Researchers propose AI-based surrogate brain framework that integrates forward modeling, inverse problem solving, and evaluation to build next-generation data-driven models. The framework enables applications such as predicting future whole-brain activity, performing dynamical systems analysis, and guiding neurostimulation strategies.
This review systematically outlines deubiquitinases' roles in various liver diseases, including metabolic dysfunction-associated steatotic liver disease, liver fibrosis, viral hepatitis, and hepatocellular carcinoma. It highlights their potential as therapeutic targets and emerging technologies for targeting DUBs.
Researchers developed a new formulation for neutral triple gauge couplings, ensuring compatibility with the Standard Model Effective Field Theory. They estimated that future electron-positron colliders can probe these effects, outperforming the LHC and a future 100-TeV proton-proton collider
Research reveals that Methanogenic archaea, particularly M. smithii, play a crucial role in postnatal growth retardation by depleting β-hydroxybutyrate levels and inducing liver inflammation. Transplanting fecal microbiome from PGR piglets to mice confirms the same phenotypes.
The Battery Large Model system revolutionizes battery design, manufacturing, operation, and recycling through AI-simulation synergy. It provides a novel technological path for the industry's intelligent upgrade, enabling autonomous design scheme generation, accurate performance prediction, and intelligent defect detection.
Researchers discovered that locusts regurgitate to repel ant attacks, and the mixture of diethyl glutarate, 3-methylindole, and 2-(formylamino)benzoic acid stimulates ant gustation, leading to aversion
The VTA method creates an optimal internal architecture within photovoltaic material, resulting in devices with high performance and extended stability. Champion cells reached 20.5% power conversion efficiency and demonstrated improved structural organization and reduced degradation.
Researchers discovered that moderate ROS levels increase cell vitality and resistance to senescence in endometrial stromal cells, contributing to endometriosis progression. Identifying the CHK1/SGK1 axis as a crucial sensor of ROS, the study suggests that targeting this pathway could lead to more effective treatments for endometriosis.
Researchers investigated the geochemical behavior of calcium isotopes during carbonate weathering in the Lancang River. The study found that dissolved Ca showed variations of δ44/40Ca values along the river flow, with suspended sediments enriched in light Ca isotopes controlled by mineralogy.
Researchers propose combining altermagnetism with molecular ferroelectrics for precise spin polarization control. This breakthrough enables electrically writable, multi-level magnetic memories and ultra-low-power spintronic devices.
A new biomimetic mRNA delivery platform improves PTEN expression levels in patients with colorectal cancer. The system boosts precision immunotherapy by targeting tumors and evading the immune system.
A new bio-heterojunction platform integrates electrogenic bacteria with piezoelectric nanoparticles to eradicate colorectal tumors and restore the gut microbiome. The platform induces two distinct forms of tumor cell death, apoptosis and pyroptosis, and effectively remolds the tumor microenvironment.
A research team at the Purple Mountain Observatory confirms Stephen Hawking's prediction that a black hole's horizon area cannot shrink when two black holes merge. The analysis of GW230814 shows strong support for the black-hole area law, validating general relativity in extreme astrophysical environments.
Researchers have developed two novel fullerene derivatives to stabilize inverted perovskite solar cells, achieving higher efficiency and stability. The new electron transport layers show improved performance and operational stability under continuous light exposure.
Researchers propose femtoscopy to distinguish between resonance, virtual state, and bound state scenarios for tetraquarks Z_c (3900) and Z_cs (3985). The method reveals distinct momentum-dependent behaviors in the low-momentum region.
A study found that fungal oxalic acid (OA) regulates the extracellular domain (ECD) of CERK1 through site-specific deamidation, impairing chitin-triggered plant immunity. This mechanism enables fungal pathogens to suppress host defenses.
Researchers developed a unified theory for integrated radiation-scattering manipulation, enabling on-demand design of RIS. The meta-atom combines phase, polarization, amplitude, waveform, frequency, and time properties, providing multifunctional capabilities within a single platform.
