A phase 3 trial found tolvaptan slows the rate of decline in kidney function in patients with autosomal dominant polycystic kidney disease. The condition affects millions in the US and has no cure. The drug targets a mechanism contributing to cyst growth, potentially delaying transplant or dialysis need.
A study published in Annals of Oncology has identified genetic markers that may predict resistance to a specific therapy used for treating advanced prostate cancer. The researchers found that understanding the genetic markers of tumors can help healthcare providers match a therapy that is likely to succeed on the first try.
A study found that proton beam therapy in combination with chemotherapy prior to surgery reduces postoperative heart and lung problems and mortality rates in elderly patients. Researchers followed 571 patients treated with traditional radiation therapy and chemotherapy followed by surgery at Mayo Clinic Cancer Center.
A recent study led by Mayo Clinic researchers found that tumor-infiltrating lymphocytes present in high-grade ovarian cancer tumors can predict patient survival. The study analyzed over 5,500 patients from nine countries and discovered that higher levels of these immune cells were associated with better outcomes.
Midlife women experience significant weight gain, mainly in the midsection, increasing cardiovascular disease risk. Researchers recommend primary care providers screen for overweight and establish behavioral interventions, including psychological support and physical activity.
A recent study by Mayo Clinic found that nearly 40% of physicians hesitate to seek mental health care due to concerns about their medical license. The researchers discovered that states with licensing requirements asking about past mental health conditions have more reluctant physicians.
Researchers found that patients with pre-existing psychiatric diagnoses had higher acute and follow-up costs, particularly in emergency department and hospital outpatient costs. Addressing psychiatric comorbidities proactively may mitigate cost differences for these patients.
Researchers found ED opioid prescriptions were 44% less likely to exceed a three-day supply and 46% less likely to progress to long-term use. Patients in non-ED settings received higher doses, with one in five exceeding CDC guidelines, leading to a higher risk of long-term use.
Mayo Clinic researchers found that reducing radiation therapy intensity by 50% resulted in fewer side effects without compromising survival or cure rates. The study followed 80 patients with HPV-related throat cancer and reported a 95% tumor control rate at two years, with only one regional recurrence.
A Mayo Clinic study found that Liraglutide slowed stomach emptying and led to significant weight loss in treated patients. The degree of stomach emptying delay was associated with the degree of weight loss, suggesting a potential biomarker for individualizing obesity treatment.
A new Mayo Clinic study found that sleeping with dogs can help people sleep better, but only if they're in the bedroom, not in bed. The study of 40 healthy adults and their dogs over five months showed that having pets nearby can provide comfort and security.
Senolytic agents target senescent cells, which accumulate with age and contribute to chronic conditions like diabetes, cardiovascular disease, and cancer. Mayo Clinic researchers have identified new screening platforms to find additional senolytic drugs, potentially leading to transformative treatments for aging-related diseases.
Researchers have identified two key genes that contribute to the aggressive spread of neuroblastomas. The study found that high levels of LMO1 expression promote metastasis in MYCN-induced neuroblastoma by dysregulating extracellular matrix genes, paving the way for new therapies.
Researchers found that Z-endoxifen provided substantial drug exposure, acceptable toxicity, and promising anti-tumor activity in patients with metastatic breast cancer who had progressed on standard anti-estrogen treatments. The treatment resulted in tumor shrinkage, with some cases lasting over two years without disease progression.
A new study from Mayo Clinic researchers found that women with a history of pre-eclampsia are more likely to experience atherosclerosis, hardening and narrowing of the arteries, decades after their pregnancy. This condition can pose a risk to the mother's cardiovascular health even after menopause.
Researchers discovered a causal link between senescent cells and age-related bone loss in mice. Targeting these cells increased bone mass and strength. The study's findings suggest that senolytic drugs may have widespread application in treating multiple chronic diseases, including osteoporosis.
Researchers at Mayo Clinic have identified a link between SPOP gene mutations and treatment resistance in prostate cancer. The discovery suggests ways to improve therapy by using these mutations as biomarkers. This breakthrough could lead to more effective treatments for this common and deadly form of cancer.
