A Mayo Clinic study found that extended chemotherapy, a normal CA 19-9 tumor marker, and a dead tumor after surgery can significantly increase survival time for patients with advanced pancreatic cancer. The study achieved an average survival time of 58.8 months, or nearly five years.
Removing senescent cells, also known as 'zombie cells,' from fat tissue in obese mice improves glucose levels and insulin sensitivity. The study also shows a decline in inflammatory factors and restored normal fat cell function.
Mayo Clinic researchers have identified a potential new therapy for liver diseases, finding that the drug sivelestat may effectively lower portal hypertension. The study showed that deposits of fibrin and inflammatory cells contributed to portal hypertension, which was successfully inhibited by sivelestat.
A recent study using big data analysis has found that catheter ablation is associated with a lower risk of stroke, death, and major bleeding in patients with atrial fibrillation. The research, led by Mayo Clinic, used a large cohort of patients to replicate the results of a clinical trial and provide complementary evidence for clinicians.
New research reveals catheter ablation is effective in reducing atrial fibrillation recurrence and improving quality of life for patients, while drug therapy offers no significant benefit. However, the study found that catheter ablation did not reduce death or stroke risk compared to drug therapy.
A study found that rural areas have higher levels of ambiguity and fatalism regarding cancer, which can discourage participation in screenings. Researchers hope to develop customized interventions based on community needs and values.
A Mayo Clinic study found that people with sleep apnea had higher accumulations of the toxic protein tau in the entorhinal cortex, a part of the brain responsible for memory, navigation, and perception. This association may suggest a link between sleep disruption and an increased risk of dementia.
Researchers identified a gene called UCP-1 that may predict the development of pancreatic cancer in people with Type 2 diabetes. The study found three distinct metabolic phases prior to diagnosis, characterized by rising blood glucose levels and changes in body fat.
A national survey of physicians found that burnout is improving, but the risk remains high, particularly due to electronic health record demands. Physicians report reduced emotional exhaustion and improved satisfaction with work-life integration, but more organizational change and research are needed to sustain this trajectory.
Researchers identified nine patients with leprosy treated at Mayo Clinic from 1994 to 2017, revealing common factors such as Micronesian lineage and extensive travel while immunosuppressed. The study highlights the importance of treatment and vigilance for immunosuppressed individuals traveling to areas with high rates of leprosy.
Researchers at Mayo Clinic reviewed health records of 89 people with osteoporosis or osteopenia and found 29 bony injuries, including compression fractures. They recommend modifying yoga poses to accommodate these conditions.
A Mayo Clinic study found that patients with a poor immune response to follicular lymphoma exhibited reduced costimulatory receptors on their T-cells, leading to shorter survival rates. The research may lead to the development of new therapies for some patients with follicular lymphoma.
A study of 1,625 brain tissue samples found Hispanic-American patients with Alzheimer's disease lived an average of 12 years from symptom onset, compared to 9 and 8 years for non-Hispanic whites and African-Americans. The research also identified subtle differences in the severity of Alzheimer's-related protein clumps among ethnoracial...
Researchers at Mayo Clinic have created a more efficient method for reprogramming induced pluripotent stem cells, reducing the process from four factors to one. The new system combines genetic cocktails into a single measles virus vector, making it faster and safer for clinical translation.
The study, published in JAMA Network Open, demonstrates that an individualized approach to diet considering a person's unique gut microbiome is more accurate in predicting blood glucose response to food. The research found that this approach was superior to traditional models based on carbohydrates or calories.
Researchers used data from Olmsted County, Minnesota to develop an online prediction tool that predicts the likelihood of future kidney stone episodes. The tool takes into account factors such as age, sex, body mass index, pregnancy history, and family history of stones.
Researchers have conducted a safety and feasibility clinical trial on removing senescent cells from patients with pulmonary fibrosis, showing clinically meaningful improvement in physical function. The study used a drug to clear senescent cells and found benefits in gait speed, walking speed, chair rise test, and physical function tests.
A Mayo Clinic study found that applying artificial intelligence to a standard electrocardiogram (EKG) results in an affordable and accessible early indicator of asymptomatic left ventricular dysfunction, a precursor to heart failure. The AI/EKG test accuracy compares favorably with other common screening tests.
Researchers identified genetic alterations in low-risk prostate cancers that may indicate higher-risk cancer presence, guiding men to consider treatment. The study suggests a potential test to validate these alterations, enabling personalized treatment decisions.
Researchers found that obesity increases levels of senescent cells in the brain, which are linked to anxiety. Clearing these cells with senolytic drugs reduces anxious behavior and improves neurological function in mice.
Researchers developed a strategy to block GM-CSF protein, reducing toxicities and improving CAR-T cell efficacy. A second strategy involves combining CAR-T cell therapy with a drug targeting AXL protein, potentially enhancing potency and lowering toxicity.
Mayo Clinic researchers find that viruses can hijack the ADAR1 enzyme to avoid immune detection, but at a threshold of 1,000 double-stranded RNA molecules. This discovery offers hope for new antiviral therapies targeting ADAR1.
A small observational study suggests that rose geranium oil spray can help alleviate nasal vestibulitis, a common and painful condition caused by cancer drug treatment. The study found that 55% of participants experienced moderate benefit from using the oil, with some reporting complete symptom resolution.
A new radiation treatment approach, hippocampal-avoidance whole-brain radiotherapy with memantine, demonstrated better preservation of cognitive function compared to traditional whole-brain radiotherapy. The study found similar cancer control and overall survival outcomes for both groups.
Researchers identified three specific subtypes of myeloma linked to higher risk in African-Americans due to genetic translocations and increased African ancestry. The study provides insight into the mechanisms of health disparity and potential treatment strategies for this population.
