacts the brain's limbic system. The syndrome, called Limbic-predominant Amnestic Neurodegenerative Syndrome (LANS), progresses more slowly and has a better prognosis than Alzheimer's disease.
Mayo Clinic's surgical team successfully performed the rare procedure, which included multiple organs, on a Massachusetts man with a rare form of laryngeal cancer. The landmark surgery, conducted as part of a clinical trial, marks a significant step towards making larynx transplantation available to a wider population.
A recent Mayo Clinic study published in Nature Medicine found that senolytic drugs can have beneficial effects on bone formation in older women with a high number of senescent cells. However, these drugs may not be effective for everyone and more research is needed to better identify potential beneficiaries.