Researchers at Mayo Clinic report significant improvements in fertility preservation techniques, including egg freezing and embryo storage. The advancements provide new options for young cancer patients seeking to conceive after treatment.
Researchers at Mayo Clinic have identified a gene variant that appears to protect against frontotemporal lobar degeneration (FTLD) in high-risk individuals with progranulin mutations. The study found that carrying two copies of the protective TMEM106B allele delays or prevents FTLD onset, suggesting it may increase progranulin levels.
HER2 test results can vary in up to 10% of patients when multiple tumor blocks are analyzed, according to Mayo Clinic researchers. This variability has significant implications for patient treatment and highlights the need for additional testing.
Researchers developed a new imaging technique that uses single photon emission computed tomography (SPECT) with computerized tomography (CT) scans to pinpoint critical lymph nodes under the arm. This allows physicians to block these nodes from X-ray beams, reducing radiation and subsequent lymphedema in breast cancer patients.
Researchers found that brain regions surrounding seizure-generating areas have reduced synchrony, a key finding in understanding epilepsy. The study suggests that this isolation could be used as a clinical biomarker to identify individuals with abnormal brain function.
The Mayo Clinic Health Policy Center hosted a symposium on high-value health care, emphasizing the need for payment reform and collaborative approaches. Panelists stressed the importance of integrated care, ACOs, and electronic health records in achieving better health outcomes.
The Mayo Clinic study found that more than half of children with cryptogenic epilepsy had a significantly better long-term outcome than those with symptomatic epilepsy. Approximately 68% of the cryptogenic group achieved seizure freedom compared to 46% in the symptomatic group.
Researchers at Mayo Clinic found that JAK inhibitors CYT387 and TG101348 effectively reduce spleen size and alleviate constitutional symptoms in myelofibrosis patients. These targeted treatments have shown significant clinical benefits, including improved anemia rates and reduced white blood cell counts.
New analysis suggests that stenting can perform as well as surgery for treating narrowed carotid vessels, with age being a significant factor. For younger patients (under 70) with symptoms related to the condition, stenting proved effective in reducing stroke risk.
Researchers found that certain mutations in the virus render it ineffective against drugs, but also impair its ability to kill immune cells. This discovery may lead to a new diagnostic tool and more effective treatments for HIV patients.
Researchers found increased vascular reactivity and decreased endothelial function in women with broken heart syndrome compared to postmenopausal women and those who had regular heart attacks. This unique risk factor highlights the importance of mental stress in ABS syndrome, which may lead to the development of specific therapies.
A Mayo Clinic study found that aggressive surgery to completely remove low-grade brain tumors (gliomas) in children offers the highest chance of overall survival. If complete removal is not possible, adding radiation therapy yields similar results.
Mayo Clinic researchers discovered a connection between two proteins, progranulin and sortilin, which may lead to new treatment options for frontotemporal lobar degeneration. The study found strong associations between genetic variants in the same region of chromosome 1 and plasma progranulin levels.
Researchers tested genetic variations in 1,262 people with no history of heart disease and found that genetic scores can modify the estimated risk of heart attack. The study suggests that genetic screening may be most valuable for individuals thought to be at intermediate risk using current models.
Researchers at Mayo Clinic have shown that iron buildup is prevalent in unstable coronary artery plaque, making it a potential marker for risk of myocardial infarction and sudden death. Non-invasive imaging techniques, such as micro-CT scans, may soon be able to detect these plaques, allowing for earlier intervention.
A Mayo Clinic study found that morbidly obese heart failure patients who underwent bariatric surgery experienced significant improvements in disease symptoms and quality of life. The surgery led to better breathing during exercise and reduced swelling in the legs, even if most patients remained obese after weight loss.
Researchers found that CLL patients with insufficient vitamin D levels progressed faster, were twice as likely to die, and had shorter survival times. Vitamin D supplements may offer a way to slow leukemia progression.
Researchers found that khat chewing increases the risk of stroke and death in patients with acute coronary syndrome, while excess energy beverage consumption may lead to adverse effects. Withdrawing pacemakers and ICDs at end-of-life raises complex questions about patient autonomy and medical professional perspectives.
Researchers at Mayo Clinic have found that mortality rates from liver diseases are underestimated, with the condition ranking as high as fourth for certain age groups. The study analyzed data from 1979-2006 and found a significant correlation between national statistics and local mortality data.
Researchers at Mayo Clinic discovered that epithelial cadherin (E-cadherin), a protein believed to be a beneficial tumor suppressor, can act as an oncogene in some lethal brain tumors. This finding suggests E-cadherin expression may promote tumor growth and migration, challenging current understanding of its role in cancer progression.
Researchers at Mayo Clinic have successfully treated eosinophilic esophagitis using fluticasone nasal spray, clearing the condition in 68% of participants. However, symptoms persisted despite treatment, suggesting confounding factors such as questionnaire limitations.
Researchers found that increased abdominal fat increases the risk of metabolic disease, while fat gain in the thighs lowers the risk. The study challenges the concept that the number of fat cells remains stable in adults and suggests a potential protective effect of lower-body fat cells.
Mayo Clinic researchers have identified five genes that relate directly to radiation response, which could lead to the development of novel therapies tailored to individual cancer patients. The findings may enhance treatment outcomes for roughly half of all cancer patients who undergo radiation therapy.
The Mayo Clinic review article distinguishes between withholding or withdrawing life-sustaining treatments and physician-assisted suicide or euthanasia. Palliative sedation is recognized as a legitimate therapy for refractory suffering, with informed patient consent and medical involvement.
A recent study by Mayo Clinic found that radical prostatectomy significantly improves survival rates for men with localized prostate cancer. The procedure has led to excellent overall survival rates, with only 3% of patients dying from prostate cancer.