Researchers have identified estradiol as a potential new treatment for triple-negative breast cancer with estrogen receptor beta expression, effectively inhibiting tumor growth in studies. Estradiol stimulates the expression of cystatins, which exhibit tumor-suppressing effects on neighboring and distant cancer cells.
Researchers found that obese patients who underwent a combined liver transplant and weight-loss surgery experienced significant weight loss maintenance and reduced metabolic complications. The study suggests that this dual approach is safe and effective over the long term for treating obesity-related liver disease.
Researchers at Mayo Clinic developed a new genetics-based prognostic tool for myelodysplastic syndrome, which integrates genetic and clinical information to provide more accurate predictions. The tool identifies favorable gene mutations, such as SF3B1, and unfavorable mutations, like ASXL1 and RUNX1, to guide treatment decisions.
Researchers at Mayo Clinic have successfully used spinal cord stimulation and physical therapy to enable a paralyzed man to stand and walk with assistance. The patient, who was paralyzed since 2013, achieved significant milestones during rehabilitation sessions, including walking over 102 meters and taking 331 steps.
A Mayo Clinic study found that enrollment in an opioid controlled substance agreement significantly reduces primary care visits, hospitalizations, and specialty visits among patients with chronic health conditions. The agreement also leads to increased radiology visits, but not emergency department services.
A Mayo Clinic study found that premenopausal women who have their ovaries surgically removed face an increased risk of developing chronic kidney disease. The risk is highest for those younger than 46, with a 7.5% increased risk.
Scientists report that senescent cells accumulate in certain brain cells prior to cognitive loss, but eliminating them diminishes tau protein aggregation and memory loss. The study identifies two brain cell types, microglia and astrocytes, as prone to senescence.
Burnout among US resident physicians is widespread, with high rates in urology, neurology, and emergency medicine. High levels of anxiety during medical school are associated with burnout symptoms during residency.
Researchers at Mayo Clinic have discovered that a dietary supplement called cyclocreatine may block the growth of HER2 positive breast cancer. The study found that cyclocreatine effectively targets mitochondrial creatine kinase 1 enzyme and reduces cancer growth without toxicity.
Researchers at Mayo Clinic and Arizona State University have discovered that a type of clay can kill certain bacteria causing infections in wounds. The clay's antibacterial properties were tested against various bacterial strains, including those resistant to antibiotics.
A Mayo Clinic research team has identified specific genes associated with an increased risk for developing triple-negative breast cancer. Alternations in BARD1, BRCA1, BRCA2, PALB2 and RAD51D genes were linked to a high risk for this subtype of breast cancer, while mutations in BRIP1 and RAD51C genes showed a moderate risk.
A Mayo Clinic study found that specific gut bacteria, such as Phascolarctobacterium and Dialister, are associated with weight loss success and failure, respectively. The research suggests that individualized strategies may be needed to address the unique metabolic needs of each person.
Researchers found that opioid prescription rates have remained flat for commercially insured patients over the past decade, but rates for some Medicare patients are leveling off. The study of 48 million U.S. patients showed high rates of opioid use among disabled Medicare Advantage recipients.
A new Mayo Clinic research study found that general anesthesia and surgery are associated with a subtle decline in memory and thinking skills in adults over 70. The study analyzed nearly 2,000 participants and found that exposure to anesthesia after age 70 was linked to long-term changes in brain function.
Researchers at Mayo Clinic have identified a neurological cause for the yips in golfers, which can be measured using quantitative methods. The study found that five out of 27 golfers had a neurologic cause for their condition, with greater acceleration of wrist and arm movement and more variability in wrist acceleration and rotation.
Researchers at Mayo Clinic found that senolytic drugs can significantly improve health span and life span in elderly mice by removing senescent cells. The study showed that administering senolytics orally improved physical function, increased daily activity, and extended remaining life span by 36 percent.
Researchers used precision genomics to identify new genetic abnormalities associated with short telomeres, which can cause premature aging. The study aimed to find better ways to screen, diagnose, and treat patients with these rare conditions.
Researchers at Mayo Clinic have discovered how the DNA repair protein 53BP1 relocates to chromosomes to fix damage, using RNA molecules as an off/on switch. This finding could lead to new therapies for ovarian cancer by targeting a specific protein called TIRR.
Researchers have discovered a potential diagnostic method for pancreatic cancer in patients with early onset diabetes by analyzing blood sugar levels over time. The ENDPAC score model identifies patients at high risk of developing pancreatic cancer, providing a new way to diagnose the disease at an earlier stage.
Researchers found six genes with mutations that substantially increase a person's risk for pancreatic cancer, even in those without family history. The study recommends genetic testing for all pancreatic cancer patients as the new standard of care.
Researchers at the Mayo Clinic have discovered genetically engineered bacteria that produce tryptamine, which helps food pass through the intestines with potentially less risk of side effects. This finding is significant as there are few approved constipation remedies on the market and traditional probiotics don't work for everyone.
Researchers at Mayo Clinic have developed a DNA test that can detect liver cancer with high accuracy, outperforming current methods. The test uses abnormal DNA markers found in liver cancer tissues and has been shown to detect over 90% of patients with curable stage tumors.
A new study found that hot flashes and night sweats can persist well into women's 60s, 70s, and 80s. Researchers suggest that women with these symptoms should discuss treatment options with their healthcare providers.
A study found that closing the left atrial appendage during coronary artery bypass or heart valve surgery reduces stroke and mortality risks, especially for patients with pre-existing atrial fibrillation. However, this procedure may increase risk in patients without prior atrial fibrillation.
A recent study by Mayo Clinic researchers found that the FDA-approved drug decitabine may be effective in treating triple-negative breast cancer. The study identified a subset of patients who could benefit from this therapy based on the presence of certain critical proteins.