Researchers have linked T cell dysfunction in rheumatoid arthritis to a metabolic deficiency, suggesting a new therapeutic strategy. The study found that supplying the amino acid aspartate may provide a solution by repairing mitochondrial defects and suppressing TNF production.
Gastric cancer is the sixth most common cancer worldwide, with 1.09 million new cases in 2020. Recent research offers hope for improved treatment options, making it a critical area of focus for medical oncologists like Dr. Mohamad Sonbol.
A commentary by Mayo Clinic researchers emphasizes the importance of addressing bias in biomedical research funding to improve diversity and equity. The authors note that underfunding and lack of opportunities for minority clinicians and researchers exacerbate health disparities, highlighting the need for inclusive funding decisions.
A retrospective study published in Mayo Clinic Proceedings found that dasatinib lowers serum glucose levels in patients with pre-existing type 2 diabetes to a greater degree than imatinib and comparable to first-line diabetic medications. Researchers suggest further study is needed to determine the primary mechanism behind dasatinib's ...
Researchers developed a wrist-worn monitoring device that identified patterns in patients with drug-resistant epilepsy, providing about 30 minutes of warning before a seizure occurred. The device worked well most of the time for five of six patients studied, offering a potential solution to forecast seizures and minimize their effects.
A comprehensive patient blood management program implemented at Mayo Clinic reduced allogenic transfusion use by 33% and improved hospital length of stay and adverse events. The program's multi-faceted approach included education efforts, computerized order entry processes, and analytics to inform decision-making.
A national survey of over 7,000 US nurses found that they experience suicidal ideation at a rate nearly 1% higher than the general workforce, with 40% screening positive for depression and 33% exhibiting burnout symptoms. The findings highlight the need for urgent attention and system-based interventions to address nurse well-being
A new study published in Mayo Clinic Proceedings found that patients with acute kidney injury who receive continuous renal replacement therapy (CRRT) have a high incidence of needing CRRT reinstitution after removal. This contributes to poor 90-day outcomes. Successful CRRT liberation is marginally associated with fewer major adverse k...
Women with dense breast tissue are at increased risk of developing breast cancer, which can be masked by mammograms. Mayo Clinic expert Suneela Vegunta recommends supplemental screening to diagnose additional cancers; however, consensus-based guidelines and randomized controlled studies are needed.
A Mayo Clinic expert suggests that people with serrated polyps, which are flat and difficult to spot during colonoscopies, should be checked more frequently for bowel cancer. The presence of serrated polyps alone or with adenomas increases cancer risk, similar to adenomas alone, according to a new study.
Mayo Clinic researchers propose a comprehensive approach to breast cancer prevention, including risk assessment, lifestyle modification, and preventive medications. The approach aims to reduce hormone-sensitive breast cancers with good prognosis and unfavorable triple-negative tumors.
Researchers at Mayo Clinic's Center for Individualized Medicine found that the gut microbiome is connected to a patient's outcome in rheumatoid arthritis. By analyzing stool samples from 32 patients with rheumatoid arthritis, they identified several traits of the gut microbiome linked to future prognosis.
Researchers developed a new AI algorithm called 'basis profile curve identification' to simplify comparisons between effects of electrical stimulation on the brain. The algorithm may help understand which brain regions interact with each other, guiding placement of electrodes for treating network brain diseases.
The study evaluated the impact of the program on patient engagement and clinical outcomes. Patient engagement rates reached 78.9%, highlighting the efficacy of virtual care at home during the pandemic.
A Mayo Clinic study found that a combination of casirivimab and imdevimab reduced hospitalization rates among high-risk patients with mild to moderate COVID-19 by 60%–70%. The treatment allowed these patients to recover safely at home.
Researchers at Mayo Clinic and MIT have developed a rapid-sealing paste that can stop bleeding from organs without clotting. The paste works like barnacles, exuding an oil matrix to clean the surface and repelling moisture, before applying a protein that cross-links with tissue molecules.