The Mayo Clinic Center for Social Media has launched a global Social Media Health Network, bringing together institutions from around the world to harness the power of social media in healthcare. The network aims to share best practices, develop training resources and facilitate growth of social media programs.
A team of scientists from Mayo Clinic, University of Illinois at Urbana-Champaign, and J. Craig Venter Institute are investigating the relationship between vaginal microbiota and preterm birth. They aim to identify microbial risk predictors for preterm birth using genomic information from the Human Microbiome Project.
A Mayo Clinic collaboration identified four genetic variants on chromosome 14 associated with aromatase inhibitor-induced arthritis. These findings provide a new clue for identifying women at risk and developing treatments, allowing more women to take lifesaving breast cancer therapy.
Researchers found that surgery provides high survival rates of 92% for patients with aggressive prostate cancer, outperforming radiation therapy alone in terms of cancer-specific and overall survival. The study suggests that limiting hormone therapy may avoid adverse health consequences for these patients.
A Mayo Clinic study found that nerve inflammation may cause postsurgical neuropathy in some patients, leading to pain, numbness, and weakness. Immunotherapy can quickly improve symptoms in these cases.
A consortium of cancer researchers has identified four chromosome locations with genetic changes that may alter a woman's risk of developing ovarian cancer. These findings are based on a large genome-wide association study and could lead to individualized risk assessments for ovarian cancer.
Researchers identified five genetic variants associated with increased breast cancer risk in BRCA1 carriers, including those related to estrogen-receptor-negative and triple-negative disease. These findings may help identify individuals at lower or higher risk of cancer, enabling tailored cancer prevention strategies.
Researchers at Mayo Clinic found that pazopanib significantly decreased progression rate in patients with metastatic, rapidly progressive differentiated thyroid cancers. The median progression-free survival time was 11.7 months, with an overall survival rate of 81 percent at one year.
A Mayo Clinic study of 4,400 medical students reveals that burnout is widespread and associated with dishonest behavior in patient care. Burned-out students were less likely to hold altruistic attitudes towards their role in society.
A Mayo Clinic study found that mild cognitive impairment was 1.5 times higher in men than women, affecting 16% of individuals aged 70-89 without dementia. The study highlights the need for early diagnosis and therapeutic intervention to address the growing prevalence of dementia.
The Mayo Clinic team created four new ATC cell lines with distinct molecular mutations, which will aid in testing new treatments and potentially lead to improved survival rates. The researchers also found that these cell lines reactivate a tumor suppressor gene called RhoB, leading to growth suppression.
Researchers at Mayo Clinic found that healthy young people who gained as little as 9 pounds of fat in their abdomens developed endothelial cell dysfunction, impairing blood flow regulation. In contrast, those who gained weight evenly throughout their bodies showed less affected blood flow regulation.
Researchers demonstrate that rationally guided human adult stem cells can effectively heal, repair, and regenerate damaged heart tissue. The study shows improved heart function recovery, reduced scars, and increased survival rate in mouse models with heart failure.
Researchers at Mayo Clinic have developed a new image-processing algorithm that reduces perfusion CT radiation doses by up to 20 times, improving image quality and patient safety. The algorithm has been successfully tested in animal models and is being explored for clinical implementation.
Patients with severe heart failure who request withdrawal of ventricular assist device (VAD) support have the right to do so, according to Mayo Clinic investigators. The VAD is a long-term treatment option for patients with severe heart failure, but some experience complications that lead them to request its removal.
Researchers find vascular disease in the brain causes dementia in diabetics, while Alzheimer's-related plaque is more common in nondiabetics. A new blood test may be more accurate for predicting Alzheimer's disease in nondiabetics.
A history of sexual abuse is associated with an increased risk of multiple psychiatric disorders, including depression, anxiety disorders, and post-traumatic stress disorder. The study found that survivors of rape had strengthened associations with these disorders.
A Mayo Clinic study found that individuals with mild cognitive impairment (MCI) who experience depression or apathy are at a higher risk of developing dementia. Researchers identified biomarkers for MCI progression, highlighting the importance of evaluating patients for neuropsychiatric symptoms.
Researchers found gabapentin to be effective in reducing ocular symptoms and improving quality of life for four patients with these conditions. Treatment was well-tolerated, with no adverse effects reported.
A Mayo Clinic study found that interrupting blood flow for more than 20 minutes during kidney cancer surgery increases the risk of chronic kidney disease. Limiting ischemia time can help avoid this complication.
A phase II clinical trial by Mayo Clinic found that green tea extract, specifically epigallocatechin gallate (EGCG), had a significant response rate among CLL patients. The study showed that 69% of patients experienced a biological response to EGCG, with notable reductions in blood lymphocyte count and lymph node size.
Patients with stage II colon cancer treated after 1995 had longer time to recurrence, but improved overall survival. Stage III colon cancer patients treated after 1995 also showed improved overall survival without change in time to recurrence compared to those treated before 1995.
Researchers tested methylphenidate, a psychostimulant medication, to treat cancer-related fatigue. While the study found no significant difference between treatment and placebo groups, there was a trend of improved satisfaction with treatment among patients receiving methylphenidate, particularly those with stage III/IV cancer.
A new Mayo Clinic study found that complete removal of all tumors that spread can significantly improve prognosis for kidney cancer patients. Patients who underwent complete tumor removal had an average cancer-specific survival rate of 5 years, compared to just 1 year for those without metastatic tumors removed.
A 17-year study of over 2,000 men found that surgery significantly reduces urinary incontinence and lower urinary tract symptoms compared to medication. Transurethral resection of the prostate (TURP) showed the greatest improvement in symptom scores and incontinence rates.