Researchers at Mayo Clinic have found that mortality rates from liver diseases are underestimated, with the condition ranking as high as fourth for certain age groups. The study analyzed data from 1979-2006 and found a significant correlation between national statistics and local mortality data.
Researchers at Mayo Clinic discovered that epithelial cadherin (E-cadherin), a protein believed to be a beneficial tumor suppressor, can act as an oncogene in some lethal brain tumors. This finding suggests E-cadherin expression may promote tumor growth and migration, challenging current understanding of its role in cancer progression.
Researchers at Mayo Clinic have successfully treated eosinophilic esophagitis using fluticasone nasal spray, clearing the condition in 68% of participants. However, symptoms persisted despite treatment, suggesting confounding factors such as questionnaire limitations.
Researchers found that increased abdominal fat increases the risk of metabolic disease, while fat gain in the thighs lowers the risk. The study challenges the concept that the number of fat cells remains stable in adults and suggests a potential protective effect of lower-body fat cells.
Mayo Clinic researchers have identified five genes that relate directly to radiation response, which could lead to the development of novel therapies tailored to individual cancer patients. The findings may enhance treatment outcomes for roughly half of all cancer patients who undergo radiation therapy.
The Mayo Clinic review article distinguishes between withholding or withdrawing life-sustaining treatments and physician-assisted suicide or euthanasia. Palliative sedation is recognized as a legitimate therapy for refractory suffering, with informed patient consent and medical involvement.
A recent study by Mayo Clinic found that radical prostatectomy significantly improves survival rates for men with localized prostate cancer. The procedure has led to excellent overall survival rates, with only 3% of patients dying from prostate cancer.
The Mayo Clinic Center for Social Media has launched a global Social Media Health Network, bringing together institutions from around the world to harness the power of social media in healthcare. The network aims to share best practices, develop training resources and facilitate growth of social media programs.
A team of scientists from Mayo Clinic, University of Illinois at Urbana-Champaign, and J. Craig Venter Institute are investigating the relationship between vaginal microbiota and preterm birth. They aim to identify microbial risk predictors for preterm birth using genomic information from the Human Microbiome Project.
A Mayo Clinic collaboration identified four genetic variants on chromosome 14 associated with aromatase inhibitor-induced arthritis. These findings provide a new clue for identifying women at risk and developing treatments, allowing more women to take lifesaving breast cancer therapy.
Researchers found that surgery provides high survival rates of 92% for patients with aggressive prostate cancer, outperforming radiation therapy alone in terms of cancer-specific and overall survival. The study suggests that limiting hormone therapy may avoid adverse health consequences for these patients.
A Mayo Clinic study found that nerve inflammation may cause postsurgical neuropathy in some patients, leading to pain, numbness, and weakness. Immunotherapy can quickly improve symptoms in these cases.
A consortium of cancer researchers has identified four chromosome locations with genetic changes that may alter a woman's risk of developing ovarian cancer. These findings are based on a large genome-wide association study and could lead to individualized risk assessments for ovarian cancer.
Researchers identified five genetic variants associated with increased breast cancer risk in BRCA1 carriers, including those related to estrogen-receptor-negative and triple-negative disease. These findings may help identify individuals at lower or higher risk of cancer, enabling tailored cancer prevention strategies.
Researchers at Mayo Clinic found that pazopanib significantly decreased progression rate in patients with metastatic, rapidly progressive differentiated thyroid cancers. The median progression-free survival time was 11.7 months, with an overall survival rate of 81 percent at one year.
A Mayo Clinic study of 4,400 medical students reveals that burnout is widespread and associated with dishonest behavior in patient care. Burned-out students were less likely to hold altruistic attitudes towards their role in society.
A Mayo Clinic study found that mild cognitive impairment was 1.5 times higher in men than women, affecting 16% of individuals aged 70-89 without dementia. The study highlights the need for early diagnosis and therapeutic intervention to address the growing prevalence of dementia.
The Mayo Clinic team created four new ATC cell lines with distinct molecular mutations, which will aid in testing new treatments and potentially lead to improved survival rates. The researchers also found that these cell lines reactivate a tumor suppressor gene called RhoB, leading to growth suppression.
Researchers at Mayo Clinic found that healthy young people who gained as little as 9 pounds of fat in their abdomens developed endothelial cell dysfunction, impairing blood flow regulation. In contrast, those who gained weight evenly throughout their bodies showed less affected blood flow regulation.
Researchers demonstrate that rationally guided human adult stem cells can effectively heal, repair, and regenerate damaged heart tissue. The study shows improved heart function recovery, reduced scars, and increased survival rate in mouse models with heart failure.
Researchers at Mayo Clinic have developed a new image-processing algorithm that reduces perfusion CT radiation doses by up to 20 times, improving image quality and patient safety. The algorithm has been successfully tested in animal models and is being explored for clinical implementation.
Patients with severe heart failure who request withdrawal of ventricular assist device (VAD) support have the right to do so, according to Mayo Clinic investigators. The VAD is a long-term treatment option for patients with severe heart failure, but some experience complications that lead them to request its removal.
Researchers find vascular disease in the brain causes dementia in diabetics, while Alzheimer's-related plaque is more common in nondiabetics. A new blood test may be more accurate for predicting Alzheimer's disease in nondiabetics.
A history of sexual abuse is associated with an increased risk of multiple psychiatric disorders, including depression, anxiety disorders, and post-traumatic stress disorder. The study found that survivors of rape had strengthened associations with these disorders.
A Mayo Clinic study found that individuals with mild cognitive impairment (MCI) who experience depression or apathy are at a higher risk of developing dementia. Researchers identified biomarkers for MCI progression, highlighting the importance of evaluating patients for neuropsychiatric symptoms.