Researchers at Mayo Clinic found that wearing masks and maintaining physical distance significantly reduce the spread of COVID-19. The study showed that both disposable paper medical masks and two-layer cloth masks were effective in blocking aerosol particles, with increased distance reducing particle counts to near baseline levels.
Mayo Clinic researchers used advanced imaging technology to visualize the BRCA1-BARD1 protein complex and its interaction with chromatin. The study provides new insights into how BRCA1-BARD1 functions, which could lead to improved cancer prevention efforts and drug development.
Recent Mayo Clinic research reveals a significant increase in opioid overdose-related emergency department visits during the COVID-19 pandemic. Opioid overdoses accounted for 1 in every 313 visits, up from 1 in every 400 visits in previous years.
A 20-year Mayo Clinic study suggests that allowing athletes with genetic heart diseases to return to play can be managed through a shared decision-making process. The study found no deaths related to sports and only minor cardiac events, showing that the risks can be minimized with proper testing, treatment, and safety measures.
A new study by Mayo Clinic researchers suggests that most women with breast cancer diagnosed over 65 should be offered hereditary cancer genetic testing. The study found mutations in actionable breast cancer risk genes in 3.2% of women with breast cancer, highlighting the need for broader testing regardless of age or family history.
A large observational study found that two monoclonal antibodies reduced hospitalizations among high-risk patients with COVID-19, regardless of comorbidities. The study showed a low rate of hospitalizations when patients received the treatment early on.
Researchers at Mayo Clinic have found that COVID-19 can induce a strong immune response in patients, contributing to kidney injury. Mitochondrial dysfunction is also commonly found in kidney injury related to COVID-19, suggesting it may be a potential target for therapies.
The study analyzed data from 9,859 COVID-19 infections and found that people under 45 with certain chronic conditions had a greater than threefold increased risk of severe infection. Cancer was the biggest difference in risk between younger and older age groups.
Researchers studied inflammation's role in scarring of the central nervous system in three diseases: multiple sclerosis, aquaporin-4 antibody positive neuromyelitis optica spectrum disorder, and myelin oligodendrocyte glycoprotein antibody associated disorder. In MS, scars lead to nerve fiber degeneration and slow worsening of disabili...
Researchers found that MET oncogene amplification creates a hostile environment for immunotherapy, making it ineffective in treating some lung cancers. A combination of a MET inhibitor and anti-PD1 immunotherapy was effective in treating cancers with MET amplification.
Researchers at Mayo Clinic have discovered a single-gene cause of a neurodevelopmental disorder, identifying 28 unique variants in the SPTBN1 gene. The study provides hope for diagnosis and potential treatment for affected individuals.
Researchers found 23 men in the U.S. military developed severe chest pain and elevated cardiac troponin levels within four days of receiving a second dose of mRNA COVID-19 vaccines, but most recovered quickly. The risk of myocarditis from vaccination is low compared to COVID-19 infection.
Researchers at Mayo Clinic Cancer Center are studying a potential new chimeric antigen receptor-T cell therapy (CAR-T cell therapy) treatment for multiple myeloma. The overall response rate to the treatment was 97%, while the complete response rate and progression-free survival rates were 67% and 77%, respectively.
An AI-enhanced EKG can detect subtle electrical changes in the heart associated with COVID-19 infection, offering a potential rapid and reliable screening test. The technology achieved positive predictive values of up to 37% and negative predictive values of 99.2% in real-world populations.
A recent study published in Open Forum Infectious Diseases found that monoclonal antibody therapy is safe and effective in treating mild to moderate cases of COVID-19 in transplant patients. The study showed that these patients had a lower risk of severe illness and death compared to those who did not receive the treatment.
Researchers discovered that senolytic drugs significantly reduced inflammation, illness, and mortality from COVID infection in older mice. Treating infected mice with senolytics before or after infection led to a decrease in senescent cells, inflammation, and mortality, resulting in improved survival rates similar to younger mice.
Researchers at Mayo Clinic Cancer Center found that remote patient monitoring reduced the risk of hospitalization for cancer patients with COVID-19 by 78%. The program used in-home technology to monitor oxygen levels and vital signs, resulting in fewer hospitalizations and ICU admissions.