A new unified mathematical description model for coastal tipping points has been introduced, addressing escalating risks in coastal zones. The model classifies tipping points into six types, including bifurcation-driven, noise-driven, and shock-driven, highlighting the need for integrated strategies to mitigate regime shifts.
Scientists have discovered that Earth's inner core exists in a superionic state, where light elements flow through a solid iron lattice, dramatically softening it. This discovery redefines our understanding of the planet's deepest interior and offers new perspectives on seismic anisotropy and Earth's magnetic field.
The study found that the SAA proton flux center has been drifting westward and northward over five years, with lower-energy protons responding faster to geomagnetic inhomogeneity. The CSES satellite data also showed a significant decrease in the area of the SAA proton flux between 2019 and 2024, correlated with solar activity.
Researchers have discovered that certain seawater ions can be intentionally utilized to enhance electrochemical performance, rather than hindering it. This involves carefully designing catalysts and electrolytes to mitigate the negative effects of these ions while maximizing their benefits.
LD-110, a potent LSD1 PROTAC degrader, induces ER stress and apoptosis in cancer cells by degrading LSD1 and increasing H3K4me2 levels. This study reports the discovery of LD-110 as a highly effective therapeutic agent with potential synergistic effects when combined with GSPT1 degraders.
A team of researchers from Fudan University developed an ultrafast non-volatile memory using a 2D van der Waals heterostructure and metal-nanocrystal storage layer. The device achieves a large memory window, sharp interfaces, and significant endurance, making it suitable for high-speed and robust memory applications.
Researchers successfully established an Hmgn3-overexpressing embryonic stem cell line that exhibits advanced cellular plasticity and can differentiate into extraembryonic tissues. Overexpression of Hmgn3 enables these cells to stably contribute to the fetus, placenta, and yolk sac in vivo.
A recent study found that Mongolia has become a major source of dust emissions in Central East Asia, with total emissions increasing sevenfold from 2020 to 2023. The study attributes this shift to stronger surface winds, vegetation degradation, and reduced soil moisture.
Researchers propose a closed-loop system combining peripheral nerve stimulation (PNS) with brain-computer interfaces (BCIs) to personalize neuromodulation. This approach aims to address treatment-resistant depression and schizophrenia by dynamically tailoring interventions to individual neural signatures.
Researchers discovered that more symmetric states can restore symmetry faster than less symmetric ones in MBL systems, exhibiting the quantum Mpemba effect. This phenomenon occurs even without thermalization, shedding light on universal principles of nonequilibrium dynamics.
ADCs use targeted antibodies to deliver cytotoxic payloads directly into cancer cells, destroying tumors while minimizing harm to healthy cells. Two ADCs have been approved by the FDA for gynecological cancer treatment, and numerous others are in clinical trials.
Researchers have discovered a new polar order in a hybrid crystal, ferrielectricity, which enables electric control of spin-orbit coupling and circular photogalvanic effect. The material's switchable net polarization, asynchronous switching, and field-driven polar-to-polar transition demonstrate its unique properties.
Researchers propose a multi-pronged strategy to boost grain number in wheat by unlocking branched varieties, maintaining meristem activity, improving floret fertility, and enhancing nutrient transport. A multi-omics approach integrating genomics, metabolomics, and phenomics will be used to re-engineer wheat inflorescence architecture a...
Researchers have designed a new oligomer-based organic photodetector that achieves efficient SWIR (Short-Wavelength Infrared) photoresponse. The device features a thiophene-fused BODIPY tetramer with meta-dicyanophenyl end groups, enabling J-aggregation and cooperative molecular packing behavior.
Researchers designed a SPAN||Gr battery system with an optimized N/P ratio, achieving increased energy density. The anion-mediated electrolyte LH enabled stable electrochemical kinetics and improved cycle life. Lithium deposition on graphite showed a compact and smooth morphology in the LH system.
Researchers developed a universal texture-controlled approach for scalable fabrication of large-scale single-crystal metal foils. The method involves three stages: tailored cold rolling, controlled low-temperature recrystallization, and high-temperature annealing.
