A recent study found that smoking produces major changes in the flow of endogenous opioids, matching changes in how smokers feel before and after smoking. This system is also stimulated by heroin and morphine, suggesting a promising road for further discovery.
Scientists have identified 313 up-regulated and 207 down-regulated E.coli genes in mouse urine, revealing new insights into bacterial growth and virulence factors. The study provides valuable information on growing conditions and could lead to more effective treatments for urinary tract infections.
A multi-university study found that levels of fibroblast growth factors (FGFs) and their receptors were significantly lower in people with severe clinical depression. The researchers also found that those who had been taking antidepressants before death had levels closer to normal.
Researchers compared two animal-derived surfactants and found that Infasurf improved lung function with fewer doses required. The study suggests a cost savings, as Infasurf was more effective over time.
Researchers found that estrogen significantly reduces MMP-9 enzyme activity in male rat aortas, leading to smaller aneurysms and less damage. The study suggests that host environment is the critical factor in aneurysm formation, with male rats more prone to AAA development.
Researchers at the University of Michigan are collaborating on a three-year project to address racial disparities in pregnancy outcomes. The study aims to develop more comprehensive and coordinated prenatal care strategies, as well as evaluate the role of leadership, providers, and patients in improving health equity.
Researchers at U-M used a technology called ubiquitin-mediated fluorescence complementation to study a cell-signaling mechanism. They discovered how ubiquitin modified protein Jun's function and location, and found that an E3 ligase binding enzyme called Itch played a key role in this process.
A study found that one in six chronically ill adults skip medication due to cost, with those paying more out-of-pocket or having no coverage being the most likely. The researchers estimate that this skimping leads to over a million Americans using less medication and 1.6 million missing doses.
Researchers at Michigan Medicine found that using child-specific data improved quality of care for asthmatic children's hospital stays. The team reduced length and cost growth of hospital stays and readmission rates by 50% through targeted quality improvement efforts.
Researchers at the University of Michigan have found that a potential small molecule inhibitor, (-)-gossypol, can boost the effectiveness of radiation therapy and chemotherapy in human prostate tumors in mice. The study demonstrates increased induction of apoptosis, making cancer cells more sensitive to treatment.
A study finds that two-thirds of chronically ill patients cut back on prescription drugs due to cost concerns, but few inform their doctors. The researchers recommend healthcare providers take the initiative to ask patients about cost issues and educate them on necessary medications. Most patients who spoke up received help through fre...
The chicken pox vaccine has resulted in a 74% decrease in national hospital discharges for the disease, saving $100 million annually. Herd immunity also protects unvaccinated individuals, leading to lower hospital costs among teens and adults.
A study using CellSearch technology found that women with high tumor cell levels in their blood had poor treatment outcomes. Women whose circulating tumor cell levels dropped after starting therapy fared much better.
A new study found that only half of parents' anti-asthma efforts are likely to work, while the other half may be unproven or potentially harmful. The study highlights a need for better education and support for parents, as well as healthcare providers, to effectively manage childhood asthma.
Researchers found VA patients received standard processes of care more often, including recommended tests and services, and had better diabetes control. The study suggests the VA's national system provides excellent quality care due to its integrated care and tracking mechanisms.
A recent study by Michigan Medicine reveals that Mexican-Americans are twice as likely to experience a stroke or near-stroke compared to non-Hispanic whites. The disparity holds true across various age groups, including younger populations, with unique genetic predispositions and potential factors contributing to the increased risk.
Researchers found DNA and proteins from BK virus in prostate tissue with abnormal cell changes, a precursor stage of prostate cancer. The virus may induce uncontrolled cell growth, leading to cancer.
A Michigan Medicine study found that female and black legislators are more likely to sponsor child health bills, with proposals making up 37% of all child health bills. Child health bills were a small percentage of overall health bills, but states with higher legislative passage rates had more success in enacting these bills.
Researchers used gemcitabine and low doses of radiation to treat muscle-invasive bladder cancer in 24 patients. Most were able to keep their bladders intact and were cancer-free after four years, with 65% still cancer-free.
A new study by Michigan Medicine suggests that insured individuals are willing to make sacrifices to help cover the costs of the uninsured. When given the opportunity to discuss their concerns and priorities in a group setting, many participants chose to cover both adults and children, with 76% opting for some form of coverage. The res...
Women with vulvodynia process pain differently, exhibiting lower pain tolerance at multiple sites throughout the body. The study suggests a neurological basis for the condition, recommending treatment aimed at central pain processing.
The number of pediatricians in the US has more than doubled since 1978, with a higher concentration in wealthier states. This disparity affects access to care among children in poorer states.
A study found that mice with a hyperactive Wnt10b gene consumed more food but had half the body fat of normal mice. The protein inhibited fat cell development and had contrasting effects on white and brown fat, leading to robust health despite reduced adipose tissue.
A long-term study of 8,000 seniors found that those who cut back on prescription medicines due to cost had significantly worse overall and heart-related health outcomes. The study also showed that patients with depression over age 70 were more likely to experience a worsening of their condition if they cut back on their medications.
A U-M study found that hospitals meeting Leapfrog quality standards for high-risk surgeries can save thousands of lives. Implementing these standards would reduce mortality rates for procedures like open heart surgery and angioplasty.
Researchers discovered Stat3 regulates the inflammatory response in lung tissue, preventing excessive activation and tissue damage. The study suggests enhancing Stat3 activity could lead to new therapeutic drugs for immune-related diseases like COPD.
