A team of Mayo Clinic medical experts and community leaders developed a playbook to reduce health disparities related to COVID-19. The approach focused on communication gaps, community priorities, and access to resources, resulting in beneficial systems and policy changes that improved health equity for immigrant and refugee populations.
A new scoring system, MIAAH, accurately identifies patients at highest risk of death and those likely to survive from alcohol-associated hepatitis. The tool incorporates laboratory variables and demographic data, offering a valuable prognostic model for clinicians.
Researchers at Mayo Clinic Cancer Center developed a machine learning algorithm that integrates genetic data from over 5,000 patients to predict patient benefit from chemotherapy and immunotherapy. A 32-gene molecular signature was identified, providing prognostic information and predicting patient response to immunotherapy.
Researchers at Mayo Clinic developed a non-opioid pain management approach that provides equivalent or better pain control and patient satisfaction compared to traditional opioid regimens. This approach eliminates opioids after common sports surgeries, such as knee and shoulder procedures.
A recent study found that individuals with an accurate self-assessment of their skin cancer risk are less likely to use tanning beds within the next year. This association was observed even among those who perceived a high risk of skin cancer development.
A new study published in Mayo Clinic Proceedings found that patients with alcohol-associated cirrhosis had significantly higher post-ICU death rates and mortality at 30 days after ICU discharge compared to those with cirrhosis attributed to other causes. The study, which analyzed case files of 1,174 patients, suggests that early diagno...
A study by Mayo Clinic researchers found that cancer patients receiving chemotherapy and targeted therapies may mount inadequate immune responses to COVID-19 vaccination. The authors recommend antibody level testing and booster vaccinations for these patients.
A new study published in Mayo Clinic Proceedings found that direct oral anticoagulants significantly decrease cancer-associated venous thrombosis recurrence without increasing bleeding. The study involved 2,894 patients and showed a 41% decrease in thrombosis recurrence with direct oral anticoagulants compared to parenteral dalteparin.
A recent study published in Transplantation Direct highlights the increased risk of death from cancer and infection for kidney transplant patients. Focusing on lifestyle changes such as weight loss, exercise, and diabetes management can improve long-term outcomes for these patients.
A new study from the Mayo Clinic finds that people who vape and test positive for COVID-19 are more likely to experience common symptoms such as headaches, muscle aches, and chest pain. The study also shows that those who vape and smoke tobacco have labored breathing and more frequent emergency department visits compared to non-vapers.
A Mayo Clinic study reveals that cardiovascular risks, including coronary artery disease and diabetes, have a stronger association with memory and thinking skills decline in middle-aged women. The research found that women with these conditions experience an annual decline in global cognition more than two times greater than men.
African American adults in Minnesota have nearly double the rate of death from cardiovascular disease compared to their white counterparts. The study found that basic health beliefs and demographics are associated with risk factors for cardiovascular disease, including hypertension, hyperlipidemia, and diabetes.
A global study published in JAMA Network Open found that patients hospitalized with COVID-19 who have metabolic syndrome are at a higher risk of developing acute respiratory distress syndrome and dying. The study examined records of over 46,000 patients across 26 countries and found that those with metabolic syndrome were 36% more like...
Researchers used AI and genomic data to predict which patients with early-stage rheumatoid arthritis are most likely to benefit from methotrexate treatment within the first three months. The study identified potential personalized medicine approaches for rheumatoid arthritis treatment, paving the way for further research.
Researchers at Mayo Clinic found that mRNA therapy improves the response of patients who weren't responding to cancer immunotherapy. The study identified a weak spot in T cells, white blood cells crucial for fighting cancer, and developed an mRNA-based strategy to enhance their response.
A study found that primary care clinicians prefer noninvasive options for patients who are unwilling to undergo invasive procedures, concerned about work time, or unconvinced of the need for screening. The researchers suggest tailoring recommendations to patient preferences to improve adherence to colorectal cancer screening.
A Mayo Clinic study reveals sex and race disparities in the management of patients with hypertrophic cardiomyopathy, with women and patients of color receiving ICDs less frequently. Regional variations in ICD use were also observed, with underuse in some areas and overuse in others.
