Researchers at Salk Institute discover a unique molecular signature in induced pluripotent stem cells, consisting of nine genes that govern epigenetic changes. This finding could help overcome hurdles to using induced stem cells in regenerative medicine and provide a new understanding of their safety profile.
Researchers have identified a key genetic mechanism in plant hormone signaling that helps plants balance between drought resistance and growth. The discovery may lead to new methods to help plants thrive in tough conditions and reduce crop losses from stress.
Scientists discovered that exposure to pathogens causes significant changes in a plant's epigenetic code, which helps the plant develop resistance. These epigenetic changes are linked to genes responsible for coordinating stress responses, suggesting the epigenome plays a role in disease resistance.
Researchers at the Salk Institute found that a molecular link between circadian rhythm disturbances and an increased inflammatory response can lead to chronic diseases. The absence of cryptochrome leads to the activation of a signaling system that elevates levels of inflammatory molecules, causing low-grade, chronic inflammation.
Scientists at the Salk Institute have developed a protocol to convert cord blood cells into neuron-like cells, which may represent a new therapeutic option for neurological conditions. The method uses a single protein, Sox2, and demonstrates the conversion of cord blood cells into functional neurons.
A study published in PLoS One found that individuals with Williams syndrome exhibit abnormal hormonal responses to emotional triggers, particularly increased levels of oxytocin and arginine vasopressin. This may help understand human social behavior and inform treatment for related disorders.
Researchers at the Salk Institute found that embryonic stem cells enter a unique, privileged state during early embryo development where specific genes are activated, allowing them to differentiate into any cell type. This discovery may provide insight into how to improve the clinical value of ES cells for therapy.
Researchers at Salk Institute create cell-free expression system to synthesize and analyze integral membrane proteins, solving their three-dimensional structures in just 18 months. This breakthrough enables precise biochemical mechanisms understanding and targets the proteins with new drugs.
Stem cells, essential building blocks of life, gradually lose their ability to maintain tissues and organs as they age. Researchers at the Salk Institute found that the stem cell niche's biological events contribute to this decline, but also discovered a mechanism to reverse it by increasing expression of Imp.
Scientists at Salk Institute found that mice who ate for 8 hours a day were healthier than those who ate freely, regardless of diet quality. Regular eating times and extended fasting may help prevent obesity, diabetes, and liver disease.
Researchers at Salk Institute and Iowa State University identified three plant proteins involved in regulating fatty acid production. The discovery may lead to improved crop yields and higher quality oils for food, nutrition, biorenewable chemicals, and biofuels.
Scientists at the Salk Institute have identified fibroblast growth factor 1 (FGF1) as a crucial protein in maintaining insulin sensitivity and regulating fat storage. The discovery offers new avenues for treating type 2 diabetes, potentially providing a more natural alternative to existing antidiabetic drugs.
Researchers found that phytochrome interacting factor 7 (PIF7) serves as key messenger between plant's cellular light sensors and production of auxins, hormones that stimulate stem growth. This discovery could lead to high-yield crops that gather light more efficiently and make better use of farmland.
Researchers at Salk Institute discover molecular switch controlling liver glucose production, potentially offering new avenue for treating insulin-resistant type II diabetes. The discovery may lead to agents that can selectively damp down activity of the IP3 spigot and calcineurin accelerator to lower blood sugar levels.
Researchers at Salk Institute find that two cellular switches play a crucial role in maintaining normal sleeping and eating cycles and metabolism. The discovery suggests a powerful link between circadian rhythms and metabolism, potentially leading to new treatments for disorders such as sleep problems, obesity, and diabetes.
Scientists at Salk Institute create worm model that relies on alternative lengthening of telomeres (ALT) pathway to maintain telomeres, a key strategy used by cancer cells. The study provides valuable tool to block ALT and induce senescence in tumor cells, with potential for developing new anti-cancer drugs.
