Researchers found that restoring two small molecules in human chronic lymphocytic leukemia cells can block tumor growth and affect 70 genes involved in critical functions. These findings suggest a possible new treatment strategy for CLL.
A recent study found that the American Founder Mutation, a common cause of Lynch syndrome, is older and more prevalent than thought. The new research includes 32 additional families and estimates that the mutation is present in 32,150 Americans.
Researchers found a link between low microRNA levels and high gene activity in AML, suggesting new therapeutic targets. The study identified two genes in the Hox family that are over-active in leukemia cells, providing new insights into AML treatment.
Researchers at Ohio State University have discovered two genes, E2F7 and E2F8, that play a vital role in preventing massive cell death in developing embryos. The study shows that these genes suppress the activity of another gene, E2f1, which is involved in triggering programmed cell death.
A study published in Clinical Cancer Research found that patients with poor disease-free survival had lower levels of specific microRNAs compared to those with better survival rates. The researchers hope that restoring these microRNAs could lead to improved treatment options for liver cancer patients.
A study found that two microRNAs, miR-191 and miR-199a, are associated with patient survival in high-risk acute-leukemia patients. These molecules may serve as targets for future therapies, offering hope for patients with limited treatment options.
Researchers found that the Wwox protein keeps ErbB-4 on the cell surface, associated with better survival in breast-cancer patients. The absence of Wwox is linked to shorter survival, particularly in triple-negative breast cancers.
Research reveals ultraconserved non-coding RNAs may play a role in cancer development and could help diagnose the disease, determine prognosis, and even guide treatment. The study found specific activity patterns for these molecules in different types of cancer, suggesting they might serve as genetic markers.
Scientists have developed a novel method for capturing and genome-wide screening of blood vessel cells in their actual disease state, advancing potential for genetic research. The technique allows for precise cell-specific information and has implications for diseases such as cancer and chronic wounds.
Mercury has been shown to activate phospholipase D enzyme in cells lining blood vessels, causing damage and contributing to vascular disorders. Chelation therapy and antioxidants have been found to suppress this activity, suggesting potential preventive measures against mercury-induced cardiovascular disease.
Researchers at Ohio State University found that male mice developed squamous cell carcinoma tumors earlier and had more aggressive tumors than female mice. The study suggests that gender-linked differences in antioxidants may be the key reason behind this disparity.
A Phase I clinical trial suggests gene therapy is a safe treatment option for patients with poor circulation and blocked blood vessels in their lower limbs. The study found that almost half of patients reported complete resolution of chronic pain and over a quarter experienced complete healing of chronic wounds after one year.
A study of 93 women at Ohio State University Medical Center found no correlation between the frequency of sexual intercourse and the onset of labor. Women who were sexually active during the final weeks of their pregnancies carried their babies an average of 39.9 weeks, compared to 39.3 weeks among those who abstained from sex.
A new study suggests that lixivaptan, a drug blocking vasopressin, is as effective as diuretics in reducing fluid retention in patients with congestive heart failure while also retaining proper sodium levels. The drug may offer an alternative treatment for heart failure patients and help clarify the role of vasopressin in water retention.
A new study reveals that regular use of COX-2 inhibitors, such as celecoxib and rofecoxib, significantly reduces the risk of breast cancer. Women who used these drugs for at least two years experienced a 71% lower risk of breast cancer compared to non-users.
A study by Ohio State University researchers discovered a set of 17 miRNAs turned off during normal megakaryocyte differentiation, creating a molecular signature for healthy platelets. In contrast, 10 miRNAs were found to be turned on in acute megakaryoblastic leukemia cells, suggesting a potential target for new therapies.
Researchers found that early placement of cardiac resynchronization therapy devices can prolong patient lives and reduce rehospitalizations. The study analyzed data from 5,791 patients and showed a significant reduction in deaths and rehospitalizations among those who received the devices.
Researchers have identified 23 microRNAs that are significantly altered in the cancerous tissue compared to normal samples, with three miRs dramatically overexpressed and forming a signature that predicts the presence of malignant tissue. The study provides evidence for the regulatory role of microRNA in thyroid cancer development.