A study published in Archives of Otolaryngology – Head and Neck Surgery found that 52% of employed head and neck cancer patients reported work-related disability after treatment. Chemotherapy, neck surgery, and pain were linked to increased disability risk.
A new study from the University of Michigan Health System found that pulsed dye laser therapy was not effective in treating acne. Researchers compared the changes in acne severity on both sides of the face, with no significant difference between treated and untreated sides.
Researchers developed a simple, pocket-sized risk-prediction tool to calculate the chances of dying within six months for patients after a heart attack or unstable chest pain episode. The tool combines nine variables and has been proven accurate in predicting patient outcomes.
Nearly half of patients prescribed statins fail to fill their prescriptions often enough or stop taking the drug altogether due to high out-of-pocket costs. Co-pay levels above $20 increase the likelihood of non-adherence, with four times more patients stopping medication when co-pays exceed $20 compared to those under $10.
A recent study by the University of Michigan Comprehensive Cancer Center found that breast cancer patients who made their own treatment decisions were more likely to choose mastectomies over breast-conserving surgeries. The study also revealed that fewer than a third of women with mastectomies received reconstructive surgery, and those...
Perfusion CT scans can reveal how much blood is present in the brain and how quickly it's moving, helping doctors decide on treatments such as surgery or clotbuster drugs. The technique has shown promise in assessing patients with stroke or carotid artery issues, potentially improving treatment outcomes.
Researchers created a virtual model of the human immune system to study M. tuberculosis, a bacterium that causes TB. The computer model revealed key findings on granuloma formation and the immune response, shedding light on why some people fight off infection while others get sick.
Researchers found that antibiotics can alter the gut microbiome, leading to increased lung sensitivity to allergens. This disruption can trigger a hyperactive immune response, producing allergy symptoms or even asthma. The study suggests that maintaining a healthy balance of gut microbes is crucial in regulating the immune system.
A study by Michigan Medicine found that over 5.7 million low-income children experience a transition in their health insurance each year, leading to postponed doctor visits and prescriptions. The study highlights the need for consistent coverage and minimized barriers to ensure these children receive needed care.
Researchers from Michigan Medicine have discovered a protein biomarker and cell-signaling pathway that may aid in the detection and treatment of pancreatic cancer. The study found that a specific protein called CEACAM 1 is elevated in the blood of pancreatic cancer patients, allowing for better differentiation from normal tissue.
A survey of fourth and fifth-grade pupils and their parents found significant discrepancies between reported and actual use of bike helmets and seatbelts. The study emphasizes the need for injury prevention programs targeting both parents and children to address these gaps and reduce child injuries.
A nationwide study found that patients undergoing kidney cancer surgery at high-volume hospitals have a 32% lower risk of dying compared to those at medium- and low-volume hospitals. High-volume hospitals also performed more partial nephrectomies, a procedure with equally effective cancer control.
A recent study found that even health-conscious women are more likely to have had a mammogram or Pap smear than undergone a colonoscopy. Doctors suggest using breast cancer screening appointments as an opportunity to educate women about colorectal cancer risk and increase awareness.
A unique computer system developed at the University of Michigan Health System reduces risks while improving patient care quality and continuity. The Discharge Navigator system automates information transfer, streamlines handoffs, and enhances patient education and satisfaction.
A gene mutation may cause misrouting of proteins in retinal cells, leading to macular degeneration. Research aims to understand the biological function of the gene and its role in fatty acid metabolism.
Researchers found that quality of life for men treated for prostate cancer continues to evolve long-term, with some experiencing improvements and others worsening. Sexual function remains a significant concern for survivors, with reported lower quality of life compared to non-cancerous individuals.
A comprehensive review of hundreds of studies on living wills finds they fail to meet five key criteria for success. The researchers argue that living wills offer a false promise of control over end-of-life treatment and recommend using durable powers of attorneys instead.
A UMHS study found that African-American men with a history of gonorrhea are more likely to develop prostate cancer. The research suggests an inflammatory effect from the bacterial infection may trigger pre-existing cancerous cells to multiply, increasing risk.
A University of Michigan team found that only half of pharmacies in non-white areas had a sufficient supply of opioid painkillers. Pharmacies in wealthier ZIP codes tended to have better supplies, while those in poorer areas were less likely to carry the drugs due to perceived threats of robbery and street value.
A recent multi-center trial has shown cryoablation to be effective in killing cancerous cells in small tumors, offering a promising alternative to traditional surgery for early-stage breast cancer. The study found that the procedure was equally effective for tumors between 1.0 and 1.5 centimeters in diameter, but not larger than 1.5 cm.
A nationwide sample of children with asthma found that 13% of parents still smoke, triggering year-round symptoms. Pediatricians should counsel parents on quitting to improve their children's health.
Researchers have developed a technique called 2D CSI MRS that uses chemical signatures to distinguish between tumor recurrence, normal tissue, and treatment-related changes in the brain. This method has shown significant differences in chemical ratios for recurrent tumors versus treatment-altered tissue.
A University of Michigan study found that most prostate cancer treatment guides overlook key details and favor active treatment over watchful waiting. The researchers recommend complete information on risks and benefits, clear writing styles, and visual elements to engage readers.
A recent study published in the American Journal of Psychiatry found that moderately depressed seniors require significantly more hours of care than those without symptoms. If caregivers were paid for their work, the annual cost would be approximately $9 billion, highlighting the impact of depression on seniors and their loved ones.