Researchers trained AI to identify subtle differences in normal EKGs that indicate changes caused by atrial fibrillation. The AI-enabled EKG correctly identified the condition with 90% accuracy, improving treatment options and efficiency of heart disease screening.
Researchers at Mayo Clinic have identified two distinct pathways for lung adenocarcinoma development, which can inform treatment strategies and predict patient response. The study's findings suggest that targeting specific pathways may provide alternative treatment options for patients with limited response to traditional therapies.
A longitudinal study of 3,756 U.S. medical students found that racism in medical school was associated with graduating students' decisions to provide care in high-need communities. Strategies such as service learning experiences and a curriculum focused on minority health can increase intention to practice in underserved areas.
A recent study by Mayo Clinic researchers found an association between increased symptoms of burnout and heightened racial bias in medical residents. Physicians experiencing high symptoms of burnout tended to exhibit more racial bias, both explicit and implicit, but recoveries from burnout were linked to reductions in bias.
A phase I clinical trial demonstrates the potential of regenerative therapy for hypoplastic left heart syndrome through collecting, processing and injecting an infant's own stem cells directly into the heart at the time of surgery. The study showed no deaths or significant safety concerns over six months following surgery.
A study of over 1,800 cases found that the need for additional surgery was twice as high after transobturator sling surgery compared to retropubic sling. The study also revealed lower reoperation rates and fewer complications with the retropubic procedure.
A study by Mayo Clinic researchers found that micronutrient deficiencies are common in adults diagnosed with celiac disease. The most frequent deficiency was zinc, observed in 59.4% of patients, while vitamin D, iron, copper, vitamin B12, and folate were also prevalent.
A recent study found that only 5.5% of glioblastoma patients survive five years after diagnosis, highlighting the need for more aggressive treatments to improve long-term survival. The research analyzed 48,652 cases and identified factors associated with five-year survival, including age, race, gender, and treatment with radiotherapy.
A new study by Mayo Clinic researchers found that generic and brand-name levothyroxine therapy are similar in terms of cardiovascular event rates, with lower pharmacy costs for the generic drug. The analysis used deidentified claims data from a large private health plan and included over 87,000 patients.
A Mayo Clinic study of 444,764 patients found that tramadol was more likely than other opioids to result in prolonged use, challenging its classification as a lower-risk medication. The researchers used de-identified data from the OptumLabs Data Warehouse to examine prescription fills after surgery.
A randomized, double-blind, placebo-controlled study found that eculizumab significantly reduced the risk of relapse in patients with neuromyelitis optica spectrum disorder. Nearly 98% of patients treated with eculizumab had not relapsed after 48 weeks, compared to 63% for those on the placebo.
A Mayo Clinic study shows that less-invasive mastectomy is a safe option for more patients, including those with locally advanced cancer or surgical complication risk factors. The procedure's complications declined significantly between 2009 and 2017, and reconstruction success rates were high at one year after surgery.
Research suggests that daily activities such as eating and walking are affected early in the course of rheumatoid arthritis, with most patients experiencing functional disabilities. The study also found that persistent excess in functional disability continued even after diagnosis and treatment.
A new report calls for increased research into 'limbic-predominant age-related TDP-43 encephalopathy,' or LATE, a degenerative brain disease that affects the elderly and mimics Alzheimer's. Researchers aim to improve prevention, diagnosis, and treatment through better understanding of the condition.
Cancer cells use PD-L1 to evade immune surveillance and resist chemotherapy and radiation therapy. Researchers propose using an antibody that disrupts PD-L1's internal function to make cancer cells more sensitive to treatment.
A majority of US states restrict decision-making for incapacitated pregnant women, with 25 laws invalidating advance directives during pregnancy. Thirty-eight states have laws that identify pregnancy as a condition affecting decisions for incapacitated women, but these laws vary widely in content.
