A new study by Mayo Clinic researchers examines the direct medical costs of falls in adults with a transfemoral amputation, finding that high-functioning patients are often denied more expensive prosthetic knee technologies. The study aims to provide evidence for policymakers to evaluate the value of these advanced technologies.
Patients with diabetes who experience severe dysglycemia are at highest risk for recurrent episodes and readmission. Discharge planning and post-hospital follow-up can help prevent readmissions.
Researchers found that patients with Parkinson's were four times more likely to have a history of melanoma than those without the disease. In contrast, people with melanoma had a fourfold higher risk of developing Parkinson's. The study suggests that common environmental or genetic factors may underlie both conditions.
A simple blood test measuring carcinoembryonic antigen (CEA) levels could change treatment options for 17% of stage 2 colon cancer patients. The test may improve survival rates and quality of life for thousands with the disease.
Dementia with Lewy bodies affects 1.4 million Americans, often misdiagnosed as Alzheimer's or Parkinson's disease. The new guidelines provide detailed guidance for diagnosing and treating the condition, which includes symptoms like visual hallucinations and sleep difficulties.
A new study by Mayo Clinic researchers found that women who experienced physical, emotional, or sexual abuse are 62% more likely to have their ovaries removed before age 46. The study suggests that gynecological symptoms such as abdominal pain or excessive bleeding may lead to unnecessary and harmful surgeries.
A new study using linked dental records shows that dentists are in good compliance with AHA guidelines on prophylactic antibiotic use. The study found no significant increase in cases of infective endocarditis following the introduction of updated guidelines.
Researchers identified a key protein, SMAD3, that facilitates pro-fibrotic TGF-beta signaling. By blocking this protein, they created a peptide-carrying SNX9 that prevents SMAD3 from entering the nucleus and impacting genes regulated by TGF-beta. This approach may lead to effective treatments for fibrosis-related diseases.
Researchers discovered a link between a donor and infection in heart, lung transplant recipients caused by Mycoplasma hominis. The bacteria resists most antibiotics and can cause serious complications like pleurisy, surgical site infections, and mediastinitis.
A Mayo Clinic study found that patients with Parkinson's disease, Lewy body dementia, and related conditions died 2-6 years earlier than the general population. The study used data from 1991 to 2010 and compared 461 patients with these diseases to 452 patients in the general population.
Researchers found that squamous cell carcinoma diagnoses increased by 263% and basal cell carcinomas by 145% between 2000-2010. Women in specific age groups experienced the greatest increase in basal cell carcinoma diagnoses, while men's diagnosis trends varied across time periods.
Researchers from Mayo Clinic have made significant progress in understanding the DNA damage response proteins and their role in repairing double-strand breaks. The study reveals how these proteins work together to fix damaged DNA, potentially leading to new therapeutic strategies for cancer treatment.
Mayo Clinic's new imaging technologies use computerized tomography scans to measure the firmness of brain tumors and how attached they are to normal brain tissue. This information helps surgeons plan the safest method for extraction, potentially reducing complications and improving patient outcomes.
A Mayo Clinic research team has developed a new type of cancer-fighting nanoparticle that can shrink breast cancer tumors by up to 70-80% and prevent recurrence. The nanoparticles work by engaging the entire immune system to kill cancer cells, prompting the body to create its own memory system to minimize tumor recurrence.
A recent study published in The Journal of Urology found that surgery to remove secondary tumor growths, called metastases, significantly improves survival rates for patients with late-stage kidney cancer. Patients who underwent surgery had a life expectancy of three to 12 years, compared to eight months and two years without surgery.
A study by Mayo Clinic researchers found that nearly 90% of patients who sought second opinions received either a new diagnosis or a refined version of their original diagnosis. This significant finding highlights the importance of second opinions in ensuring accurate diagnoses and improving patient outcomes. The study's lead author no...