Researchers found that telomeres send out a molecular SOS signal when cells take too long to divide, leading to the activation of DNA damage pathways and cell death. This discovery has implications for cancer chemotherapy, suggesting ways to make therapy more potent by combining mitotic inhibitors with other drugs.
Scientists at Salk Institute find that a single injection of cocaine or methamphetamine produces a long-lasting cellular memory trace, which could be the brain's way of resisting powerful psychostimulants. This protective response might be harnessed to treat addiction, according to the study.
Salk researchers have identified a new potential drug target for treating certain types of lung cancer. By blocking the activity of the enzyme IKK2, which regulates inflammation, the study found that tumors grew more slowly and animals lived longer.
A study published in Cell reveals that only a handful of genes and proteins guide the growth of motor neurons, which eventually connect with muscles. This discovery may lead to new therapies for ALS and provide insight into certain cancers.
Researchers found striking similarities between genetic signatures of human breast cancer and those of stem cells in mouse embryos, revealing a new way to predict and personalize cancer therapies. The discovery could lead to the development of targeted treatments for aggressive forms of triple-negative breast cancer.
Researchers at the Salk Institute found that certain proteins, called extremely long-lived proteins (ELLPs), last a lifetime without being replaced. Damage to these proteins weakens the ability of transport channels to safeguard the cell's nucleus from toxins, leading to cellular aging.
Researchers at the Salk Institute discovered a gene called multicilin that tells cells to develop multiple cilia, tiny structures moving fluids through the lungs and brain. This finding may help create new therapies using stem cells to replace damaged lung tissues with healthy ones.
Researchers at the Salk Institute have produced neuron-by-neuron maps of the mouse brain's visual processing system, laying the groundwork for decoding brain circuitry using genetic research techniques. The study revealed specialized roles for different areas in processing visual information, including direction and fine detail.
Researchers at Salk Institute find connection between cryptochromes and glucocorticoid receptors to regulate sugar metabolism, potentially avoiding side effects of asthma, allergies, and arthritis drugs. The discovery may lead to new therapies targeting the biological clock.
Researchers at the Salk Institute have developed a new gene editing technique that uses patients' own cells to correct genetic mutations in the HBB gene, which causes sickle cell disease. The method repairs the beta-globin gene without introducing harmful genes into cells and appears to be more efficient than traditional techniques.
Researchers have discovered a new way to build muscle by suppressing a natural inhibitor, resulting in mice and worms with super-strong muscles. This breakthrough could lead to treatments for age-related or genetics-related muscle degeneration, as well as applications for athletes and individuals with genetic muscular dystrophy.
Researchers found that boosting a gene in fruit flies' intestinal stem cells extended their lifespan by up to 50% and delayed the aging of their intestine. The study suggests that the gene, PGC-1, can act as a biological dial for slowing the aging process and may serve as a target for new therapies.
Researchers at Salk Institute discover a protein that defends against cancer also plays a key role in steroids' anti-inflammatory action. Targeting this protein could lead to new drugs without steroid side effects. The study suggests some cancer patients may not need steroid treatment due to genetic mutations.
Scientists at Salk Institute discovered a new form of RDS in newborn mice and traced it to cellular receptor for thyroid hormone. Drugs used for treating overactive thyroid glands saved mice with deadly genetic alteration mimicking the lung problem, offering clues for new treatments.
Scientists have discovered a new component of the biological clock, a gene responsible for starting the clock from its restful state every morning. This discovery may help explain the genetic underpinnings of sleeplessness, aging and chronic illnesses such as cancer and diabetes.
Researchers at Salk Institute have discovered how a hormone turns on molecular switches inside the pancreas, increasing insulin production. The finding raises the possibility of new designer drugs to help Americans with type 2 diabetes or pre-diabetic insulin resistance.
Researchers at Salk Institute developed bacteria that can incorporate unnatural amino acids into proteins, enabling the creation of new synthetic chemicals. This breakthrough may lead to the development of drugs that last longer in the bloodstream and environmentally friendly manufacturing methods.