A research team led by Professor Shushi Peng has estimated global biological nitrogen fixation for natural land ecosystems, revealing substantial biases in widely used Earth System Models. The team found that the models underestimate natural terrestrial nitrogen fixation by up to 18%, with a multi-model mean of ~67.7 Tg N yr-1.
Researchers developed a biocatalytic platform using CYP152 peroxygenases for efficient α-hydroxylation of aromatic carboxylic acids, achieving high enantiomeric excess values and isolated yields above 92%. This green alternative offers a sustainable solution for the cost-effective production of enantiopure hydroxy acids.
The first 2D semiconductor FPGA has successfully integrated approximately 4,000 transistors on a wafer scale, marking a significant transition for 2D electronics. The device utilizes an independently innovated integration process platform to overcome critical challenges and achieve reliable operation.
Researchers studied mechanical properties of solids as a function of grain size and boundary thickness, revealing that thick boundaries improve strength and ductility in single-component face-centered cubic materials. However, for other materials, increasing boundary thickness softens the material due to dislocation-dominated plasticity.
Researchers designed a self-powered, compact tactile interface using an MXene/Bi 2D heterojunction. The device combines sensing, encoding, and low-power readout, achieving high sensitivity, fast response, and durability.
A new gradient anode design addresses key challenges in sodium batteries, achieving high-energy-density and stable performance. The symmetric cell demonstrates ultralong cycle life and unprecedented energy density of 200 Wh kg-1.
A new study found that failing to degrade maternal mRNAs triggers genomic traffic jams in mouse embryos, halting development at the first step. The research team discovered that increased chromatin accessibility and abnormal transcription regulation lead to R-loop formation, causing replication stress and DNA damage.
A new study finds that rare and common genetic variants counterbalance each other to maintain telomere stability. The researchers used data from 379,764 participants and found a compensatory genetic mechanism that prevents extreme shortening or lengthening of telomeres.
A swarm of miniature magnetic soft robots, inspired by fish schools, can coordinate their movements to deliver targeted drug therapy to diseased tissue. The robots can navigate through narrow passages and adapt their shape to conform to the lesion's boundaries for optimal drug delivery coverage.
The study reveals that North America and Europe will experience significant warming (3.7-3.8°C) and drought expansion by the end of the 21st century due to land-air coupling, which amplifies the impact of GHG emissions. If uncontrolled, this could lead to severe climate risks, including reduced Gross Primary Productivity.
A Chinese research team developed an innovative device that skips CO₂ purification, cuts costs, and produces commercial-grade HCOOH directly from dilute emissions. The membrane-integrated electrolyzer concentrates CO2 to high levels for efficient conversion, producing a valuable liquid fuel and industrial chemical.
Researchers have designed a new catalyst that stabilizes oxidized copper species under reducing potentials, enabling highly efficient and stable CO2 conversion to C2+ products. The cerium oxide nano-islands act as nanoscale anchors, preserving the active copper oxidation states.
Researchers from China have developed a bistatic dual-comb ranging approach that achieves nanometer-level absolute distance measurement over 113 kilometers, surpassing previous limitations. This technology provides breakthrough technical support for large-scale space research programs.
The SQUIRE project deploys quantum spin sensors on the China Space Station to search for pseudomagnetic fields induced by exotic interactions. These interactions can induce energy shifts in atomic energy levels, which can be detected as pseudomagnetic fields by quantum spin sensors.
Microbial metabolites from the gut microbiome influence gene expression, cellular function, and host health. The MDME axis proposes a unified theoretical framework explaining this complex dialogue.
A glassy metal-organic framework coating accelerates ion desolvation, stripping solvent molecules from lithium ions, while a second layer enables rapid transport into the graphite bulk. This synergistic design results in unprecedented fast-charging performance, with batteries maintaining high capacity and stability.
A recent study analyzed data from 4,348 pediatric patients with congenital heart disease to identify key predictors of prolonged ICU stays. The research highlights the importance of patient-specific and post-operative management factors in reducing extended care.