Researchers at Mayo Clinic successfully stimulated a man's paralyzed legs using electrical current, enabling him to move and stand. The study suggests that people with discomplete spinal cord injuries may be candidates for epidural stimulation therapy.
A study found that heart failure patients who transition to skilled nursing facilities are 50 percent more likely to end up back in the hospital. The researchers identified a key factor in estimating likelihood of rehospitalization as the patient's ability to carry on daily activities upon entering the facility.
Researchers at Mayo Clinic have identified an interaction between focal adhesion kinase and myosin that drives the production of secreted cancer-promoting proteins. This discovery may lead to the development of new drugs to inhibit cancer progression by blocking this interaction.
Research at Mayo Clinic found that patients using gastric acid suppression medications are at a higher risk for developing recurrent C-diff infections. The study suggests these medications may increase the risk, and caution is advised when prescribing them to patients with a prior C-diff episode.
A Mayo Clinic study found that high-intensity aerobic exercise can reverse cellular aspects of aging, improving lean body mass and insulin sensitivity. The study also showed that high-intensity interval training enhanced muscle protein content, causing muscle enlargement and improving energetic functions.
Researchers from Mayo Clinic report that tumor genomic alterations did not differ significantly between chemotherapy-sensitive and -resistant tumors. However, the study identified an uncommon type of aggressive breast cancer with a unique mutation in p53, which was less likely to respond to chemotherapy.
Researchers at Mayo Clinic have identified a specific protein implicated in drug resistance, as well as a possible therapeutic tool. By engineering a peptide that blocks the activity of another protein ERK, the team found that it can prevent chemotherapy resistance and tumor growth.
Researchers discovered an experimental drug, LCL161, that stimulates the immune system and causes tumor shrinkage in patients with multiple myeloma. The study highlights the importance of studying drug interactions with the tumor microenvironment.
Researchers found that markers of cellular senescence were higher in individuals with idiopathic pulmonary fibrosis, and senescent cell burden increased with the progression of the disease. The findings suggest targeting senescent cells could be a viable treatment option for individuals suffering from idiopathic pulmonary fibrosis.
Scientists discover a culture method that unlocks the natural fighter function of immune T cells when exposed to alarm signals, allowing for the growth of natural armies trained to recognize and target cancer proteins. The method has been tested on three cancer-associated proteins and shown success in stimulating T cell responses.
Researchers from Mayo Clinic have quantified the numbers of various immune cells associated with the risk of developing breast cancer. The study found that women who later developed breast cancer showed lower amounts of antibody-producing immune cells in their breast tissue.
A study published in JAMA Oncology found that patients with autoimmune diseases taking azathioprine had a higher risk of developing therapy-related myeloid neoplasms. Researchers also identified other medications used by these patients, but only azathioprine showed a statistically significant association.
Researchers at Mayo Clinic are testing a vaccine that aims to establish lifelong immunity against precancerous breast lesions. The vaccine targets human epidermal growth factor 2 (HER-2) and has shown promise in a phase I clinical study, eliciting an immune response in all tested individuals.
Researchers studied millennial medical students' learning preferences and found a need for personalized assessment and mentorship. The study attributes these traits to the global environment in which millennials were raised, influencing a generation that values technology, teamwork, and personalization.
Researchers found that cognitively normal people 70 and older who engaged in computer use, craft activities, social activities, or playing games had a decreased risk of developing mild cognitive impairment. The study's findings suggest that mentally stimulating activities can be beneficial even for those at genetic risk.
A Mayo Clinic study using robotic telemedicine for assessing comatose patients in intensive care units shows promising results. The study found that patients with depressed levels of consciousness can be assessed reliably through telemedicine, alleviating a shortage of ICU providers and facilities.
Researchers found that treating subclinical hypothyroidism in pregnancy can reduce pregnancy loss, especially for those with higher TSH levels. However, treated women were more likely to experience preterm delivery and gestational diabetes.