Researchers found gabapentin to be effective in reducing ocular symptoms and improving quality of life for four patients with these conditions. Treatment was well-tolerated, with no adverse effects reported.
A Mayo Clinic study found that interrupting blood flow for more than 20 minutes during kidney cancer surgery increases the risk of chronic kidney disease. Limiting ischemia time can help avoid this complication.
A phase II clinical trial by Mayo Clinic found that green tea extract, specifically epigallocatechin gallate (EGCG), had a significant response rate among CLL patients. The study showed that 69% of patients experienced a biological response to EGCG, with notable reductions in blood lymphocyte count and lymph node size.
Patients with stage II colon cancer treated after 1995 had longer time to recurrence, but improved overall survival. Stage III colon cancer patients treated after 1995 also showed improved overall survival without change in time to recurrence compared to those treated before 1995.
Researchers tested methylphenidate, a psychostimulant medication, to treat cancer-related fatigue. While the study found no significant difference between treatment and placebo groups, there was a trend of improved satisfaction with treatment among patients receiving methylphenidate, particularly those with stage III/IV cancer.
A new Mayo Clinic study found that complete removal of all tumors that spread can significantly improve prognosis for kidney cancer patients. Patients who underwent complete tumor removal had an average cancer-specific survival rate of 5 years, compared to just 1 year for those without metastatic tumors removed.
A 17-year study of over 2,000 men found that surgery significantly reduces urinary incontinence and lower urinary tract symptoms compared to medication. Transurethral resection of the prostate (TURP) showed the greatest improvement in symptom scores and incontinence rates.
A study published in the American Society of Clinical Oncology annual meeting showed that lenalidomide significantly improved response rates and complete remission in patients with transformed lymphoma. Patients treated with lenalidomide had a remarkable response rate, with some experiencing complete remission for over a year.
The review article provides a comprehensive guide to pain management in cirrhotic patients, recommending reduced dosing of acetaminophen and avoiding NSAIDs due to risk of acute renal failure. The authors emphasize the need for diligent follow-up for toxicity and adverse effects.
A large national clinical trial has shown that carotid artery surgery and stenting are equally effective in preventing stroke, with personalized treatment options available for individual patients. The study found excellent safety and long-term results for both symptomatic and asymptomatic patients.
Researchers at Mayo Clinic have found a new aggressive treatment approach for anaplastic thyroid carcinoma to be highly effective, resulting in 70% one-year survival rate. The treatment combines surgery, intensity modulated radiation therapy, and chemotherapy, and is being tested in a nationwide clinical trial.
Researchers at Mayo Clinic have identified a key gene called GATA3 that is silenced in common kidney cancer, promoting its development. The discovery suggests that a combination of agents may turn the gene back on, providing a much-needed therapy for difficult-to-treat kidney cancer.
Researchers at Mayo Clinic have discovered gene signatures that explain the biology of clear cell renal cell carcinoma (ccRCC), a common and difficult-to-treat kidney cancer. They identified master genes lost in ccRCC that likely drive its development, as well as stem cell-like properties that contribute to its resistance to treatment.
Researchers discovered a specific mutation that promotes fibril development, leading to organ damage and death. The study suggests this finding could be a target for future drug development in treating the fatal condition.
A Mayo-led research team has developed potent molecules that can inhibit the breakdown of insulin in the body, keeping it working longer and potentially leading to new treatments for diabetes. The discovery may also have implications for other diseases involving insulin, such as Alzheimer's disease.
Researchers found over 2,000 genes reprogrammed in peripheral nervous system of rodent models, leading to potential 'transcription therapy' for chronic pain. The study's high-throughput sequencing revealed novel exons and gene candidates, offering a new approach for neuroscientific research.
The Mayo Clinic research team identified genetic variants in serotonin genes that impact IBS, suggesting a complex molecular mechanism involving multiple genes. The study found several previously unknown associations between IBS and serotonin-related SNPs, providing new insights into the condition.
A Mayo Clinic study reveals a 50% decrease in the number of patients listed for a second liver transplant within three years, indicating improved treatment outcomes for some patients with hepatitis B. Researchers found that new medications have improved ability to control hepatitis B recurrence.
Research at Mayo Clinic reveals stool DNA testing can identify two types of colorectal pre-cancers in IBD patients and serrated polyps. The tests show a high detection rate for these precancerous lesions, offering promise for improving colon cancer prevention.
Researchers at Mayo Clinic are testing new endoscopic optics to detect precancerous polyps and micrometastasis. The pCLE system shows the highest accuracy yet in detecting small polyps, with a specificity of 100%. This technology has the potential to perform virtual biopsies, reducing unnecessary procedures.
Mayo Clinic researchers discovered chronic mild kidney injury in the kidneys of healthy adults, increasing with age. The study, published in Annals of Internal Medicine, highlights the need for new tests to detect mild kidney disease more accurately.
Researchers found that colon polyp detection rates remained consistent throughout the day at Mayo Clinic, contradicting previous findings. Shorter daily shifts did not result in decreased polyp detection rates, unlike traditional half-day shifts.
A Mayo Clinic study found a 30% difference in risk for failed transplant between transplant centers. The study analyzed data from 12,233 patients and showed that quality of care, donor organ selection, and geographical location all contribute to outcome differences.
A recent study published by Mayo Clinic has found that older women with diabetes are at a more than doubled risk for certain types of colorectal cancer. The research team analyzed data from over 37,000 participants and identified associations between diabetes and specific molecular markers.
Researchers found that patients dismissed from hospital with noncardiac chest pain continue to experience cardiac events, suggesting a need for more aggressive cardiovascular risk factor management. The study also identified a substantial number of cardiac deaths in this population, potentially related to overlapping risk factors.