The study found that rivaroxaban is safe for patients with luminal gastrointestinal cancer, while apixaban should be used cautiously due to higher bleeding risk. DOACs can also be used in non-luminal GI cancers like pancreatic and hepatobiliary cancers.
Researchers found that a significant gap between numerical age and biological age, as predicted by AI-enabled EKGs, is associated with increased risk of death from heart disease. The study validated the use of AI-aged EKGs in predicting mortality rates.
A Mayo Clinic study reports on the first 100 patients with post-COVID-19 syndrome, experiencing symptoms like fatigue, respiratory complaints, and neurologic issues. The study highlights the need for healthcare providers to prepare for prolonged symptoms and provide effective treatment, including psychosocial support.
A new AI-powered ECG screening tool detected asymptomatic low ejection fraction in patients with improved diagnosis rates. The study found that the AI intervention increased the diagnosis of low ejection fraction by 32% relative to usual care.
A high rate of vaccination is vital to reducing COVID-19 cases and controlling the pandemic, according to new research from the Mayo Clinic. If Minnesota had achieved a 75% vaccination rate by early April, case numbers and hospitalizations would plummet by July.
Researchers developed an acellular product, PEP, derived from platelets that heals ischemic wounds by delivering healing messages to cells. The study demonstrates restoration of skin integrity and function in preclinical animal models.
A small study from Mayo Clinic researchers raises concerns that some transplant patients may have a limited immune response after receiving an mRNA COVID-19 vaccine. The study found that infected vaccinated solid organ transplant recipients had a 10 times higher infection rate compared to the general population.
Researchers analyzed tissue samples from 385 brains with Alzheimer's disease, identifying the SERPINA5 gene as strongly associated with tau protein tangle progression. The study aimed to clarify the relevance of gene expression changes in Alzheimer's disease and provide new targets for treatment.
A Mayo Clinic study found that 15.5% of patients with colorectal cancer had inherited gene mutations, which can be detected through universal testing and broader gene panels. This discovery has the potential to lead to targeted cancer therapies and earlier disease detection in families.
A Mayo Clinic study found that pregnancy significantly increases the risk of a first-time symptomatic kidney stone. The risk peaks close to delivery and improves by one year after delivery.
A new surgical approach at Mayo Clinic has shown promising results in reducing antibody-mediated rejection in highly sensitized patients. The reverse-order heart-liver transplant procedure involves transplanting the liver first, followed by the heart, and has been successful in all seven patients who underwent the procedure.
A new Mayo Clinic research found that tumor mutation burden is significantly inflated in Black patients with cancer compared to White patients, affecting therapy selection. The study suggests that accurate tumor mutational burden is crucial for predicting optimal treatment for patients with diverse ancestral backgrounds.
A Mayo Clinic study found that vaccinated patients without symptoms had an 80% lower adjusted risk of testing positive for COVID-19 after their last dose. The Pfizer-BioNTech and Moderna messenger RNA vaccines showed efficacy in limiting the spread of COVID-19 among asymptomatic individuals.
The study found a significant increase in loneliness and a decrease in feelings of friendship during the pandemic. Women reported higher levels of loneliness compared to men, while those with poorer health experienced decreased emotional support.
Researchers at Mayo Clinic have combined a functional test with clinical information to determine the clinical importance of BRCA2 gene variants of uncertain significance. The findings improved reclassification rates for VUS from 10% to 86%, enabling more accurate patient care and targeted therapy options.
Researchers at Mayo Clinic have developed LEAP, a proton therapy technique that targets cancer cells with defects in the ATM-BRCA1-BRCA2 DNA repair pathway, sparing surrounding normal tissues. The technique uses concentrated proton energy deposition to induce biologic responses in treatment-resistant cancers.
A study by Mayo Clinic researchers has identified USP24 as a frequently missing gene in pediatric patients with neuroblastoma, an aggressive form of childhood cancer. The gene plays a crucial role in protecting cells against errors during cell division and its loss may contribute to the development of aggressive tumors.