A recent study published in JAMA found that magic mouthwash significantly reduced pain from oral mucositis, a common side effect of radiation therapy for head and neck cancers. The treatment, which contains diphenhydramine, lidocaine, and antacids, was well-tolerated by patients and outperformed placebo.
A telerehabilitation program has been shown to improve the physical function, pain, and quality of life of patients with late-stage cancers. The study found that these patients who received remotely delivered rehabilitation services had fewer hospital and nursing home stays.
A Mayo Clinic study found that extended chemotherapy, a normal CA 19-9 tumor marker, and a dead tumor after surgery can significantly increase survival time for patients with advanced pancreatic cancer. The study achieved an average survival time of 58.8 months, or nearly five years.
Removing senescent cells, also known as 'zombie cells,' from fat tissue in obese mice improves glucose levels and insulin sensitivity. The study also shows a decline in inflammatory factors and restored normal fat cell function.
Mayo Clinic researchers have identified a potential new therapy for liver diseases, finding that the drug sivelestat may effectively lower portal hypertension. The study showed that deposits of fibrin and inflammatory cells contributed to portal hypertension, which was successfully inhibited by sivelestat.
A recent study using big data analysis has found that catheter ablation is associated with a lower risk of stroke, death, and major bleeding in patients with atrial fibrillation. The research, led by Mayo Clinic, used a large cohort of patients to replicate the results of a clinical trial and provide complementary evidence for clinicians.
New research reveals catheter ablation is effective in reducing atrial fibrillation recurrence and improving quality of life for patients, while drug therapy offers no significant benefit. However, the study found that catheter ablation did not reduce death or stroke risk compared to drug therapy.
A study found that rural areas have higher levels of ambiguity and fatalism regarding cancer, which can discourage participation in screenings. Researchers hope to develop customized interventions based on community needs and values.
A Mayo Clinic study found that people with sleep apnea had higher accumulations of the toxic protein tau in the entorhinal cortex, a part of the brain responsible for memory, navigation, and perception. This association may suggest a link between sleep disruption and an increased risk of dementia.
Researchers identified a gene called UCP-1 that may predict the development of pancreatic cancer in people with Type 2 diabetes. The study found three distinct metabolic phases prior to diagnosis, characterized by rising blood glucose levels and changes in body fat.
A national survey of physicians found that burnout is improving, but the risk remains high, particularly due to electronic health record demands. Physicians report reduced emotional exhaustion and improved satisfaction with work-life integration, but more organizational change and research are needed to sustain this trajectory.
Researchers identified nine patients with leprosy treated at Mayo Clinic from 1994 to 2017, revealing common factors such as Micronesian lineage and extensive travel while immunosuppressed. The study highlights the importance of treatment and vigilance for immunosuppressed individuals traveling to areas with high rates of leprosy.
Researchers at Mayo Clinic reviewed health records of 89 people with osteoporosis or osteopenia and found 29 bony injuries, including compression fractures. They recommend modifying yoga poses to accommodate these conditions.
A Mayo Clinic study found that patients with a poor immune response to follicular lymphoma exhibited reduced costimulatory receptors on their T-cells, leading to shorter survival rates. The research may lead to the development of new therapies for some patients with follicular lymphoma.
A study of 1,625 brain tissue samples found Hispanic-American patients with Alzheimer's disease lived an average of 12 years from symptom onset, compared to 9 and 8 years for non-Hispanic whites and African-Americans. The research also identified subtle differences in the severity of Alzheimer's-related protein clumps among ethnoracial...
Researchers at Mayo Clinic have created a more efficient method for reprogramming induced pluripotent stem cells, reducing the process from four factors to one. The new system combines genetic cocktails into a single measles virus vector, making it faster and safer for clinical translation.
The study, published in JAMA Network Open, demonstrates that an individualized approach to diet considering a person's unique gut microbiome is more accurate in predicting blood glucose response to food. The research found that this approach was superior to traditional models based on carbohydrates or calories.