Researchers at Mayo Clinic and University of Iowa found a human gut microbe, Prevotella histicola, that effectively suppresses immune disease in a mouse model of MS. The study suggests that this microbe may play a role in treating MS, an autoimmune disease caused by the immune system's attack on the myelin sheath.
A new study by Mayo Clinic researchers examines the direct medical costs of falls in adults with a transfemoral amputation, finding that high-functioning patients are often denied more expensive prosthetic knee technologies. The study aims to provide evidence for policymakers to evaluate the value of these advanced technologies.
Patients with diabetes who experience severe dysglycemia are at highest risk for recurrent episodes and readmission. Discharge planning and post-hospital follow-up can help prevent readmissions.
Researchers found that patients with Parkinson's were four times more likely to have a history of melanoma than those without the disease. In contrast, people with melanoma had a fourfold higher risk of developing Parkinson's. The study suggests that common environmental or genetic factors may underlie both conditions.
A simple blood test measuring carcinoembryonic antigen (CEA) levels could change treatment options for 17% of stage 2 colon cancer patients. The test may improve survival rates and quality of life for thousands with the disease.
Dementia with Lewy bodies affects 1.4 million Americans, often misdiagnosed as Alzheimer's or Parkinson's disease. The new guidelines provide detailed guidance for diagnosing and treating the condition, which includes symptoms like visual hallucinations and sleep difficulties.
A new study by Mayo Clinic researchers found that women who experienced physical, emotional, or sexual abuse are 62% more likely to have their ovaries removed before age 46. The study suggests that gynecological symptoms such as abdominal pain or excessive bleeding may lead to unnecessary and harmful surgeries.
A new study using linked dental records shows that dentists are in good compliance with AHA guidelines on prophylactic antibiotic use. The study found no significant increase in cases of infective endocarditis following the introduction of updated guidelines.
Researchers identified a key protein, SMAD3, that facilitates pro-fibrotic TGF-beta signaling. By blocking this protein, they created a peptide-carrying SNX9 that prevents SMAD3 from entering the nucleus and impacting genes regulated by TGF-beta. This approach may lead to effective treatments for fibrosis-related diseases.
Researchers discovered a link between a donor and infection in heart, lung transplant recipients caused by Mycoplasma hominis. The bacteria resists most antibiotics and can cause serious complications like pleurisy, surgical site infections, and mediastinitis.
A Mayo Clinic study found that patients with Parkinson's disease, Lewy body dementia, and related conditions died 2-6 years earlier than the general population. The study used data from 1991 to 2010 and compared 461 patients with these diseases to 452 patients in the general population.
Researchers found that squamous cell carcinoma diagnoses increased by 263% and basal cell carcinomas by 145% between 2000-2010. Women in specific age groups experienced the greatest increase in basal cell carcinoma diagnoses, while men's diagnosis trends varied across time periods.
Researchers from Mayo Clinic have made significant progress in understanding the DNA damage response proteins and their role in repairing double-strand breaks. The study reveals how these proteins work together to fix damaged DNA, potentially leading to new therapeutic strategies for cancer treatment.
Mayo Clinic's new imaging technologies use computerized tomography scans to measure the firmness of brain tumors and how attached they are to normal brain tissue. This information helps surgeons plan the safest method for extraction, potentially reducing complications and improving patient outcomes.
A Mayo Clinic research team has developed a new type of cancer-fighting nanoparticle that can shrink breast cancer tumors by up to 70-80% and prevent recurrence. The nanoparticles work by engaging the entire immune system to kill cancer cells, prompting the body to create its own memory system to minimize tumor recurrence.
A recent study published in The Journal of Urology found that surgery to remove secondary tumor growths, called metastases, significantly improves survival rates for patients with late-stage kidney cancer. Patients who underwent surgery had a life expectancy of three to 12 years, compared to eight months and two years without surgery.