A novel AI algorithm developed at Mayo Clinic can predict long-term patient survival after cardiac surgery using a single-lead EKG. The study found a clear correlation between long-term mortality and a positive AI ECG screen for reduced left ventricular ejection fraction among patients without apparent severe cardiomyopathy.
Researchers have linked T cell dysfunction in rheumatoid arthritis to a metabolic deficiency, suggesting a new therapeutic strategy. The study found that supplying the amino acid aspartate may provide a solution by repairing mitochondrial defects and suppressing TNF production.
Gastric cancer is the sixth most common cancer worldwide, with 1.09 million new cases in 2020. Recent research offers hope for improved treatment options, making it a critical area of focus for medical oncologists like Dr. Mohamad Sonbol.
A commentary by Mayo Clinic researchers emphasizes the importance of addressing bias in biomedical research funding to improve diversity and equity. The authors note that underfunding and lack of opportunities for minority clinicians and researchers exacerbate health disparities, highlighting the need for inclusive funding decisions.
A retrospective study published in Mayo Clinic Proceedings found that dasatinib lowers serum glucose levels in patients with pre-existing type 2 diabetes to a greater degree than imatinib and comparable to first-line diabetic medications. Researchers suggest further study is needed to determine the primary mechanism behind dasatinib's ...
Researchers developed a wrist-worn monitoring device that identified patterns in patients with drug-resistant epilepsy, providing about 30 minutes of warning before a seizure occurred. The device worked well most of the time for five of six patients studied, offering a potential solution to forecast seizures and minimize their effects.
A comprehensive patient blood management program implemented at Mayo Clinic reduced allogenic transfusion use by 33% and improved hospital length of stay and adverse events. The program's multi-faceted approach included education efforts, computerized order entry processes, and analytics to inform decision-making.
A national survey of over 7,000 US nurses found that they experience suicidal ideation at a rate nearly 1% higher than the general workforce, with 40% screening positive for depression and 33% exhibiting burnout symptoms. The findings highlight the need for urgent attention and system-based interventions to address nurse well-being
A new study published in Mayo Clinic Proceedings found that patients with acute kidney injury who receive continuous renal replacement therapy (CRRT) have a high incidence of needing CRRT reinstitution after removal. This contributes to poor 90-day outcomes. Successful CRRT liberation is marginally associated with fewer major adverse k...
Women with dense breast tissue are at increased risk of developing breast cancer, which can be masked by mammograms. Mayo Clinic expert Suneela Vegunta recommends supplemental screening to diagnose additional cancers; however, consensus-based guidelines and randomized controlled studies are needed.
A Mayo Clinic expert suggests that people with serrated polyps, which are flat and difficult to spot during colonoscopies, should be checked more frequently for bowel cancer. The presence of serrated polyps alone or with adenomas increases cancer risk, similar to adenomas alone, according to a new study.
Mayo Clinic researchers propose a comprehensive approach to breast cancer prevention, including risk assessment, lifestyle modification, and preventive medications. The approach aims to reduce hormone-sensitive breast cancers with good prognosis and unfavorable triple-negative tumors.
Researchers at Mayo Clinic's Center for Individualized Medicine found that the gut microbiome is connected to a patient's outcome in rheumatoid arthritis. By analyzing stool samples from 32 patients with rheumatoid arthritis, they identified several traits of the gut microbiome linked to future prognosis.
Researchers developed a new AI algorithm called 'basis profile curve identification' to simplify comparisons between effects of electrical stimulation on the brain. The algorithm may help understand which brain regions interact with each other, guiding placement of electrodes for treating network brain diseases.
The study evaluated the impact of the program on patient engagement and clinical outcomes. Patient engagement rates reached 78.9%, highlighting the efficacy of virtual care at home during the pandemic.
A Mayo Clinic study found that a combination of casirivimab and imdevimab reduced hospitalization rates among high-risk patients with mild to moderate COVID-19 by 60%–70%. The treatment allowed these patients to recover safely at home.