A large registry study found that vasodilators, such as nitroglycerin and nesiritide, have a lower in-hospital mortality rate compared to positive inotropes like dobutamine and milrinone for treating acute decompensated heart failure. The study suggests reserving inotropes for patients who fail with vasodilators or are severely ill.
Functional MRI can help identify tumor heterogeneity and biological quirks that predict response to treatment. The imaging technology offers insight into a tumor's character beyond its superficial structure, enabling targeted therapies for specific sites.
A study by Dr. Barbara Andersen and Kristen Carpenter found that women with gynecological cancers face significant sexual adjustment issues due to complex recovery processes. The researchers identified key factors influencing sexual adjustment, including relationship satisfaction and emotional state.
Dr. Albert de la Chapelle, an Ohio State University scientist, has spent 40 years studying the complex relationship between genetic mutation and disease. He has made groundbreaking discoveries on inherited diseases, including leukemia and lymphoma, as well as rare disorders like diastrophic dysplasia and Usher syndrome.
Dr. Paskett will lead a study comparing the effects of low-fat and low-sugar diets on breast cancer risk in pre-menopausal women. The study aims to explore potential biomarkers for nutrition's role in preventing breast cancer.
Researchers at Ohio State University Wexner Medical Center have been awarded a $9.5 million grant to study the innate immune system and develop new cancer therapies. The project will explore how targeted therapies can be more potent in the presence of certain agents, and will involve multiple clinical trials and laboratory projects.
Researchers investigate potential link between low-level exposure to zeranol and breast cancer risk. The study explores the biological effects of zeranol, a synthetic non-steroidal agent used in cattle feed, on human breast tissue.
A new study found that risperidone, an antipsychotic agent, was effective in reducing irritability and behavioral problems in children with severe autism. The trial involved 101 children between ages 5 and 17, showing a significant positive response to treatment, with 69% experiencing marked improvement.
Researchers at Ohio State University have developed an intensification therapy regimen that combines chemotherapy and radiation to treat advanced head and neck cancers. The treatment has shown promising results, with a significant increase in survival rates and minimal patient non-compliance.
A new two-part therapy combining acyclovir with gradual reductions in immunosuppressive drugs has shown significant success in treating post-transplant lymphoma, with all patients achieving complete response and 82% maintaining it. The treatment stimulates the immune system to destroy EBV-infected cancer cells.
A study of 271 patients with pheochromocytomas found that 24% carried one or more genetic mutations, including those in the VHL and RET genes. These mutations were associated with earlier symptom onset, multiple tumors, and specific tumor profiles.
Researchers found that the most accurate method of detecting genetic mutations, direct nucleotide sequence analysis, is also the most expensive and labor-intensive. This method was used correctly to identify all previously identified mutations, while other methods, such as SSCP and CSGE, failed to detect over 20% of the mutations.
Researchers at Ohio State University are studying a new treatment that blocks the production of Bcl-2, a protein overexpressed in many cancers, and found nearly half of 20 patients responding favorably. The treatment showed safety and induced disease remission in some patients.
A study by Ohio State University researchers reveals minute genetic changes in normal colonic tissue that may signal later development of certain types of colon cancer. The changes, which occur through hypermethylation, appear to be age-related and associated with microsatellite instability.
Researchers have uncovered evidence suggesting that genetic changes leading to breast cancer occur first in epithelial cells of breast tissue. LOH analysis reveals frequent mutations in both epithelial and stromal cells, indicating a multi-step process.
Researchers found that 71% of women experienced ovarian function loss and rapid bone loss after six months of chemotherapy, leading to significant bone loss by the end of one year. The study suggests that earlier intervention with calcium, vitamin D, weight-bearing exercise, and counseling may help prevent bone loss in these patients.
A study published in The New England Journal of Medicine reveals that weight gain and chemotherapy-induced ovarian failure are common problems among younger women with early-stage breast cancer. Researchers emphasize the importance of monitoring bone density and taking calcium supplements to mitigate potential long-term side effects.