A study by Mayo Clinic researchers found that nearly 90% of patients who sought second opinions received either a new diagnosis or a refined version of their original diagnosis. This significant finding highlights the importance of second opinions in ensuring accurate diagnoses and improving patient outcomes. The study's lead author no...
Researchers at Mayo Clinic successfully stimulated a man's paralyzed legs using electrical current, enabling him to move and stand. The study suggests that people with discomplete spinal cord injuries may be candidates for epidural stimulation therapy.
A study found that heart failure patients who transition to skilled nursing facilities are 50 percent more likely to end up back in the hospital. The researchers identified a key factor in estimating likelihood of rehospitalization as the patient's ability to carry on daily activities upon entering the facility.
Researchers at Mayo Clinic have identified an interaction between focal adhesion kinase and myosin that drives the production of secreted cancer-promoting proteins. This discovery may lead to the development of new drugs to inhibit cancer progression by blocking this interaction.
Research at Mayo Clinic found that patients using gastric acid suppression medications are at a higher risk for developing recurrent C-diff infections. The study suggests these medications may increase the risk, and caution is advised when prescribing them to patients with a prior C-diff episode.
A Mayo Clinic study found that high-intensity aerobic exercise can reverse cellular aspects of aging, improving lean body mass and insulin sensitivity. The study also showed that high-intensity interval training enhanced muscle protein content, causing muscle enlargement and improving energetic functions.
Researchers from Mayo Clinic report that tumor genomic alterations did not differ significantly between chemotherapy-sensitive and -resistant tumors. However, the study identified an uncommon type of aggressive breast cancer with a unique mutation in p53, which was less likely to respond to chemotherapy.
Researchers at Mayo Clinic have identified a specific protein implicated in drug resistance, as well as a possible therapeutic tool. By engineering a peptide that blocks the activity of another protein ERK, the team found that it can prevent chemotherapy resistance and tumor growth.
Researchers discovered an experimental drug, LCL161, that stimulates the immune system and causes tumor shrinkage in patients with multiple myeloma. The study highlights the importance of studying drug interactions with the tumor microenvironment.
Researchers found that markers of cellular senescence were higher in individuals with idiopathic pulmonary fibrosis, and senescent cell burden increased with the progression of the disease. The findings suggest targeting senescent cells could be a viable treatment option for individuals suffering from idiopathic pulmonary fibrosis.
Scientists discover a culture method that unlocks the natural fighter function of immune T cells when exposed to alarm signals, allowing for the growth of natural armies trained to recognize and target cancer proteins. The method has been tested on three cancer-associated proteins and shown success in stimulating T cell responses.
Researchers from Mayo Clinic have quantified the numbers of various immune cells associated with the risk of developing breast cancer. The study found that women who later developed breast cancer showed lower amounts of antibody-producing immune cells in their breast tissue.
A study published in JAMA Oncology found that patients with autoimmune diseases taking azathioprine had a higher risk of developing therapy-related myeloid neoplasms. Researchers also identified other medications used by these patients, but only azathioprine showed a statistically significant association.
Researchers at Mayo Clinic are testing a vaccine that aims to establish lifelong immunity against precancerous breast lesions. The vaccine targets human epidermal growth factor 2 (HER-2) and has shown promise in a phase I clinical study, eliciting an immune response in all tested individuals.
Researchers studied millennial medical students' learning preferences and found a need for personalized assessment and mentorship. The study attributes these traits to the global environment in which millennials were raised, influencing a generation that values technology, teamwork, and personalization.
Researchers found that cognitively normal people 70 and older who engaged in computer use, craft activities, social activities, or playing games had a decreased risk of developing mild cognitive impairment. The study's findings suggest that mentally stimulating activities can be beneficial even for those at genetic risk.
A Mayo Clinic study using robotic telemedicine for assessing comatose patients in intensive care units shows promising results. The study found that patients with depressed levels of consciousness can be assessed reliably through telemedicine, alleviating a shortage of ICU providers and facilities.