Researchers used data from Olmsted County, Minnesota to develop an online prediction tool that predicts the likelihood of future kidney stone episodes. The tool takes into account factors such as age, sex, body mass index, pregnancy history, and family history of stones.
Researchers have conducted a safety and feasibility clinical trial on removing senescent cells from patients with pulmonary fibrosis, showing clinically meaningful improvement in physical function. The study used a drug to clear senescent cells and found benefits in gait speed, walking speed, chair rise test, and physical function tests.
A Mayo Clinic study found that applying artificial intelligence to a standard electrocardiogram (EKG) results in an affordable and accessible early indicator of asymptomatic left ventricular dysfunction, a precursor to heart failure. The AI/EKG test accuracy compares favorably with other common screening tests.
Researchers identified genetic alterations in low-risk prostate cancers that may indicate higher-risk cancer presence, guiding men to consider treatment. The study suggests a potential test to validate these alterations, enabling personalized treatment decisions.
Researchers found that obesity increases levels of senescent cells in the brain, which are linked to anxiety. Clearing these cells with senolytic drugs reduces anxious behavior and improves neurological function in mice.
Researchers developed a strategy to block GM-CSF protein, reducing toxicities and improving CAR-T cell efficacy. A second strategy involves combining CAR-T cell therapy with a drug targeting AXL protein, potentially enhancing potency and lowering toxicity.
Mayo Clinic researchers find that viruses can hijack the ADAR1 enzyme to avoid immune detection, but at a threshold of 1,000 double-stranded RNA molecules. This discovery offers hope for new antiviral therapies targeting ADAR1.
A small observational study suggests that rose geranium oil spray can help alleviate nasal vestibulitis, a common and painful condition caused by cancer drug treatment. The study found that 55% of participants experienced moderate benefit from using the oil, with some reporting complete symptom resolution.
A new radiation treatment approach, hippocampal-avoidance whole-brain radiotherapy with memantine, demonstrated better preservation of cognitive function compared to traditional whole-brain radiotherapy. The study found similar cancer control and overall survival outcomes for both groups.
Researchers identified three specific subtypes of myeloma linked to higher risk in African-Americans due to genetic translocations and increased African ancestry. The study provides insight into the mechanisms of health disparity and potential treatment strategies for this population.
Researchers have identified estradiol as a potential new treatment for triple-negative breast cancer with estrogen receptor beta expression, effectively inhibiting tumor growth in studies. Estradiol stimulates the expression of cystatins, which exhibit tumor-suppressing effects on neighboring and distant cancer cells.
Researchers found that obese patients who underwent a combined liver transplant and weight-loss surgery experienced significant weight loss maintenance and reduced metabolic complications. The study suggests that this dual approach is safe and effective over the long term for treating obesity-related liver disease.
Researchers at Mayo Clinic developed a new genetics-based prognostic tool for myelodysplastic syndrome, which integrates genetic and clinical information to provide more accurate predictions. The tool identifies favorable gene mutations, such as SF3B1, and unfavorable mutations, like ASXL1 and RUNX1, to guide treatment decisions.
Researchers at Mayo Clinic have successfully used spinal cord stimulation and physical therapy to enable a paralyzed man to stand and walk with assistance. The patient, who was paralyzed since 2013, achieved significant milestones during rehabilitation sessions, including walking over 102 meters and taking 331 steps.
A Mayo Clinic study found that enrollment in an opioid controlled substance agreement significantly reduces primary care visits, hospitalizations, and specialty visits among patients with chronic health conditions. The agreement also leads to increased radiology visits, but not emergency department services.
A Mayo Clinic study found that premenopausal women who have their ovaries surgically removed face an increased risk of developing chronic kidney disease. The risk is highest for those younger than 46, with a 7.5% increased risk.
Scientists report that senescent cells accumulate in certain brain cells prior to cognitive loss, but eliminating them diminishes tau protein aggregation and memory loss. The study identifies two brain cell types, microglia and astrocytes, as prone to senescence.