Researchers at Mayo Clinic identified Ect2 as a genetic promoter of lung cancer, driving tumor formation through increased ribosome production. The study found that Ect2 supports tumor cell growth by stimulating ribosome biogenesis.
Researchers at Mayo Clinic found that two common cancer-fighting drugs sparked significant weight loss in morbidly obese mice despite a high-fat diet. The study suggests that these drugs can induce the liver to burn off excess fat, reducing obesity. Further research is needed to explore this potential approach for treating morbid obesity.
Researchers at Mayo Clinic have identified a key drug target, CDK4/6, which regulates the spread of triple-negative breast cancer. The study found that inhibiting this protein with CDK 4/6 inhibitors can prevent the metastasis of triple-negative breast cancer to distant organs.
A Mayo Clinic study finds that vaginal microbes are distinct in women with endometrial cancer compared to those without the disease. Researchers hope to use vaginal swabs as an early screening tool and investigate the role of the microbiome in preventing endometrial cancer.
A Mayo Clinic study found significant discrepancies in reporting postoperative infection complications between hospital-based administrative data and clinical registry data. The analysis of four common complications revealed that the two approaches yielded vastly different assessments, with rates varying up to fivefold.
Research suggests that nonsteroidal anti-inflammatory drugs (NSAIDs) can prevent the recurrence of advanced neoplasia after polyp removal, with ibuprofen showing superior benefits over aspirin or supplements. However, the choice of NSAID should be individualized based on patient risk factors and health considerations.
Researchers at Mayo Clinic have identified a key protein, Rab10, that helps hungry liver cells locate and break down fat for energy. This discovery could lead to new treatments for fatty liver disease.
Researchers identified four new markers of primary sclerosing cholangitis risk on the human genome, bringing the total number of known predisposing locations to 20. The study also shed light on the genetic relationship between primary sclerosing cholangitis and inflammatory bowel disease.
A Mayo Clinic study found that high school football players did not experience an increase in degenerative brain diseases, contrary to previous findings. Researchers compared the medical records of over 300 football players with those of non-football athletes, and found a higher incidence of head trauma among football players.
A recent study published in Genes & Development reveals an enzyme called UCHL3 that plays a crucial role in regulating the BRCA2 pathway. This research suggests that UCHL3 could be used as a potential therapeutic target to overcome chemotherapy resistance in breast and ovarian cancer cells.
Researchers at Mayo Clinic found that inherited pathogenic variants in genes BARD1 and RAD51D increase a woman's likelihood of developing breast cancer. The study also confirmed the involvement of other genes such as ATM, CHEK2 and PALB2 in breast cancer risk.
Using a one-minute shared decision-making aid can reduce unnecessary hospitalization and advanced cardiac testing for patients with low-risk chest pain. The study found that the aid resulted in greater patient knowledge, increased patient involvement in decision-making, and reduced admissions for observation.
Patients with a history of cancer who experience severe heart attacks have a three times higher risk of noncardiac death but not higher cardiac death rates. They also face increased risks of cardiogenic shock and need more intensive treatment.
A Mayo Clinic study comparing thousands of overlapping and non-overlapping surgeries found no difference in postoperative complications or deaths within a month. Overlapping surgeries provide greater access to qualified surgeons and more efficient use of operating rooms.
Researchers found that myocarditis is affecting both children and adults worldwide, with men being twice as likely as women to develop severe reactions. Early diagnosis is key to preventing long-term heart damage, and new investigational therapies are soon to be tested.
Researchers have pinpointed a cause and potential treatment for inflammatory myofibroblastic tumors, a rare form of sarcoma that does not respond to radiation or chemotherapy. The drug ceritinib shows promise as a new treatment option.
A study published in Mayo Clinic Proceedings found that newborn telemedicine consultations can positively impact patient care by providing enhanced access to neonatologists. This resulted in one-third of babies being able to stay with their families in the local hospital, increasing the value of care and potential cost savings.