Researchers at Mayo Clinic and MIT have developed a rapid-sealing paste that can stop bleeding from organs without clotting. The paste works like barnacles, exuding an oil matrix to clean the surface and repelling moisture, before applying a protein that cross-links with tissue molecules.
Researchers at Mayo Clinic found that wearing masks and maintaining physical distance significantly reduce the spread of COVID-19. The study showed that both disposable paper medical masks and two-layer cloth masks were effective in blocking aerosol particles, with increased distance reducing particle counts to near baseline levels.
Mayo Clinic researchers used advanced imaging technology to visualize the BRCA1-BARD1 protein complex and its interaction with chromatin. The study provides new insights into how BRCA1-BARD1 functions, which could lead to improved cancer prevention efforts and drug development.
Recent Mayo Clinic research reveals a significant increase in opioid overdose-related emergency department visits during the COVID-19 pandemic. Opioid overdoses accounted for 1 in every 313 visits, up from 1 in every 400 visits in previous years.
A 20-year Mayo Clinic study suggests that allowing athletes with genetic heart diseases to return to play can be managed through a shared decision-making process. The study found no deaths related to sports and only minor cardiac events, showing that the risks can be minimized with proper testing, treatment, and safety measures.
A new study by Mayo Clinic researchers suggests that most women with breast cancer diagnosed over 65 should be offered hereditary cancer genetic testing. The study found mutations in actionable breast cancer risk genes in 3.2% of women with breast cancer, highlighting the need for broader testing regardless of age or family history.
A large observational study found that two monoclonal antibodies reduced hospitalizations among high-risk patients with COVID-19, regardless of comorbidities. The study showed a low rate of hospitalizations when patients received the treatment early on.
Researchers at Mayo Clinic have found that COVID-19 can induce a strong immune response in patients, contributing to kidney injury. Mitochondrial dysfunction is also commonly found in kidney injury related to COVID-19, suggesting it may be a potential target for therapies.
The study analyzed data from 9,859 COVID-19 infections and found that people under 45 with certain chronic conditions had a greater than threefold increased risk of severe infection. Cancer was the biggest difference in risk between younger and older age groups.
Researchers studied inflammation's role in scarring of the central nervous system in three diseases: multiple sclerosis, aquaporin-4 antibody positive neuromyelitis optica spectrum disorder, and myelin oligodendrocyte glycoprotein antibody associated disorder. In MS, scars lead to nerve fiber degeneration and slow worsening of disabili...
Researchers found that MET oncogene amplification creates a hostile environment for immunotherapy, making it ineffective in treating some lung cancers. A combination of a MET inhibitor and anti-PD1 immunotherapy was effective in treating cancers with MET amplification.
Researchers at Mayo Clinic have discovered a single-gene cause of a neurodevelopmental disorder, identifying 28 unique variants in the SPTBN1 gene. The study provides hope for diagnosis and potential treatment for affected individuals.
Researchers found 23 men in the U.S. military developed severe chest pain and elevated cardiac troponin levels within four days of receiving a second dose of mRNA COVID-19 vaccines, but most recovered quickly. The risk of myocarditis from vaccination is low compared to COVID-19 infection.
Researchers at Mayo Clinic Cancer Center are studying a potential new chimeric antigen receptor-T cell therapy (CAR-T cell therapy) treatment for multiple myeloma. The overall response rate to the treatment was 97%, while the complete response rate and progression-free survival rates were 67% and 77%, respectively.
An AI-enhanced EKG can detect subtle electrical changes in the heart associated with COVID-19 infection, offering a potential rapid and reliable screening test. The technology achieved positive predictive values of up to 37% and negative predictive values of 99.2% in real-world populations.
A recent study published in Open Forum Infectious Diseases found that monoclonal antibody therapy is safe and effective in treating mild to moderate cases of COVID-19 in transplant patients. The study showed that these patients had a lower risk of severe illness and death compared to those who did not receive the treatment.
Researchers discovered that senolytic drugs significantly reduced inflammation, illness, and mortality from COVID infection in older mice. Treating infected mice with senolytics before or after infection led to a decrease in senescent cells, inflammation, and mortality, resulting in improved survival rates similar to younger mice.