Researchers at Salk Institute discover a "hidden" code linked to DNA that allows plants to develop and pass down new biological traits rapidly. The epigenetic code is found to evolve more quickly than the genetic code and strongly influence biological traits.
An international research team has shown that an investigational agent that sticks onto the surface of tumor cells can effectively image tumors. The 'antagonist', 111In-DOTA-BASS, outperformed the widely used 'agonist' agent, OctreoScan, in detecting neuroendocrine tumors.
Researchers found that Vax proteins deploy a weapon to disarm the dorsalizer Wnt, leaving the embryo free to develop a proper brain. The study's findings define how the embryonic nervous system develops and could shed light on mechanisms underlying colon cancer.
Researchers from Salk Institute and Dana Farber Cancer Institute mapped thousands of protein-to-protein interactions in Arabidopsis thaliana, revealing networks and functional groups. The dataset provides new insights into plant evolution and potential for breeding more resilient agricultural plants.
Scientists at the Salk Institute developed a new technique to generate large numbers of blood cells from patient cells, improving efficiency by 84% compared to previous methods. However, further refinements are needed to produce transplantable HSCs.
Researchers at Salk Institute use genetically embedded tools to study neural stem cell differentiation and protein activity in brain cells. The technique, described in a recent study, may aid in the development of regenerative medicine and help scientists understand the mysteries of stem cells.
Researchers at Salk Institute find that a short segment of p53 regulates activity in blood-forming stem cells, affecting their survival and proliferation after DNA damage. The study suggests that targeting this regulatory mechanism with drugs could reduce unwanted tissue damage from chemotherapy or radiation treatment.
Researchers found that a strawberry a day may keep doctors away, including neurologists, endocrinologists, and oncologists. Fisetin, a flavonoid compound, reduced complications of diabetes, anxiety-related behaviors, and high blood sugar levels in mice.
Joseph R. Ecker, a renowned plant biologist, has been selected as an HHMI-GBMF Investigator for his pioneering work on Arabidopsis thaliana genome sequencing and genomic methylation patterns. His research aims to explore epigenetic mechanisms in plants and their relevance to human health and disease.
Researchers at the Salk Institute will investigate the connection between genetics and social behavior using Williams syndrome as a model. They hope to gain insight into other neurodevelopmental disorders such as autism.
Researchers at Salk Institute successfully edit a diseased gene in patient-specific induced pluripotent stem cells and adult stem cells using a virus-based approach. The method provides an efficient and safe tool for cell engineering, opening the way for gene editing-based stem cell therapies suitable for clinical applications.
Researchers at the Salk Institute identified a signaling molecule called heme that drives expression of photosynthesis-related genes. This discovery may help plants overcome stress and improve growth, leading to increased crop yields and better plant health.
Researchers at Salk Institute discover a unique fasting pathway that turns up glucose production in the liver when blood sugar levels drop, providing a novel way to treat metabolic disease. Inhibiting histone deacetylases (HDACs) may help regulate blood glucose levels and prevent type II diabetes.
A study by Salk Institute scientists reveals that insulin activates a factor called SIK3, which promotes lipid storage during daytime feeding hours by blocking fat breakdown programs. This link between glucose metabolism and lipid storage has potential applications in treating metabolic conditions such as obesity and type II diabetes.
Researchers at the Salk Institute have uncovered a new structural beacon, called the C-tail, which is found in half of all telomeres in alternative lengthening of telomeres (ALT) tumors. This unique feature may be a key to understanding cancer cell immortality and developing effective treatments.
Researchers created patient-derived iPSCs, which were then differentiated into neurons to study schizophrenia. The study found that these neurons connected less frequently with each other and had misregulated gene expression profiles, but Loxapine restored connectivity. The findings provide a new model for understanding the disease mec...
Forced splicing of p21Cip1 gene leads to its down-regulation and induction of programmed cell death in cancer cells. This finding suggests new approaches to enhance chemotherapeutic drug efficacy by inhibiting splicing.